Effect of Pomegranate Juice on Intestinal Recovery Following Methotrexate-Induced Intestinal Damage in a Rat Model

References

• Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. Journal of ethnopharmacology 2012;143:397–405. doi:10.1016/j.jep.2012.07.004. PMID:22820239.
   PubMed Web of Science ®Google Scholar
• Colombo E, Sangiovanni E, Dell'agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evidence-based complementary and alternative medicine: eCAM 2013;2013:247145. doi:10.1155/2013/247145. PMID:23573120.
   PubMedGoogle Scholar
• Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Journal of ethnopharmacology 2007;109:177–206. doi:10.1016/j.jep.2006.09.006. PMID:17157465.
   PubMed Web of Science ®Google Scholar
• Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Advanced biomedical research 2014;3:100. doi:10.4103/2277-9175.129371. PMID:24800189.
   PubMedGoogle Scholar
• Danesi F, Ferguson LR. Could pomegranate juice help in the control of inflammatory diseases? Nutrients 2017;9:1–23. doi:10.3390/nu9090958. PMID:28867799.
   PubMed Web of Science ®Google Scholar
• Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. Journal of agricultural and food chemistry 2006;54:980–5. doi:10.1021/jf052005r. PMID:16448212.
   PubMed Web of Science ®Google Scholar
• Zhao F, Pang W, Zhang Z, Zhao J, Wang X, Liu Y, Wang X, Feng Z, Zhang Y, Sun W, Liu J. Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat-diet-induced obesity in rats. The Journal of nutritional biochemistry 2016;32:20–8. doi:10.1016/j.jnutbio.2016.02.003. PMID:27142733.
   PubMed Web of Science ®Google Scholar
• Li Z, Summanen PH, Komoriya T, Henning SM, Lee RP, Carlson E, Heber D, Finegold SM. Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: implications for prebiotic and metabolic effects. Anaerobe 2015;34:164–8. doi:10.1016/j.anaerobe.2015.05.012. PMID:26051169.
   PubMed Web of Science ®Google Scholar
• Mitchell EP, Schein PS. Gastrointestinal toxicity of chemotherapeutic agents. Seminars in oncology 1982;9:52–64. PMID:7071609.
   PubMed Web of Science ®Google Scholar
• Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004;100:1995–2025. doi:10.1002/cncr.20162. PMID:15108222.
   PubMed Web of Science ®Google Scholar
• Sukhotnik I, Shteinberg D, Ben Lulu S, Bashenko Y, Mogilner JG, Ure BM, Shaoul R, Coran AG. Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat. Apoptosis: an international journal on programmed cell death 2008;13:1344–55. doi:10.1007/s10495-008-0258-x. PMID:18803016.
   PubMed Web of Science ®Google Scholar
• Sukhotnik I, Shehadeh N, Coran AG, Mogilner JG, Karry R, Shamian B, Ure BM, Shamir R. Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat. Journal of pediatric gastroenterology and nutrition 2008;47:115–22. doi:10.1097/MPG.0b013e31806008f1. PMID:18664860.
   PubMed Web of Science ®Google Scholar
• Türkcü G, Alabalik U, Keles AN, Bozkurt M, Ibiloglu I, Firat U, Buyukbayram H. Protective effects of carvacrol and pomegranate against methotrexate-induced intestinal damage in rats. International journal of clinical and experimental medicine 2015;8:15474–81. PMID:26629037.
   PubMed Web of Science ®Google Scholar
• Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 1993;15:532–4, 536–7.
   PubMed Web of Science ®Google Scholar
• Kalaycioglu Z, Erim FB. Total phenolic contents, antioxidant activities, and bioactive ingredients of juices from pomegranate cultivars worldwide. Food chemistry 2017;221:496–507. doi:10.1016/j.foodchem.2016.10.084. PMID:27979233.
   PubMed Web of Science ®Google Scholar
• Kesik V, Uysal B, Kurt B, Kismet E, Koseoglu V. Ozone ameliorates methotrexate-induced intestinal injury in rats. Cancer biology & therapy 2009;8:1623–8. doi:10.4161/cbt.8.17.9203.
   PubMed Web of Science ®Google Scholar
• Coursodon-Boyiddle CF, Snarrenberg CL, Adkins-Rieck CK, Bassaganya-Riera J, Hontecillas R, Lawrence P, Brenna JT, Jouni ZE, Dvorak B. Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. American journal of physiology Gastrointestinal and liver physiology 2012;303:G744–51. doi:10.1152/ajpgi.00248.2012. PMID:22821948.
   PubMed Web of Science ®Google Scholar
• Boussetta T, Raad H, Letteron P, Gougerot-Pocidalo MA, Marie JC, Driss F, El-Benna J. Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. PloS one 2009;4:e6458. doi:10.1371/journal.pone.0006458. PMID:19649246.
   PubMed Web of Science ®Google Scholar
• Hora JJ, Maydew ER, Lansky EP, Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. Journal of medicinal food 2003;6:157–61. doi:10.1089/10966200360716553. PMID:14585180.
   PubMedGoogle Scholar
• Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer science 2004;95:481–6. doi:10.1111/j.1349-7006.2004.tb03236.x. PMID:15182427.
   PubMed Web of Science ®Google Scholar
• Mehta R, Lansky EP. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2004;13:345–8. doi:10.1097/01.cej.0000136571.70998.5a. PMID:15554563.
   PubMed Web of Science ®Google Scholar
• Bassaganya-Riera J, DiGuardo M, Climent M, Vives C, Carbo A, Jouni ZE, Einerhand AW, O'Shea M, Hontecillas R. Activation of PPARgamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. The British journal of nutrition 2011;106:878–86. doi:10.1017/S0007114511001188. PMID:21736821.
   PubMed Web of Science ®Google Scholar
• Boroushaki MT, Asadpour E, Sadeghnia HR, Dolati K. Effect of pomegranate seed oil against gentamicin -induced nephrotoxicity in rat. Journal of food science and technology 2014;51:3510–4. doi:10.1007/s13197-012-0881-y. PMID:26396355.
   PubMed Web of Science ®Google Scholar
• Boroushaki MT, Rajabian A, Farzadnia M, Hoseini A, Poorlashkari M, Taghavi A, Dolati K, Bazmandegan G. Protective effect of pomegranate seed oil against cisplatin-induced nephrotoxicity in rat. Renal failure 2015;37:1338–43. doi:10.3109/0886022X.2015.1073496. PMID:26288026.
   PubMed Web of Science ®Google Scholar
• Goldman ID, Matherly LH. The cellular pharmacology of methotrexate. Pharmacology & therapeutics 1985;28:77–102. doi:10.1016/0163-7258(85)90083-X.
   PubMed Web of Science ®Google Scholar
• Altmann GG. Changes in the mucosa of the small intestine following methotrexate administration or abdominal x-irradiation. The American journal of anatomy 1974;140:263–79. doi:10.1002/aja.1001400210. PMID:4826245.
   PubMedGoogle Scholar
• Jeynes BJ, Altmann GG. Light and scanning electron microscopic observations of the effects of sublethal doses of methotrexate on the rat small intestine. The Anatomical record 1978;191:1–17. doi:10.1002/ar.1091910102. PMID:646132.
   PubMedGoogle Scholar
• Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S, Sa G, Das T, Chattopadhyay S. Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-kappaB pathways. The Journal of nutritional biochemistry 2013;24:2040–50. doi:10.1016/j.jnutbio.2013.07.005. PMID:24231097.
   PubMed Web of Science ®Google Scholar
• Celik F, Gocmez C, Bozkurt M, Kaplan I, Kamasak K, Akil E, Dogan E, Guzel A, Uzar E. Neuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in rats. European review for medical and pharmacological sciences 2013;17:2988–93. PMID:24302176.
   PubMed Web of Science ®Google Scholar
• Selimoglu Sen H, Sen V, Bozkurt M, Turkcu G, Guzel A, Sezgi C, Abakay O, Kaplan I. Carvacrol and pomegranate extract in treating methotrexate-induced lung oxidative injury in rats. Medical science monitor : international medical journal of experimental and clinical research 2014;20:1983–90. doi:10.12659/MSM.890972. PMID:25326861.
   PubMed Web of Science ®Google Scholar
• Sen V, Bozkurt M, Soker S, Ece A, Gunes A, Uluca U, Soker M, Yel S, Kaplan I. The effects of pomegranate and carvacrol on methotrexate-induced bone marrow toxicity in rats. Clinical and investigative medicine Medecine clinique et experimentale 2014;37:E93–E101. PMID:24690424.
   PubMed Web of Science ®Google Scholar