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Research Article

The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles

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Pages 2032-2042 | Received 05 Apr 2017, Accepted 27 Jul 2017, Published online: 11 Aug 2017

References

  • BCC Research. Global markets and manufacturing technologies for protein drugs. Wellesley; 2016.
  • Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov Today. 2006;11:905–910.
  • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007;59:478–490.
  • Wurm FM. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol. 2004;22:1393–1398.
  • Frokjaer S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov. 2005;4:298–306.
  • Antosova Z, Mackova M, Kral V, et al. Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol. 2009;27:628–635.
  • Trotta M, Cavalli R, Carlotti M, et al. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion–diffusion technique. Int J Pharm. 2005;288:281–288.
  • Christophersen PC, Zhang L, Mullertz A, et al. Solid lipid particles for oral delivery of peptide and protein drugs II – the digestion of trilaurin protects desmopressin from proteolytic degradation. Pharm Res. 2014;31:2420–2428.
  • Christophersen PC, Zhang L, Yang M, et al. Solid lipid particles for oral delivery of peptide and protein drugs I – elucidating the release mechanism of lysozyme during lipolysis. Eur J Pharm Biopharm. 2013;85:473–480.
  • Yang YY, Chung TS, Ng NP. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials. 2001;22:231–241.
  • Christophersen PC, Birch D, Saarinen J, et al. Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. J Control Release. 2015;197:111–120.
  • Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur J Pharm Biopharm. 2000;50:161–177.
  • Westesen K, Bunjes H, Koch M. Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. J Control Release. 1997;48:223–236.
  • Rosenblatt KM, Bunjes H. Poly (vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the α-modification. Mol Pharm. 2008;6:105–120.
  • Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001;47:165–196.
  • Muller RH, Runge SA, Ravelli V, et al. Cyclosporine-loaded solid lipid nanoparticles (SLN): drug-lipid physicochemical interactions and characterization of drug incorporation. Eur J Pharm Biopharm. 2008;68:535–544.
  • Heurtault B, Saulnier P, Pech B, et al. Physico-chemical stability of colloidal lipid particles. Biomaterials. 2003;24:4283–4300.
  • Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release. 2000;66:115–126.
  • Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech. 2011;12:62–76.
  • Zaky A, Elbakry A, Ehmer A, et al. The mechanism of protein release from triglyceride microspheres. J Control Release. 2010;147:202–210.
  • Semwogerere D, Weeks ER. Confocal microscopy. Encyclopedia of Biomaterials & Biomedical Engineering. New York, NY: Taylor & Francis; 2005:1–10.
  • Takano M, Koyama Y, Nishikawa H, et al. Segment-selective absorption of lysozyme in the intestine. Eur J Pharmacol. 2004;502:149–155.
  • Berlier JE, Rothe A, Buller G, et al. Quantitative comparison of long-wavelength Alexa Fluor dyes to Cy dyes: fluorescence of the dyes and their bioconjugates. J Histochem Cytochem. 2003;51:1699–1712.
  • Luensmann D, Zhang F, Subbaraman L, et al. Localization of lysozyme sorption to conventional and silicone hydrogel contact lenses using confocal microscopy. Curr Eye Res. 2009;34:683–697.
  • Hames BD. One-dimensional polyacrylamide gel electrophoresis. In: Shi Q, Jackowski G, editors. Gel electrophoresis of proteins: a practical approach. 197. Oxford: Oxford University Press; 1998. p. 13–28.
  • Reithmeier H, Herrmann J, Göpferich A. Lipid microparticles as a parenteral controlled release device for peptides. J Control Release. 2001;73:339–350.
  • Maretti E, Rossi T, Bondi M, et al. Inhaled solid lipid microparticles to target alveolar macrophages for tuberculosis. Int J Pharm. 2014;462:74–82.
  • Pilcer G, Sebti T, Amighi K. Formulation and characterization of lipid-coated tobramycin particles for dry powder inhalation. Pharm Res. 2006;23:931–940.
  • Lauterbach A, Müller-Goymann CC. Design of lipid microparticle dispersions based on the physicochemical properties of the lipid and aqueous phase. Int J Pharm. 2015;494:445–452.
  • Jaspart S, Piel G, Delattre L, et al. Solid lipid microparticles: formulation, preparation, characterisation, drug release and applications. Expert Opin Drug Deliv. 2005;2:75–87.
  • Pygall SR, Whetstone J, Timmins P, et al. Pharmaceutical applications of confocal laser scanning microscopy: the physical characterisation of pharmaceutical systems. Adv Drug Deliv Rev. 2007;59:1434–1452.
  • Güres S, Kleinebudde P. Dissolution from solid lipid extrudates containing release modifiers. Int J Pharm. 2011;412:77–84.
  • Yamakawa I, Tsushima Y, Machida R, et al. In vitro and in vivo release of poly (DL-lactic acid) microspheres containing neurotensin analogue prepared by novel oil-in- water solvent evaporation method. J Pharm Sci. 1992;81:808–811.
  • Bunjes H, Westesen K, Koch MH. Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int J Pharm. 1996;129:159–173.
  • Belton P. The functional properties of fats and oils – a richness of diversity. Grasas Aceites. 2000;51:1–5.
  • Bresson S, Marssi ME, Khelifa B. Raman spectroscopy investigation of various saturated monoacid triglycerides. Chem Phys Lipids. 2005;134:119–129.
  • Lutton E, Fehl A. The polymorphism of odd and even saturated single acid triglycerides, C8-C22. Lipids. 1970;5:90–99.
  • Lopes DG, Koutsamanis I, Becker K, et al. Microphase separation in solid lipid dosage forms as the cause of drug release instability. Int J Pharm. 2017;517:403–412.
  • Xia D, Cui F, Gan Y, et al. Design of lipid matrix particles for fenofibrate: effect of polymorphism of glycerol monostearate on drug incorporation and release. J Pharm Sci. 2014;103:697–705.
  • Wong PCH, Heng PWS, Chan LW. Determination of solid state characteristics of spray-congealed ibuprofen solid lipid microparticles and their impact on sustaining drug release. Mol Pharm. 2015;12:1592–1604.
  • Sato K, Bayes-Garcia L, Calvet T, et al. External factors affecting polymorphic crystallization of lipids. Eur J Lipid Sci Technol. 2013;115:1224–1238.
  • Windbergs M, Strachan CJ, Kleinebudde P. Investigating the principles of recrystallization from glyceride melts. AAPS PharmSciTech. 2009;10:1224–1233.
  • Silva LFC, Kasten G, de Campos CEM, et al. Preparation and characterization of quercetin-loaded solid lipid microparticles for pulmonary delivery. Powder Technol. 2013;239:183–192.
  • Takeuchi M, Ueno S, Sato K. Synchrotron radiation SAXS/WAXS study of polymorph-dependent phase behavior of binary mixtures of saturated monoacid triacylglycerols. Crystal Growth Des. 2003;3:369–374.

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