REFERENCES
- Balint E. E., Vousden K. H. Activation and activities of the p53 tumor suppressor protein. Br. J. Cancer 2001; 85: 1813–1823
- Boyd S. D., Tsai K. Y., Jacks T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell. Biol. 2000; 2: 563–568
- Fang S., Jensen J. P., Ludwig R. L., Vousden K. H., Weissman A. M. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 2000; 275(12)8945–8951
- Honda R., Yasuda H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000; 19(11)1473–1476
- Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387(6630)296–299
- Kubbutat M. H., Jones S. N., Vousden K. H. Regulation of p53 stability by Mdm2. Nature 1997; 387(6630)299–303
- Lain S. Protecting p53 from degradation. Biochem Soc Trans. 2003; 31(3)482–485
- Kanovsky M., Raffo A., Drew L., Rosal R. Peptides from the amino terminal mdm2-binding domin of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proc Natl Acad Sci U S A. 2001; 98(22)1, 2438–12443
- Do T. N., Rosal R. V., Drew L., Raffo A. J. Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site. Oncogene. 2003; 22(10)1431–1444
- Hua Z., Haitao H., Huimin R. The cloning of the human neurotrophin 4 gene. J Xi'an Med Univ. (Engl. Ed.) 2001; 13(2)172–176, Chinese
- Guoxi Z., Yu Y., Hongliang Z., Quanying W., Guangxiao Y. Construction of expression vector for NT4 (Si)-ADNF fusion gene. J. Xi'an Jiaotong University (Medical Sciences) 2003; 24(5)427–430, Chinese
- Smith D. J., Leil T. A., Liu X. Neurotrophin-4 is required for tolerance to morphine in the mouse. Neurosci Lett 2003; 340(2)103–106
- Timmusk T., Belluardo N., Metsis M., Persson H. Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. J Eur Neurosci. 1993; 5(6)605–613
- Ip N. Y., Ibanez C. F., Nye S. H., McClain J. Mammalian neurotrophin -4:structure, chromosomal localization, tissue distribution receptor specificity. Proc. Natl. Acad. Sci. USA 1997; 89(7)3060–3064
- Yu Y., Jiang W., Xin Y., Senglin H. The construction of NT4 (Si)-NAP fusion gene vector and its expression in Ecoli. Journal of Neurology. 2004; 37(3)260–261, Chinese
- Lever A. M., Strappe P. M., Zhao J. Lentiviral vectors. J. Biomed. Sci. 2004; 11(4)439–49
- Naldini L., Blomer U., Gallay P., Ory D., Mulligan R. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272(5259)263–267
- Dull T., Zufferey R., Kelly M., Mandel R. J. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 1998; 72(11)8463–8471
- Zufferey R., Nagy D., Mandel R. J., Naldini L. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol. 1997; 15(9)871–875
- Rosal R., Brandt-Rauf P., Pincus M. R., Wang H. The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosiss. Adv. Drug Deliv. Rev. 2005; 57(4)653–660