Combined Administration of l-Carnitine and Ascorbic Acid Ameliorates Cisplatin-Induced Nephrotoxicity in Rats

References

• Vokes EE, Weichselbaum RR, Mick R, McEvilly JM, Haraf DJ, Panje WRJ. Favourable long term survival following induction chemotherapy with cisplatin, fluoroucil and leucovorin concomitant chemoradiotherapy for locally advance head and neck cancer. J Natl. Cancer Inst. 1992;84:877–882. doi: 10.1093/jnci/84.11.877. PMID: 1375657
   PubMedGoogle Scholar
• Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2007;334:115–124. doi: 10.1097/MAJ.0b013e31812dfe1e. PMID: 17700201
   PubMed Web of Science ®Google Scholar
• Kawai Y, Taniuchi S, Okahara S, Nakamura M, Gemba M. Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation. Biol Pharm Bull. 2005;28:1385–1388. doi: 10.1248/bpb.28.1385. PMID: 16079479
   PubMed Web of Science ®Google Scholar
• Arany I, Safirstein RL. Cisplatin nephrotoxicity. Semin Nephrol. 2003;5:460–464. doi: 10.1016/S0270-9295(03)00089-5.
   Google Scholar
• Humanes B, Lazaro A, Camano S, Moreno-Gordaliza E, Lazaro JA, Blanco-Codesido M. Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats. Kidney Int. 2012;82:652–663. doi: 10.1038/ki.2012.199. PMID: 22718191
   PubMed Web of Science ®Google Scholar
• Davis CA, Nick HS, Agarwal A. Manganese superoxide dismutase attenuates cisplatin induced renal injury: importance of superoxide. Clin J Am Soc Nephrol. 2001;12:2683–2690.
   Google Scholar
• Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of cisplatin nephrotoxicity. Toxins. 2010;2:2490–2518. doi: 10.3390/toxins2112490. PMID: 22069563
   PubMed Web of Science ®Google Scholar
• Uzunoglu S, Karagol H, Ozpuyan F, Cosar F, Cicin I, Yurutcaloglu V, et al. Protective effect of l-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats. Med Oncol. 2011;28:S690–S696. doi: 10.1007/s12032-010-9746-2. PMID: 21140244
   PubMedGoogle Scholar
• Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Hasko G, Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther. 2009;328:708–714. doi: 10.1124/jpet.108.147181. PMID: 19074681
   PubMed Web of Science ®Google Scholar
• Rebouche CJ, Chenard CA Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites. J. Nutr. 1991;121:539–546. PMID: 2007906
   PubMed Web of Science ®Google Scholar
• Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22:18–35. doi: 10.1080/07315724.2003.10719272. PMID: 12569111
   PubMed Web of Science ®Google Scholar
• Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis. 2003;41(4 Suppl 4):S4–S12. doi: 10.1016/S0272-6386(03)00112-4. PMID: 12751049
   PubMed Web of Science ®Google Scholar
• Reda E, D'Iddio S, Nicolai R, Benatti P, Calvani M. The carnitine system and body composition. Act Diabetol. 2003;40:S106–S113. doi: 10.1007/s00592-003-0040-z.
   PubMed Web of Science ®Google Scholar
• So H, Kim H, Lee JH, Park C, Kim Y, Kim E, et al. Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB. J Assoc Res Otolaryngol. 2007;8:338–355. doi: 10.1007/s10162-007-0084-9. PMID: 17516123
   PubMed Web of Science ®Google Scholar
• Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160:1–40. doi: 10.1016/j.cbi.2005.12.009. PMID: 16430879
   PubMed Web of Science ®Google Scholar
• Aleisa AM, Al-Majed AA, Al-Yahya AA, Al-Rejaie SS, Bakheet SA, Al-Shabanah OA, Sayed-Ahmed MM. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-l-carnitine in rat kidney tissues. Clin Exp Pharmacol Physiol. 2007;34:1252–1259. doi: 10.1111/j.1440-1681.2007.04714.x. PMID: 17973863
   PubMed Web of Science ®Google Scholar
• Ajith TA, Usha S, Nivitha V. Ascorbic acid and α-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice; a comparative study. Clin Chim Acta. 2007;375:82–86.
   Google Scholar
• Bartels H, Bohmer M. Serum creatinine determination method and protein precipitation. Clin Chem Acta. 1972;37:193–197. doi: 10.1016/0009-8981(72)90432-9.
   PubMed Web of Science ®Google Scholar
• Faucet JK, Sott JE A rapid and precise method for the determination of urea. Clin Pathol. 1960;13:156–159. doi: 10.1136/jcp.13.2.156.
   PubMed Web of Science ®Google Scholar
• Barham D, Trinder P. An improved color reagent for the determination of blood glucose by the oxidase system. Analyst. 1972;97:142–145. doi: 10.1039/an9729700142. PMID: 5037807
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase estimation. In: Bergmeyer HU, editor. Methods of enzymatic analysis. Weinheim (Germany)/New York (NY): Verlag Chemie/Academic Press Inc., 1974. p. 673–684. doi: 10.1016/B978-0-12-091302-2.50032-3.
   Google Scholar
• Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170–3175. PMID: 4623845
   PubMed Web of Science ®Google Scholar
• Beutler E, Durgun O, Kelly BM, Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;51:882–888.
   Google Scholar
• Skeggs LT, Hochstrasser HC. Thiocyanate (colorimetric) method of chloride estimation. Clin Chem. 1964;10:918–920. PMID: 14228271
   PubMed Web of Science ®Google Scholar
• Burtis CA, Ashwood ER. Tietz fundamentals of clinical chemistry. Philadelphia (PA): W.B. Saunders; 2001. p. 598–640.
   Google Scholar
• Alabi QK, Akomolafe RO, Olukiran OS, Adeyemi WJ, Nafiua AO, Adefisayo MA, Omole JG, Kajewole DI, Odujoko OO. The Garcinia kola biflavonoid kolaviron attenuates experimental hepatotoxicity induced by diclofenac. Pathophysiology. 2017;24(4):281–290. doi: 10.1016/j.pathophys.2017.07.003.
   Google Scholar
• Mohan Ik, Khan M, Shobha JC, Naidu MU, Prayag A, Kuppusamy P, Kutala VK. Protection against cisplatin-induced nephrotoxicity by spirulina in rats. Cancer Chemother Pharmacol. 2006;58(6):809–6. PMID: 16528527
   PubMed Web of Science ®Google Scholar
• Ateʂʂahǐn A, Ceribasi AO, Yuce A, Bulmus O, Cikim G. Role of ellegic acid against cisplatin induced nephrotoxicity and oxidative stress in rats. Basic Clin Pharmacol Toxicol. 2007;100:121–126. PMID: 17244261
   PubMed Web of Science ®Google Scholar
• Bulacio RP, Torres AM. Organic anion transporters (OAT5) renal expression and urinary excretion in rats treated with cisplatin: a potential biomarker of cisplatin induced nephrotoxicity. Arch Toxicol. 2013;87:1953–1962. doi: 10.1007/s00204-013-1062-0. PMID: 23649842
   PubMed Web of Science ®Google Scholar
• Sener G, Paskaloglu K, Satiroglu H, Alican I, Kacmaz A, Sakarcan A. l-Carnitine ameliorates oxidative damage due to chronic renal failure in rats. J Cardiovasc Pharmacol. 2004;43:698–705. doi: 10.1097/00005344-200405000-00013. PMID: 15071358
   PubMed Web of Science ®Google Scholar
• Hirose A, Sato E, Fujii H, Sun B, Nishioka H, Aruoma OI The influence of active hexose correlated compound (AHCC) on cisplatin-evoked chemotherapeutic and side effects in tumor-bearing mice. Toxicol Appl Pharmacol. 2007;222:152–158. doi: 10.1016/j.taap.2007.03.031. PMID: 17555784
   PubMed Web of Science ®Google Scholar
• Litterst CL, Torres IJ, Guarino AM. Plasma levels and organ distribution of platinum in the rat, dog, and dogfish shark following single intravenous administration of cis-diammineplatinum(II). J Clin Hematol Oncol. 1977;7:169–179.
   Google Scholar
• Goldstein RS, Noordewier B, Bond JT, Hook AB, Mayor GH. cis -Dichlorodiamineplatinum nephrotoxity: time course and dose response of renal functional impairment. Toxicol Appl Pharmacol. 1981;60:163–175. doi: 10.1016/0041-008X(91)90220-9. PMID: 7197064
   PubMed Web of Science ®Google Scholar
• Dobyn DC, Levi J, Jacobs C, Kosek J, Weiner MW. Mechanism of cis-platinum nephrotoxicity: morphologic observations. J Pharmacol Exp Ther. 1980;213:551–556.
   PubMed Web of Science ®Google Scholar
• Steven LC, Max ES. Glucosuria. In Chapter 13, editor(s). Textbook of clinical methods: the history, physical, and laboratory examinations. 3rd ed. Boston:Butterworths;1990. p.1–21.
   Google Scholar
• Safirstein R, et al. Cisplatin nephrotoxicity in rats: defect in papillary hypertonicity. Am J Physiol. 1982;241:F175.
   Google Scholar
• Katherine AS, Niamh MM, Steve RB. Hypothalamic regulation of appetite. Expert Rev Endocrinol Metab. 2008;3:577–592. doi: 10.1586/17446651.3.5.577.
   Google Scholar
• Mora Lde O, Antunes LM, Francescato HD, Bianchi Mde L. The effects of oral glutamine on cisplatin-induced nephrotoxicity in rats. Pharmacol Res. 2003;47:517–522. doi: 10.1016/S1043-6618(03)00040-9. PMID: 12742005
   PubMed Web of Science ®Google Scholar
• Ohno T, Kato S, Wakatsuki M, Noda SE, Murakami C, Nakamura M, et al. Incidence and temporal pattern of anorexia, diarrhea, weight loss and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. Gynecol Oncol. 2006;103:94–99. doi: 10.1016/j.ygyno.2006.01.048. PMID: 16527337
   PubMed Web of Science ®Google Scholar
• Brand C, Eder K. Effect of l-carnitine on weight loss and body composition of rats feed a hypocaloric diet. Ann Nutr Metab. 2002;46:205–210. doi: 10.1159/000065408.
   PubMed Web of Science ®Google Scholar
• Alabi QA, Akomolafe RO, Olukiran OS, Nafiu AO, Omole GJ, Adefisayo AM, Oladele AA Assessment of haematological and biochemical effects of kolaviron in male Wistar rats. Br J Pharm Res. 2017;16:1–14. doi: 10.9734/BJPR/2017/33517.
   Web of Science ®Google Scholar
• Sirag HM. Biochemical and hematological studies for protective effect of oyster mushroom (Pleurotus ostreatus) against glycerol induced acute renal failure in rats. J Biol Sci. 2009;9:746–752. doi: 10.3923/jbs.2009.746.752.
   Google Scholar
• Wood PA, Hrushesky WJ. Cisplatin-associated anemia: an erythropoietin deficiency syndrome. J Clin Invest. 1995;95:1650–1659. doi: 10.1172/JCI117840. PMID: 7706473
   PubMed Web of Science ®Google Scholar
• Marković SD, Žizić JB, Djačić DS, Obradović AD, Ćurčić MG, Cvetković DM, Đorđević NZ, Ognjanović BI, Štajn AS. Alteration of oxidative stress parameters in red blood cells of rats after chronic in vivo treatment with cisplatin and selenium. Arch Biol Sci Belgrade. 2011;63:991–999. doi: 10.2298/ABS1104991M.
   Web of Science ®Google Scholar
• Longchar M, Prasad SB. Ascorbic acid (vitamin ameliorates cisplatin-induced hematotoxicity in tumor-bearing mice. WJPPS. 2016;5:1870–1891.
   Google Scholar
• Xi, XB, Schlnesener HJ. Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis. Arch. Immunol. Ther. Exp. 2006;54:51–53.
   PubMed Web of Science ®Google Scholar
• Miyazaki J, Kawai K. Prevention and management of nephrotoxicity from anti-cancer agents. Nippon Rinsho. 2003;61:973–977. PMID: 12806945
   PubMedGoogle Scholar
• Santos NAG, Catao Bezerra CS, Martins NM, Curti C, Bianchi ML, Santos AC. Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer Chemother Pharmacol. 2008;61:145–155. doi: 10.1007/s00280-007-0459-y. PMID: 17396264
   PubMed Web of Science ®Google Scholar
• Livingstone C, Davis J. Review: Targeting therapeutics against glutathione depletion in diabetes and its complications. Br J Diabetes Vasc Dis. 2007;7:258–265. doi: 10.1177/14746514070070060201.
   Google Scholar