60
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Doxofylline as a steroid-sparing treatment in Mexican children with asthma

, MD, PhDORCID Icon, , MD, PhDORCID Icon, , MD, PhDORCID Icon, , MD & , MDORCID Icon
Pages 574-583 | Received 28 Jul 2023, Accepted 10 Dec 2023, Published online: 28 Dec 2023

References

  • The Global Asthma Report 2018. Auckland, New Zealand: Global Asthma Network; 2018. http://globalasthmareport.org/resources/Global_Asthma_Report_2018.pdf. [accessed 12 November 2021].
  • Global Initiative for Asthma. Global strategy for asthma management and prevention; 2018. www.ginasthma.org. [accessed 10 June 2021].
  • Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD. Asthma. Nat Rev Dis Primers. 2015;1(1):15025. doi:10.1038/nrdp.2015.25.
  • Del-Rio-Navarro BE, Berber A, Reyes-Noriega N, Navarrete-Rodriguez EM, Garcia-Almaraz R, Merida-Palacio JV, Ellwood P, Garcia-Marcos AL. Have asthma symptoms in Mexico changed in the past 15 years? Time trends from the International Study of Asthma and Allergies in Childhood to the global asthma network. Allergol Immunopathol (Madr). 2021;49(1):1–10. doi:10.15586/aei.v49i1.35.
  • Del-Río-Navarro BE, Berber A, Reyes-Noriega N, Navarrete-Rodríguez EM, García-Almaraz R, Ellwood P, Garcia-Marcos L, Saucedo-Ramírez OJ, Mérida-Palacio VJ, Ramos-García BDC, et al. Global Asthma Network Phase I study in Mexico: prevalence of asthma symptoms, risk factors and altitude associations-a cross-sectional study. BMJ Open Resp Res. 2020;7(1):e000658. doi:10.1136/bmjresp-2020-000658.
  • Larenas-Linnemann D, Salas-Hernández J, Vázquez-García JC, Ortiz-Aldana I, Fernández-Vega M, Del Río-Navarro BE, Cano-Salas MDC, Luna-Pech JA, Ortega-Martell JA, Romero-Lombard J, et al. Mexican asthma guidelines: GUIMA 2017. Rev Alerg Mex. 2017;64Suppl(1):s11–s128. doi:10.29262/ram.v64i0.272.
  • Allen DB. Inhaled corticosteroids and endocrine effects in childhood. Endocrinol Metab Clin North Am. 2020;49(4):651–665. doi:10.1016/j.ecl.2020.07.003.
  • Riffo-Vasquez Y, Venkatasamy R, Page CP. Steroid sparing effects of doxofylline. Pulm Pharmacol Ther. 2018;48:1–4. doi:10.1016/j.pupt.2017.10.008.
  • Crossingham I, Turner S, Ramakrishnan S, Fries A, Gowell M, Yasmin F, Richardson R, Webb P, O’Boyle E, Hinks TSC. Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review. BMJ Evid Based Med. 2021;27(3):178–184. doi:10.1136/bmjebm-2021-111764.
  • Chauhan BF, Chartrand C, Ni Chroinin M, Milan SJ, Ducharme FM. Addition of long-acting beta2-agonists to inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev. 2015;2015(11):CD007949. doi:10.1002/14651858.CD007949.pub2.
  • Barnes PJ, Pauwels RA. Theophylline in the management of asthma: time for reappraisal? Eur Respir J. 1994;7(3):579–591. doi:10.1183/09031936.94.07030579.
  • Cazzola M, Matera MG. The effect of doxofylline in asthma and COPD. Respir Med. 2020;164:105904. doi:10.1016/j.rmed.2020.105904.
  • Oñatibia-Astibia A, Martínez-Pinilla E, Franco R. The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respir Med. 2016;112:1–9. doi:10.1016/j.rmed.2016.01.022.
  • Bierman CW, William PV. Therapeutic monitoring of theophylline: rationale and current status. Clin Pharmacokinet. 1989;17(6):377–384. doi:10.2165/00003088-198917060-00002.
  • Calzetta L, Hanania NA, Dini FL, Goldstein MF, Fairweather WR, Howard WW, Cazzola M. Impact of doxofylline compared to theophylline in asthma: a pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2). Pulm Pharmacol Ther. 2018;53:20–26. doi:10.1016/j.pupt.2018.09.007.
  • Page CP. Doxofylline: a "novofylline. Pulm Pharmacol Ther. 2010;23(4):231–234. doi:10.1016/j.pupt.2010.04.002.
  • Sankar J, Lodha R, Kabra SK. Doxofylline: the next generation methylxanthine. Indian J Pediatr. 2008;75(3):251–254. doi:10.1007/s12098-008-0054-1.
  • Talmon M, Massara E, Brunini C, Fresu LG. Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes. Pulm Pharmacol Ther. 2019;59:101851. doi:10.1016/j.pupt.2019.101851.
  • Goldstein MF, Chervinsky P. Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma – a double-blind randomized placebo-controlled multicentre clinical trial. Med Sci Monit. 2002;8(4):CR297–304.
  • Margay SM, Farhat S, Kaur S, Teli HA. To study the efficacy and safety of doxofylline and theophylline in bronchial asthma. J Clin Diagnostic Res. 2015;9(4):FC05–8.
  • Calzetta L, Matera MG, Goldstein MF, Fairweather WR, Howard WW, Cazzola M, Rogliani P. A long-term clinical trial on the efficacy and safety profile of doxofylline in Asthma: the LESDA study. Pulm Pharmacol Ther. 2020;60:101883. doi:10.1016/j.pupt.2019.101883.
  • Bagnato GF. Tolerability of doxofylline in the maintenance therapy of pediatric patients with bronchial asthma. Eur Rev Med Pharmacol Sci. 1999;3(6):255–260.
  • Rogliani P, Calzetta L, Ora J, Cazzola M, Matera MG. Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis. Multidiscip Respir Med. 2019;14(1):25. doi:10.1186/s40248-019-0189-0.
  • van Mastbergen J, Jolas T, Allegra L, Page CP. The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism. Pulm Pharmacol Ther. 2012;25(1):55–61. doi:10.1016/j.pupt.2011.10.007.
  • Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR, American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–615. doi:10.1164/rccm.9120-11ST.
  • S.p.A. AF. Ansimar - Doxofylline, Manufactured by ABC farmaceutici, Turin, Italy; 2019. https://www.abcfarmaceutici.it/uploads/news/40_file3_en.pdf. [accessed 2 December 2021].
  • Italian Medicines Agency (AIFA). Doxofilina ABC; 2019. https://farmaci.agenziafarmaco.gov.it/aifa/servlet/PdfDownloadServlet?pdfFileName=footer_002301_033876_FI.pdf&sys=m0b1l3. [accessed 2 December 2021].
  • Incepta Pharmaceuticals Ltd. BrezofilTM - Doxofylline. Manufactured by Incepta Pharmaceuticals Ltd, Savar, Dhaka, Bangladesh; 2019. http://www.inceptapharma.com/downloads/1561361514_pdoc_Brezofil%20Leaflet.pdf. [accessed 2 December 2021].
  • Patel YA, Patel P, Bavadia H, Dave J, Tripathi CB. A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting β2 agonist in the treatment of moderate-to-severe persistent asthma. J Postgrad Med. 2010;56(4):270–274. doi:10.4103/0022-3859.70937.
  • Rajanandh MG, Nageswari AD, Ilango K. Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial. Clin Ther. 2015;37(2):418–426. doi:10.1016/j.clinthera.2014.12.008.
  • Sandrini A, Taylor DR, Thomas PS, Yates DH. Fractional exhaled nitric oxide in asthma: an update. Respirology. 2010;15(1):57–70. doi:10.1111/j.1440-1843.2009.01616.x.
  • Petsky HL, Kew KM, Chang AB. Exhaled nitric oxide levels to guide treatment for children with asthma. Cochrane Database Syst Rev. 2016;11(11):CD011439. doi:10.1002/14651858.CD011439.pub2.
  • Petsky HL, Cates CJ, Kew KM, Chang AB. Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis. Thorax. 2018;73(12):1110–1119. doi:10.1136/thoraxjnl-2018-211540.
  • Jones NR, Wang K, Yang Y, Heneghan C, Price CP, Van den Bruel A, Plüddemann A. Fractional exhaled nitric oxide monitoring in paediatric asthma management. Br J Gen Pract. 2017;67(664):531–532. doi:10.3399/bjgp17X693449.
  • Larenas-Linnemann D, Gochicoa-Rangel L, Macías-Weinmann A, Soto-Ramos M, Luna-Pech JA, Elizondo-Ríos A, Del Río-Navarro BE, Hernández-Colín DD, García-Maldonado S, Zepeda B, et al. Consenso mexicano en relación con la fracción exhalada de óxido nítrico (FeNO) en asma 2020 [Mexican consensus on fractional exhaled nitric oxide (FeNO) in asthma 2020]. Rev Alerg Mex. 2020;67Suppl 2:S1–S25. doi:10.29262/ram.v67i0.760.
  • Da Silva Salviano LD, Taglia-Ferre KD, Lisboa S, Costa ACCD, Campos HDS, March MFP. Association between fraction of exhaled nitric oxide and spriometry data and clinical control of asthma in children and adolescents. Rev Paul Pediatr. 2018;36(1):17–24. doi:10.1590/1984-0462/;2018;36;1;00015.
  • Fielding S, Pijnenburg M, de Jongste JC, Pike KC, Roberts G, Petsky H, Chang AB, Fritsch M, Frischer T, Szefler S, et al. Change in FEV1 and feno measurements as predictors of future asthma outcomes in children. Chest. 2019;155(2):331–341. doi:10.1016/j.chest.2018.10.009.
  • Lipworth B, Kuo CR, Chan R. 2020 updated asthma guidelines: clinical utility of fractional exhaled nitric oxide (Feno) in asthma management. J Allergy Clin Immunol. 2020;146(6):1281–1282. doi:10.1016/j.jaci.2020.03.006.
  • Bateman ED, Reddel HK, Eriksson G, Peterson S, Ostlund O, Sears MR, Jenkins C, Humbert M, Buhl R, Harrison TW, et al. Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol. 2010;125(3):608.e1–608.e6. doi:10.1016/j.jaci.2009.11.033.
  • Evans DJ, Taylor DA, Zetterstrom O, Chung KF, O’Connor BJ, Barnes PJ. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med. 1997;337(20):1412–1418. doi:10.1056/NEJM199711133372002.
  • Ukena D, Harnest U, Sakalauskas R, Magyar P, Vetter N, Steffen H, Leichtl S, Rathgeb F, Keller A, Steinijans VW. Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. Eur Respir J. 1997;10(12):2754–2760. doi:10.1183/09031936.97.10122754.
  • Lim S, Jatakanon A, Gordon D, Macdonald C, Chung KF, Barnes PJ. Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax. 2000;55(10):837–841. doi:10.1136/thorax.55.10.837.
  • Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013;188(8):901–906. doi:10.1164/rccm.201302-0388PP.
  • Mennini FS, Sciattella P, Marcellusi A, Marcobelli A, Russo A, Caputi AP. Treatment plan comparison in acute and chronic respiratory tract diseases: an observational study of doxophylline vs. theophylline. Expert Rev Pharmacoecon Outcomes Res. 2017;17(5):503–510. doi:10.1080/14737167.2017.1301815.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.