266
Views
0
CrossRef citations to date
0
Altmetric
Case Reports

“Patient remodeling” as a consequence of uncontrolled and prolonged OCS use in severe asthma: how biologic therapy can reverse a dangerous trend

, MD, , MD, , MD, , BSc, , MD, PhD & , MD
Pages 72-75 | Received 16 May 2023, Accepted 24 Jul 2023, Published online: 24 Aug 2023

References

  • Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham-Anderson J, Hargadon B, Arron JR, et al. Airway pathological heterogeneity in asthma: visualization of disease microclusters using topological data analysis. J Allergy Clin Immunol 2018;142(5):1457–1468. doi:10.1016/j.jaci.2017.12.982.
  • Varricchi G, Ferri S, Pepys J, Poto R, Spadaro G, Nappi E, Paoletti G, Virchow JC, Heffler E, Canonica WG, et al. Biologics and airway remodeling in severe asthma. Allergy 2022;77(12):3538–3552. doi:10.1111/all.15473.
  • Kardas G, Kuna P, Panek M. Biological therapies of severe asthma and their possible effects on airway remodeling. Front Immunol 2020;11:1134. doi:10.3389/fimmu.2020.01134.
  • Ekström M, Nwaru BI, Hasvold P, Wiklund F, Telg G, Janson C. Oral corticosteroid use, morbidity and mortality in asthma: a nationwide prospective cohort study in Sweden. Allergy 2019;74(11):2181–2190. doi:10.1111/all.13874.
  • Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A. Expert consensus on the tapering of oral corticosteroids for the treatment of asthma. A Delphi study. Am J Respir Crit Care Med 2021;203(7):871–881. doi:10.1164/rccm.202007-2721OC.
  • Lee H, Ryu J, Nam E, Chung SJ, Yeo Y, Park DW, Park TS, Moon JY, Kim TH, Sohn JW, et al. Increased mortality in patients with corticosteroid-dependent asthma: a nationwide population-based study. Eur Respir J 2019;54(5):1900804. doi:10.1183/13993003.00804-2019.
  • Global Initiative for Asthma. Global strategy for asthma management and prevention. 2022. Available from: www.ginasthma.org.
  • Bleecker ER, Menzies-Gow AN, Price DB, Bourdin A, Sweet S, Martin AL, Alacqua M, Tran TN. Systematic literature review of systemic corticosteroid use for asthma management. Am J Respir Crit Care Med 2020;201(3):276–293. doi:10.1164/rccm.201904-0903SO.
  • Price DB, Trudo F, Voorham J, Xu X, Kerkhof M, Ling Zhi Jie J, Tran TN. Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study. J Asthma Allergy 2018;11:193–204. doi:10.2147/JAA.S176026.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.