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Biomarkers

Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics

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Pages 236-243 | Received 07 Dec 2017, Accepted 19 Mar 2018, Published online: 12 Apr 2018

References

  • Busse WW, Lemanske RF Jr. Asthma. N Engl J Med. 2001;344:350–62. doi:10.1056/NEJM200102013440507. PMID:11172168.
  • Larché M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol. 2003;111:450–63. doi:10.1067/mai.2003.169. PMID:12642820.
  • Holgate ST. Pathogenesis of asthma. Clin Exp Allergy. 2008;38:872–97. doi:10.1111/j.1365-2222.2008.02971.x. PMID:18498538.
  • Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180:388–95. Erratum in: Am J RespirCrit Care Med. 2009;180: 796. doi:10.1164/rccm.200903-0392OC. PMID:19483109.
  • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18:716–25. doi:10.1038/nm.2678. PMID:22561835.
  • Bousquet J, Chanez P, Lacoste JY, Barnéon G, Ghavanian N, Enander I, et al. Eosinophilic inflammation in asthma. N Engl J Med. 1990;323:1033–9. doi:10.1056/NEJM199010113231505. PMID:2215562.
  • Louis R, Lau LCK, Bron AO, Roldaan AC, Radermecker M, Djukanović R. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med. 2000;161:9–16. doi:10.1164/ajrccm.161.1.9802048. PMID:10619791.
  • Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet. 2002;360:1715–21. doi:10.1016/S0140-6736(02)11679-5. PMID:12480423.
  • Jayaram L, Pizzichini MM, Cook RJ, Boulet LP, Lemière C, Pizzichini E, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J. 2006;27:483–94. doi:10.1183/09031936.06.00137704. PMID:16507847.
  • Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008;178:218–24. doi:10.1164/rccm.200711-1754OC. PMID:18480428.
  • Minshall EM, Leung DYM, Martin RJ, Song YL, Cameron L, Ernst P, et al. Eosinophil-associated TGFβ1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell MolBiol. 1997;17:326–33. doi:10.1165/ajrcmb.17.3.2733. PMID:9308919.
  • Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380:651–9. doi:10.1016/S0140-6736(12)60988-X. PMID:22901886.
  • Schleich FN, Manise M, Sele J, Henket M, Seidel L, Louis R. Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation. BMC Pulm Med. 2013;13:11. doi:10.1186/1471-2466-13-11. PMID:23442497.
  • Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, et al. Full blood count parameters for the detection of asthma inflammatory phenotypes. Clin Exp Allergy. 2014;44:1137–45. doi:10.1111/cea.12345. PMID:24849076.
  • Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. American Thoracic Society Committee on interpretation of exhaled nitric oxide levels (FENO) for clinical applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–15. doi:10.1164/rccm.9120-11ST. PMID:21885636.
  • Suresh V, Mih JD, George SC. Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2007;37:97–104. doi:10.1165/rcmb.2006-0419OC. PMID:17347445.
  • Chibana K, Trudeau JB, Mustovich AT, Hu H, Zhao J, Balzar S, et al. IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Clin Exp Allergy. 2008;38:936–46. doi:10.1111/j.1365-2222.2008.02969.x. PMID:18384429.
  • Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β. J Bone Miner Res. 1999;14:1239–49. doi:10.1359/jbmr.1999.14.7.1239. PMID:10404027.
  • Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, et al. Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA. 2010;107:14170–5. doi:10.1073/pnas.1009426107. PMID:20660732.
  • Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA. 2007;104:15858–63. doi:10.1073/pnas.0707413104. PMID:17898169.
  • Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, et al. Periostin: a novel component of subepithellial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol. 2006;118:98–104. doi:10.1016/j.jaci.2006.02.046. PMID:16815144.
  • Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011;365:1088–98. doi:10.1056/NEJMoa1106469. PMID:21812663.
  • Izuhara K, Ohta S, Ono J. Using Periostin as a biomarker in the treatment of asthma. Allergy Asthma Immunol Res. 2016;8:491–8. doi:10.4168/aair.2016.8.6.491. PMID:27582399.
  • Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, et al. Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest. 2012;122:2590–600. doi:10.1172/JCI58978. PMID:22684102.
  • Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, et al. A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012;42:144–55. doi:10.1111/j.1365-2222.2011.03840.x. PMID:22093101.
  • Jia G, Erichson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, et al. Bronchoscopicexploratory research study of biomarkers in corticosteroid-refractory asthma (BOBCAT) study group.Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012;130:647–54. doi:10.1016/j.jaci.2012.06.025. PMID:22857879.
  • Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al. Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulm Med. 2016;16:67. doi:10.1186/s12890-016-0230-4. PMID:27130294.
  • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis. 1987;136:225–44. PMID:3605835.
  • Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2012.
  • Ohta K, Ichinose M, Nagase H, Yamaguchi M, Sugiura H, Tohda Y, et al. Japanese Society of Allergology. Japanese Guideline for Adult Asthma 2014. Allergol Int. 2014;63:293–333. doi:10.2332/allergolint.14-RAI-0766.
  • Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al., ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005;26:319–38. doi:10.1183/09031936.05.00034805. PMID:16055882.
  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001;163:1256–76. doi:10.1164/ajrccm.163.5.2101039. PMID:11316667.
  • Fabbri LM, Romagnoli M, Corbetta L, Casoni G, Busljetic K, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:418–24. doi:10.1164/rccm.200203-183OC. PMID:12426229.
  • Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, et al. Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J. 2011;37:1119–27. doi:10.1183/09031936.00059810. PMID:21177844.
  • Fingleton J, Braithwaite I, Travers J, Bowles D, Strik R, Siebers R, et al., NZRHS Study Group. Serum periostin in obstructive airways disease. Eur Respir J. 2016;47:1383–91. doi:10.1183/13993003.01384-2015. PMID:26917610.
  • Saha SK, Berry MA, Parker D, Siddiqui S, Morgan A, May R, et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol. 2008;121:685–91. doi:10.1016/j.jaci.2008.01.005. PMID:18328894.
  • Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, Zink F, Mouy M, et al. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci U S A. 2005;102:14789–94. doi:10.1073/pnas.0409904102. PMID:16203992.
  • Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013;132:305–12. doi:10.1016/j.jaci.2013.04.050. PMID:23791506.
  • Bobolea I, Barranco P, Del Pozo V, Romero D, Sanz V, López-Carrasco V, et al. Sputum periostin in patients with different severe asthma phenotypes. Allergy. 2015;70:540–6. doi:10.1111/all.12580. PMID:25631525.
  • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103:779–88. doi:10.1172/JCI5909. PMID:10079098.
  • Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β1. J Exp Med. 2001;194:809–21. doi:10.1084/jem.194.6.809. PMID:11560996.
  • James A, Janson C, Malinovschi A, Holweg C, Alving K, Ono J, et al. Serum periostin relates to type-2 inflammation and lung function in asthma: data from the large population-based cohort Swedish GA(2)LEN. Allergy. 2017;72:1753–60. doi:10.1111/all.13181. PMID:28398635.
  • Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH, et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 2015;70:115–20. doi:10.1136/thoraxjnl-2014-205634. PMID:25422384.
  • Johansson MW, Evans MD, Crisafi GM, Holweg CTJ, Matthews JG, Jarjour NN. Serum periostin is associated with type 2 immunity in severe asthma. J Allergy Clin Immunol. 2016;137:1904–7. doi:10.1016/j.jaci.2015.12.1346. PMID:27061252.

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