Effectiveness of High Repeated Doses of Inhaled Budesonide or Fluticasone in Controlling Acute Asthma Exacerbations in Young Children

References

• Schuh S, Reisman J, Alshehri M, Dupuis A, Corey M, Arseneault R, Alothman G, Tennis O, Canny G. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med 2000; 343: 689–694
   PubMed Web of Science ®Google Scholar
• Gibson P G, Powell H. Initial corticosteroid therapy for asthma. Curr Opin Pulm Med 2006; 12(1)48–53
   PubMedGoogle Scholar
• Hendeles L, Sherman J. Are inhaled corticosteroids effective for acute exacerbations of asthma in children?. J Pediatr 2003; 142: S26–S33
   PubMed Web of Science ®Google Scholar
• Schuh S, Dick P T, Stephens D, Hartley M, Khaikin S, Rodrigues L, Coates A L. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics 2006; 118(2)644–650
   PubMedGoogle Scholar
• Volovitz B. Inhaled budesonide in the management of acute worsenings and exacerbations of asthma: A review of the evidence. Respir Med. 2007; 101(4)685–695, Epub 2006, Nov 27
   PubMedGoogle Scholar
• Rodrigo G J. Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest 2006; 130(5)1301–1311
   PubMed Web of Science ®Google Scholar
• Volovitz B, Nussinovitch M. Management of children with severe asthma exacerbation in the emergency department. Paediatr Drugs 2002; 4: 141–148
   PubMedGoogle Scholar
• GINA. Pocket guide for asthma management and prevention. The Global Initiative for Asthma (GINA). 2006; 18
   Google Scholar
• Garrett J, Williams S, Wong C, Holdaway D. Application of asthma action plans to childhood asthma: a national survey. NZ J Med. 1997; 110: 308–310
   PubMed Web of Science ®Google Scholar
• Edmonds M L, Camargo C A, Jr., Pollack C V, Rowe B H. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma (Cochrane review). The Cochrane Library, Version 4. Update Software, Oxford 2003
   Google Scholar
• McKean M, Ducharme F. Inhaled steroids for episodic viral wheeze of childhood (Cochrane review). The Cochrane Library. Update Software, Oxford 2000, Issue 4
   Google Scholar
• Volovitz B, Bentur L, Finkelstein Y, Mansour Y, Shalitin S, Nussinovitch M, Varsano I. Effectiveness and safety of inhaled corticosteroids in controlling acute asthma attacks in children who were treated in the emergency department: a controlled comparative study with oral prednisolone. J Allergy Clin Immunol 1998; 102: 605–609
   PubMed Web of Science ®Google Scholar
• Singhi S, Banerjee S, Nanjundaswamy H. Inhaled budesonide in acute asthma. J Paediatr Child Health 1999; 35: 483–487
   PubMed Web of Science ®Google Scholar
• Devidayal Singhi S, Kumar L, Jayshree M. Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma. Acta Paediatr 1999; 88: 835–840
   PubMed Web of Science ®Google Scholar
• Matthews E E, Curtis P D, McLain B I, Morris L S, Turbitt M L. Nebulized budesonide versus oral steroid in severe exacerbations of childhood asthma. Acta Paediatr 1999; 88: 841–843
   PubMed Web of Science ®Google Scholar
• Manjra A I, Price J, Lenney W, Hughes S, Barnacle H. Efficacy of nebulized fluticasone propionate compared with oral prednisolone in children with an acute exacerbation of asthma. Respir Med 2000; 94: 1206–1214
   PubMed Web of Science ®Google Scholar
• Rodrigo G, Rodrigo C. Inhaled flunisolide for acute severe asthma. Am J Respir Crit Care Med 1998; 157: 698–703
   PubMed Web of Science ®Google Scholar
• Scarfone R J, Loiselle J M, Wiley J F, 2nd, Decker J M, Henretig F M, Joffe M D. Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children. Ann Emerg Med 1995; 26: 480–486
   PubMed Web of Science ®Google Scholar
• Sung L, Osmond M H, Klassen T P. Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma. Acad Emerg Med 1998; 5: 209–213
   PubMed Web of Science ®Google Scholar
• Connett G, Lenney W. Prevention of viral induced asthma attacks using inhaled budesonide. Arch Dis Child 1993; 68: 85–87
   PubMed Web of Science ®Google Scholar
• Svedmyr J, Nyberg E, Thunqvist P, Asbrink-Nilsson E, Hedlin G. Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections. Acta Paediatr 1995; 84: 884–888
   PubMed Web of Science ®Google Scholar
• Svedmyr J, Nyberg E, Asbrink-Nilsson E, Hedlin G. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr 1999; 88: 42–47
   PubMed Web of Science ®Google Scholar
• Volovitz B, Nussinovitch M, Finkelstein Y, Harel L, Varsano I. Effectiveness of inhaled corticosteroids in controlling acute asthma exacerbations in children at home. Clin Pediatr 2001; 40: 79–86
   PubMed Web of Science ®Google Scholar
• Volovitz B, Amir J, Malik H, Kaushansky A, Varsano I. Growth and pituitary-adrenal function in children with severe asthma treated with inhaled budesonide. N Engl J Med 1993; 329: 1703–1738
   PubMed Web of Science ®Google Scholar
• Varsano I, Volovitz B, Malik H, Amir Y. Safety of one year treatment with budesonide in young children with asthma. J Allergy Clin Immunol 1990; 5: 914–920
   Google Scholar
• Volovitz B, Soferman R, Blau H, Nussinovitch M, Varsano I. Rapid induction of clinical response with a short-term high-dose starting-schedule of budesonide nebulizing suspension in young children with recurrent wheezing episodes. J Allergy Clin Immunol 1998; 101: 464–469
   PubMed Web of Science ®Google Scholar
• Garrett J, Williams S, Wong C, Holdaway D. Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid. Arch Dis Child 1998; 79: 12–17
   PubMed Web of Science ®Google Scholar
• Kaplan M A, Goldin M. The use of triacetyloleandomycin in chronic infectious asthma. Antibiotics Manual, 1958–1959, H Welch, F Marti-Ibanez. Interscience, New York 1959; 273–276
   Google Scholar
• Ferrara G, Losi M, Franco F, Corbetta L, Fabbri M, Richeldi L. Macrolides in the treatment of asthma and cystic fibrosis. Respir Med Jan, 2005; 99(1)1–10
   PubMedGoogle Scholar
• Lieberman D, Lieberman D, Printz S, Ben-Yaakov M, Lazarovich Z, Ohana B, Friedman M G, Dvoskin B, Leinonen M, Boldur I. Atypical pathogen infection in adults with acute exacerbation of bronchial asthma. Am J Respir Crit Care Med 2003; 167: 406–410
   PubMed Web of Science ®Google Scholar
• Hahn D L, Bukstein D, Luskin A, Zeitz H. Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma. Ann Allergy Asthma Immunol Jan, 1998; 80(1)45–49
   PubMed Web of Science ®Google Scholar
• Amsden G W. Anti-inflammatory effects of macrolides–an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?. J Antimicrob Chemother Jan, 2005; 55(1)10–21
   PubMed Web of Science ®Google Scholar
• Volovitz B, Shkap R, Amir J, Calderon S, Varsano I, Nussinovitch M. Absence of tooth staining with doxycycline treatment in young children. Clin Pediatr (Phila.) 2007; 46(2)121–126
   PubMedGoogle Scholar
• Hodsman A B, Toogood J H, Jennings B, Fraher L J, Baskerville J C. Differential effects of inhaled budesonide and oral prednisolone on serum osteocalcin. J Clin Endocrinol Metab 1991; 72: 530–540
   PubMed Web of Science ®Google Scholar
• Wolthers O D, Riis B J, Pedersen S. Bone turnover in asthmatic children treated with oral prednisolone or inhaled budesonide. Pediatr Pulmonol 1993; 16: 341–346
   PubMed Web of Science ®Google Scholar
• Hedlin G, Svedmyr J, Ryden A-C. Systemic effects of a short course of betamethasone compared with high-dose inhaled budesonide in early childhood asthma. Acta Paediatr 1999; 88: 48–51
   PubMedGoogle Scholar
• Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther 1972; 13: 694–702
   PubMed Web of Science ®Google Scholar
• Pedersen S. Clinical Safety of inhaled corticosteroids for asthma in children: An update of long-term trials. Drug Saf 2006; 29(7)599–612
   PubMedGoogle Scholar
• Barnes P J. Inhaled glucocorticoids for asthma. N Engl J Med 1995; 332: 868–875
   PubMed Web of Science ®Google Scholar
• Zora J A, Zimmerman D, Carey T L. Hypothalamic-pituitary-adrenal axis suppression after short-term, high-dose glucocorticoid therapy in children with asthma. J Allergy Clin Immunol 1986; 77: 9–13
   PubMed Web of Science ®Google Scholar
• Hendeles L. Selecting a systemic corticosteroid for acute asthma in young children. J Pediatr 2003; 142(2 Suppl)S40–S44
   PubMed Web of Science ®Google Scholar
• Volovitz B, Kauschansky A, Nussinovitch M, Harel I, Varsano I. Normal diurnal variation in serum cortisol concentration in asthmatic children treated with inhaled budesonide. J Allergy Clin Immunol 1995; 96: 874–878
   PubMed Web of Science ®Google Scholar
• De Benedictis F M, Del Giudice M M, Vetrella M, Tressanti F, Tronci A, Testi R, Dasic G; Flic12 Study Group. Nebulized fluticasone propionate vs. budesonide as adjunctive treatment in children with asthma exacerbation. J Asthma 2005; 42(5)331–336
   PubMed Web of Science ®Google Scholar
• Expert Panel Report 3 (EPR3): Guidelines for the Diagnosis and Management of Asthma National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. NHLBI produced publications. August 28, 2007
   Google Scholar
• FitzGerald J M, Shragge D, Haddon J, Jennings B, Lee J, Bai T, Pare P, Kassen D, Grunfeld A. A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation. Can Respir J 2000; 7(1)61–67
   PubMedGoogle Scholar