Mutual regulation between miR-21 and the TGFβ/Smad signaling pathway in human bronchial fibroblasts promotes airway remodeling

References

• Guo Z, Wu J, Zhao J, Liu F, Chen Y, Bi L, Liu S, Dong L. IL-33 promotes airway remodeling and is a marker of asthma disease severity. J Asthma. 2014;51(8):863–869. doi:10.3109/02770903.2014.921196. PMID:24796648.
   PubMed Web of Science ®Google Scholar
• Gao Y, Xu X, Ding K, Liang Y, Jiang D, Dai H. Rapamycin inhibits transforming growth factor beta1-induced fibrogenesis in primary human lung fibroblasts. Yonsei Med J. 2013;54(2):437–444. doi:10.3349/ymj.2013.54.2.437. PMID:23364979.
   PubMed Web of Science ®Google Scholar
• Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003;425(6958):577–584. doi:10.1038/nature02006. PMID:14534577.
   PubMed Web of Science ®Google Scholar
• Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 2009;11(8):943–950. doi:10.1038/ncb1905.
   PubMed Web of Science ®Google Scholar
• Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA, Jr., Wrana JL, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell. 1997;89(7):1165–1173. doi:10.1016/S0092-8674(00)80303-7.
   PubMed Web of Science ®Google Scholar
• Lan HY, Chung AC. TGF-beta/Smad signaling in kidney disease. Semin Nephrol. 2012;32(3):236–243. doi:10.1016/j.semnephrol.2012.04.002.
   PubMed Web of Science ®Google Scholar
• Gao Y, Lu J, Zhang Y, Chen Y, Gu Z, Jiang X. Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulm Pharmacol Ther. 2013;26(6):649–654. doi:10.1016/j.pupt.2013.03.006.
   PubMed Web of Science ®Google Scholar
• Schuliga M, Javeed A, Harris T, Xia Y, Qin C, Wang Z, Zhang X, Lee PV, Camoretti-Mercado B, Stewart AG. Transforming growth factor-beta-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2. Am J Respir Cell Mol Biol. 2013;48(3):346–353. doi:10.1165/rcmb.2012-0151OC. PMID:23239497.
   PubMed Web of Science ®Google Scholar
• Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002;62(1):58–64. doi:10.1124/mol.62.1.58. PMID:12065755.
   PubMed Web of Science ®Google Scholar
• Bai TR. Evidence for airway remodeling in chronic asthma. Curr Opin Allergy Clin Immunol. 2010;10(1):82–86. doi:10.1097/ACI.0b013e32833363b2. PMID:19858714.
   PubMed Web of Science ®Google Scholar
• Halwani R, Al-Muhsen S, Hamid Q. Airway remodeling in asthma. Curr Opin Pharmacol. 2010;10(3):236–245. doi:10.1016/j.coph.2010.06.004. PMID:20591736.
   PubMed Web of Science ®Google Scholar
• Warner SM, Knight DA. Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol. 2008;8(1):44–48. doi:10.1097/ACI.0b013e3282f3b5cb. PMID:18188017.
   PubMed Web of Science ®Google Scholar
• Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol. 2008;121(3):560–570; quiz 571-562. doi:10.1016/j.jaci.2008.01.031. PMID:18328887.
   PubMed Web of Science ®Google Scholar
• Stumm CL, Wettlaufer SH, Jancar S, Peters-Golden M. Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2011;301(5):L636–644. doi:10.1152/ajplung.00158.2011. PMID:21873451.
   PubMed Web of Science ®Google Scholar
• Verrecchia F, Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol. 2007;13(22):3056–3062. doi:10.3748/wjg.v13.i22.3056. PMID:17589920.
   PubMed Web of Science ®Google Scholar
• Chung AC, Dong Y, Yang W, Zhong X, Li R, Lan HY. Smad7 suppresses renal fibrosis via altering expression of TGF-beta/Smad3-regulated microRNAs. Mol Ther. 2013;21(2):388–398.doi:10.1038/mt.2012.251. PMID:23207693.
   PubMed Web of Science ®Google Scholar
• Weng H, Mertens PR, Gressner AM, Dooley S. IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads. J Hepatol. 2007;46(2):295–303. doi:10.1016/j.jhep.2006.09.014. PMID:17125875.
   PubMed Web of Science ®Google Scholar
• Lan HY. Diverse roles of TGF-beta/Smads in renal fibrosis and inflammation. Int J Biol Sci. 2011;7(7):1056–1067. doi:10.7150/ijbs.7.1056. PMID:21927575.
   PubMed Web of Science ®Google Scholar
• James AJ, Penrose JF, Cazaly AM, Holgate ST, Sampson AP. Human bronchial fibroblasts express the 5-lipoxygenase pathway. Respir Res. 2006;7:102. doi:10.1186/1465-9921-7-102. PMID:16872537.
   PubMed Web of Science ®Google Scholar
• Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454(7200):56–61. doi:10.1038/nature07086. PMID:18548003.
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol. 2013;132(1):3–13; quiz 14. doi:10.1016/j.jaci.2013.04.039. PMID:23735656.
   PubMed Web of Science ®Google Scholar
• Jazbutyte V, Thum T. MicroRNA-21: from cancer to cardiovascular disease. Curr Drug Targets. 2010;11(8):926–935. doi:10.2174/138945010791591403. PMID:20415649.
   PubMed Web of Science ®Google Scholar
• Lai JY, Luo J, O'Connor C, Jing X, Nair V, Ju W, Randolph A, Ben-Dov IZ, Matar RN, Briskin D, et al. MicroRNA-21 in glomerular injury. J Am Soc Nephrol. 2015;26(4):805–816. doi:10.1681/ASN.2013121274. PMID:25145934.
   PubMed Web of Science ®Google Scholar
• Loboda A, Sobczak M, Jozkowicz A, Dulak J. TGF-beta1/Smads and miR-21 in Renal Fibrosis and Inflammation. Mediators Inflamm. 2016;2016:8319283. doi:10.1155/2016/8319283. PMID:27610006.
   PubMed Web of Science ®Google Scholar
• Kim YJ, Hwang SJ, Bae YC, Jung JS. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells. 2009;27(12):3093–3102. PMID:19816956.
   PubMed Web of Science ®Google Scholar
• Li XZ, Feng JT, Hu CP, Chen ZQ, Gu QH, Nie HP. Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats. Lab Invest. 2010;90(7):997–1003. doi:10.1038/labinvest.2010.78. PMID:20386537.
   PubMed Web of Science ®Google Scholar
• Marquez RT, Bandyopadhyay S, Wendlandt EB, Keck K, Hoffer BA, Icardi MS, Christensen RN, Schmidt WN, McCaffrey AP. Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest. 2010;90(12):1727–1736. doi:10.1038/labinvest.2010.126. PMID:20625373.
   PubMed Web of Science ®Google Scholar
• Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res. 2008;68(19):8164–8172. doi:10.1158/0008-5472.CAN-08-1305. PMID:18829576.
   PubMed Web of Science ®Google Scholar
• Tay HL, Plank M, Collison A, Mattes J, Kumar RK, Foster PS. MicroRNA: potential biomarkers and therapeutic targets for allergic asthma? Ann Med. 2014;46(8):633–639. doi:10.3109/07853890.2014.958196. PMID:25307360.
   PubMed Web of Science ®Google Scholar
• Greene CM, Gaughan KP. microRNAs in asthma: potential therapeutic targets. Curr Opin Pulm Med. 2013;19(1):66–72. doi:10.1097/MCP.0b013e32835a5bc8. PMID:23095468
   PubMed Web of Science ®Google Scholar