Combination Treatment of Human Umbilical Cord Matrix Stem Cell-Based Interferon-Beta Gene Therapy and 5-Fluorouracil Significantly Reduces Growth of Metastatic Human Breast Cancer in SCID Mouse Lungs

REFERENCES

• Dvorak H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl Med 1986; 315: 1650–1659
   PubMed Web of Science ®Google Scholar
• Natsu K., Ochi M., Mochizuki Y., Hachisuka H., Yanada S., Yasunaga Y. Allogeneic bone marrow-derived mesenchymal stromal cells promote the regeneration of injured skeletal muscle without differentiation into myofibers. Tissue Eng 2004; 10: 1093–1112
   PubMedGoogle Scholar
• Rojas M., Xu J., Woods C. R., Mora A. L., Spears W., Roman J., et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33: 145–152
   PubMed Web of Science ®Google Scholar
• Aboody K. S., Brown A., Rainov N. G., Bower K. A., Liu S., Yang W., et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000; 97: 12846–12851
   PubMed Web of Science ®Google Scholar
• Brown A. B., Yang W., Schmidt N. O., Carroll R., Leishear K. K., Rainov N. G., et al. Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin. Hum Gene Ther 2003; 14: 1777–1785
   PubMed Web of Science ®Google Scholar
• Nakamura K., Ito Y., Kawano Y., Kurozumi K., Kobune M., Tsuda H., et al. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 2004; 11: 1155–1164
   PubMed Web of Science ®Google Scholar
• Studeny M., Marini F. C., Champlin R. E., Zompetta C., Fidler I. J., Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002; 62: 3603–3608
   PubMed Web of Science ®Google Scholar
• Studeny M., Marini F. C., Dembinski J. L., Zompetta C., Cabreira-Hansen M., Bekele B. N., et al. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004; 96: 1593–1603
   PubMed Web of Science ®Google Scholar
• Mitchell K. E., Weiss M. L., Mitchell B. M., Martin P., Davis D., Morales L., et al. Matrix cells from Wharton's jelly form neurons and glia. Stem Cells 2003; 21: 50–60
   PubMed Web of Science ®Google Scholar
• Carlin R., Davis D., Weiss M., Schultz B., Troyer D. Expression of early transcription factors Oct4, Sox2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reprod Biol Endocrinol 2006; 4: 8
   PubMedGoogle Scholar
• Weiss M. L., Medicetty S., Bledsoe A. R., Rachakatla R. S., Choi M., Merchav S., et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 2006; 24: 781–792
   PubMed Web of Science ®Google Scholar
• Arnhold S., Klein H., Semkova I., Addicks K., Schraermeyer U. Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space. Invest Ophthalmol Vis Sci 2004; 45: 4251–4255
   PubMed Web of Science ®Google Scholar
• Ishikawa T., Nakayama S., Nakagawa T., Horiguchi K., Misawa H., Kadowaki M., et al. Characterization of in vitro gutlike organ formed from mouse embryonic stem cells. Am J Physiol Cell Physiol 2004; 286: C1344–C1352
   Google Scholar
• Thomson J. A., Marshall V. S. Primate embryonic stem cells. Curr Top Dev Biol 1998; 38: 133–165
   PubMed Web of Science ®Google Scholar
• Wakitani S., Takaoka K., Hattori T., Miyazawa N., Iwanaga T., Takeda S., et al. Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the joint. Rheumatology (Oxford) 2003; 42: 162–165
   PubMed Web of Science ®Google Scholar
• Karahuseyinoglu S., Cinar O., Kilic E., Kara F., Akay G. G., Demiralp D. O., et al. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 2007; 25: 319–331
   PubMed Web of Science ®Google Scholar
• Rachakatla R. S., Marini F., Weiss M. L., Tamura M., Troyer D. Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Ther 2007
   PubMed Web of Science ®Google Scholar
• Qin X. Q., Runkel L., Deck C., DeDios C., Barsoum J. Interferon-beta induces S phase accumulation selectively in human transformed cells. J Interferon Cytokine Res 1997; 17: 355–367
   PubMed Web of Science ®Google Scholar
• Qin X. Q., Tao N., Dergay A., Moy P., Fawell S., Davis A., et al. Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice. Proc Natl Acad Sci USA 1998; 95: 14411–14416
   PubMed Web of Science ®Google Scholar
• Sidky Y. A., Borden E. C. Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses. Cancer Res 1987; 47: 5155–5161
   PubMed Web of Science ®Google Scholar
• Singh R. K., Gutman M., Bucana C. D., Sanchez R., Llansa N., Fidler I. J. Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 1995; 92: 4562–4566
   PubMed Web of Science ®Google Scholar
• Stark G. R., Kerr I. M., Williams B. R., Silverman R. H., Schreiber R. D. How cells respond to interferons. Ann Rev Biochem 1998; 67: 227–264
   PubMed Web of Science ®Google Scholar
• Douillard J. Y., Cunningham D., Roth A. D., Navarro M., James R. D., Karasek P., et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355: 1041–1047
   PubMed Web of Science ®Google Scholar
• Choi E. A., Lei H., Maron D. J., Mick R., Barsoum J., Yu Q. C., et al. Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. Clin Cancer Res 2004; 10: 1535–1544
   PubMed Web of Science ®Google Scholar
• Koka V., Wang W., Huang X. R., Kim-Mitsuyama S., Truong L. D., Lan H. Y. Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications. Circulation 2006; 113: 1353–1360
   PubMed Web of Science ®Google Scholar
• Richards A. B., Scheel T. A., Wang K., Henkemeyer M., Kromer L. F. EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. Eur J Neurosci 2007; 25: 2619–2628
   PubMed Web of Science ®Google Scholar
• Klubes P., Cerna I. Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil. Cancer Res 1983; 43: 3182–3186
   PubMed Web of Science ®Google Scholar
• Gresser I. Wherefore interferon?. J Leukoc Biol 1997; 61: 567–574
   PubMed Web of Science ®Google Scholar
• Morris A., Zvetkova I. Cytokine research: the interferon paradigm. J. Clin Pathol 1997; 50: 635–639
   PubMed Web of Science ®Google Scholar
• Wang B., Xiong Q., Shi Q., Le X., Abbruzzese J. L., Xie K. Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. Cancer Res 2001; 61: 71–75
   PubMed Web of Science ®Google Scholar
• Kito M., Akao Y., Ohishi N., Yagi K. Induction of apoptosis in cultured colon cancer cells by transfection with human interferon beta gene. Biochem Biophys Res Commun 1999; 257: 771–776
   PubMed Web of Science ®Google Scholar
• Morrison B. H., Bauer J. A., Hu J., Grane R. W., Ozdemir A. M., Chawla-Sarkar M., et al. Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene 2002; 21: 1882–1889
   PubMed Web of Science ®Google Scholar
• Leaman D. W., Chawla-Sarkar M., Vyas K., Reheman M., Tamai K., Toji S., et al. Identification of X–linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. J Biol Chem 2002; 277: 28504–28511
   PubMed Web of Science ®Google Scholar
• Hu G., Mancl M. E., Barnes B. J. Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death. Cancer Res 2005; 65: 7403–7412
   PubMed Web of Science ®Google Scholar
• Kuniyasu H., Yasui W., Kitahara K., Naka K., Yokozaki H., Akama Y., et al. Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line. Cell Growth Differ 1997; 8: 47–52
   PubMedGoogle Scholar
• Einat M., Resnitzky D., Kimchi A. Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor. Proc Natl Acad Sci USA 1985; 82: 7608–7612
   PubMed Web of Science ®Google Scholar
• Gibson D. F., Johnson D. A., Goldstein D., Langan-Fahey S. M., Borden E. C., Jordan V C. Human recombinant interferon-beta SER and tamoxifen: growth suppressive effects for the human breast carcinoma MCF-7 grown in the athymic mouse. Breast Cancer Res Treat 1993; 25: 141–150
   PubMed Web of Science ®Google Scholar
• Tlsty T. D., Hein P. W. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev 2001; 11: 54–59
   PubMed Web of Science ®Google Scholar
• van Kempen L. C., Ruiter D. J., van Muijen G. N., Coussens L. M. The tumor microenvironment: a critical determinant of neoplastic evolution. Eur J Cell Biol 2003; 82: 539–548
   PubMed Web of Science ®Google Scholar
• Nakamizo A., Marini F., Amano T., Khan A., Studeny M., Gumin J., et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307–3318
   PubMed Web of Science ®Google Scholar
• Kulbe H., Levinson N. R., Balkwill F., Wilson J. L. The chemokine network in cancer–much more than directing cell movement. Int J Dev Biol 2004; 48: 489–496
   PubMed Web of Science ®Google Scholar
• Cohenuram M., Saif M. W. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future. J Pancreas 2007; 8: 4–15
   PubMedGoogle Scholar