Moving toward consensus on diagnosis and management of severe asthma in children

References

• Papadopoulos NG, Arakawa H, Carlsen KH, et al. International Consensus On (ICON) Pediatric Asthma. Allergy 2012;67:976-97
   PubMed Web of Science ®Google Scholar
• Lang A, Carlsen KH, Haaland G, et al. Severe asthma in childhood: assessed in 10 year olds in a birth cohort study. Allergy 2008;63:1054-60
   PubMed Web of Science ®Google Scholar
• Hedlin G, Bush A, Lodrup Carlsen K, et al. Problematic severe asthma in children, not one problem but many: a GA2LEN initiative. Eur Respir J 2010;36:196-201
   PubMed Web of Science ®Google Scholar
• Lodrup Carlsen KC, Hedlin G, Bush A, et al. Assessment of problematic severe asthma in children. Eur Respir J 2011;37:432-40
   PubMed Web of Science ®Google Scholar
• Larsen GL. Differences between adult and childhood asthma. J Allergy Clin Immunol 2000;106(3 Suppl):S153-S7
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43:343-73
   PubMed Web of Science ®Google Scholar
• Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218-24
   PubMed Web of Science ®Google Scholar
• Jenkins HA, Cherniack R, Szefler SJ, et al. A comparison of the clinical characteristics of children and adults with severe asthma. Chest 2003;124:1318-24
   PubMed Web of Science ®Google Scholar
• Yunginger JW, Reed CE, O’Connell EJ, et al. A community-based study of the epidemiology of asthma. Incidence rates, 1964–1983. Am Rev Respir Dis 1992;146:888-94
   PubMed Web of Science ®Google Scholar
• Bacharier LB, Mauger DT, Lemanske RF, et al. Classifying asthma severity in children: is measuring lung function helpful? J Allergy Clin Immunol 2002;109(1 Suppl 1):S266
   Web of Science ®Google Scholar
• Fitzpatrick AM, Baena-Cagnani CE, Bacharier LB. Severe asthma in childhood: recent advances in phenotyping and pathogenesis. Curr Opin Allergy Clin Immunol 2012;12:193-201
   PubMed Web of Science ®Google Scholar
• Bønnelykke K, Sleiman P, Nielsen K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 2014;46:51-5
   PubMed Web of Science ®Google Scholar
• Mochizuki H, Shigeta M, Morikawa A. Development of bronchial hyperresponsiveness during childhood. J Asthma 2001;38:1-21
   PubMed Web of Science ®Google Scholar
• Global initiative for asthma. Global strategy for asthma management and prevention. In: Editor Book Global initiative for asthma. Global strategy for asthma management and prevention. City, Global strategy for asthma management and prevention. 2017, http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/
   Google Scholar
• Turner SW, Young S, Goldblatt J, et al. Childhood asthma and increased airway responsiveness: a relationship that begins in infancy. Am J Respir Crit Care Med 2009;179:98-104
   PubMed Web of Science ®Google Scholar
• Haland G, Carlsen KC, Sandvik L, et al. Reduced lung function at birth and the risk of asthma at 10 years of age. N Engl J Med 2006;355:1682-9
   PubMed Web of Science ®Google Scholar
• Stern DA, Morgan WJ, Wright AL, et al. Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study. Lancet 2007;370:758-64
   PubMed Web of Science ®Google Scholar
• Carlsen KH. The breathless adolescent asthmatic athlete. Eur Respir J 2011;38:713-20
   PubMed Web of Science ®Google Scholar
• Moeller A, Carlsen KH, Sly PD, et al. Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation. Eur Respir Rev 2015;24:204-15
   PubMed Web of Science ®Google Scholar
• Guilbert TW, Bacharier LB, Fitzpatrick AM. Severe asthma in children. J Allergy Clin Immunol Pract 2014;2:489-500
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM. Severe asthma in children: lessons learned and future directions. J Allergy Clin Immunol Pract 2016;4:11-19
   PubMed Web of Science ®Google Scholar
• Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010;126:926-38
   PubMed Web of Science ®Google Scholar
• Engelkes M, Janssens HM, de Jongste JC, et al. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J 2015;45:396-407
   PubMed Web of Science ®Google Scholar
• Akinbami LJ, Schoendorf KC. Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics 2002;110(2 Pt 1):315-22
   PubMed Web of Science ®Google Scholar
• Akinbami LJ, Moorman JE, Bailey C, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief 2012;94:1-8 [Database][Mismatch]
   PubMedGoogle Scholar
• Gold DR, Wang X, Wypij D, et al. Effects of cigarette smoking on lung function in adolescent boys and girls. N Engl J Med 1996;335:931-7
   PubMed Web of Science ®Google Scholar
• Tai A, Tran H, Roberts M, et al. The association between childhood asthma and adult chronic obstructive pulmonary disease. Thorax 2014;69:805-10
   PubMed Web of Science ®Google Scholar
• Shaw DE, Sousa AR, Fowler SJ, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J 2015;46:1308-21
   PubMed Web of Science ®Google Scholar
• Godard P, Chanez P, Siraudin L, et al. Costs of asthma are correlated with severity: a 1-yr prospective study. Eur Respir J 2002;19:61-7
   PubMed Web of Science ®Google Scholar
• Plaza AM, Ibáñez MD, Sánchez-Solís M, et al. Consensus-based approach for severe paediatric asthma in routine clinical practice. An Pediatr (Barc) 2006;84:122.e1-11
   Web of Science ®Google Scholar
• Rice JP, Saccone NL, Rasmussen E. Definition of the phenotype. Adv Genet 2001;42:69-76
   PubMed Web of Science ®Google Scholar
• Stein RT, Holberg CJ, Morgan WJ, et al. Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood. Thorax 1997;52:946-52
   PubMed Web of Science ®Google Scholar
• Cowan K, Guilbert TW. Pediatric asthma phenotypes. Curr Opin Pediatr 2012;24:344-51
   PubMed Web of Science ®Google Scholar
• Guilbert TW, Mauger DT, Lemanske RF Jr. Childhood asthma-predictive phenotype. J Allergy Clin Immunol Pract 2014;2:664-70
   PubMed Web of Science ®Google Scholar
• Siroux V, González JR, Bouzigon E, et al. Genetic heterogeneity of asthma phenotypes identified by a clustering approach. Eur Respir J 2014;43:439-52
   PubMed Web of Science ®Google Scholar
• Howrylak JA, Fuhlbrigge AL, Strunk RC, et al. Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications. J Allergy Clin Immunol 2014;133:1289-300
   PubMed Web of Science ®Google Scholar
• Gibeon D, Chung KF. The investigation of severe asthma to define phenotypes. Clin Exp Allergy 2012;42:678-92
   PubMed Web of Science ®Google Scholar
• Bossley CJ, Fleming L, Ullmann N, et al. Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach. J Allergy Clin Immunol 2016;138:413-20
   PubMed Web of Science ®Google Scholar
• Nagakumar P, Denney L, Fleming L, et al. Type 2 innate lymphoid cells in induced sputum from children with severe asthma. J Allergy Clin Immunol 2016;137:624-6
   PubMed Web of Science ®Google Scholar
• Brown SD, Brown LA, Stephenson S, et al. Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma. J Allergy Clin Immunol 2015;135:1651-4
   PubMed Web of Science ®Google Scholar
• Castanhinha S, Sherburn R, Walker S, et al. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. J Allergy Clin Immunol 2015;136:312-22
   PubMed Web of Science ®Google Scholar
• Bossley CJ, Fleming L, Gupta A, et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol 2012;129:974-82
   PubMed Web of Science ®Google Scholar
• Rathkopf MM. Passive smoking impairs histone deacetylase-2 in children with severe asthma. Pediatrics 2014;134(Suppl3):S147-S8
   PubMedGoogle Scholar
• Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008;372:1107-19
   PubMed Web of Science ®Google Scholar
• Siroux V, Garcia-Aymerich J. The investigation of asthma phenotypes. Curr Opin Allergy Clin Immunol 2011;11:393-9
   PubMed Web of Science ®Google Scholar
• Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy 2012;67:835-46
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011;127:382-9
   PubMed Web of Science ®Google Scholar
• Just J, Gouvis-Echraghi R, Couderc R, et al. Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze. J Allergy Clin Immunol 2012;130:103-10
   PubMed Web of Science ®Google Scholar
• Just J, Gouvis-Echraghi R, Rouve S, et al. Two novel, severe asthma phenotypes identified during childhood using a clustering approach. Eur Respir J 2012;40:55-60
   PubMed Web of Science ®Google Scholar
• Just J, Saint-Pierre P, Gouvis-Echraghi R, et al. Childhood allergic asthma is not a single phenotype. J Pediatr 2014;164:815-20
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181:315-23
   PubMed Web of Science ®Google Scholar
• Reddy MB, Covar RA. Asthma phenotypes in childhood. Curr Opin Allergy Clin Immunol 2016;16:127-34
   PubMed Web of Science ®Google Scholar
• Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008;372:1107-19
   PubMed Web of Science ®Google Scholar
• Gelfand EW, Kraft M. The importance and features of the distal airways in children and adults. J Allergy Clin Immunol 2009;126(6 Suppl):S84-S7
   Web of Science ®Google Scholar
• Fleming L, Tsartsali L, Wilson N, et al. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 2012;67:675-81
   PubMed Web of Science ®Google Scholar
• Coverstone A1, Bacharier LB, Fitzpatrick AM. Severe asthma in school-age children: evaluation and phenotypic advances. Curr Allergy Asthma Rep 2015;15:20
   PubMed Web of Science ®Google Scholar
• Fainardi V1, Saglani S. The need to differentiate between adults and children when treating severe asthma. Expert Rev Respir Med 2015;9:419-28
   PubMed Web of Science ®Google Scholar
• Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 2012;42:650-8
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012;18:716-25
   PubMed Web of Science ®Google Scholar
• Lötvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011;127:355-60
   PubMed Web of Science ®Google Scholar
• Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med 2001;164(8 Pt 2):S1-S5
   PubMed Web of Science ®Google Scholar
• Colodenco D, Palomares O, Celis C, et al. Moving toward consensus on diagnosis and management of severe asthma in adults. Curr Med Res Opin 2017
   PubMed Web of Science ®Google Scholar
• Holgate S, Casale T, Wenzel S, et al. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol 2005;115(3):459-65
   PubMed Web of Science ®Google Scholar
• Rabe KF, Calhoun WJ, Smith N, Jimenez P. Can anti-IgE therapy prevent airway remodeling in allergic asthma? Allergy 2011;66:1142-51
   PubMed Web of Science ®Google Scholar
• Burrows B, Martinez FD, Halonen M, et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271-7
   PubMed Web of Science ®Google Scholar
• von Garnier C, Filgueira L, Wikstrom M, et al. Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract. J Immunol 2005;175:1609-18
   PubMed Web of Science ®Google Scholar
• Kitamura K, Takeda K, Koya T, et al. Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J Immunol 2007;178:480-8
   PubMed Web of Science ®Google Scholar
• Smit JJ, Lukacs NW. A closer look at chemokines and their role in asthmatic responses. Eur J Pharmacol 2006;533:277-88
   PubMed Web of Science ®Google Scholar
• Williams PV. Management of asthma. Clin Symp 1997;49:1-32
   PubMedGoogle Scholar
• James A. Airway remodeling in asthma. Curr Opin Pulm Med 2005;11:1-16
   PubMed Web of Science ®Google Scholar
• Hirota N, Martin JG. Mechanisms of airway remodeling. Chest 2013;144:1026-32
   PubMed Web of Science ®Google Scholar
• Samitas K, Delimpoura V, Zervas E, Gaga M. Anti-IgE treatment, airway inflammation and remodelling in severe allergic asthma: current knowledge and future perspectives. Eur Respir Rev 2015;24:594-601
   PubMed Web of Science ®Google Scholar
• Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol 2007;19:676-80
   PubMed Web of Science ®Google Scholar
• Kay AB, Phipps S, Robinson DS. A role for eosinophils in airway remodelling in asthma. Trends Immunol 2004;25:477-82
   PubMed Web of Science ®Google Scholar
• Campbell AM, Vachier I, Chanez P, et al. Expression of the high-affinity receptor for IgE on bronchial epithelial cells of asthmatics. J Am J Respir Cell Mol Biol 1998;19:92-7
   PubMed Web of Science ®Google Scholar
• Roth M, Tamm M. The effects of omalizumab on IgE-induced cytokine synthesis by asthmatic airway smooth muscle cells. Ann Allergy Asthma Immunol 2010;104:152-60
   PubMed Web of Science ®Google Scholar
• Roth M, Zhong J, Zumkeller C, et al. The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. PLoS One 2013;8:e56015
   PubMed Web of Science ®Google Scholar
• Minor TE, Dick EC, DeMeo AN, et al. Viruses as precipitants of asthmatic attacks in children. JAMA 1974;227:292-8
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Trujillo-Torralbo MB, del-Rosario J, et al. The influence of asthma control on the severity of virus-induced asthma exacerbations. J Allergy Clin Immunol 2015;136:497-500
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Sykes A, Mallia P, Johnston SL. Asthma exacerbations: origin, effect, and prevention. J Allergy Clin Immunol 2011;128:1165-74
   PubMed Web of Science ®Google Scholar
• Kloepfer KM, Gern JE. Virus/allergen interactions and exacerbations of asthma. Immunol Allergy Clin North Am 2010;30:553-vii
   PubMed Web of Science ®Google Scholar
• Gill MA, Bajwa G, George TA, et al. Counterregulation between the FceRI pathway and antiviral responses in human plasmacytoid dendritic cells. 2010;184(11):5999-6006
   Google Scholar
• Janeway CJ, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002;20:197-216
   PubMed Web of Science ®Google Scholar
• Schroeder JT, Bieneman AP, Xiao H, et al. TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression. J Immunol 2005;175:5724-31
   PubMed Web of Science ®Google Scholar
• Busse WW, Pedersen S, Pauwels RA, et al. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol 2008;121:1167-74
   PubMed Web of Science ®Google Scholar
• Selroos O, Pietinalho A, Löfroos AB, Riska H. Effect of early vs late intervention with inhaled corticosteroids in asthma. Chest 1995;108:1228-34
   PubMed Web of Science ®Google Scholar
• Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 2004;170:836-44
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Martin RJ, King TS, et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002;109:410-18
   PubMed Web of Science ®Google Scholar
• Using beta 2-stimulants in asthma. Drug Ther Bull 1997;35:1-4
   PubMedGoogle Scholar
• Rodrigo GJ, Castro-Rodríguez JA. What is the role of tiotropium in asthma? A systematic review with meta-analysis. Chest 2015;147:388-96
   PubMed Web of Science ®Google Scholar
• Virchow JCJ, Prasse A, Naya I, et al. Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids. Am J Respir Crit Care Med 2000;162(2 Pt 1):578-85
   PubMed Web of Science ®Google Scholar
• Tamaoki J, Kondo M, Sakai N, et al. Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. The Tokyo Joshi-Idai Asthma Research Group. Am J Respir Crit Care Med 1997;155:1235-40
   PubMed Web of Science ®Google Scholar
• Rivington RN, Boulet LP, Côté J, et al. Efficacy of uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids. Am J Respir Crit Care Med 1995;151(2 Pt 1):325-32
   PubMed Web of Science ®Google Scholar
• Licari A, Marseglia G, Castagnoli R, et al. The discovery and development of omalizumab for the treatment of asthma. Expert Opin Drug Discov 2015;10:1033-42
   PubMed Web of Science ®Google Scholar
• Chipps BE, Lanier B, Milgrom H, et al. Omalizumab in children with uncontrolled allergic asthma: review of clinical trial and real-world experience. J Allergy Clin Immunol 2017;139:1431-44
   PubMed Web of Science ®Google Scholar
• Brodlie M, McKean MC, Moss S, Spencer DA. The oral corticosteroid-sparing effect of omalizumab in children with severe asthma. Arch Dis Child 2012;97:604-9
   PubMed Web of Science ®Google Scholar
• Normansell R, Walker S, Milan SJ, et al. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev 2014;13:CD003559
   Web of Science ®Google Scholar
• Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-84
   PubMed Web of Science ®Google Scholar
• Stevenson DD. Diagnosis, prevention, and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. J Allergy Clin Immunol 1984;74(4 Pt 2):617-22
   PubMed Web of Science ®Google Scholar
• Malinovschi A, Fonseca JA, Jacinto T, et al. Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects. J Allergy Clin Immunol 2013;132:821-7
   PubMed Web of Science ®Google Scholar
• Katz LE, Gleich GJ, Hartley BF, et al. Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. Ann Am Thorac Soc 2014;11:531-6
   PubMedGoogle Scholar
• Konradsen JR, James A, Nordlund B, et al. The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma. J Allergy Clin Immunol 2013;132:328-35 e5
   PubMed Web of Science ®Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011;184:602-15
   PubMed Web of Science ®Google Scholar
• Yang S, Park J, Lee YK, et al. Association of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic children. Respir Med 2015;109:572-9
   PubMed Web of Science ®Google Scholar
• Kerstjens HA, Brand PL, de Jong PM, et al. Influence of treatment on peak expiratory flow and its relation to airway hyperresponsiveness and symptoms. The Dutch CNSLD Study Group. Thorax 1994;49:1109-15
   PubMed Web of Science ®Google Scholar
• Brand PL, Duiverman EJ, Waalkens HJ, et al. Peak flow variation in childhood asthma: correlation with symptoms, airways obstruction, and hyperresponsiveness during long term treatment with inhaled corticosteroids. Thorax 1999;54:103-7
   PubMed Web of Science ®Google Scholar
• Fuhlbrigge AL, Kitch BT, Paltiel AD, et al. FEV1 is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol 2001;107:61-7
   PubMed Web of Science ®Google Scholar
• Asthma Control Test. In: Editor Book Asthma Control Test. https://www.asthma.com/content/dam/NA_Pharma/Country/US/Unbranded/Consumer/Common/Images/MPY/documents/816207R0_asthmacontroltest_printable.pdf
   Google Scholar
• Liu AH, Zeiger R, Sorkness C, et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 2007;119:817-25
   PubMed Web of Science ®Google Scholar
• Zeiger RS, Mellon M, Chipps B, et al. Test for Respiratory and Asthma Control in Kids (TRACK): clinically meaningful changes in score. J Allergy Clin Immunol 2011;128:983-8
   PubMed Web of Science ®Google Scholar
• Toelle BG, Xuan W, Peat JK, Marks GB. Childhood factors that predict asthma in young adulthood. Eur Respir J 2004;23:66-70
   PubMed Web of Science ®Google Scholar
• Tai A, Tran H, Roberts M, et al. Outcomes of childhood asthma to the age of 50 years. J Allergy Clin Immunol 2014;133:1572-8 e3
   PubMed Web of Science ®Google Scholar
• Plaza AM, Ibanez MD, Sanchez-Solis M, et al. [Consensus-based approach for severe paediatric asthma in routine clinical practice]. An Pediatr (Barc) 2016;84:122 e1-11
   Web of Science ®Google Scholar
• Schatz M, Rachelefsky G, Krishnan JA. Follow-up after acute asthma episodes: what improves future outcomes? J Allergy Clin Immunol 2009;124(2 Suppl):S35-S42
   PubMed Web of Science ®Google Scholar
• Liu AH, Jaramillo R, Sicherer SH, et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol 2010;126:798-806
   PubMed Web of Science ®Google Scholar
• Blair H. Natural history of childhood asthma. 20-year follow-up. Arch Dis Child 1977;52:613-19
   PubMed Web of Science ®Google Scholar
• Wu TJ, Wu CF, Lee YL, et al. Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan. Respir Res 2014;15:135
   PubMed Web of Science ®Google Scholar
• Roorda RJ, Gerritsen J, Van Aalderen WM, et al. Risk factors for the persistence of respiratory symptoms in childhood asthma. Am Rev Respir Dis 1993;148(6 Pt 1):1490-5
   PubMed Web of Science ®Google Scholar
• Guilbert TW, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006;354:1985-97
   PubMed Web of Science ®Google Scholar
• Fleming L, Murray C, Bansal AT, et al. The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. Eur Respir J 2015;46:1322-33
   PubMed Web of Science ®Google Scholar
• Nieto A, Wahn U, Bufe A, et al. Allergy and asthma prevention 2014. Pediatr Allergy Immunol 2014;25:516-33
   PubMed Web of Science ®Google Scholar
• Irvine L, Crombie IK, Clark RA, et al. Advising parents of asthmatic children on passive smoking: randomised controlled trial. BMJ 1999;318:1456-9
   PubMed Web of Science ®Google Scholar
• Kim JM, Lin SY, Suarez-Cuervo C, et al. Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: a systematic review. Pediatrics 2013;131:1155-67
   PubMed Web of Science ®Google Scholar
• Arshad SH, Bojarskas J, Tsitoura S, et al. Prevention of sensitization to house dust mite by allergen avoidance in school age children: a randomized controlled study. Clin Exp Allergy 2002;32:843-9
   PubMed Web of Science ®Google Scholar
• Liu AH, Murphy JR. Hygiene hypothesis: fact or fiction? J Allergy Clin Immunol 2003;111:471-8
   PubMed Web of Science ®Google Scholar
• Becker AB. Prevention strategies for asthma – primary prevention. CMAJ 2005;173(6 Suppl):S20-S4
   PubMed Web of Science ®Google Scholar
• Xolair (omalizumab) full prescribing information. City, 2016 https://www.gene.com/download/pdf/xolair_prescribing.pdf accessed 24 November
   Google Scholar
• Kulus M, Hebert J, Garcia E, et al. Omalizumab in children with inadequately controlled severe allergic (IgE-mediated) asthma. Curr Med Res Opin 2010;26:1285-93
   PubMed Web of Science ®Google Scholar
• Lanier B, Bridges T, Kulus M, et al. Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. J Allergy Clin Immunol 2009;124:1210-16
   PubMed Web of Science ®Google Scholar
• Hoshino M, Ohtawa J. Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma. Respiration 2012;83:520-8
   PubMed Web of Science ®Google Scholar
• Riccio AM, Dal Negro RW, Micheletto C, et al. Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients. Int J Immunopathol Pharmacol 2012;25:475-84
   PubMed Web of Science ®Google Scholar
• Tagiyeva N, Devereux G, Fielding S, et al. Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study. Am J Respir Crit Care Med 2016;193:23-30
   PubMed Web of Science ®Google Scholar
• Hasegawa K, Ahn J, Brown MA, et al. Underuse of guideline-recommended long-term asthma management in children hospitalized to the intensive care unit: a multicenter observational study. Ann Allergy Asthma Immunol 2015;115:10-16
   PubMed Web of Science ®Google Scholar
• Chan AH, Stewart AW, Harrison J, et al. The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial. Lancet Respir Med 2015;3:210-19
   PubMed Web of Science ®Google Scholar
• Bender B, Zhang L. Negative affect, medication adherence, and asthma control in children. J Allergy Clin Immunol 2008;122:490-5
   PubMed Web of Science ®Google Scholar
• Ordonez GA, Phelan PD, Olinsky A, Robertson CF. Preventable factors in hospital admissions for asthma. Arch Dis Child 1998;78:143-7
   PubMed Web of Science ®Google Scholar
• Strunk RC. Asthma deaths in childhood: identification of patients at risk and intervention. J Allergy Clin Immunol 1987;80(3 Pt 2):472-7
   PubMed Web of Science ®Google Scholar
• Cramer JA. Feedback on medication dosing enhances patient compliance. Chest 1993;104:333-4
   PubMed Web of Science ®Google Scholar
• Kim H, Kieckhefer GM, Greek AA, et al. Health care utilization by children with asthma. Prev Chronic Dis 2009;6:A12
   PubMed Web of Science ®Google Scholar
• Jones R, Lin S, Munsie JP, et al. Racial/ethnic differences in asthma-related emergency department visits and hospitalizations among children with wheeze in Buffalo, New York. J Asthma 2008;45:916-22
   PubMed Web of Science ®Google Scholar
• Bilal M, Haseeb A, Khan MH, et al. Factors associated with patient visits to the emergency department for asthma therapy in Pakistan. Asia Pac Fam Med 2016;15:1
   PubMedGoogle Scholar
• Al-Muhsen S, Horanieh N, Dulgom S, et al. Poor asthma education and medication compliance are associated with increased emergency department visits by asthmatic children. Ann Thorac Med 2015;10:123-31
   PubMed Web of Science ®Google Scholar
• Baena-Cagnani CE, Gomez RM, Baena-Cagnani R, Canonica GW. Impact of environmental tobacco smoke and active tobacco smoking on the development and outcomes of asthma and rhinitis. Curr Opin Allergy Clin Immunol 2009;9:136-40
   PubMed Web of Science ®Google Scholar
• Mackay D, Haw S, Ayres JG, et al. Smoke-free legislation and hospitalizations for childhood asthma. N Engl J Med 2010;363:1139-45
   PubMed Web of Science ®Google Scholar
• Kristiansen M, Dhami S, Netuveli G, et al. Allergen immunotherapy for the prevention of allergy: a systematic review and meta-analysis. Pediatr Allergy Immunol 2017;28:18-29
   PubMed Web of Science ®Google Scholar
• Lin SY, Erekosima N, Kim JM, et al. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. JAMA 2013;309:1278-88
   PubMed Web of Science ®Google Scholar