Herbal Isoprenols Induce Apoptosis in Human Colon Cancer Cells Through Transcriptional Activation of PPARγ

REFERENCES

• Moertel C. G., Fleming T. R., Macdonald J. S., et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 22: 352–358
   Google Scholar
• De Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938–2947
   PubMed Web of Science ®Google Scholar
• Tin M. M., Cho C. H., Chan K., James A. E., Ko J. K. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogen 2007; 28: 1347–1355
   PubMed Web of Science ®Google Scholar
• Ko J. K., Leung W. C., Ho W. K., Chiu P. Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. Eur J Pharmacol 2007; 559: 1–13
   PubMed Web of Science ®Google Scholar
• Sacchettini J. C., Poulter C. D. Creating isoprenoid diversity. Science. 1997; 277: 1788–1789
   PubMed Web of Science ®Google Scholar
• Edwards P. A., Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Ann Rev Biochem 1999; 68: 157–185
   PubMed Web of Science ®Google Scholar
• Haug J. S., Goldner C. M., Yazlovitskaya E. M., Voziyan P. A., Melnykovych G. Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. Biochim Biophys Acta 1994; 1223: 133–140
   PubMed Web of Science ®Google Scholar
• Ohizumi H., Masuda Y., Nakajo S., Sakai I., Ohsawa S., Nakaya K. Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J Biochem (Tokyo). 1995; 117: 11–13
   PubMed Web of Science ®Google Scholar
• Miquel K., Pradines A., Favre G. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. Biochem Biophys Res Commun 1996; 225: 869–876
   PubMed Web of Science ®Google Scholar
• Masuda Y., Nakaya M., Nakajo S., Nakaya K. Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells. Biochem Biophys Res Commun 1997; 234: 641–645
   PubMed Web of Science ®Google Scholar
• Takeda Y., Nakao K., Nakata K., et al. Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression. Jpn J Cancer Res 2001; 92: 918–925
   PubMedGoogle Scholar
• Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645–650
   PubMed Web of Science ®Google Scholar
• Escher P., Wahli W. Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat Res 2000; 448: 121–138
   PubMed Web of Science ®Google Scholar
• Roberts-Thomson S. J. Peroxisome proliferator-activated receptors in tumorigenesis: targets of tumour promotion and treatment. Immunol Cell Biol 2000; 78: 436–441
   PubMed Web of Science ®Google Scholar
• Gupta R. A., Dubois R. N. Controversy: PPARgamma as a target for treatment of colorectal cancer. Am J Physiol Gastrointest Liver Physiol 2002; 283: G266–G269
   PubMed Web of Science ®Google Scholar
• Sato H., Ishihara S., Kawashima K., et al. Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists. Br J Cancer 2000; 83: 1394–1400
   PubMed Web of Science ®Google Scholar
• Shiau C. W., Yang C. C., Kulp S. K., et al. Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma. Cancer Res 2005; 65: 1561–1569
   PubMed Web of Science ®Google Scholar
• Perez-Ortiz J. M., Tranque P., Vaquero C. F., et al. Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J Biol Chem 2004; 279: 8976–8985
   PubMed Web of Science ®Google Scholar
• Clay C. E., Monjazeb A., Thorburn J., Chilton F. H., High K P. 15-Deoxy-delta 12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res 2002; 43: 1818–1828
   PubMed Web of Science ®Google Scholar
• Takahashi N., Kawada T., Goto T., et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett 2002; 514: 315–322
   PubMed Web of Science ®Google Scholar
• Hodgson V. J., Walker G. M., Button D. A rapid colorimetric assay of killer toxin activity in yeast. FEMS Microbiol Lett 1994; 120: 201–205
   PubMed Web of Science ®Google Scholar
• Marcus S. L., Miyata K. S., Zhang B., Subramani S., Rachubinski R. A., Capone J. P. Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc Natl Acad Sci USA 1993; 90: 5723–5727
   PubMed Web of Science ®Google Scholar
• Kim R., Tanabe K., Uchida Y., Emi M., Inoue H., Toge T. Current status of the molecular mechanisms of anticancer drug-induced apoptosis. Cancer Chemother Pharmacol 2002; 50: 343–352
   PubMed Web of Science ®Google Scholar
• Debatin K. M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 2004; 53: 153–159
   PubMed Web of Science ®Google Scholar
• Kastan M. B., Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432: 316–323
   PubMed Web of Science ®Google Scholar
• Reed J. C. Mechanisms of apoptosis avoidance in cancer. Curr Opin Oncol 1999; 11: 68–75
   PubMedGoogle Scholar
• Sertznig P., Seifert M., Tilgen W., Reichrath J. Present concepts and future outlook: Function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer. J Cell Physiol 2007; 212: 1–12
   PubMed Web of Science ®Google Scholar
• Koeffler H. P. Peroxisome proliferator-activated receptor gamma and cancers. Clin Cancer Res 2003; 9: 1–9
   PubMed Web of Science ®Google Scholar
• Chen G. G., Lee J. F., Wang S. H., Chan U. P., Ip P. C., Lau W. Y. Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. Life Sci 2002; 70: 2631–2646
   PubMed Web of Science ®Google Scholar
• Lefebvre A. M., Chen I., Desreumaux P., et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998; 4: 1053–1057
   PubMed Web of Science ®Google Scholar
• O'Brien M. L., Rangwala S. M., Henry K. W., Weinberger C., Crick D. C., Waechter C. J., Feller D. R., Noonan D. J. Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis. Carcinogene 1996; 17: 185–190
   PubMed Web of Science ®Google Scholar
• Baek S. J., Wilson L. C., His L. C., Eling T. E. Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. J Biol Chem 2003; 278: 5845–5
   PubMed Web of Science ®Google Scholar
• Carnesecchi S., Schneider Y., Ceraline J., et al. Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 2001; 298: 197–200
   PubMed Web of Science ®Google Scholar
• He L., Mo H., Hadisusilo S., Qureshi A. A., Elson C. E. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 1997; 127: 668–674
   PubMed Web of Science ®Google Scholar
• Sporn M. B., Suh N., Mangelsdorf D. J. Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs). Trends Mol Med 2001; 7: 395–400
   PubMed Web of Science ®Google Scholar
• Rumi M. A.K., Ishihara S., Kadowaki Y., et al. Peroxisome proliferator-activated receptor γ -dependent and -independent growth inhibition of gastrointestinal tumor cells. Genes Cells 2004; 9: 1113–1123
   PubMed Web of Science ®Google Scholar