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LETTER TO THE EDITOR

Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas

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Pages 340-341 | Received 21 Oct 2005, Published online: 26 Aug 2009

References

  • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: Targets for cancer therapy. Nat Rev Cancer 2004; 4: 361–70
  • Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 2004; 15: 161–70
  • Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, et al. Colorectal cancer: Mutations in a signalling pathway. Nature 2005; 436: 792
  • Harris TK. PDK1 and PKB/Akt: Ideal targets for development of new strategies to structure-based drug design. IUBMB Life 2003; 55: 117–26
  • Zeng X, Xu H, Glazer RI. Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. Cancer Res 2002; 62: 3538–43
  • Xie Z, Zeng X, Waldman T, Glazer RI. Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1. Cancer Res 2003; 63: 5370–5

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