111
Views
17
CrossRef citations to date
0
Altmetric
Original

Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure

, , , &
Pages 93-103 | Received 03 Jun 2007, Accepted 21 Nov 2007, Published online: 09 Jul 2009

References

  • Bell LN, Ward JL, Degawa-Yamauchix M, Bovenkerk JE, Jones R, Cacucci BM, Gupta CE, Sheridan C, Sheridan K, Shankar SS, et al. Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity. Am J Physiol Endocrinol Metab 2006; 291: E843–E848
  • Boros P, Miller CM. Hepatocyte growth factor: A multifunctional cytokine. Lancet 1995; 345: 293–295
  • Bray GA, Bellanger T. Epidemiology, trends, and morbidities of obesity and the metabolic syndrome. Endocrine 2006; 29: 109–117
  • Butte NF, Comuzzie AG, Cai G, Cole SA, Mehta NR, Bacino CA. Genetic and environmental factors influencing fasting serum adiponectin in Hispanic children. J Clin Endocrinol Metab 2005; 90: 4170–4176
  • Dalton M, Cameron AJ, Zimmet PZ, Shaw JE, Jolley D, Dunstan DW, Welborn TA. Waist circumference, waist–hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. J Intern Med 2003; 254: 555–563, AusDiab Steering Committee
  • Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity, and the metabolic syndrome. J Clin Endocrinol Metab 2001; 86: 4321–4325
  • Fain JN. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 2006; 74: 443–477
  • Farooqi IS, O’Rahilly S. Recent advances in the genetics of severe childhood obesity. Arch Dis Child 2000; 83: 31–34
  • Feuerherm AJ, Borset M, Seidel C, Sundan A, Leistad L, Ostensen M, Faxvaag A. Elevated levels of osteoprotegerin (OPG) and hepatocyte growth factor (HGF) in rheumatoid arthritis. Scand J Rheumatol 2001; 30: 229–234
  • Gohda E, Matsunaga T, Kataoka H, Yamamoto I. TGF-beta is a potent inhibitor of hepatocyte growth factor secretion by human fibroblasts. Cell Biol Int Rep 1992; 16: 917–926
  • Hayashi Y, Saitoh S, Takagi S, Tuchihashi K, Miura T, Shimamoto K. Hepatocyte growth factor and 24-hour ambulatory blood pressure monitoring. Hypertens Res 2002; 25: 655–660
  • Hiratsuka A, Adachi H, Fujiura Y. Strong association between serum hepatocyte growth factor and metabolic syndrome. J Clin Endocrinol Metab 2005; 90: 2927–2931
  • Huerta MG. Adiponectin and leptin: Potential tools in the differential diagnosis of pediatric diabetes?. Rev Endocr Metab Disord 2006; 7: 187–196
  • Jiang JG, Gao B, Zarnegar R. The concerted regulatory functions of the transcription factors nuclear factor-1 and upstream stimulatory factor on a composite element in the promoter of the hepatocyte growth factor gene. Oncogene 2000; 19: 2786–2790
  • Lamblin N, Susen S, Dagorn J, Mouquet F, Jude B, Van Belle E, Bauters C, de Groote P. Prognostic significance of circulating levels of angiogenic cytokines in patients with congestive heart failure. Am Heart J 2005; 150: 137–143
  • Livshits G, Gerber LM. Familial factors of blood pressure and adiposity covariation. Hypertension 2001; 37: 928–935
  • Livshits G, Ginsburg E, Kobyliansky E. Heterogeneity of genetic control of blood pressure in ethnically different populations. Hum Biol 1999; 71: 685–708
  • Livshits G, Karasik D, Kobyliansky E. Complex segregation analysis of the radiographic phalanges bone mineral density and their age-related changes. J Bone Miner Res 2002; 17: 152–161
  • Livshits G, Pantsulaia I, Gerber LM. Association of leptin levels with obesity and blood pressure: Possible common genetic variation. Int J Obes 2005; 29: 85–92
  • Livshits G, Pantsulaia I, Trofimov S, Kobyliansky E. Genetic variation of circulating leptin is involved in genetic variation of hand bone size and geometry. Osteoporos Int 2003; 14: 476–483
  • Livshits G. Quantitative genetics of circulating molecules associated with bone metabolism: A review. J Musculoskelet Neuronal Interact 2006; 6: 47–61
  • Malkin I, Ginsburg E. Program package for pedigree analysis (version MAN-7). Technical Report. Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University. 2007
  • Mikroulis D, Papanas N, Maltezos E, Bougioukas G. Angiogenic growth factors in the treatment of peripheral arterial disease. Curr Vasc Pharmacol 2007; 5: 195–209
  • Morishita R, Aoki M, Yo Y, Ogihara T. Hepatocyte growth factor as cardiovascular hormone: Role of HGF in the pathogenesis of cardiovascular disease. Endocr J 2002; 49: 273–284
  • Motone M, Katsuya T, Ishikawa K, Iwashima Y, Iwashima Y, Sugimoto K, Yamamoto K, Fu Y, Matsuo A, Ohishi M, et al. Association between hepatocyte growth factor gene polymorphism and essential hypertension. Hypertens Res 2004; 27: 247–251
  • Nakamura S, Moriguchi A, Morishita R, Aoki M, Yo Y, Hayashi S, Nakano N, Katsuya T, Nakata S, Takami S, et al. A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension. Biochem Biophys Res Commun 1998; 242: 238–243
  • Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, Tracy RP. Familial and genetic determinants of systemic markers of inflammation: The NHLBI family heart study. Atherosclerosis 2001; 154: 681–689
  • Rehman J, Considine RV, Bovenkerk JE, Li J, Slavens CA, Jones RM, March KL. Obesity is associated with increased levels of circulating hepatocyte growth factor. J Am Coll Cardiol 2003; 41: 1408–1413
  • Retterstol L, Eikvar L, Berg K. A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease. Atherosclerosis 2003; 169: 2279–2282
  • Robak E, Wozniacka A, Sysa-Jedrzejowska A, Stepien H, Robak T. Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. Eur Cytokine Netw 2001; 12: 445–452
  • Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: An update. Clin Endocrinol 2006; 64: 355–365
  • Scherer PE. Adipose tissue: From lipid storage compartment to endocrine organ. Diabetes 2006; 55: 1537–1545
  • See R, Abdullah SM, McGuire DK, Khera A, Patel MJ, Lindsey JB, Grundy SM, de Lemos JA. The association of differing measures of overweight and obesity with prevalent atherosclerosis: The Dallas Heart Study. J Am Coll Cardiol 2007; 50: 752–759
  • Shmulewitz D, Heath SC, Blundell ML, Han Z, Sharma R, Salit J, Auerbach SB, Signorini S, Breslow JL, Stoffel M, et al. Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci USA 2006; 103: 3502–3509
  • Sturm R. The effects of obesity, smoking, and problem drinking on chronic medical problems and health care costs. Health Affairs 2002; 21: 245–253
  • Swierczynski J, Korczynska J, Goyke E. Serum hepatocyte growth factor concentration in obese women decreases after vertical banded gastroplasty. Obes Surg 2005; 15: 803–808
  • Visscher TL, Kromhout D, Seidell JC. Long-term and recent time trends in the prevalence of obesity among Dutch men and women. Int J Obes Relat Metab Disord 2002; 26: 1218–1224
  • Wallace AM, Banfield E, Ingram M. Glucocorticoids contribute to the heritability of leptin in Scottish adult female twins. Clin Endocrinol 2004; 61: 149–154
  • Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum Mol Genet 2006; 15: R124–30
  • Zarnegar R. Regulation of HGF and HGFR gene expression. EXS 1995; 74: 33–49

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.