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ORIGINAL ARTICLE

Oncogene-Driven Hemostatic Changes in Cancer

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Pages 28-35 | Published online: 11 Jun 2009

REFERENCES

  • Buller H. R., van Doormaal F. F., van Sluis G. L., Kamphuisen P. W. Cancer and thrombosis: from molecular mechanisms to clinical presentations. J Thromb Haemost 2007; 5(Suppl. 1)246–254
  • Zwicker J. I., Furie B. C., Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol 2007; 62: 126–136
  • Falanga A. Thrombophilia in cancer. Semin Thromb Hemost 2005; 31: 104–110
  • Rickles F. R. Mechanisms of cancer-induced thrombosis in cancer. Pathophysiol Haemost Thromb 2006; 35: 103–110
  • Trousseau A. Phlegmasia alba dolens. Clinique Medicale de l'Hotel -Dieu de Paris. The Sydenham Society 2nd. 1865; 654–712, Paris, France. Ref Type: Serial (Book, Monograph)
  • Varki A. Trousseau's syndrome: multiple definitions and multiple mechanisms. Blood 2007; 110: 1723–1729
  • Tesselaar M. E., Romijn F. P., van dL I., et al. Microparticle-associated tissue factor activity: a link between cancer and thrombosis?. J Thromb Haemost 2007; 5: 520–527
  • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932–936
  • Jain R. K., di T. E., Duda D. G., et al. Angiogenesis in brain tumors. Nat Rev Neurosci 2007; 8: 610–622
  • Rickles F. R., Patierno S., Fernandez P. M. Tissue factor, thrombin, and cancer. Chest 2003; 124: 58S–68S
  • Petralia G. A., Lemoine N. R., Kakkar A. K. Mechanisms of disease: the impact of antithrombotic therapy in cancer patients. Nat Clin Pract Oncol 2005; 2: 356–363
  • Rak J., Yu J. L., Luyendyk J., Mackman N. Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res 2006; 66: 10643–10646
  • Blom J. W., Doggen C. J., Osanto S., Rosendaal F. R. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA 2005; 293: 715–722
  • Svendsen E., Karwinski B. Prevalence of pulmonary embolism at necropsy in patients with cancer. J Clin Pathol 1989; 42: 805–809
  • Levitan N., Dowlati A., Remick S. C., et al. Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using medicare claims data. Medicine (Baltimore) 1999; 78: 285–291
  • Mackman N. Tissue-specific hemostasis in mice. Arterioscler Thromb Vasc Biol 2005; 25: 2273–2281
  • Iversen L. H., Thorlacius-Ussing O. Systemic coagulation reactivation in recurrence of colorectal cancer. Thromb Haemost 2003; 89: 726–734
  • Kuenen B. C., Rosen L., Smit E. F., et al. Dose-finding and pharmacokinetic study of cisplatin, gGemcitabine, and SU5416 in patients with solid tumors. J Clin Oncol 2002; 20: 1657–1667
  • Rickles F. R., Levine M. N. Venous thromboembolism in malignancy and malignancy in venous thromboembolism. Haemostasis 1998; 28(Suppl. 3)43–49
  • Reya T., Morrison S. J., Clarke M. F., Weissman I. L. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105–111
  • Folkman J., Kalluri R. Tumor angiogenesis. Cancer Medicine, D. W. Kufe, R. E. Pollock, R. R. Weichselbaum, et al. BC Decker Inc., Hamilton, London 2003; 161–194
  • Brown L. F., Guidi A. J., Schnitt S. J., et al. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res 1999; 5: 1041–1056
  • Kaplan R. N., Riba R. D., Zacharoulis S., et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820–827
  • Hanahan D., Weinberg R. A. The hallmarks of cancer. Cell 2000; 100: 57–70
  • Bishop J. M. Cancer: the rise of the genetic paradigm. Genes Dev 1995; 9: 1309–1315
  • Rak J., Yu J. L., Klement G., Kerbel R. S. Oncogenes and angiogenesis: signaling three-dimensional tumor growth. J Investig Dermatol Symp Proc 2000; 5: 24–33
  • Rak J., Mitsuhashi Y., Bayko L., et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995; 55: 4575–4580
  • Kerbel R. S. Tumor angiogenesis. N Engl J Med 2008; 358: 2039–2049
  • Ocak I., Baluk P., Barrett T., McDonald D. M., Choyke P. The biologic basis of in vivo angiogenesis imaging. Front Biosci 2007; 12: 3601–3616
  • Seaman S., Stevens J., Yang M. Y., et al. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007; 11: 539–554
  • Dvorak H. F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368–4380
  • Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004; 24: 1015–1022
  • Mechtcheriakova D., Schabbauer G., Lucerna M., et al. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. FASEB J 2001; 15: 230–242
  • Contrino J., Hair G., Kreutzer D. L., Rickles F. R. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 1996; 2: 209–215
  • Fidler I. J. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 2003; 3: 453–458
  • Dvorak H. F., Quay S. C., Orenstein N. S., et al. Tumor shedding and coagulation. Science 1981; 212: 923–924
  • Yu J. L., May L., Lhotak V., et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 2005; 105: 1734–1741
  • Rak J., Milsom C., Yu J. Tissue factor in cancer. Curr Opin Hematol 2008; 15: 522–528
  • Rak J., Klement G. Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer. Cancer Metastasis Rev 2000; 19: 93–96
  • Rastinejad F., Polverini P. J., Bouck N. Regulation of the activity of a new inhibitor by angiogenesis by a cancer suppressor gene. Cell 1989; 56: 345–355
  • Dameron K. M., Volpert O. V., Tainsky M. A., Bouck N. The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin. Cold Spring Harb Symp Quant Biol 1994; 59: 483–489
  • Bouck N., Stellmach V., Hsu S. C. How tumors become angiogenic. Adv Cancer Res 1996; 69: 135–174
  • Grugel S., Finkenzeller G., Weindel K., Barleon B., Marme D. Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem 1995; 270: 25915–25919
  • Izumi H., Takahashi C., Oh J., Noda M. Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes. FEBS Lett 2000; 481: 31–36
  • Mazzieri R., Furlan F., D'Alessio S., et al. A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts. Oncogene 2007; 26: 725–732
  • Zhao Y., Xiao A., Dipierro C. G., et al. H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway. Glia 2008; 56: 917–924
  • Pakneshan P., Szyf M., Rabbani S. A. Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells. Carcinogenesis 2005; 26: 557–564
  • Scibetta A. G., Albanese I., Morris J., et al. Regulation of MUC1 expression in human mammary cell lines by the c-ErbB2 and ras signaling pathways. DNA Cell Biol 2001; 20: 265–274
  • Jahner D., Hunter T. The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes. Oncogene 1991; 6: 1259–1268
  • Yu J. L., May L., Klement P., Weitz J. I., Rak J. Oncogenes as regulators of tissue factor expression in cancer: implications for tumor angiogenesis and anti-cancer therapy. Semin Thromb Hemost 2004; 30: 21–30
  • Al-Nedawi K., Meehan B., Micallef J., et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumor cells. Nat Cell Biol 2008; 10: 619–624
  • Koizume S., Jin M. S., Miyagi E., et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res 2006; 66: 9453–9460
  • Schulze E. B., Hedley B. D., Goodale D., et al. The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. Breast Cancer Res Treat 2008; 112: 243–254
  • Tallman M. S., Lefebvre P., Baine R. M., et al. Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia. J Thromb Haemost 2004; 2: 1341–1350
  • Boccaccio C., Sabatino G., Medico E., et al. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature 2005; 434: 396–400
  • Rong Y., Post D. E., Pieper R. O., et al. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res 2005; 65: 1406–1413
  • Ruf W. Redundant signaling of tissue factor and thrombin in cancer progression?. J Thromb Haemost 2007; 5: 1584–1587
  • Pineo G. F., Brain M. C., Gallus A. S., et al. Tumors, mucus production, and hypercoagulability. Ann NY Acad Sci 1974; 230: 262–270
  • Mackman N., Morrissey J. H., Fowler B., Edgington T. S. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 1989; 28: 1755–1762
  • Chen J., Bierhaus A., Schiekofer S., et al. Tissue factor–a receptor involved in the control of cellular properties, including angiogenesis. Thromb Haemost 2001; 86: 334–345
  • Fernandez P. M., Rickles F. R. Tissue factor and angiogenesis in cancer. Curr Opin Hematol 2002; 9: 401–406
  • Morrissey J. H. Tissue factor: an enzyme cofactor and a true receptor. Thromb Haemost 2001; 86: 66–74
  • Giesen P. L., Rauch U., Bohrmann B., et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA 1999; 96: 2311–2315
  • Colman R. W., Marder V. J., Salzman E. W., Hirsh J. Overview of hemostasis. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, R. B. Coleman, J. Hirsh, V. J. Marder, J. B. Salzman. Lippincott Company, Philadelphia 1994; 3–18
  • Coughlin S. R. Protease-activated receptors in vascular biology. Thromb Haemost 2001; 86: 298–307
  • Degen J. L. Genetic interactions between the coagulation and fibrinolytic systems. Thromb Haemost 2001; 86: 130–137
  • Shoji M., Abe K., Nawroth P. P., Rickles F. R. Molecular mechanisms linking thrombosis and angiogenesis in cancer. Trends Cardiovasc Med 1997; 7(2)52–59
  • Wojtukiewicz M. Z., Sierko E., Klement P., Rak J. The hemostatic system and angiogenesis in malignancy. Neoplasia 2001; 3: 371–384
  • Ueno T., Toi M., Koike M., Nakamura S., Tominaga T. Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration. Br J Cancer 2000; 83: 164–170
  • Sawada M., Miyake S., Ohdama S., et al. Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis. Br J Cancer 1999; 79: 472–477
  • Kakkar A. K., Lemoine N. R., Scully M. F., Tebbutt S., Williamson R. C. Tissue factor expression correlates with histological grade in human pancreatic cancer. Br J Surg 1995; 82: 1101–1104
  • Koomagi R., Volm M. Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: correlation between tissue factor and angiogenesis. Int J Cancer 1998; 79: 19–22
  • Seto S., Onodera H., Kaido T., et al. Tissue factor expression in human colorectal carcinoma: correlation with hepatic metastasis and impact on prognosis. Cancer 2000; 88: 295–301
  • Shigemori C., Wada H., Matsumoto K., et al. Tissue factor expression and metastatic potential of colorectal cancer. Thromb Haemost 1998; 80: 894–898
  • Nakasaki T., Wada H., Shigemori C., et al. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Am J Hematol 2002; 69: 247–254
  • Denko N. C., Giaccia A. J. Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis. Cancer Res 2001; 61: 795–798
  • Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006; 7: 505–516
  • Rak J., Milsom C., May L., Klement P., Yu J. Tissue factor in cancer and angiogenesis: the molecular link between genetic tumor progression, tumor neovascularization, and cancer coagulopathy. Semin Thromb Hemost 2006; 32: 54–70
  • Milsom C., Yu J., May L., et al. The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thromb Res 2007; 120(Suppl. 2)S82–S91
  • Yu J. L., Rak J. W. Shedding of tissue factor (TF)-containing microparticles rather than alternatively spliced TF is the main source of TF activity released from human cancer cells. J Thromb Haemost 2004; 2: 2065–2067
  • Del I. C., Shrimpton C. N., Thiagarajan P., Lopez J. A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005; 106: 1604–1611
  • Sanderson M. P., Keller S., Alonso A., et al. Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion. J Cell Biochem 2008; 103: 1783–1797
  • Guan M., Jin J., Su B., Liu W. W., Lu Y. Tissue factor expression and angiogenesis in human glioma. Clin Biochem 2002; 35: 321–325
  • Ohgaki H., Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am J Pathol 2007; 170: 1445–1453
  • Brat D. J., Van Meir E. G. Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma. Lab Invest 2004; 84: 397–405
  • Furnari F. B., Fenton T., Bachoo R. M., et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007; 21: 2683–2710
  • Mellinghoff I. K., Wang M. Y., Vivanco I., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 2005; 353: 2012–2024
  • Pandolfi P. P. Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Hum Mol Genet 2001; 10: 769–775
  • Milsom C., Anderson G. M., Weitz J. I., Rak J. Elevated tissue factor procoagulant activity in CD133-positive cancer cells. J Thromb Haemost 2007; 5: 2550–2552
  • Belting M., Ahamed J., Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 2005; 25: 1545–1550
  • Zacharski L. R. Malignancy as a solid-phase coagulopathy: implications for the etiology, pathogenesis, and treatment of cancer. Semin Thromb Hemost 2003; 29: 239–246
  • Lee A. Y., Rickles F. R., Julian J. A., et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism. J Clin Oncol 2005; 23: 2123–2129
  • Kakkar A. K., Levine M. N., Kadziola Z., et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 2004; 22: 1944–1948
  • Altinbas M., Coskun H. S., Er O., et al. A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer. J Thromb Haemost 2004; 2: 1266–1271
  • Versteeg H. H., Schaffner F., Kerver M., et al. Inhibition of tissue factor signaling suppresses tumor growth. Blood 2008; 111: 190–199
  • Hu Z., Garen A. Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostate cancer. Proc Natl Acad Sci USA 2002; 99: 6269–6273
  • Milsom C. C., Yu J. L., Mackman N., Micallef J., Anderson G. M., Guha A., Rak J. Tissue factor regulation by epithelial growth factor receptor and epithelial-to-mesenchymal transitions: Effect on tumor initiation and angiogenesis. Cancer Res. 2008; 68: 10068–10076
  • Yu J., May L., Milsom C. C., Anderson G. M., Weitz J. I., Luyendyk J. P., Broze G., Mackman N., Rak J. Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler Thromb Vasc Biol, 2008; 28: 1975–1981

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