536
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Effect of 12-months testosterone replacement therapy on bone mineral density and markers of bone turnover in testicular cancer survivors – results from a randomized double-blind trial

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 689-695 | Received 15 Oct 2022, Accepted 31 Mar 2023, Published online: 07 May 2023

References

  • Albers P, Albrecht W, Algaba F, et al. Guidelines on testicular cancer: 2015 update. Eur Urol. 2015;68(6):1054–1068.
  • Cheng L, Albers P, Berney DM, et al. Testicular cancer. Nat Rev Dis Primers. 2018;4(1):29.
  • Oldenburg J, Fosså SD, Nuver J, et al. Testicular seminoma and non-seminoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6(Suppl 6):vi125–32.
  • Ehrlich Y, Margel D, Lubin MA, et al. Advances in the treatment of testicular cancer. Transl Androl Urol. 2015;4(3):381–390.
  • Fosså SD, Gilbert E, Dores GM, et al. Noncancer causes of death in survivors of testicular cancer. J Natl Cancer Inst. 2007;99(7):533–544.
  • Rajpert-De Meyts E, McGlynn KA, Okamoto K, et al. Testicular germ cell tumours. Lancet. 2016;387(10029):1762–1774.
  • Bandak M, Jørgensen N, Juul A, et al. A randomized double-blind study of testosterone replacement therapy or placebo in testicular cancer survivors with mild leydig cell insufficiency (Einstein-intervention). BMC Cancer. 2017;17(1):461.
  • Nord C, Bjøro T, Ellingsen D, et al. Gonadal hormones in long-term survivors 10 years after treatment for unilateral testicular cancer. Eur Urol. 2003;44(3):322–328.
  • Sprauten M, Brydøy M, Haugnes HS, et al. Longitudinal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels in a population-based sample of long-term testicular cancer survivors. J Clin Oncol. 2014; 32(6):571–578.
  • Sprauten M, Brydoy M, Haugnes HS, et al. Testosterone (T), luteinizing hormone (LH), and follicle stimulating hormone (FSH) levels in testicular cancer survivors (TCSs) 11 and 19 years after orchiectomy. J Clin Oncol. 2013; 1(15_suppl):4562–4562.
  • Bandak M, Jørgensen N, Juul A, et al. Leydig cell dysfunction, systemic inflammation and metabolic syndrome in long-term testicular cancer survivors. Eur J Cancer. 2017;84:9–17.
  • Rochira V, Balestrieri A, Madeo B, et al. Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology. Eur J Endocrinol. 2006;154(2):175–185.
  • Schubert M, Bullmann C, Minnemann T, et al. Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism. Horm Res. 2003;60(1):21–28.
  • Holmboe SA, Vradi E, Jensen TK, et al. The association of reproductive hormone levels and all-cause, cancer, and cardiovascular disease mortality in men. J Clin Endocrinol Metab. 2015;100(12):4472–4480.
  • Højer EG, Kreiberg M, Dehlendorff C, et al. Effect of testosterone replacement therapy on quality of life and sexual function in testicular cancer survivors with mild leydig cell insufficiency: results from a randomized double-blind trial. Clin Genitourin Cancer. 2022;20(4):334–343.
  • Eastell R, Pigott T, Gossiel F, et al. Diagnosis of endocrine disease: bone turnover markers: are they clinically useful? Eur J Endocrinol. 2018;178(1):R19–R31.
  • Lorentzon M, Branco J, Brandi ML, et al. Algorithm for the use of biochemical markers of bone turnover in the diagnosis, assessment and follow-up of treatment for osteoporosis. Adv Ther. 2019; 36(10):2811–2824.
  • Tan RZ, Loh TP, Vasikaran S. Bone turnover marker monitoring in osteoporosis treatment response. Eur J Endocrinol. 2020;183(1):C5–C7.
  • Søeborg T, Frederiksen H, Johannsen TH, et al. Isotope-dilution turboflow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum. Clin Chim Acta. 2017;468:180–186.
  • Damgaard-Olesen A, Johannsen TH, Holmboe SA, et al. Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by turboflow-LC-MS/MS and associations to health markers in 304 men. Clin Chim Acta. 2016;454:82–88.
  • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84(10):3666–3672.
  • Twisk J, Bosman L, Hoekstra T, et al. Different ways to estimate treatment effects in randomised controlled trials. Contemp Clin Trials Commun. 2018;10:80–85.
  • Wang C, Cunningham G, Dobs A, et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 2004;89(5):2085–2098.
  • Behre HM, Kliesch S, Leifke E, et al. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 1997;82(8):2386–2390.
  • Wang C, Eyre DR, Clark R, et al. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men–a clinical research center study. J Clin Endocrinol Metab. 1996;81(10):3654–3662.
  • Wang C, Swerdloff RS, Iranmanesh A, et al. Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clin Endocrinol . 2001;54(6):739–750.
  • Jørgensen NR, Møllehave LT, Hansen YBL, et al. Comparison of two automated assays of BTM (CTX and P1NP) and reference intervals in a Danish population. Osteoporos Int. 2017; 28(7):2103–2113.
  • Walsh JS, Marshall H, Smith IL, et al. Testosterone replacement in young male cancer survivors: a 6-month double-blind randomised placebo-controlled trial. PLOS Med. 2019;16(11):e1002960.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.