On the Mechanism of Hepatocarcinogenesis of Benzodiazepines: Evidence that Diazepam and Oxazepam are CYP2B Inducers in Rats, and both CYP2B and CYP4A Inducers in Mice

References

• Arlotto M. P., Greenway D. J., Parkinson A. Purification of two isozyme of rat liver microsomal cytochrome P-450 with testosterone 7α-hydroxylase activity. Arch. Biochem. Biophys. 1989; 270: 441–457, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Balbi A., Muscettalo G., Staiano N., Martire G., De Lorenzo F. Psychotropic drugs: evaluation of mutagenic effects. Pharmacol. Res. Commun. 1980; 12: 423–432, [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Berger J. P., Akiyama T. E., Meinke P. T. PPARs: therapeutic targets for metabolic disease. Trends Pharmacol. Sci. 2005; 26: 244–251, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bertagni P., Marcucci E. M., Mussini E., Grattini S. Biliary excretion of conjugated hydroxyl benzodiazepines after administration of several benzodiazepines to rats, guinea pigs and mice. J. Pharm. Sci. 1972; 61: 965–966, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bosgra S., Mennes W., Seinen W. Proceedings in uncovering the mechanism behind peroxisome proliferator-induced hepatocarcinogenesis. Toxicology 2005; 206: 309–323, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bucher J. R., Haseman J. K., Herbert R. A., Hejtmancik M., Ryan M. J. Toxicity and carcinogenicity studies of oxazepam in the Fischer 334 rat. Toxicol. Sci. 1998; 42: 1–12, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bucher J. R., Shackleford C. C., Haseman J. K., Johnson J. D., Kurtz P. J., Persing R. L. Carcinogenicity studies of oxazepam in mice. Fund. Appl. Toxicol. 1994; 23: 280–297, [CSA]
   PubMedGoogle Scholar
• Burke M. D., Mayer R. T. Ethoxyresorufin: direct fluorimetric assay of microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 1974; 2: 583–588, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Clemmesen J., Hjalgrim-Jensen S. Is phenobarbital carcinogenic? A follow-up of 8078 epileptics. Ecotoxicol. Environ. 1978; Supp. 1: 457–470, [CSA]
   Web of Science ®Google Scholar
• Cunningham M. L., Maronpot R. R., Thompson M., Bucher J. R. Early responses of the liver of B6C3F1 mice to the hepatocarcinogen oxazepam in mice. Toxicol. Appl. Pharmacol. 1994; 124: 31–38, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• de la Iglesia A., Barsoum N., Gough A., Mitchell A., Martin R. A., di Fonzo C., McGuire E.J. Carcinogenesis bioassay of prazepam (Verstran) in rats and mice. Toxicol. Appl. Pharmacol. 1981; 57: 39–54, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Devereux T. R., White C. M., Sills R. C., Bucher J. R., Maronpot R. R., Anderson M. W. Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet. Carcinogenesis 1994; 15: 1083–1097, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Diwan B. A., Rice J. M., Ward J. M. Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. Carcinogenesis 1986; 7: 789–794, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Dutton D. R., Parkinson A. Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. Arch. Biochem. Biophys. 1989; 268: 617–629, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Fox K. A., Lachen R. B. Liver-cell adenomas and peliosis hepatitis in mice associated with oxazepam. Res. Commun. Chem. Pathol. Pharmacol. 1974; 8: 481–488, [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Grasso P., Hinton R. H. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver. Mutat. Res. 1991; 248: 271–290, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Grasso P., Sharatt M., Cohen A. J. Role of persistent, nongenotoxic tissue damage in rodent cancer and relevance to humans. Ann. Rev. Pharmacol. Toxicol. 1991; 36: 253–81, [CSA]
   Google Scholar
• Griffin R. J., Burka L. T. Metabolism and elimination of oxazepam in B6C3F1 and Swiss-Webster mice. Drug Metab. Dispos. 1993; 21: 918–926, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Griffin R. J., Burka L. T. Metabolism and elimination of oxazepam in F344 rats. Drug Metab. Dispos. 1994; 23: 232–239, [CSA]
   Web of Science ®Google Scholar
• Griffin R. J., Burka L. T., Cunningham M. L. Activity of hepatic drug metabolizing enzymes following oxazepam feed treatment in B6C3F1 mice. Toxicol. Lett. 1995; 76: 251–256, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Griffin R. J., Dudley C. N., Cunningham M. L. Biochemical effects of the mouse hepatocarcinogen oxazepam: Similarities to phenobarbital. Fund. Appl. Toxicol. 1996; 29: 147–154, [CSA]
   PubMedGoogle Scholar
• Harlow B. L., Cramer D. W. Self-reported use of antidepressants or benzodiazepine tranquilizers and risk of epithelial ovarian cancer: Evidence from two combined case-control studies (Massachusetts, United States). Canc. Causes Control. 1995; 6: 130–134, [CSA]
   PubMed Web of Science ®Google Scholar
• Hino O., Kitagawa T. Effects of diazepam on hepatocarcinogenesis in the rat. Toxicol. Lett. 1982; 11: 155–157, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Iida M., Anna C. H., Hartis J., Bruno M., Wetmore B., Dubin J. R., Sieber S., Bennett L., Cunningham M. L., Paules R. S., Tomer K. B., Houle C. D., Merrick A. B., Sills R. C., Devereux T. R. Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. Carcinogenesis 2003; 24: 757–770, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Klaunig J. E., Babich M. A., Baetcke K. P., Cook J. C., Corton J. C., David R. M., DeLuca J. G., Lai D. Y., McKee R. H., Peters J. M., Roberts R. A., Fenner-Crisp P. A. PPARα agonist-induced rodent tumors: modes of action and human relevance. Crit. Rev. Toxicol. 2003; 33: 655–780, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lai D.Y. Rodent carcinogenicity of peroxisome proliferators and issues on human relevance. J. Environ. Sci. Health. 2004; C22: 37–55, [CSA]
   Google Scholar
• Lehman-McKeeman L. D., Caudill D., Vassallo J. D., Pearce R. E., Madan A., Parkinson A. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol. Lett. 1999; 111: 105–115, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lu A. Y. H., Levin W. Partial purification of cytochrome P-450 and P-448 from rat liver microsomes. Biochem. Biophys. Res. Commun. 1972; 46: 1334–1339, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Matsubara T., Kioke M., Touchi A., Tochino Y., Sugeno K. Quantitative determination of cytochrome P-450 in rat liver homogenates. Anal. Biochem. 1976; 75: 596–603, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• McClain R. M. Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment. Prog. Clin. Biol. Res. 1995; 391: 325–336, [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in Swiss Webster and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser. 1993; 443: 1–321, [CSA]
   PubMedGoogle Scholar
• NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F334/N Rats (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser. 1998; 468: 1–189, [CSA]
   PubMedGoogle Scholar
• Olsen J. H., Boice J. D., Fraumeni J. F. Cancer in children of epileptic mothers and the possible relation to maternal anticonvulsant therapy. Br. J. Cancer. 1990; 62: 996–999, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Olsen J. H., Boice J. D., Jensen J. P. A., Fraumeni J. F. Cancer among epileptic patients exposed to anticonvulsant drugs. J. Natl. Cancer Inst. 1989; 81: 803–808, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Olsen J. H., Wallin H., Boice J. D., Rask K., Schulgen G., Fraumeni J. F. Phenobarbital, drug metabolism and human cancer. Cancer Epidemol. 1993; 2: 449–452, [CSA]
   PubMed Web of Science ®Google Scholar
• Parkinson A., Gemzik B. Production and purification of antibodies against rat liver P-450 enzymes. Meth. Enzymol. 1991; 206: 233–245, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Pedrick M. S., Rumsby P. C., Wright V., Phillmore H. E., Butler W. H., Evans J. G. Growth characterisitcs and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours. Carcinogenesis 1994; 15: 1847–1852, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Preiss A. M., Scheutwinkel-Reich M., Fulle I., Grohmann H. G., Stan H. J. Investigation with the salmonella/microsome test of psychopharmaceuticals used in meat production. Mutat. Res. 1982; 104: 333–337, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Remandet B., Gouy D., Berthe J., Mazue G., Williams G. M. Lack of initiating or promoting activity of six benzodiazepine tranquilizers in rat liver limited bioassay monitored by histopathology and assay of liver and plasma enzymes. Fund. Appl. Toxicol. 1984; 4: 152–163, [CSA]
   PubMedGoogle Scholar
• Romano M. C., Straub K. M., Yodis L. A. P., Eckardt R. D., Newton J. F. Anal. Biochem. 1988; 170: 83–93, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Rosenberg L., Palmer J. R., Zauber A. G., Warshauer M. E., Strom B. L., Harlap S., Shapiro S. Relation of benzodiazepine use to the risk of selected cancers: breast, large bowel, malignant melanoma, lung, endometrium, ovary, non-Hodgkin's lymphoma, testis, Hodgkin's disease, thyroid and liver. Amer. J. Epidemiol. 1995; 141: 1153–1160, [CSA]
   PubMed Web of Science ®Google Scholar
• Shirts S. B., Annegers J. F., Hauser W. A., Kurland L. T. Cancer incidence in a cohort of patients with seizure disorders. J. Cancer. Inst. 1986; 77: 83–87, [CSA]
   PubMed Web of Science ®Google Scholar
• Singh G., Driever P. H., Sander J. W. Cancer risk in people with epilepsy: the role of antiepileptic drugs. Brain 2005; 128: 7–17, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sonderfan A. J., Parkinson A. Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal P-450. Arch. Biochem. Biophys. 1988; 265: 208–218, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sonderfan A. J., Arlotto M. P., Dutton D. R., McMillen S. K., Parkinson A. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch. Biochem. Biophys. 1987; 255: 27–41, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Tierney D. J., Haas A. L., Koop D. R. Degradation of cytochrome P-450 2E1: selective loss after labilization of the enzyme. Arch. Biochem. Biophys. 1992; 293: 9–16, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA. 1979; 76: 4350–4354, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Whysner J., Ross P. M., Williams G. M. Phenobarbital mechanistic data and risk assessment: enzyme induction enhanced cell proliferation and tumor promotion. Pharmac. Ther. 1996; 71: 153–191, [CSA]
   PubMed Web of Science ®Google Scholar
• Williams G. M., Iatropoulos M. J. Alteration of liver cell function and proliferation: Differentiation between adaptation and toxicity. Toxicol. Pathol. 2002; 30: 41–52, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Wood A. W., Ryan D. E., Thomas P. E., Levin W. Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. J. Biol. Chem. 1983; 258: 8839–8847, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar