MG-132 Inhibits Telomerase Activity, Induces Apoptosis and G₁ Arrest Associated with Upregulated p27kip1 Expression and Downregulated Survivin Expression in Gastric Carcinoma Cells

REFERENCES

• Fuchs S. Y. The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol Ther 2002; 1(4)337–341
   PubMed Web of Science ®Google Scholar
• Romero-Perez L., Chen L., Lambertson D., Madura K. Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway. J Biol Chem 2007; 282(49)35574–35582
   PubMed Web of Science ®Google Scholar
• Li W., Zhang X., Olumi A. F. MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res 2007; 67(5)2247–2255
   PubMed Web of Science ®Google Scholar
• Aoyama T., Okamoto T., Nagayama S., Nishijo K., Ishibe T., Yasura K., Nakayama T., Nakamura T., Toguchida J. Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. J Biol Chem 2004; 279(27)28789–28797
   PubMed Web of Science ®Google Scholar
• Hellmann H., Estelle M. Plant development: regulation by protein degradation. Science 2002; 297(5582)793–797
   PubMed Web of Science ®Google Scholar
• Wang X., Guerrero C., Kaiser P., Huang L. Proteomics of proteasome complexes and ubiquitinated proteins. Expert Rev Proteomics 2007; 4(5)649–665
   PubMed Web of Science ®Google Scholar
• Li M., Chen D., Shiloh A., Luo J., Nikolaev A. Y., Qin J., Gu W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002; 416(6881)648–653
   PubMed Web of Science ®Google Scholar
• Gregory M. A., Hann S. R. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol Cell Biol 2000; 20(7)2423–2435
   PubMed Web of Science ®Google Scholar
• Butler M. W., Robertson I., Greene C. M., O'Neill S. J., Taggart C. C., McElvaney N G. Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem 2006; 281(46)34730–34735
   PubMed Web of Science ®Google Scholar
• Qi X., Pohl N. M., Loesch M., Hou S., Li R., Qin J. Z., Cuenda A., Chen G. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. J Biol Chem 2007; 282(43)31398–31408
   PubMed Web of Science ®Google Scholar
• Mailhes J. B., Hilliard C., Lowery M., London S. N. MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes. Cell Chromosome 2002; 1(1)2
   PubMedGoogle Scholar
• Polyak K., Kato J. Y., Solomon M. J., Sherr C. J., Massague J., Roberts J. M., Koff A. p27kip1, a cyclin-CDK inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 1994; 8(1)9–22
   PubMed Web of Science ®Google Scholar
• Manne U., Jhala N. C., Jones J., Weiss H. L., Chatla C., Meleth S., Suarez-Cuervo C., Grizzle W. E. Prognostic significance of p27kip1 expression in colorectal adenocarcinomas is associated with tumor stage. Clin Cancer Res 2004; 10(5)1743–1752
   PubMed Web of Science ®Google Scholar
• Liang J., Zubovitz J., Petrocelli T., Kotchetkov R., Connor M. K., Han K., Lee J. H., Ciarallo S., Catzavelos C., Beniston R., Franssen E., Slingerland J. M. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002; 8(10)1153–1160
   PubMed Web of Science ®Google Scholar
• Wu Q. M., Yu J. P., Tong Q., Wang X. H., Xie G. J. Inhibition of adenovirus-mediated p27kip1 gene on growth of esophageal carcinoma cell strain. World J Gastroenterol 2003; 9(11)2404–2408
   PubMed Web of Science ®Google Scholar
• Zhang W. G., Wu Q. M., Yu J. P., Tong Q., Xie G. J., Wang X. H., Li S. B. Adenovirus expressing p27kip1 suppresses growth of established esophageal carcinoma xenografts. World J Gastroenterol 2005; 11(42)6582–6586
   PubMed Web of Science ®Google Scholar
• Ambrosini G., Adida C., Altieri D. C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997; 3(8)917–921
   PubMed Web of Science ®Google Scholar
• Li F., Ambrosini G., Chu E. Y., Plescia J., Tognin S., Marchisio P. C., Altieri D. C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998; 396(6711)580–584
   PubMed Web of Science ®Google Scholar
• Ling Y. H., Liebes L., Ng B., Buckley M., Elliott P. J., Adams J., Jiang J. D., Muggia F. M., Perez-Soler R. PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis. Mol Cancer Ther 2002; 1(10)841–849
   PubMed Web of Science ®Google Scholar