Summary of evidence pointing to a role of the dorsal cochlear nucleus in the etiology of tinnitus

References

• Soussi T, Otto SR. Effects of electrical brainstem stimulation on tinnitus. Acta Otolaryngol (Stockh) 1994; 114: 135–40
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, Zhang J, Finlayson P. Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Hear Res 2005; 206: 200–26
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, McCaslin DL. Increases in spontaneous activity in the dorsal cochlear nucleus following exposure to high intensity sound: a possible neural correlate of tinnitus. Aud Neurosci 1996; 3: 57–78
   Google Scholar
• Kaltenbach JA, Godfrey DA, Neumann JB, McCaslin DL, Afman CE, Zhang J. Changes in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: relation to threshold shift. Hear Res 1998; 124: 78–84
   PubMed Web of Science ®Google Scholar
• Brozoski TJ, Bauer CA, Caspary DM. Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. J Neurosci 2002; 22: 2383–90
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, Afman CE. Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: a physiological model for tinnitus. Hear Res 2000; 140: 165–72
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, Zhang J, Afman CE. Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure. Hear Res 2000; 147: 282–92
   PubMed Web of Science ®Google Scholar
• Imig TJ, Durham D. Unilateral noise exposure causes low-frequency enhancement of spontaneous activity in the ipsilateral cochlear nucleus and the contralateral inferior colliculus of intact and decorticate rats. ARO Abs 2005; 28: 959
   Google Scholar
• Shore S, Lu J, Koehler S. Responses of dorsal cochlear nucleus neurons to trigeminal stimulation are altered following noise damage. ARO Abs 2005; 28: 950
   Google Scholar
• Zhang JS, Kaltenbach JA. Increases in spontaneous activity in the dorsal cochlear nucleus of the rat following exposure to high-intensity sound. Neurosci Lett 1998; 250: 197–200
   PubMedGoogle Scholar
• Wallhausser-Franke E, Mahlke C, Oliva R, Braun S, Wenz G, Langner G. Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus. Exp Brain Res 2003; 153: 649–54
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, Heffner HE, Zhang J, Mathog TA, Zacharek MA. Neurophysiological mechanisms of noise-induced tinnitus. Noise induced hearing loss, basic mechanisms, prevention and control, D Henderson, D Prasher, R Kopke, R Salvi, R Hamernik. Noise Research Network Publications, London 2001; 153–68
   Google Scholar
• Kaltenbach JA, Rachel JD, Mathog TA, Zhang J, Falzarano PR, Lewandowski M. Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair cell loss: relevance to tinnitus. J Neurophysiol 2002; 88: 699–714
   PubMed Web of Science ®Google Scholar
• Kaltenbach JA, Zacharek MA, Zhang J, Frederick S. Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure. Neurosci Lett 2004; 355: 121–5
   PubMedGoogle Scholar
• Atherley GR, Hempstock TI, Noble WG. Study of tinnitus induced temporarily by noise. J Acoust Soc Am 1968; 44: 1503–6
   PubMed Web of Science ®Google Scholar
• Loeb M, Smith RP. Relation of induced tinnitus to physical characteristics of the inducing stimuli. J Acoust Soc Am 1967; 43: 453–55
   Google Scholar
• Axelsson A, Barrenas ML. Tinnitus in noise-induced hearing loss. Noise-induced hearing loss, AL Dancer, D Henderson, RJ Salvi, RP Hamernik. Mosby Year Book, Boston 1992; 269–76
   Google Scholar
• Evans EF. Place and time coding of frequency in the peripheral auditory system: some physiological pros and cons. Audiology 1978; 17: 369–420
   PubMedGoogle Scholar
• Kaltenbach JA, Lazor J. Tonotopic maps obtained from the surface of the dorsal cochlear nucleus of the hamster and rat. Hear Res 1991; 51: 149–60
   PubMed Web of Science ®Google Scholar
• Norena A, Micheyl C, Chery-Croze S, Collet L. Psychoacoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus. Audiol Neurootol 2002; 7: 358–69
   PubMed Web of Science ®Google Scholar
• Heffner HE, Harrington IA. Tinnitus in hamsters following exposure to intense sound. Hear Res 2002; 170: 83–95
   PubMed Web of Science ®Google Scholar
• Moller AR, Moller MB, Jannetta PJ, Jho HD. Compound action potentials recorded from the exposed eighth nerve in patients with intractable tinnitus. Laryngoscope 1992; 102: 187–97
   PubMed Web of Science ®Google Scholar
• Rubinstein B. Tinnitus and craniomandibular disorders – is there a link?. Swed Dent J Suppl 1993; 95: 1–46
   PubMedGoogle Scholar
• Levine RA. Somatic (craniocervical) tinnitus and the dorsal cochlear nucleus hypothesis. Am J Otolaryngol 1999; 20: 351–62
   PubMed Web of Science ®Google Scholar
• Levine RA. Somatic tinnitus. Tinnitus: theory and management, JB Snow. BC Decker, Hamilton 2004; 108–24
   Google Scholar
• Weinberg RJ, Rustioni A. A cuneocochlear pathway in the rat. Neuroscience 1987; 20: 209–19
   PubMed Web of Science ®Google Scholar
• Itoh K, Kamiya H, Mitani A, Yasui Y, Takada M, Mizuno N. Direct projections from the dorsal column nuclei and the spinal trigeminal nuclei to the cochlear nuclei in the cat. Brain Res 1987; 400: 145–50
   PubMed Web of Science ®Google Scholar
• Wright DD, Ryugo DK. Mossy fiber projections from the cuneate nucleus to the cochlear nucleus in the rat. J Comp Neurol 1996; 365: 159–72
   PubMed Web of Science ®Google Scholar
• Shore SE, Vass Z, Wys NL, Altschuler RA. Trigeminal ganglion innervates the auditory brainstem. J Comp Neurol 2000; 419: 271–85
   PubMed Web of Science ®Google Scholar
• Shore SE. Sensory nuclei in tinnitus. Tinnitus: theory and management, JB Snow. BC Decker, Hamilton 2004; 125–39
   Google Scholar
• Young ED, Nelken I, Conley RA. Somatosensory effects on neurons in dorsal cochlear nucleus. J Neurophysiol 1995; 73: 743–65
   PubMed Web of Science ®Google Scholar
• Davis KA, Miller RL, Young ED. Effects of somatosensory and parallel-fiber stimulation on neurons in dorsal cochlear nucleus. J Neurophysiol 1996; 76: 3012–24
   PubMedGoogle Scholar
• Kanold PO, Young ED. Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. J Neurosci 2001; 21: 7848–58
   PubMed Web of Science ®Google Scholar
• Seligman H, Podoshin L, Ben-David J, Fradis M, Goldsher M. Drug-induced tinnitus and other hearing disorders. Drug Saf 1996; 14: 198–212
   PubMedGoogle Scholar
• Lonsbury-Martin BL, Martin GK. Otoacoustic emissions and tinnitus. Tinnitus: theory and management, JB Snow. BC Decker, Hamilton 2004; 69–78
   Google Scholar
• Brownell WE. Outer hair cell electromotility and otoacoustic emissions. Ear Hear 1990; 11: 82–92
   PubMed Web of Science ®Google Scholar
• House JW, Brackmann DE. Tinnitus: surgical treatment. Ciba Found Symp 1981; 85: 204–16
   PubMedGoogle Scholar
• Berliner KI, Shelton C, Hitselberger WE, Luxford WM. Acoustic tumors: effect of surgical removal on tinnitus. Am J Otol 1992; 13: 13–17
   PubMedGoogle Scholar
• Kim J, Morest DK, Bohne BA. Degeneration of axons in the brainstem of the chinchilla after auditory overstimulation. Hear Res 1997; 103: 169–91
   PubMedGoogle Scholar
• Muly SM, Gross JS, Potashner SJ. Noise trauma alters D-[3H]aspartate release and AMPA binding in chinchilla cochlear nucleus. J Neurosci Res 2004; 75: 585–96
   PubMed Web of Science ®Google Scholar
• Kim JJ, Gross J, Potashner SJ, Morest DK. Fine structure of long-term changes in the cochlear nucleus after acoustic overstimulation: chronic degeneration and new growth of synaptic endings. J Neurosci Res 2004; 77: 817–28
   PubMedGoogle Scholar
• Potashner SJ, Suneja SK, Benson CG. Altered glycinergic synaptic activities in guinea pig brain stem auditory nuclei after unilateral cochlear ablation. Hear Res 2000; 147: 125–36
   PubMedGoogle Scholar
• Suneja SK, Potashner SJ, Benson CG. Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. Exp Neurol 1998; 151: 273–88
   PubMedGoogle Scholar
• Francis HW, Manis PB. Effects of deafferentation on the electrophysiology of ventral cochlear nucleus neurons. Hear Res 2000; 149: 91–105
   PubMed Web of Science ®Google Scholar
• Zacharek MA, Kaltenbach JA, Mathog TA, Zhang JS. Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications on the origin of noise-induced tinnitus. Hear Res 2002; 172: 137–44
   PubMedGoogle Scholar