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Hemoglobin
international journal for hemoglobin research
Volume 32, 2008 - Issue 1-2
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Original Article

Pharmacogenomics and Therapeutics of Hemoglobinopathies

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Pages 229-236 | Received 03 May 2007, Accepted 11 Jul 2007, Published online: 07 Jul 2009

REFERENCES

  • Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST. Pharmacogenetics Research Network. Pharmacogenomics: challenges and opportunitites. Ann Intern Med 2006; 145(10)749–757
  • Pace BS, Zein S. Understanding mechanisms of γ-globin gene regulation to develop strategies for pharmacological fetal hemoglobin induction. Dev Dyn 2006; 235(7)1727–1737
  • Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, McMahon RP, Bonds DR. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med 1995; 332(20)1317–1322
  • Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, Dover GJ. Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea. 1997; 89(3)1078–1088, Blood
  • Bakanay SM, Dainer E, Clair B, Adekile A, Daitch L, Wells L, Holley L, Smith D, Kutlar A. Mortality in sickle cell patients on hydroxyurea therapy. Blood 2005; 105(2)545–547
  • Yavarian M, Karimi M, Bakker E, Harteveld CL, Giordano PC. Response to hydroxyurea treatment in Iranian transfusion-dependent β-thalassemia patients. Haematologica 2004; 89(10)1172–1178
  • Alebouyeh M, Moussavi F, Haddad-Deylami H, Vossough P. Hydroxyurea in the treatment of major β-thalassemia and importance of genetic screening. Ann Hematol 2004; 83(7)430–433
  • Dixit A, Chatterjee TC, Mishra P, Choudhry DR, Mahapatra M, Tyagi S, Kabra M, Saxena R, Choudhry VP. Hydroxyurea in thalassemia intermedia-a promising therapy. Ann Hematol 2005; 84(7)441–446
  • Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea. Pharmacogenomics J 2007; 7(6)386–394
  • Gilman JG, Huisman THJ. DNA sequence variation associated with elevated Gγ globin production. Blood 1985; 66(4)783–787
  • Patrinos GP, Loutradi-Anagnostou A, Papadakis MN. A novel DNA polymorphism of the human Aγ-globin gene (Aγ −588, A→G) is linked with the XMN I polymorphism (Gγ −158, C→T). Hemoglobin 1995; 19(6)419–423
  • Patrinos GP, Kollia P, Papapanagiotou E, Loutradi-Anagnostou A, Loukopoulos D, Papadakis MN. Aγ-Haplotypes: a new group of genetic markers for thalassemic mutations inside the 5′ regulatory region of the human Aγ-globin gene. Am J Hematol 2001; 66(2)99–104
  • Labie D, Pagnier J, Lapoumeroulie C, Rouabbi F, Dunda-Belkhodja O, Chardin P, Beldjord C, Wajcman H, Fabry ME, Nagel RL. Common haplotype dependency of high Gγ-globin gene expression and high Hb F levels in β-thalassemia and sickle cell anemia patients. Proc Natl Acad Sci USA 1985; 82(7)2111–2114
  • Lanclos KD, Oner C, Dimovski AJ, Gu YC, Huisman THJ. Sequence variations in the 5′ flanking and IVS-II regions of the Gγ- and Aγ-globin genes of βS chromosomes with five different haplotypes. Blood 1991; 77(11)2488–2496
  • Papachatzopoulou A, Kourakli A, Markopoulou P, Kakagianne T, Sgourou A, Papadakis M, Athanassiadou A. Genotypic heterogeneity and correlation to intergenic haplotype within high Hb F β-thalassemia intermedia. Eur J Haematol 2006; 76(4)322–330
  • Papachatzopoulou A, Kaimakis P, Pourfarzad F, Menounos PG, Evangelakou P, Kollia P, Grosveld FG, Patrinos GP. Increased γ-globin gene expression in β-thalassemia intermedia patients correlates with a mutation in 3′HS1. Am J Hematol 2007; 82(11)1005–1009
  • Shi JY, Shi ZZ, Zhang SJ, Zhu YM, Gu BW, Li G, Bai XT, Gao XD, Hu J, Jin W, Huang W, Chen Z, Chen SJ. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. Pharmacogenetics 2004; 14(11)759–768
  • Kutlar A. Sickle cell disease: a multigenic perspective of a single gene disorder. Hemoglobin 2007; 31(2)209–224
  • Patrinos GP, Kollia P, Papadakis MN. Molecular diagnosis of inherited disorders: lessons from hemoglobinopathies. Hum Mutat 2005; 26(5)399–412
  • Hershko C, Link G, Konijn AM, Cabantchik ZI. Objectives and mechanism of iron chelation therapy. Ann NY Acad Sci 2005; 1054: 124–135

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