Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion

References

• Sakkas L. I., Platsoucas C. D. Is systemic sclerosis an antigen‐driven T cell disease?. Arthritis Rheum 2004; 50: 1721–33
   PubMed Web of Science ®Google Scholar
• Mavalia C., Scaletti C., Romagnani P., Carossibo A. M., Pignone A., Emmi L., et al. Type 2 helper T‐cell predominance and high CD30 expression in systemic sclerosis. Am J Pathol 1997; 151: 1751–8
   PubMed Web of Science ®Google Scholar
• Annunziato F., Cosmi L., Galli G., Beltrame C., Romagnani P., Maneti R., et al. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol 1999; 65: 691–9
   PubMed Web of Science ®Google Scholar
• Hasegawa M., Fujimoto M., Kikuchi K., Takehara K. Elevated serum levels of interleukin 4 (IL‐4), IL‐10, and IL‐13 in patients with systemic sclerosis. J Rheumatol 1997; 24: 328–32
   PubMed Web of Science ®Google Scholar
• Kucharz E. J., Brzezinska‐Wcislo L., Kotulska A., Gasiorowska‐Kielkowska W., Gozdzik J. Elevated serum level of interleukin‐10 in patients with systemic sclerosis. Clin Rheumatol 1997; 16: 638–9
   PubMedGoogle Scholar
• Atamas S. P., White B. The role of chemokines in the pathogenesis of scleroderma. Curr Opin Rheumatol 2003; 15: 772–7
   PubMedGoogle Scholar
• Fujii H., Shimada Y., Hasegawa M., Takehara K., Sato S. Serum levels of a Th1 chemoattractant IP‐10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis. J Dermatol Sci 2004; 35: 43–51
   PubMedGoogle Scholar
• Adema G. J., Hartgers F., Verstraten R., de Vries E., Marland G., Menon S., et al. A dendritic‐cell‐derived C‐C chemokine that preferentially attracts naive T cells. Nature 1997; 387: 713–17
   PubMed Web of Science ®Google Scholar
• Hieshima K., Imai T., Baba M. A novel human CC chemokine PARC that is most homologous to macrophage‐inflammatory protein‐1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immunol 1997; 159: 1140–9
   PubMed Web of Science ®Google Scholar
• Kodelja V., Muller C., Politz O., Hakij N., Orfanos C. E., Goerdt S. Alternative macrophage activation‐associated CC‐chemokine‐1, a novel structural homologue of macrophage inflammatory protein‐1 alpha with a Th2‐associated expression pattern. J Immunol 1998; 160: 1411–18
   PubMed Web of Science ®Google Scholar
• van Lieshout A. W., van der Voort R., le Blanc L. M., Roelofs M. F., Schreurs B. W., van Riel P. L., et al. Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, Toll‐like receptors and rheumatoid synovial fluid. BMC Immunol 2006; 7: 23
   PubMedGoogle Scholar
• van der Voort R., Kramer M., Lindhout E., Figdor C. G., Adema G. J. Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC‐CK1 in serum and body fluids in pathological conditions. J Leukoc Biol 2005; 77: 739–47
   PubMedGoogle Scholar
• Vissers J. L., Hartgers F. C., Lindhout E., Teunissen M. B., Figdor C. G., Adema G. J. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. J Leukoc Biol 2001; 69: 785–93
   PubMed Web of Science ®Google Scholar
• Atamas S. P., Luzina I. G., Choi J., Tsymbulyuk N., Carbonetti N. H., Singh I. S., et al. Pulmonary and activation‐regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol 2003; 29: 743–9
   PubMed Web of Science ®Google Scholar
• Luzina I. G., Tsymbalyuk N., Choi J., Hasday J. D., Atamas S. P. CCL18‐stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity. J Cell Physiol 2005; 206: 221–8
   Google Scholar
• Kodera M., Hasegawa M., Komura K., Yanaba K., Takehara K., Sato S. Serum pulmonary and activation‐regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis. Arthritis Rheum 2005; 52: 2889–96
   PubMed Web of Science ®Google Scholar
• Prasse A., Pechkovsky D. V., Toews G. B., Schafer M., Eggeling S., Ludwig C., et al. CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. Arthritis Rheum 2007; 56: 1685–93
   PubMed Web of Science ®Google Scholar
• Luzina I. G., Atamas S. P., Wise R., Wigley F. M., Xiao H. Q., White B. Gene expression in bronchoalveolar lavage cells from scleroderma patients. Am J Respir Cell Mol Biol 2002; 26: 549–57
   PubMed Web of Science ®Google Scholar
• Radstake T. R., van Lent P. L., Pesman G. J., Blom A. B., Sweep F. G., Ronnelid J., et al. High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering. Ann Rheum Dis 2004; 63: 696–702
   PubMed Web of Science ®Google Scholar
• Roelofs M. F., Joosten L. A., Abdollahi‐Roodsaz S., van Lieshout A. W., Sprong T., van den Hoogen F. H., et al. The expression of toll‐like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll‐like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005; 52: 2313–22
   PubMed Web of Science ®Google Scholar
• Steinman R. M., Nussenzweig M. C. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 2002; 99: 351–8
   PubMed Web of Science ®Google Scholar
• Matzinger P. The danger model: a renewed sense of self. Science 2002; 296: 301–5
   PubMed Web of Science ®Google Scholar
• Roelofs M. F., Abdollahi‐Roodsaz S., Joosten L. A., van den Berg W. B., Radstake T. R. The orchestra of Toll‐like receptors and their potential role in frequently occurring rheumatic conditions. Arthritis Rheum 2008; 58: 338–48
   PubMed Web of Science ®Google Scholar
• Vogl T., Tenbrock K., Ludwig S., Leukert N., Ehrhardt C., van Zoelen M. A. Mrp8 and Mrp14 are endogenous activators of Toll‐like receptor 4, promoting lethal, endotoxin‐induced shock. Nat Med 2007; 13: 1042–9
   PubMed Web of Science ®Google Scholar
• Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23: 581–90
   PubMed Web of Science ®Google Scholar
• LeRoy E. C., Black C., Fleischmajer R. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202–5
   PubMed Web of Science ®Google Scholar
• Clements P. J., Lachenbruch P. A., Seibold J. R. Skin thickness score in systemic sclerosis: an assessment of interobserver variability in 3 independent studies. J Rheumatol 1993; 20: 1892–6
   PubMed Web of Science ®Google Scholar
• Radstake T. R., Blom A. B., Sloetjes A. W., van Gorselen E. O., Pesman G. J., Engelen L., et al. Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis. Ann Rheum Dis 2004; 63: 1556–63
   PubMedGoogle Scholar
• Radstake T. R., van der Voort R., ten Brummelhuis M., de Waal Malefijt M., Looman M., Figdor C. G., van den Berg W. B., et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis and regulation by Fc gamma receptors. Ann Rheum Dis 2005; 64: 359–67
   PubMed Web of Science ®Google Scholar
• Lien E., Means T. K., Heine H., Yoshimura A., Kusumoto S., Fukase K. Toll‐like receptor 4 imparts ligand‐specific recognition of bacterial lipopolysaccharide. J Clin Invest 2000; 105: 497–504
   PubMed Web of Science ®Google Scholar
• Netea M. G., Kullberg B. J., de Jong D. J., Franke B., Sprong T., Naber T. H., van der Meer J. W. M. NOD2 mediates anti‐inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol 2004; 34: 2052–9
   PubMed Web of Science ®Google Scholar
• van Lieshout A. W., Barrera P., Smeets R. L., Adema G. J., Figdor C. G., van den Berg W. B., et al. Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi‐mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis. Ann Rheum Dis 2005; 64: 408–14
   PubMedGoogle Scholar
• Radstake T. R., van Lent P. L., Pesman G. J., Blom A. B., Sweep F. G., Ronnelid J., et al. High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering. Ann Rheum Dis 2004; 63: 696–702
   PubMed Web of Science ®Google Scholar
• Roelofs M. F., Boelens W. C., Joosten L. A., van den Berg W. B., van Riel P. L., Radstake T. R. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 2006; 176: 7021–7
   PubMed Web of Science ®Google Scholar
• Liu Y., Zhang P., Li J., Kulkarni A. B., Perruche S., Chen W. A critical function for TGF‐beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 2008; 9: 632–40
   PubMed Web of Science ®Google Scholar
• Volpe E., Servant N., Zollinger R., Bogiatzi S. I., Hupe P., Barillot E., Soumelis V. A critical function for transforming growth factor‐beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)‐17 responses. Nat Immunol 2008; 9: 650–7
   PubMed Web of Science ®Google Scholar
• Seki E., De Minicis S., Osterreicher C. H., Kluwe J., Osawa Y., Brenner D. A. TLR4 enhances TGF‐beta signaling and hepatic fibrosis. Nat Med 2007; 13: 1324–32
   PubMed Web of Science ®Google Scholar
• Winau F., Quack C., Darmoise A., Kaufmann S. H. Starring stellate cells in liver immunology. Curr Opin Immunol 2008; 20: 68–74
   PubMedGoogle Scholar
• Chen C. J., Kono H., Golenbock D., Reed G., Akira S., Rock K. L. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 2007; 13: 851–6
   PubMed Web of Science ®Google Scholar
• Duan H., Fleming J., Pritchard D. K., Amon L. M., Xue J., Arnett H. A. Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma. Arthritis Rheum 2008; 58: 1465–74
   PubMedGoogle Scholar