54
Views
24
CrossRef citations to date
0
Altmetric
Article

Differential CCR5Δ32 allelic frequencies in juvenile idiopathic arthritis subtypes: evidence for different regulatory roles of CCR5 in rheumatological diseases

, , , , , , , , , & show all
Pages 13-17 | Accepted 15 Aug 2007, Published online: 12 Jul 2009

References

  • Silverman E. D., Isacovics B., Petsche D., Laxer R. M. Synovial fluid cells in juvenile arthritis: evidence of selective T cell migration to inflamed tissue. Clin Exp Immunol 1993; 91: 90–5
  • Wedderburn L. R., Robinson N., Patel A., Varsani H., Woo P. Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis. Arthritis Rheum 2000; 43: 765–74
  • Chistopherson K 2nd., Hromas R. Chemokine regulation of normal and pathologic immune responses. Stem Cells 2001; 19: 388–96
  • Liu R., Paxton W. A., Choe S., Ceradini D., Martin S. R., Horuk R., et al. Homozygous defect in HIV‐1 coreceptor accounts for resistance of some multiply exposed individual to HIV‐infection. Cell 1996; 86: 367–77
  • Pokorny V., McQueen F., Yeoman S., Merriman M., Merriman A., Harrison A., et al. Evidence for negative association of the chemokine receptor CCR5d32 polymorphism with rheumatoid arthritis. Ann Rheum Dis 2005; 64: 487–90
  • Thompson S. D., Luyrink L. K., Graham T. B., Tsoras M., Ryan M., Passo M. H., et al. Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL‐4: IFN‐γ mRNA ratios. J Immunol 2001; 166: 6899–906
  • Chiesa S., Prigione I., Morandi F., Buoncompagni A., Picco P., Bocca P., et al. Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis. J Rheumatol 2004; 31: 2048–54
  • Gattorno M., Prigione I., Morandi F., Gregorio A., Chiesa S., Ferlito F., et al. Phenotypic and functional characterisation of CCR7+ and CCR7− CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis. Arthritis Res Ther 2004; 7: R256–67
  • Petty R. E., Southwood T. R., Manners P., Baum J., Glass D. N., Goldenberg J., et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390–2
  • Vargas A. E., Marrero A. R., Salzano F. M., Bortolini M. C., Chies J. A. B. Frequency of CCR5Δ32 in Brazilian populations. Braz J Med Biol Res 2006; 39: 321–5
  • Chies J. A. B., Hutz M. H. High frequency of the CCR5▵32 variant among individuals from an admixed Brazilian population with sickle cell anemia. Braz J Med Biol Res 2003; 36: 71–5
  • Zapico I., Coto E., Rodriguez A., Alvarez C., Torre J. C., Alvarez V. CCR5 (chemokine receptor‐5) DNA‐polymorphism influences the severity of rheumatoid arthritis. Genes Immun 2000; 1: 288–9
  • Prahalad S. Negative association between the chemokine receptor CCR5‐Δ32 polymorphism and rheumatoid arthritis: a meta‐analysis. Genes Immun 2006; 7: 264–8
  • Prahalad S., Bohnsack J. F., Jorde L. B., Whiting A., Clifford B., Dunn D., et al. Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Genes Immun 2006; 7: 468–75
  • Passos GA J. r., Picanco V. P. Frequency of the ΔCCR5 deletion allele in the urban Brazilian population. Immunol Lett 1998; 61: 205–7
  • Pereira R. W., Pires R. E., Duarte A. P. M., Moura R. P., Monteiro E., Torloni H., et al. Frequency of the CCR5Δ32 allele in Brazilians: a study in colorectal cancer and in HTLV‐I infection. Genet Mol Biol 2000; 23: 523–6
  • Dawson T. C., Beck M. A., Kuziel W. A., Henderson F., Maeda N. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol 2000; 156: 1951–9
  • de Kleer I. M., Wedderburn L. R., Taams L. S., Patel A., Varsani H., Klein M., et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 2004; 172: 6435–43
  • Ruprecht C. R., Gattorno M., Ferlito F., Gregorio A., Martini A., Lanzavecchia A., et al. Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med 2005; 201: 1793–803

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.