The effects of antisense interleukin-4 gene transferred by recombinant adeno-associated virus vector on the airway remodeling in allergic rats

References

• Jenkins HA, Cool C, Szefler SJ, Covar R, Brugman S, Gelfand EW, Spahn JD. Histopathology of severe childhood asthma: a case series. Chest 2003; 124(1):32–41.
   PubMed Web of Science ®Google Scholar
• Heaney LG, Robinson DS. Severe asthma treatment: need for characterising patients. Lancet 2005; 365(9463):974–976.
   PubMed Web of Science ®Google Scholar
• Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008; 121(3):560–570.
   PubMed Web of Science ®Google Scholar
• Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol 2007; 19(6):676–680.
   PubMedGoogle Scholar
• Miller M, Cho JY, McElwain K, McElwain S, Shim JY, Manni M, Baek JS, Broide DH. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am J Physiol Lung Cell Mol Physiol 2006; 290(1):L162–L169.
   Google Scholar
• Saglani S, Payne DN, Zhu J, Wang Z, Nicholson AG, Bush A, Jeffery PK. Early detection of airway wall remodelling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007; 176(9):858–864.
   PubMed Web of Science ®Google Scholar
• Phipps S, Benyahia F, Ou TT, Barkans J, Robinson DS, Kay AB. Acute allergen-induced airway remodeling in atopic asthma. Am J Respir Cell Mol Biol 2004; 31(6):626–632.
   PubMedGoogle Scholar
• Molet S, Rumos-Barbon D, Martin JG, Hamid Q. Adoptively transferred late allergic response is inhibited by IL-4, but not IL-5, antisense oligonucleotide. J Allergy Clin Immunol 1999; 104(1):205–214.
   PubMedGoogle Scholar
• Nishikubo K, Murata Y, Tamaki S, Sugama K, Imanaka-Yoshida K, Yuda N, Kai M, Takamura S, Sebald W, Adachi Y, Yasutomi Y. A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. Gene Ther 2003; 10(26):2119–2125.
   PubMedGoogle Scholar
• Zavorotinskaya T, Tomkinson A, Murphy JE. Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13. Mol Ther 2003; 7(2):155–162.
   PubMedGoogle Scholar
• Ahn JH, Kim CH, Kim YH, Kim SJ, Lee SY, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kwon SS. Inflammatory and remodeling events in asthma with chronic exposure to house dust mites: a murine model. J Korean Med Sci 2007; 22(6):1026–1033.
   PubMedGoogle Scholar
• Cao Y, Xiong WN, Xu YJ, Zhang ZX, Gao BA, Du CL, Lu JY, Ye T. Recombinant adeno-associated virus-mediated inhibiting of interleukin-4 expression in rat model of asthma. Chin Med J (Engl) 2006; 119(3):223–225.
   PubMedGoogle Scholar
• Ma Y, Hayglass KT, Becker AB, Halayko AJ, Basu S, Simons FE, Peng Z. Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice. Allergy 2007; 62(6):675–682.
   PubMed Web of Science ®Google Scholar
• Steinke JW. Anti-interleukin-4 therapy. Immunol Allergy Clin North Am 2004; 24(4):599–614.
   PubMed Web of Science ®Google Scholar
• Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 2002; 130(1):93–100.
   PubMed Web of Science ®Google Scholar
• Steinke JW, Borish L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res 2001; 2(2):66–70.
   PubMed Web of Science ®Google Scholar
• Leigh R, Ellis R, Wattie JN, Hirota JA, Matthaei KI, Foster PS, O'Byrne PM, Inman MD. Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med 2004; 169(7):860–867.
   PubMedGoogle Scholar
• Hildinger M, Auricchio A. Advances in AAV-mediated gene transfer for the treatment of inherited disorders. Eur J Hum Genet 2004; 12(4):263–271.
   PubMedGoogle Scholar
• Rabinowitz JE, Rolling F, Li C, Conrath H, Xiao W, Xiao X, Samulski RJ. Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol 2002; 76(2):791–801.
   PubMed Web of Science ®Google Scholar
• Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther 2006; 14(3):316–327.
   PubMed Web of Science ®Google Scholar
• Xiao X, Li J, Samulski RJ. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol 1998; 72(3):2224–2232.
   PubMed Web of Science ®Google Scholar
• Auricchio A, Hildinger M, O'Connor E, Gao GP, Wilson JM. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum Gene Ther 2001; 12:71–76.
   PubMed Web of Science ®Google Scholar
• Tang HF, Song YH, Chen JC, Chen JQ, Wang P. Upregulation of phosphodiesterase-4 in the lung of allergic rats. Am J Respir Crit Care Med 2005; 171:823–828.
   PubMedGoogle Scholar
• Zeng D, Cao Y, Song Q, Cao C, Liu X, Xu Y, Xiong W. Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic rats. Respirology 2010; 15:132–140.
   PubMedGoogle Scholar
• Renzi PM, Olivenstein R, Martin JG. Inflammatory Cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Respir Dis 1993; 147:967–974.
   PubMed Web of Science ®Google Scholar
• Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med 2000; 161:627–635.
   PubMed Web of Science ®Google Scholar
• Song DJ, Min MG, Miller M, Cho JY, Yum HY, Broide DH. Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int Arch Allergy Immunol 2010; 151:285–296.
   PubMedGoogle Scholar
• Vanacker NJ, Palmans E, Kips JC, Pauwels RA. Fluticasone inhibits but does not reverse allergen-induced structural airway changes. Am J Respir Crit Care Med 2001; 163(3 Pt 1):674–679.
   PubMed Web of Science ®Google Scholar
• Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol 2001; 166(4):2760–2767.
   PubMedGoogle Scholar
• Coyle AJ, Le Gros G, Bertrand C, Tsuyuki S, Heusser CH, Kopf M, Anderson GP. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol 1995; 13(1):54–59.
   PubMed Web of Science ®Google Scholar
• Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA, Pauwels RA, Bluethmann H. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 1994; 24(1):73–80.
   PubMed Web of Science ®Google Scholar
• Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca AM, Bellia V, Bonsignore G, Bousquet J. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156(2 Pt 1):591–599.
   PubMedGoogle Scholar
• Bottoms SE, Howell JE, Reinhardt AK, Evans IC, McAnulty RJ. TGF-beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. PLoS One 2010; 5:e9674.
   PubMed Web of Science ®Google Scholar
• Doucet C, Brouty-Boyé D, Pottin-Clémenceau C, Canonica GW, Jasmin C, Azzarone B. Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Invest 1998; 101(10):2129–2239.
   PubMed Web of Science ®Google Scholar
• Hashimoto S, Gon Y, Takeshita I, Maruoka S, Horie T. IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway. J Allergy Clin Immunol 2001; 107(6):1001–1008.
   PubMed Web of Science ®Google Scholar
• Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol 2002; 282(5):L1049–L1056.
   Google Scholar
• Saito A, Okazaki H, Sugawara I, Yamamoto K, Takizawa H. Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol 2003; 132(2):168–176.
   PubMedGoogle Scholar
• Plante S, Semlali A, Joubert P, Bissonnette E, Laviolette M, Hamid Q, Chakir J. Mast cells regulate procollagen I (alpha 1) production by bronchial fibroblasts derived from subjects with asthma through IL-4/IL-4 delta 2 ratio. J Allergy Clin Immunol 2006; 117(6):1321–1327.
   PubMedGoogle Scholar
• Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol 2008; 83(6):1323–1333.
   PubMed Web of Science ®Google Scholar
• Zhang S, Smartt H, Holgate ST, Roche WR. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab Invest 1999; 79(4):395–405.
   PubMed Web of Science ®Google Scholar
• Wicks J, Haitchi HM, Holgate ST, Davies DE, Powell RM. Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts. Thorax 2006; 61(4):313–319.
   PubMedGoogle Scholar
• Serpero L, Petecchia L, Sabatini F, Giuliani M, Silvestri M, Di Blasi P, Rossi GA. The effect of transforming growth factor (TGF)-beta1 and (TGF)-beta2 on nasal polyp fibroblast activities involved upper airway remodeling: modulation by fluticasone propionate. Immunol Lett 2006; 105(1):61–67.
   PubMedGoogle Scholar
• Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res 2006; 83(1):212–222.
   PubMed Web of Science ®Google Scholar
• Nath P, Leung SY, Williams AS, Noble A, Xie S, McKenzie AN, Chung KF. Complete inhibition of allergic airway inflammation and remodeling in quadruple IL-4/5/9/13 –/– mice. Clin Exp Allergy 2007; 37:1427–1435.
   PubMed Web of Science ®Google Scholar
• Borowski A, Kuepper M, Horn U, Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts. Clin Exp Allergy 2008; 38:619–628.
   PubMed Web of Science ®Google Scholar
• Komai M, Tanaka H, Masuda T, Nagao K, Ishizaki M, Sawada M, Nagai H. Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma. Br J Pharmacol 2003; 138(5):912–920.
   PubMedGoogle Scholar