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Hemoglobin
international journal for hemoglobin research
Volume 32, 2008 - Issue 1-2
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Original

Insights on Regulation and Function of the Iron Regulatory Protein 1 (IRP1)

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Pages 109-115 | Published online: 07 Jul 2009

REFERENCES

  • Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann NY Acad Sci 2004; 1012: 1–13
  • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts; molecular control of mammalian iron metabolism. Cell 2004; 117(3)285–297
  • Smith SR, Ghosh MC, Ollivierre-Wilson H, Hang Tong W, Rouault TA. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol Dis 2006; 36(2)283–287
  • Rouault TA. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2006; 2(8)406–414
  • Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute T, Brazzolotto X, Berger UV, Land W, Ollivierre-Wilson H, Grinberg A, Love P, Rouault TA. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J 2004; 23(2)386–395
  • Cooperman SS, Meyron-Holtz EG, Olivierre-Wilson H, Ghosh MC, McConnell JP, Rouault TA. Microcytic anemia, erythropoietic protoporphyria and neurodegeneration in mice with targeted deletion of iron regulatory protein 2. Blood 2005; 106(3)1084–1091
  • Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schumann K, Hentze MW. Altered body iron distribution and microcytosis in mice deficient for iron regulatory protein 2 (IRP2). Blood 2005; 106(7)2580–2589
  • LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer R, 3rd, Grinberg A, Love P, Tresser N, Rouault TA. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 2001; 27(2)209–214
  • Ghosh MC, Ollivierre-Wilson H, Cooperman S, Rouault TA. Reply to “Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse”. Nat Genet 2006; 38(9)969–970
  • Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet 2006; 38(9)967–969
  • Wang J, Pantopoulos K. Conditional de-repression of ferritin synthesis in cells expressing a constitutive IRP1 mutant. Mol Cell Biol 2005; 22(13)4638–4651
  • Lill R, Muhlenhoff U. Iron-sulfur-protein biogenesis in eukaryotes. Trends Biochem Sci 2005; 30(3)133–141
  • Wang J, Fillebeen C, Chen G, Biederbick A, Lill R, Pantopoulos K. Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway. Mol Cell Biol 2007; 27(7)2423–2430
  • Chen G, Fillebeen C, Wang J, Pantopoulos K. Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts. Carcinogenesis 2007; 28(4)785–791

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