Antiproliferative and Survival Properties of PMA in MCF-7 Breast Cancer Cell

REFERENCES

• Yuspa S. H., Lichti U., Ben T., Patterson E., Hennings H., Slaga T. J., Colburn N., Kelsey W. Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures. Nature 1976; 262: 402–404
   PubMed Web of Science ®Google Scholar
• Kikkawa U., Takai Y., Tanaka Y., Miyake R., Nishizuka Y. Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J. Biol. Chem. 1983; 258: 11442–11445
   PubMed Web of Science ®Google Scholar
• Kazanietz M. G. Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection. Mol. Pharmacol. 2002; 6(14)759–767
   Google Scholar
• Lambert Q. T., Reuther G. W. Activation of ras proteins by ras Guanine nucleotide releasing protein family members. Methods Enzymol. 2005; 407: 82–98
   Web of Science ®Google Scholar
• Caloca M. J., Wang H., Kazanietz M. G. Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a ‘non-protein kinase C’ phorbol ester receptor. Biochem. J. 2003; 375(Pt2)313–321
   PubMedGoogle Scholar
• Welsh C. F. Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation. Breast Cancer Res. Treat. 2004; 84(1)33–42
   PubMed Web of Science ®Google Scholar
• Yang C., Liu Y., Leskow F. C., Weaver V. M., Kazanietz M. G. Rac-GAP-dependent inhibition of breast cancer cell proliferation by beta2-chimaerin. J. Biol. Chem. 2005; 280(26)24363–24370
   PubMed Web of Science ®Google Scholar
• Fortino V., Torricelli C., Gardi C., Valacchi G., Rossi Paccani S., Maioli E. ERKs are the point of divergence of PKA and PKC activation by PTHrP in human skin fibroblasts. Cell. Mol. Life Sci. 2002; 59(12)2165–2171
   PubMed Web of Science ®Google Scholar
• Huang S., Maher V. M., McCormick. Involvement J. of intermediary metabolites in the pathway of extracellularCa2+-induced mitogen-activated protein kinase activation in human fibroblasts. Cell Signal 1999; 11(4)263–274
   PubMed Web of Science ®Google Scholar
• Miao D., Tong X. K., Chan G. K., Panda D., McPherson P. S., Goltzman D. Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 2001; 276(34)32204–32213
   PubMed Web of Science ®Google Scholar
• Yokoyama G., Fujii T., Tayama K., Yamana H., Kuwano M., Shirouzu K. PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells. Biochem. Biophys. Res. Commun. 2005; 327(3)720–726
   PubMed Web of Science ®Google Scholar
• Salabat M. R., Ding X. Z., Flesche J. B., Ujiki M. B., Robin T. P., Talamonti M. S., Bell R. H., Adrian T. E. On the mechanisms of 12-otetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells. Pancreas 2006; 33(2)148–155
   PubMed Web of Science ®Google Scholar
• Shanmugam M., Krett N. L., Maizels E. T., Murad F. M., Rosen S. T., Hunzicker-Dunn M. A role for Protein Kinase Cδ in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21WAF1/CIP1 induction. Cancer Lett. 2001; 172(1)43–53
   PubMed Web of Science ®Google Scholar
• Maioli E., Torricelli C., Fortino V. Functional interactions of protein kinase A and C in signalling networks: a recapitulation. Cell. Mol. Life Sci. 2006; 63(6)637–41
   PubMed Web of Science ®Google Scholar
• Maioli E., Fortino V. PTHrP on MCF-7 breast cancer cells: a growth factor or an antimitogenic peptide?. Br. J. Cancer 2004; 90(6)1293–1294
   PubMed Web of Science ®Google Scholar
• Falzon M., Du P. Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide. Endocrinology 2000; 141(5)1882–1892
   PubMed Web of Science ®Google Scholar
• Weldon C. B., McKee A., Collins-Burow B. M., Melnik L. I., Scandurro A. B., McLachlan J. A., Burow M. E., Beckman B. S. PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling. Int. J. Oncol. 2005; 26(3)763–768
   PubMed Web of Science ®Google Scholar
• Schmid I., Uittenbogaart C., Jamieson B. D. Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D. Nat. Protoc. 2007; 2(1)187–190
   PubMed Web of Science ®Google Scholar
• Wang X., Studzinski G. P. Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by “MEK-specific” inhibitors PD 098059 and U0126 in differentiating HL60 cells. Exp. Cell. Res. 2001; 268(2)294–300
   PubMed Web of Science ®Google Scholar
• Balmanno K., Cook S. J., Sustained M AP. kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 1999; 18(20)3085–3097
   PubMed Web of Science ®Google Scholar
• Milanini-Mongiat J., Pouyssegur J., Pages G. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J. Biol. Chem. 2002; 277(23)20631–20639
   PubMed Web of Science ®Google Scholar
• Das D., Pintucci G., Stern A. MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells. FEBS Lett. 2000; 472(1)50–52
   PubMed Web of Science ®Google Scholar
• Cozzi S. J., Parsons P. G., Ogbourne S. M., Pedley J., Boyle G. M. Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res. 2006; 66(20)10083–10091
   PubMed Web of Science ®Google Scholar
• el-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Kinzler K. W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75(4)817–825
   PubMed Web of Science ®Google Scholar
• Lu R., Wang X., Chen Z. F., Sun D. F., Tian X. Q., Fang J. Y. Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decrease DNA methylation in colon cancer cells. J. Biol. Chem. 2007; 282(16)12249–12259
   PubMed Web of Science ®Google Scholar
• Sakakibara K., Kubota K., Worku B., Ryer E. J., Miller J. P., Koff A., Kent K. C., Liu B. PDGF-BB regulates p27 expression through ER K-dependent RNAturn-over in vascular smooth muscle cells. J. Biol. Chem. 2005; 280(42)25470–25477
   PubMedGoogle Scholar
• Vidal A., Koff A. Cell-cycle inhibitors: three families united by a common cause. Gene 2000; 247(1–2)1–15
   PubMed Web of Science ®Google Scholar
• Luo Y., Hurwitz J., Massague J. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 1995; 375(6527)159–161
   PubMed Web of Science ®Google Scholar
• Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?. Trends Cell Biol. 2003; 13(2)65–70
   PubMed Web of Science ®Google Scholar
• Asada M., Yamada T., Ichijo H., Delia D., Miyazono K., Fukumuro K., Mizutani S. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J. 1999; 18(5)1223–1234
   PubMed Web of Science ®Google Scholar
• Suzuki A, Tsutomi Y, Yamamoto N, Shibutani T, Akahane K. Mitochondrial regulation of cell death: mitochondria are essential for procaspase 3-p21 complex formation to resist Fas-mediated cell death. Mol. Cell. Biol. 1999; 19(5)3842–3847
   PubMed Web of Science ®Google Scholar
• Shen S. C., Huang T. S., Jee S. H., Kuo M. L. Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells. Cell Growth Differ. 1998; 9(1)23–29
   PubMedGoogle Scholar
• Canfield S. E., Zhu K., Williams S. A, McConkey, Bortezomib D. J. inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells. Mol. Cancer Ther. 2006; 5(8)2043–2050
   PubMed Web of Science ®Google Scholar
• Jin S., Zhuo Y., Guo W., Field J. p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J. Biol. Chem. 2005; 280(26)24698–24705
   PubMed Web of Science ®Google Scholar
• Han Z. T., Zhu X. X., Yang R. Y., Sun J. Z., Tian G. F., Liu X. J., Cao G. S., Newmark H. L., Conney A. H., Chang R. L. Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity. Proc. Natl. Acad. Sci. U S A 1998; 95(9)5357–5361
   PubMed Web of Science ®Google Scholar
• Torricelli C., Fortino V., Capurro E., Sacchi G., Ponzo P., Pacini A., Muscettola M., Maioli E. Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion. Matrix Biol. 2006; 25(2)104–111
   PubMed Web of Science ®Google Scholar
• De Siervi A., Marinissen M., Diggs J., Wang X. F., Pages G., Senderowicz A. Transcriptional Activation of p21waf1/cip1 by Alkylphospholipids: Role of the Mitogen-Activated Protein Kinase Pathway in the Transactivation of the Human p21waf1/cip1 Promoter by Sp1. Cancer Res. 2004; 64(2)743–750
   PubMed Web of Science ®Google Scholar
• Facchinetti M. M., De Siervi A., Toskos D., Senderowicz A. M. UCN-01-Induced Cell Cycle Arrest Requires the Transcriptional Induction of p21waf1/cip1 by Activation of Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway. Cancer Res. 2004; 64(10)3629–3637
   PubMed Web of Science ®Google Scholar