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ORIGINAL ARTICLE

The Safety and Efficacy of Zileuton Controlled-Release Tablets as Adjunctive Therapy to Usual Care in the Treatment of Moderate Persistent Asthma: A 6-Month Randomized Controlled Study

, M.D., , M.D., , M.D., , M.D., , M.D., , PhD., , M.Sc., cSTAT, , Ph.D. & , B.Sc. (Hons) show all
Pages 305-310 | Published online: 02 Jul 2009

References

  • MacGlashan D W, Schleimer R P, Peters S P, Schulman E S, Adam G K, Newball H H, et al. Generation of leukotrienes by purified human lung mast cells. J Clin Invest 1982; 70: 747–751
  • Fels A O, Pawlowski N A, Cramer E B, Kin T K, Cohn Z A, Scott W A. Human alveolar macrophages produce leukotriene B4. Proc Natl Acad Sci U SA 1982; 79: 7866–7870
  • Weller P F, Lee C W, Foster D W, Corey E J, Austern K F, Lewis R A. Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc Natl Acad Sci U SA 1983; 80: 7626–7630
  • Henderson W R. The role of leukotrienes in inflammation. Ann Int Med 1994; 121: 684–697
  • Currie G P, Lee D KC, Srivastava P. Long-acting bronchodilator or leukotriene modifier as add-on therapy to inhaled corticosteroids in persistent asthma?. Chest 2005; 128: 2954–2962
  • Dworski R, Fitzgerald G A, Oates J A, et al. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. Am J Respir Crit Care Med 1994; 149: 953–959
  • Dempsey O J. Leukotriene receptor antagonist therapy. Post-grad Med J 2000; 76: 767–773
  • Dube L M, Swanson L J, Awni W M, Bell R L, Carter G W, Ochs R F. Zileuton: the first leukotriene synthesis inhibitor for use in the management of chronic asthma. Five-Lipoxygenase Products in Asthma, J M Drazen, S-E Dahlen, T H Lee. Marcel Dekker, Inc., New York 1998; 391–428
  • Israel E, Cohn J, Dubé L, Drazen J M, for the Zileuton Clinical Trial Group. Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. JAMA 1996; 275: 931–936
  • Product Label, Zyflo® (Zileuton Tablets), Revised November 2005
  • Juniper E F, Guyatt G H, Epstein R S, Ferrie P J, Jaeschke R, Hiller T K. Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax 1992; 46: 76–83
  • Benichou C, et al. Criteria of drug-induced liver disorders: report of an international consensus meeting. J Hepatol 1990; 1: 272–276
  • Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nature Rev/Drug Discov 2005; 4: 489–499

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