A randomized trial comparing omega-3 fatty acid plasma levels after ingestion of emulsified and non-emulsified cod liver oil formulations

References

• Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr 2012;142:592S-9S
   PubMed Web of Science ®Google Scholar
• Food and Agriculture Organization of the United Nations. Fats and fatty acids in human nutrition: report of an expert consultation. Rome, Italy: Food and Agriculture Organization of the United Nations; 2010
   Google Scholar
• Nettleton JA, Katz R. n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc 2005;105:428-40
   PubMed Web of Science ®Google Scholar
• Surette ME. The science behind dietary omega-3 fatty acids. CMAJ 2008;178:177-80
   PubMed Web of Science ®Google Scholar
• Poudyal H, Panchal SK, Diwan V, et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. Prog Lipid Res 2011;50:372-87
   PubMed Web of Science ®Google Scholar
• Kuratko CN, Barrett EC, Nelson EB, et al. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. Nutrients 2013;5:2777-810
   PubMed Web of Science ®Google Scholar
• Montgomery P, Burton JR, Sewell RP, et al. Low blood long chain omega-3 fatty acids in UK children are associated with poor cognitive performance and behavior: a cross-sectional analysis from the DOLAB study. PLoS One 2013;8:e66697
   PubMed Web of Science ®Google Scholar
• Jeffrey BG, Weisinger HS, Neuringer M, et al. The role of docosahexaenoic acid in retinal function. Lipids 2001;36:859-71
   PubMed Web of Science ®Google Scholar
• Innis SM. Dietary omega 3 fatty acids and the developing brain. Brain Res 2008;1237:35-43
   PubMed Web of Science ®Google Scholar
• Weiser MJ, Butt CM, Mohajeri MH. Docosahexaenoic acid and cognition throughout the lifespan. Nutrients 2016;8:99
   PubMed Web of Science ®Google Scholar
• Stark KD, Holub BJ. Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr 2004;79:765-73
   PubMed Web of Science ®Google Scholar
• EFSA Panel on Dietetic Products NaA. Scientific opinion on the substantiation of health claims related to eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and maintenance of normal cardiac function (ID 504, 506, 516, 527, 538, 703, 1128, 1317, 1324, 1325), maintenance of normal blood glucose concentrations (ID 566), maintenance of normal blood pressure (ID 506, 516, 703, 1317, 1324), maintenance of normal blood HDL-cholesterol concentrations (ID 506), maintenance of normal (fasting) blood concentrations of triglycerides (ID 506, 527, 538, 1317, 1324, 1325), maintenance of normal blood LDL-cholesterol concentrations (ID 527, 538, 1317, 1325, 4689), protection of the skin from photo-oxidative (UV-induced) damage (ID 530), improved absorption of EPA and DHA (ID 522, 523), contribution to the normal function of the immune system by decreasing the levels of eicosanoids, arachidonic acid-derived mediators and pro-inflammatory cytokines (ID 520, 2914), and "immunomodulating agent" (4690) pursuant to article 13(1) of regulation (EC) No 1924/2006. EFSA J 2010;8:1796
   Google Scholar
• Earnest CP, Kupper JS, Thompson AM, et al. Complementary effects of multivitamin and omega-3 fatty acid supplementation on indices of cardiovascular health in individuals with elevated homocysteine. Int J Vitam Nutr Res 2012;82:41-52
   PubMed Web of Science ®Google Scholar
• Skulas-Ray AC, Kris-Etherton PM, Harris WS, et al. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr 2011;93:243-52
   PubMed Web of Science ®Google Scholar
• Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 2006;83(6 Suppl):1467S-76S
   PubMed Web of Science ®Google Scholar
• Micha R, Khatibzadeh S, Shi P, et al. Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. BMJ 2014;348:g2272
   PubMed Web of Science ®Google Scholar
• Armand M, Pasquier B, Andre M, et al. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am J Clin Nutr 1999;70:1096-106
   PubMed Web of Science ®Google Scholar
• Haug IJ, Sagmo LB, Zeiss D, et al. Bioavailability of EPA and DHA delivered by gelled emulsions and soft gel capsules. Eur J Lipid Sci Technol 2011;113:137-45
   Web of Science ®Google Scholar
• Garaiova I, Guschina IA, Plummer SF, et al. A randomised cross-over trial in healthy adults indicating improved absorption of omega-3 fatty acids by pre-emulsification. Nutr J 2007;6:4
   PubMed Web of Science ®Google Scholar
• Lane KE, Li W, Smith C, et al. The bioavailability of an omega-3-rich algal oil is improved by nanoemulsion technology using yogurt as a food vehicle. Int J Food Sci Technol 2014;49:1264-71
   Web of Science ®Google Scholar
• Hussey EK, Portelli S, Fossler MJ, et al. Relative bioavailability of an emulsion formulation for omega-3-acid ethyl esters compared to the commercially available formulation: a randomized, parallel-group, single-dose study followed by repeat dosing in healthy volunteers. Clin Pharmacol Drug Dev 2012;1:14-23
   PubMed Web of Science ®Google Scholar
• Raatz SK, Redmon JB, Wimmergren N, et al. Enhanced absorption of n-3 fatty acids from emulsified compared with encapsulated fish oil. J Am Diet Assoc 2009;109:1076-81
   PubMed Web of Science ®Google Scholar
• Raatz SK, Johnson LK, Bukowski MR. Enhanced bioavailability of EPA from emulsified fish oil preparations versus capsular triacylglycerol. Lipids 2016;51:643-51
   PubMed Web of Science ®Google Scholar
• Morrison WR, Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. J Lipid Res 1964;5:600-8
   Google Scholar
• Hodges JL, Lehmann EL. Estimation of location based on ranks. Ann Mathematic Stat 1963;34:598-611
   Google Scholar
• Abrahamse E, Minekus M, van Aken GA, et al. Development of the digestive system—experimental challenges and approaches of infant lipid digestion. Food Dig 2012;3:63-77
   PubMedGoogle Scholar
• Lindquist S, Hernell O. Lipid digestion and absorption in early life: an update. Curr Opin Clin Nutr Metab Care 2010;13:314-20
   PubMed Web of Science ®Google Scholar
• Fernandez E, Perez R, Hernandez A, et al. Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics 2011;3:53-72
   PubMedGoogle Scholar
• Rings EH, Minich DM, Vonk RJ, et al. Functional development of fat absorption in term and preterm neonates strongly correlates with ability to absorb long-chain fatty acids from intestinal lumen. Pediatr Res 2002;51:57-63
   PubMed Web of Science ®Google Scholar