Exercise prehabilitation may lead to augmented tumor regression following neoadjuvant chemoradiotherapy in locally advanced rectal cancer

References

• Folkesson J, Birgisson H, Pahlman L, et al. Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol. 2005;23:5644–5650.
   PubMed Web of Science ®Google Scholar
• Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373:811–820.
   PubMed Web of Science ®Google Scholar
• Bosset J-F, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355:1114–1123.
   PubMed Web of Science ®Google Scholar
• Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740.
   PubMed Web of Science ®Google Scholar
• Taylor FGM, Quirke P, Heald RJ, et al. One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Br J Surg. 2011;98:872–879.
   PubMed Web of Science ®Google Scholar
• Taylor FGM, Quirke P, Heald RJ, et al. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study. Ann Surg. 2011;253:711–719.
   PubMed Web of Science ®Google Scholar
• Abraha I, Aristei C, Palumbo I, et al. Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma (Review). Cochrane Database of Systematic Reviews 2018;10:CD002102. DOI: 10.1002/14651858.CD002102.pub3
   Google Scholar
• Kerr SF, Norton S, Glynne-Jones R. Delaying surgery after neoadjuvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis. Br J Surg. 2008;95:1534–1540.
   PubMed Web of Science ®Google Scholar
• Foster JD, Jones EL, Falk S, et al. Timing of surgery after long-course neoadjuvant chemoradiotherapy for rectal cancer: a systematic review of the literature. Dis Colon Rectum. 2013;56:921–930.
   PubMed Web of Science ®Google Scholar
• Renehan AG, Malcomson L, Emsley R, et al. Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis. Lancet Oncol. 2015;2045:1–10.
   Google Scholar
• West MA, Loughney L, Barben CP, et al. The effects of neoadjuvant chemoradiotherapy on physical fitness and morbidity in rectal cancer surgery patients. Eur J Surg Oncol. 2014;40:1421–1428.
   PubMed Web of Science ®Google Scholar
• West MA, Loughney L, Lythgoe D, et al. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth. 2015;114:244–251.
   PubMed Web of Science ®Google Scholar
• West M, Loughney L, Lythgoe D, et al. The effect of neoadjuvant chemoradiotherapy on whole-body physical fitness and skeletal muscle mitochondrial oxidative phosphorylation in vivo in locally advanced rectal cancer patients – an observational pilot study. PLoS One. 2014;9:1–15.
   Web of Science ®Google Scholar
• Thomas RJ, Kenfield SA, Jimenez A. Exercise-induced biochemical changes and their potential influence on cancer: a scientific review. Br J Sports Med. 2017;51:640–644.
   PubMed Web of Science ®Google Scholar
• Hawley JA, Hargreaves M, Joyner MJ, et al. Review integrative biology of exercise. Cell. 2014;159:738–749.
   PubMed Web of Science ®Google Scholar
• Koelwyn GJ, Quail DF, Zhang X, et al. Exercise-dependent regulation of the tumour microenvironment. Nat Rev Cancer. 2017;17:620–632.
   PubMed Web of Science ®Google Scholar
• Sobin LH, Fleming ID. TNM classification of malignant tumors, Fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer. 1997;80:1803–1804.
   PubMed Web of Science ®Google Scholar
• Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–655.
   PubMed Web of Science ®Google Scholar
• Levett DZH, Jack S, Swart M, et al. Preoperative Cardiopulmonary Exercise Testing (PCPET): consensus clinical guidelines on indications, organisation, conduct and physiological interpretation. Br J Anaesth. 2018;120:484–500.
   PubMed Web of Science ®Google Scholar
• Slade SC, Dionne CE, Underwood M, et al. Consensus on Exercise Reporting Template (CERT): explanation and elaboration statement. Br J Sports Med. 2016;50:1428–1437.
   PubMed Web of Science ®Google Scholar
• Patel UB, Brown G, Rutten H, et al. Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer. Ann Surg Oncol. 2012;19:2842–2852.
   PubMed Web of Science ®Google Scholar
• Patel UB, Blomqvist LK, Taylor F, et al. MRI after treatment of locally advanced rectal cancer: how to report tumor response—the MERCURY experience. Am J Roentgenol. 2012;199:W486–W495.
   PubMed Web of Science ®Google Scholar
• Moran B, Brown G, Cunningham D, et al. Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: “y'' “u” and “p” need “mr” and “ct”. Colorect Dis. 2008;10:242–243.
   PubMed Web of Science ®Google Scholar
• West MA, Dimitrov B, Moyses H, et al. Timing of surgery following neoadjuvant chemoradiotherapy in locally advanced rectal cancer—a comparison of magnetic resonance imaging at two time points. Eur J Surg Oncol. 2016;42:1350–1358.
   PubMed Web of Science ®Google Scholar
• MacFarlane JK, Ryall RDH, Heald RJ. Mesorectal excision for rectal cancer. Lancet. 1993;341:457–460.
   PubMed Web of Science ®Google Scholar
• Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Intern J Color Dis. 1997;12:19–23.
   PubMed Web of Science ®Google Scholar
• Willett CG, Badizadegan K, Ancukiewicz M, et al. Prognostic factors in stage T3N0 rectal cancer: do all patients require postoperative pelvic irradiation and chemotherapy? Dis Colon Rectum. 1999;42:167–173.
   PubMed Web of Science ®Google Scholar
• Van Blarigan EL, Meyerhardt JA. Role of physical activity and diet after colorectal cancer diagnosis. J Clin Oncol. 2015;33:1825–1834.
   PubMed Web of Science ®Google Scholar
• Friedenreich CM, Neilson HK, Farris MS, et al. Physical activity and cancer outcomes: a precision medicine approach. Clin Cancer Res. 2016;22:4766–4775.
   PubMed Web of Science ®Google Scholar
• Ekelund U, Steene-Johannessen J, Brown WJ, et al. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. Lancet. 2016;388:13002–13010.
   Web of Science ®Google Scholar
• Wen CP, Wai JPM, Tsai MK, et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet. 2011;378:1244–1253.
   PubMed Web of Science ®Google Scholar
• Kerr J, Anderson C, Lippman SM. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol. 2017;18:e457–e471.
   PubMed Web of Science ®Google Scholar
• Jones LW, Eves ND, Peddle CJ, et al. Effects of presurgical exercise training on systemic inflammatory markers among patients with malignant lung lesions. Appl Physiol Nutr Metab. 2009;34:197–202.
   PubMed Web of Science ®Google Scholar
• Jones LW, Eves ND, Haykowsky M, et al. Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol. 2009;10:598–605.
   PubMed Web of Science ®Google Scholar
• Jones LW, Eves ND, Haykowsky M, et al. Cardiorespiratory exercise testing in clinical oncology research: systematic review and practice recommendations. Lancet Oncol. 2008;9:757–765.
   PubMed Web of Science ®Google Scholar
• Jones LW, Fels DR, West M, et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res. 2013;6:925–937.
   PubMed Web of Science ®Google Scholar
• Betof AS, Lascola CD, Weitzel D, et al. Modulation of murine breast tumor vascularity, hypoxia, and chemotherapeutic response by exercise. J Natl Cancer Inst. 2015;107:1–5.
   Google Scholar
• Jones LW, Friedman AH, West MJ, et al. Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. Cancer. 2010;116:695–704.
   PubMed Web of Science ®Google Scholar
• Higgins KA, Park D, Lee GY, et al. Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer. 2014;120:3302–3310.
   PubMed Web of Science ®Google Scholar
• Fairey AS, Courneya KS, Field CJ, et al. Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions. Cancer. 2002;94:539–551.
   PubMed Web of Science ®Google Scholar
• Hoffman-Goetz L, Pedersen BK. Exercise and the immune system: a model of the stress response? Immunol Today. 1994;15:382–387.
   PubMedGoogle Scholar
• Barker HE, Paget JTE, Khan AA, et al. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015;15:409–425.
   PubMed Web of Science ®Google Scholar
• Nikolaidis MG, Kyparos A, Spanou C, et al. Redox biology of exercise: an integrative and comparative consideration of some overlooked issues. J Exp Biol. 2012;215:1615–1625.
   PubMed Web of Science ®Google Scholar
• Jackson MJ, Vasilaki A, McArdle A. Cellular mechanisms underlying oxidative stress in human exercise. Free Radic Biol Med. 2016;98:13–17.
   PubMed Web of Science ®Google Scholar
• Margaritelis NV, Kyparos A, Paschalis V, et al. Reductive stress after exercise: the issue of redox individuality. Redox Biol. 2014;2:520–528.
   PubMed Web of Science ®Google Scholar
• Fiuza-Luces C, Garatachea N, Berger NA, et al. Exercise is the real polypill. Physiology (Bethesda). 2013;28:330–358.
   PubMed Web of Science ®Google Scholar
• Ji LL. Exercise-induced modulation of antioxidant defense. Ann N Y Acad Sci. 2002;959:82–92.
   PubMed Web of Science ®Google Scholar
• Kojda G, Hambrecht R. Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc Res. 2005;67:187–197.
   PubMed Web of Science ®Google Scholar
• Hvid T, Winding K, Rinnov A, et al. Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy. Endocr Relat Cancer. 2013;20:621–632.
   PubMed Web of Science ®Google Scholar
• Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev. 2011;17:6–63.
   PubMed Web of Science ®Google Scholar
• Loughney L, West MA, Kemp GJ, et al. The effects of neoadjuvant chemoradiotherapy and an in-hospital exercise training programme on physical fitness and quality of life in locally advanced rectal cancer patients (The EMPOWER Trial): study protocol for a randomised controlled trial. Trials. 2016;17:24.
   PubMed Web of Science ®Google Scholar