364
Views
2
CrossRef citations to date
0
Altmetric
Neuroradiology

Regional Metabolic Changes in the Hippocampus and Posterior Cingulate Area Detected with 3-Tesla Magnetic Resonance Spectroscopy in Patients with Mild Cognitive Impairment and Alzheimer Disease

, , , &
Pages 312-319 | Published online: 09 Jul 2009

References

  • Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, et al. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging 2004; 25: 303–10
  • Jack CR, Jr, Petersen RC, Xu YC, O'Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999; 52: 1397–403
  • Vogt BA, Van Hoesen GW, Vogt LJ. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer disease. Acta Neuropathol 1990; 80: 581–9
  • Soher BJ, Doraiswamy PM, Charles HC. A review of 1H MR spectroscopic findings in Alzheimer's disease. Neuroimag Clin N Am 2005; 15: 847–52
  • Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, et al. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology 2002; 58: 928–35
  • Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, et al. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology 2003; 61: 358–64
  • Kantarci K, Jack CRJ, Xu YC, Campeau NG, O'Brien PC, Smith GE, et al. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease. A 1H MRS study. Neurology 2000; 55: 210–7
  • Chantal S, Braun CM, Bouchard RW, Labelle M YB. Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease. Brain Res 2004; 1003: 26–35
  • Kantarci K, Xu Y, Shiung MM, O'Brien PC, Cha RH, Smith GE, et al. Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord 2002; 14: 198–207
  • Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, et al. Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology 2001; 57: 930–2
  • Kantarci K, Reynolds G, Petersen RC, Boeve BF, Knopman DS, Edland SD, et al. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Am J Neuroradiol 2003; 24: 843–9
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, D.C; American Psychiatric Association; 1994.
  • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984; 225: 1168–70
  • Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56: 303–8
  • Miller BL, Moats RA, Shonk T, Ernst T, Woolley S, Ross BD. Alzheimer disease: depiction of increased cerebral myoinositol with proton MR spectroscopy. Radiology 1993; 187: 433–37
  • Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI, et al. Brain metabolite concentration and dementia severity in Alzheimer's disease: a 1H MRS study. Neurology 2001; 57: 626–32
  • Block W, Jessen F, Träber F, Flacke S, Manka C, Lamerichs R, et al. Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol 2002; 59: 828–34
  • Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO. In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch General Psychiatry 1999; 56: 185–92
  • Parnetti L, Tarducci R, Presciutti O, Lowenthal DT, Pippi M, Palumbo B, et al. Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging. Mech Ageing Dev 1997; 97: 9–14
  • Lazeyras F, Charles HC, Tupler LA, Erickson R, Boyko OB, Krishnan KR. Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy. Psychiatry Res 1998; 82: 95–106
  • MacKay S, Ezekiel F, Di Sciafani V, Meyerhoff DJ, Gerson J, Norman D, et al. Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and 1H MR spectroscopic imaging. Radiology 1996; 198: 537–45
  • Rose SE, de Zubicaray GI, Wang D, Galloway G, Chalk J, Eagle S, et al. A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magn Reson Imaging 1999; 17: 291–9
  • Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, et al. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord 2006; 20: 77–85
  • Frederick BD, Lyoo IK, Satlin A, Ahn KH, Kim MJ, Yurgelun-Todd DA, et al. In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28: 1313–22
  • Valenzuela MJ, Sachdev P. Magnetic resonance spectroscopy in AD. Neurology 2001; 56: 592–8
  • Moats RA, Ernst T, Shonk TK, Ross BD. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease. Magn Reson Med 1994; 32: 110–5
  • Schuff N, Ezekiel F, Gamst A, Amend DL, Capizzano AA, Maudsley AA, et al. Region and tissue differences of metabolites in normally aged brain using 1H magnetic resonance spectroscopic imaging. Magn Reson Med 2001; 45: 899–907
  • Catani M, Cherubini A, Howard R, Howard R, Tarducci R, Pelliccioli GP, et al. 1H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport 2001; 12: 2315–7
  • Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2005; 384: 23–8
  • Chantal S, Labelle M, Bouchard RW, Braun CM, Boulanger Y. Correlation of regional proton magnetic resonance spectroscopic metabolic changes with cognitive deficits in mild Alzheimer disease. Arch Neurol 2002; 59: 955–62
  • Martinez-Bisbal MC, Arana E, Marti-Bonmati L, Mollá E, Celda B. Cognitive impairment: classification by 1H magnetic resonance spectroscopy. Eur J Neurol 2004; 11: 187–93
  • Engelhardt E, Moreira DM, Laks J, Cavalcanti JL. Alzheimer's disease and proton magnetic resonance spectroscopy of limbic regions: a suggestion of a clinical-spectroscopic staging. Arq-Neuropsiquiatr 2005; 63: 195–200

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.