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Drug Development and Industrial Pharmacy Volume 34, 2008 - Issue 10
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Research Article

Quantification of Lubricant Activity of Magnesium Stearate by Atomic Force Microscopy

Daniel Weber Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
,
Yu Pu Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
&
Charles L. Cooney Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USACorrespondence[email protected]
Pages 1097-1099 | Published online: 05 Nov 2008

REFERENCES

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  • P. Begat, D. A. V. Morton, J. N. Staniforth, and R. Price. (2004). The cohesive–adhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy. Pharm. Res. 21 (9):1591–1597.
  • V. Berard, E. Lesniewska, C. Andres, D. Pertuy, C. Laroche, and Y. Pourcelot. (2002). Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy. Int. J. Pharm. 247 (1–2):127–137.
  • K. D. Ertel, and J. T. Carstensen. (1988). Chemical, physical, and lubricant properties of magnesium stearate. J. Pharm. Sci.—USA 77 (7):625–629.
  • J. K. Eve, N. Patel, S. Y. Luk, S. J. Ebbens, and C. J. Roberts. (2002). A study of single drug particle adhesion interactions using atomic force microscopy. Int. J. Pharm. 238 (1–2):17–27.
  • J. C. Hooton, C. S. German, S. Allen, M. C. Davies, C. J. Roberts, S. J. B. Tendler, and P. M. Williams. (2003). Characterization of particle-interactions by atomic force microscopy: Effect of contact area. Pharm. Res. 20 (3):508–514.
  • J. Lee. (2004). Intrinsic adhesion force of lubricants to steel surface. J. Pharm. Sci.—USA 93 (9):2310–2318.
  • M. Otsuka, I. Yamane, and Y. Matsuda. (2004). Effects of lubricant mixing on compression properties of various kinds of direct compression excipients and physical properties of the tablets. Adv. Powder Technol. 15 (4):477–493.
  • U. Sindel, and I. Zimmermann. (2001). Measurement of interaction forces between individual powder particles using an atomic force microscope. Powder Technol. 117 (3):247–254.
  • Y. Wada, and T. Matsubara. (1994). Pseudopolymorphism and lubricating properties of magnesium stearate. Powder Technol. 78 (2):109–114.

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