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Original Article

Activation of Cellular Oncogenes in Human and Mouse Leukemia-Lymphomas: Spontaneous and Induced Oncogene Expression in Murine B Lymphocytic Neoplasms

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Pages 345-368 | Published online: 24 Mar 2010

References

  • Hayward W., Neel B. C., Astrin S. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 1981; 290: 475–480
  • Potter M., Mushinski J. F. Oncogenes in B cell neoplasia. Cancer Invest 1984; 2: 285–300
  • Bishop J. M. Cellular oncogenes and retroviruses. Ann Rev Biochem 1983; 52: 301–354
  • Hunter T. Oncogenes and proto-oncogenes: how do they differ?. J Natl Cancer Inst 1985; 73: 773–786
  • Bishop J. M. Viral oncogenes. Cell 1985; 42: 23–38
  • Weinberg R. A. The action of oncogenes in the cytoplasm and nucleus. Science 1985; 230: 770–776
  • Slamon D. J., de Kernion J. B., Verma I. M., et al. Expression of cellular oncogenes in human malignancies. Science 1984; 224: 256–262
  • Varmus H. E. The molecular genetics of cellular oncogenes. Ann Rev Genet 1984; 18: 553–612
  • Heldin C-H., Westermark B. Growth factors: mechanism of action and relation to oncogenes. Cell 1984; 37: 9–20
  • Doolittle R. F., Hunkapiller M. W., Hood L. E., et al. Simian sarcoma virus one gene, v-sis is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 1983; 221: 275–277
  • Waterfield M. D., Scrace G. T., Whittle N., et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 1983; 304: 35–39
  • Downward J., Yarden Y., Mayes E., et al. Close similarity of epidermal growth factor receptor and v-erb B oncogenic protein sequences, Nature 1984; 307: 521–527
  • Sherr C. J., Rettenmier C. W., Sacca R., et al. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor CSF-1. Cell 1985; 41: 665–672
  • Goubin G., Goldman D. S., Luce J., et al. Molecular cloning and nucleotide sequence of a transforming gene detected by transfec-tion of chicken B-cell lymphoma DNA. Nature 1983; 302: 114–119
  • Lane M. A., Sainten A., Doherty K. M., et al. Isolation and characterization of a stage-specific transforming gene, Tlym-l, from T cell lymphomas. Proc Natl Acad Sci (USA) 1984; 81: 2227–2231
  • Rogers J. Relationship of Blym genes to repeated sequences. Nature 1986; 320: 579
  • Groffen J., Stephenson J. R., Heisterkamp N., et al. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984; 36: 93–99
  • Tsujimoto Y., Yunis J., Onorato-Showe L., et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(ll;14) chromosome translocation. Science 1984; 224: 1403–1406
  • Pegoraro L., Palumbo A., Erikson J., et al. A 14; 18 and an 8; 14 chromosome translocation in a cell line derived from an acute B-cell leukemia. Proc Natl Acad Sci (USA) 1984; 81: 7166–7170
  • Nusse R., van Ooyen A., Cox D., et al. Modeof proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 1984; 307: 131–136
  • Peters G., Brookes S., Smith R., et al. Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors. Cell 1983; 33: 369–377
  • Selten G., Cuypers H. T., Berns A. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J 1985; 4: 1793–1798
  • Crawford L. V. The 53,000-dalton cellular protein and its role in transformation. Int Rev Exp Pathol 1983; 25: 1–50
  • Wolf D., Admon S., Aron M., et al. Abelson murine leukemia virus transformed cells that lack p53 protein synthesis express aberrant p53 RNA species. Mol Cell Biol 1984; 4: 552–558
  • Parada L. F., Land H., Weinberg R. A., et al. Cooperation between gene encoding p53 tumour antigen and ras in p53 cellular transformation. Nature 1984; 312: 649–651
  • Wolf D., Harris N., Rotter V. Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene. Cell 1984; 38: 119–126
  • Cooper C. M., Neiman P. E. Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature 1980; 287: 656–659
  • Cory S. Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv Cancer Res 1986; 47: 189–234
  • Brodeur G. M., Seeger R. C., Schwab M., et al. Amplification of N-myc in untreated human neuroblastoma correlates with advanced disease stage. Science 1984; 224: 1121–1124
  • Schwab M., Ramsay G., Alitalo K., et al. Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells. Nature 1985; 315: 345–347
  • Little C. D., Nau M. M., Carney D. N., et al. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 1983; 306: 194–196
  • Kozbor D., Croce C. M. Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines. Cancer Res 1984; 44: 438–441
  • Dalla-Favera R., Wong-Staal F., Gallo R. C. onc gene amplification in promyelocyte leukemia line HL-60 and primary leukaemic cells of the same patient. Nature 1982; 299: 61–63
  • Collins S., Groudine M. Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature 1982; 298: 679–681
  • Wirschubsky Z., Wiener F., Spira J., et al. Triplication of one chromosome no. 15 with an altered c-myc containing EcoRI fragment and elimination of the normal homologue in a T-cell lymphoma line of AKR origin (TIKAUT). Int J Cancer 1984; 33: 477–481
  • Sumegi J., Hedberg T., Bjorkholm M., et al. Amplification of the c-myc oncogene in human plasma-cell luekemia. Int J Cancer 1985; 36: 367–371
  • Cooper G. M., Lane M-A. Cellular transforming genes and oncogenesis. Biochim Biophys Acta 1984; 738: 9–20
  • Tabin C. J., Bradley J. M., Bergmann C. I., et al. Mechanism of activation of a human oncogene. Nature 1982; 300: 143–149
  • Reddy E. P., Reynolds R. K., Santos E., et al. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature 1982; 300: 149–152
  • Schwab M., Alitalo K., Varmus H. E., et al. A cellular oncogene (c-Ki-ras) is amplified, overexpressed and located within karyotypic abnormalities in mouse adrenocortical tumor cells. Nature 1983; 303: 497–501
  • Shen-Ong G. L. C., Keath E., Piccoli S. P., et al. Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas. Cell 1982; 31: 443–452
  • Mushinski J. F., Bauer S. R., Potter M., et al. Increased expression of myc-related oncogene messenger RNA characterizes most BALB/c plasmacytomas induced by pristane or Abelson murine leukemia virus. Proc Natl Acad Sci (USA) 1983; 80: 1073–1077
  • Sumegi J., Spira J., Bazin H., et al. Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6;7) chromosomal translocation. Nature 1983; 306: 497–498
  • Erikson J., Ar-Rushdi A., Drwinga H. L., et al. Transcriptional activation of the translocated c-myc oncogene in Burkitt lymphoma. Proc Natl Acad Sci (USA) 1983; 80: 820–824
  • Dalla-Favera R., Martinotti S., Gallo R. C., et al. Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science 1983; 219: 963–967
  • Klein G. Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men. Cell 1983; 32: 311–315
  • Kelly K., Siebenlist U. The role of c-myc in the proliferation of normal and neoplastic cells. J Clin Immunol 1985; 5: 65–77
  • Maguire R. T., Robins T. S., Thorgeirsson S. S., et al. Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types. Proc Natl Acad Sci (USA) 1983; 80: 1947–1950
  • Roy-Burman P., Devi B. G., Parker J. W. Differential expression of c-erb B, c-myc and c-myb oncogene loci in human lymphomas and leukemias. Int J Cancer 1983; 32: 185–191
  • Chinsky J., Lilly F., Childs G. Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: differential expression of c-myc of c-myb. Proc Natl Acad Sci (USA) 1985; 82: 565–569
  • Baba T. W., Giroir B. P., Humphries E. H. Cell lines derived from avian lymphomas exhibit two distinct phenotypes. Virology 1985; 144: 139–151
  • Hayflick J., Seeburg P. H., Ohlsson R., et al. Nucleotide sequence of two overlapping myc-related genes in avian carcinoma verus OK10 and their relation to the myc genes of other viruses and the cell. Proc Natl Acad Sci (USA) 1985; 82: 2718–2722
  • Taub R., Moulding C., Battey J., et al. Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells. Cell 1984; 36: 339–348
  • Yang J-Q., Bauer S. R., Mushinski J. F., et al. Chromosomal translocations clustered 5′ of the murine c-myc gene qualitatively affect promoter usage: implications for the site of normal c-myc regulation. EMBO J 1985; 4: 1441–1447
  • Remmers E. F., Yang J-Q., Marcu K. B. A negative transcriptional control element located upstream of the murine c-myc gene. EMBO J 1986; 5: 899–904
  • Chung J., Sinn E., Reed R. R., Leder P. Transacting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells. Proc Natl Acad Sci (USA) 1986; 83: 7918–7922
  • Gelman E. P., Psallidopoulos M. C., Papas T. S., et al. Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma. Nature 1983; 306: 799–803
  • Corcoran L. M., Cory S., Adams J. M. Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma. Cell 1985; 40: 71–79
  • Fahrlander P. D., Sumegi J., Yang J-Q., et al. Activation of the c-myc oncogene by the immunoglobulin heavy-chain enhancer after multiple switch region mediated chromosome rearrangements in a murine plasmacytoma. Proc Natl Acad Sci (USA) 1985; 82: 3746–3750
  • Bernard O., Cory S., Gerondakis S., et al. Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours. EMBO J 1983; 2: 2375–2383
  • Ar-Rushdi A., Nishikura K., Erikson J., et al. Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science 1983; 222: 390–393
  • Croce C. M., Erikson J., Ar-Rushdi A., et al. Translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells. Proc Natl Acad Sci (USA) 1984; 81: 3170–3174
  • Feo S., Ar-Rushdi A., Heubner K., et al. Suppression of the normal mouse c-myc oncogene in human lymphoma cells. Nature 1985; 313: 493–495
  • Nishikura K., Ar-Rushdi A., Erikson J., et al. Repression of rearranged mu gene and translocated c-myc in mouse 3T3 cells X Burkitt lymphoma cell hybrids. Science 1984; 224: 399–402
  • Croce C. M., Erikson J., Huebner K., et al. Coexpression of translocated and normal c-myc oncogenes in hybrids between Daudi and lymphoblastoid cells. Science 1985; 227: 1235–1238
  • Cory S., Graham M., Webb E., et al. Variant (6; 15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene. EMBO J 1985; 4: 675–681
  • Erikson J., Nishikura K., Ar-Rushdi A., et al. Translocation of an immunoglobulin kappa locus to a region 3′ of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci (USA) 1983; 80: 7581–7585
  • Hollis G. F., Mitchell K. F., Battey J., et al. A variant translocation places the lambda immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphoma. Nature 1984; 307: 752–755
  • Payne G. S., Bishop J. M., Varmus H. E. Multiple arrangements of viral DNA and an activated host oncogene (c-myc) in bursal lymphomas. Nature 1982; 295: 209–217
  • Graham M., Adams J. M., Cory S. Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations. Nature 1985; 314: 740–743
  • Corcoran L. M., Adams J. M., Dunn A. R., et al. Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 1984; 37: 113–122
  • Steffen D. Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas. Proc Natl Acad Sci (USA) 1984; 81: 2097–2101
  • Cuypers H. T., Selten G., Quint W., et al. Murine leukemia virus-induced T cell lymphomagenesjs: integration of proviruses in a distinct chromosomal region. Cell 1984; 37: 141–150
  • Selten G., Cuypers H. T., Zijlstra M., et al. Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO J 1984; 3: 3215–3222
  • Li Y., Holland C. A., Hartley J. W., et al. Viral integration near c-myc in 10–20% of MCF247-induced AKR lymphomas. Proc Natl Acad Sci (USA) 1984; 81: 6808–6811
  • Romberg P. G., Erisman M. D., Diehl R. E., et al. Structure and expression of the oncogene c-myc in fresh tumor material from patients with hematopoietic malignancies. Mol Cell Biol 1984; 4: 1096–1103
  • Linial M., Gunderson N., Groudine M. Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis. Science 1985; 230: 1126–1132
  • Einat M., Resnitzky D., Kimchi A. Close link between reduction of c-myc expression by interferon and G0/G1 arrest. Nature 1985; 313: 597–600
  • Knight E., Jr, Anton E. D., Fahey D., et al. Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level. Proc Natl Acad Sci (USA) 1985; 82: 1151–1154
  • Matsui T., Takahashi R., Mihara K., et al. Cooperative regulation of c-myc expression in differentiation of human promyelocytic leukemia induced by recombinant gamma-interferon and 1,25-dihydroxy vitamin D3. Cancer Res 1985; 45: 4366–4371
  • Kelly K., Cochran B. H., Stiles C. D., et al. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 1983; 35: 603–610
  • McCormack J. E., Pepe V. H., Kent R. B., et al. Specific regulation of c-myc oncogene expression in a murine B cell lymphoma. Proc Natl Acad Sci (USA) 1984; 81: 5546–5550
  • Armelin H. A., Armelin M. C. S., Kelly K., et al. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature 1984; 310: 655–660
  • Reed J. C., Nowell P. C., Hoover R. G. Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation. Proc Natl Acad Sci (USA) 1985; 82: 4221–4224
  • Reed J. C., Sabath D. E., Hoover R. G., et al. Recombinant interleukin 2 regulates levels of c-myc RNA in a cloned murine T lymphocyte. Mol Cell Biol 1985; 5: 3361–3368
  • Zimmerman K. A., Vancopoulos G. D., Collum R. G., et al. Differential expression of myc family genes during murine development. Nature 1986; 319: 780–783
  • Thompson C. B., Challoner P. B., Neiman P. E., et al. Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature 1985; 314: 363–366
  • Hann S. R., Thompson C. B., Eisenman R. N. C-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells. Nature 1985; 314: 366–369
  • Greenberg M. E., Ziff E. B. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 1983; 311: 433–438
  • Dani C., Blanchard J. M., Piechaczyk M., et al. Extreme instability of myc mRNA in normal and transformed human cells. Proc Natl Acad Sci (USA) 1984; 81: 7046–7050
  • Piechaczyk M., Yang J. Q., Blanchard J. M., et al. Post-transcriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors. Cell 1985; 42: 589–597
  • Land H., Parada L. F., Weinberg R. A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983; 304: 596–601
  • Lee W. M. F., Schwab M., Westaway D., et al. Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells wth a mutant ras gene. Mol Cell Biol 1985; 5: 3345–3356
  • Keath E. J., Caimi P. G., Cole M. D. Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals. Cell 1984; 39: 339–348
  • Palmieri S., Kahn P., Graf T. Quail embryo fibroblasts transformed by four v-myc-containing virus isolates show enhanced proliferation but are non tumorigenic. EMBO J 1983; 2: 2385–2389
  • Neiman P., Wolf C., Enrietto P. J., et al. A retroviral myc gene induces preneoplastic transformation of lymphocytes in a bursal transplantation assay. Proc Natl Acad Sci (USA) 1985; 82: 222–226
  • Klein G., Klein E. Oncogene activation and tumor progression. Carcinogenesis 1984; 5: 429–435
  • Yokota J., Tsunetsugu-Yokota Y., Baltitora H., et al. Alterations of myc, myb and rasHa protooncogenes in cancers are frequent and show clinical correlation. Science 1986; 231: 261–265
  • Duesberg P. H. Activated proto-onc genes: sufficient or necessary for cancer?. Science 1985; 228: 669–677
  • Rosenberg N., Baltimore D. Abelson virus. Viral Oncol 1980; 1: 187–203
  • Serunian L. A., Rosenberg N. Abelson virus potentiates long-term growth of mature B lymphocytes. Mol Cell Biol 1986; 6: 183–194
  • Potter M., Sklar M. D., Rowe W. P. Rapid viral induction of plasmacytomas in pristane-primed BALB/c mice. Science 1973; 182: 592–594
  • Shtivelman E., Lifshitz B., Gale R. P., et al. Fused transcript of abl and brc genes in chronic myelogenous leukaemia. Nature 1985; 315: 550–554
  • Heisterkamp N., Stam K., Groffen J., et al. Structural organization of the bcr gene and its role in the Ph1 translocation. Nature 1985; 315: 758–761
  • Collins S. I., Kubonishi I., Miyoshi I., et al. Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells. Science 1984; 225: 72–74
  • Konopka J. B., Watanabe S. M., Witte O. N. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 1984; 37: 1035–1042
  • Collins S. J., Groudine M. T. Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci (USA) 1983; 80: 4813–4817
  • Bartram C. R., Kleihauer E., De Klein A., et al. C-abl and bcr are rearranged in Ph1-negative CML patient. EMBO J 1985; 4: 683–686
  • Konopka J. B., Clark S., McLaughlin J., et al. Variable expression of the translocated c-abl gene in Ph1-positive B-lymphoid cell lines from chronic myelogenous leukemic patients. Proc Nad Acad Sci (USA) 1986; 83: 4049–4052
  • Westin E., Wong-Staal F., Gelmann E. P., et al. Expression of cellular homologues of retroviral one genes in human hematopoietic cells. Proc Natl Acad Sci (USA) 1982; 79: 2490–2494
  • Clarke M. F., Westin E., Schmidt D., et al. Transformation of NIH 3T3 cells by a human c-sis cDNA clone. Nature 1984; 308: 464–467
  • Chinsky J., Lilly F., Childs G. Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: differential expression of c-myc and c-myb. Proc Natl Acad Sci (USA) 1985; 82: 565–569
  • Mally M. I., Vogt M., Swift S. E., et al. Oncogene expression in murine splenic T cells and in murine T-cell neoplasms. Virology 1985; 144: 115–126
  • Eva A., Robbins K. C., Andersen P. R., et al. Cellular genes analogous to retroviral one genes are transcribed in human tumour cells. Nature 1982; 295: 116–119
  • Winberry L., Priehs C., Friderici K., et al. Expression of protooncogenes in normal and papovavirus-transformed or -infected rat fibroblasts. Virology 1985; 147: 154–168
  • Woolford J., Rothwell V., Rohrschneider L. Characterization of the human c-fins gene product and its expression in cells of the monocyte-macrophage lineage. Mol Cell Biol 1985; 5: 3458–3466
  • LeBeau M. M., Westbrook C. A., Diaz M. O., et al. Evidence for the involvement of GM-CSF and fins in the deletion (5q) in myeloid disorders. Science 1986; 231: 984–987
  • Rosson D., Tereba A. Transcription of hematopoietic-associated oncogenes in childhood leukemia. Cancer Res 1983; 43: 3912–3918
  • Pierce J., Gazit A., DiFióre P. P., et al. Mammalian cell transformation by a recombinant murine retrovirus containing the avian erythroblastosis virus erb B gene. Curr Top Micro Immunol 1986; 132: 55–61
  • Blick M., Westin E., Gutterman J., et al. Oncogene expression in human leukemia. Blood 1984; 64: 1234–1239
  • Coll J., Saule S., Martin P. The cellular oncogenes c-myc, c-myb and c-erb are transcribed in defined types of avian hematopoietic cells. Exp Cell Res 1983; 149: 151–162
  • Rosson D., Tereba A. Transcription of hematopoietic associated oncogenes in childhood leukemia. Cancer Res 1983; 43: 3912–3918
  • Sheiness D., Gardinier M. Expression of a proto-oncogene (proto-myb) in hemopoietic tissues of mice. Mol Cell Biol 1984; 4: 1206–1212
  • Ferrari S., Torelli U., Selleri L., et al. Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage. Leuk Res 1985; 9: 833–842
  • Pelicci P-G., Lanfrancone L., Brathwaite M. D., et al. Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia. Science 1984; 224: 1117–1121
  • Griffin C. A., Baylin S. B. Expression of the c-myb oncogene in human small cell lung carcinoma. Cancer Res 1985; 45: 272–275
  • Alitalo K., Winquist R., Liu C. C., et al. Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proc Natl Acad Sci (USA) 1984; 81: 4534–4538
  • Mushinski J. F., Potter M., Bauer S. R., et al. DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas. Science 1983; 220: 795–798
  • Shen-Ong G. L. C., Potter M., Mushinski J. F., et al. Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas. Science 1984; 226: 1077–1080
  • Shen-Ong G. L. C., Morse H. C., III, Potter M., et al. Two modes of c-myb activation in virus-induced mouse myeloid tumors. Mol Cell Biol 1986; 6: 380–392
  • Torelli G., Selleri L., Donelli A., et al. Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes. Mol Cell Biol 1985; 5: 2874–2877
  • Thompson C. B., Challoner P. B., Neiman P. E., et al. Expression of the c-myb proto-oncogene during cellular proliferation. Nature 1986; 319: 374–380
  • Klinman D. M., Mushinski J. F., Honda M., et al. Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. J Exp Med 1986; 163: 1292–1307
  • Seldin M. F., Mountz J. D., Mushinski J. F., et al. IL-2 modulation of murine T-cell oncogene expression. Proc Soc Exp Biol Med 1987; 184: 186–190
  • Gonda T. J., Metcalf D. Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature 1984; 310: 249–251
  • Craig R. W., Bloch A. Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1984; 44: 442–446
  • Tabin C. J., Weinberg R. A. Analysis of viral and somatic activations of the cHa-ras gene. J Virol 1985; 53: 260–265
  • Bos J. L., Verlaan-de Vries M., Jansen A. M., et al. Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. Nucleic Acids Res 1984; 12: 9155–9163
  • McGrath J. P., Capon D. J., Goeddel D. V., et al. Comparative biochemical properties of normal and activated human ras p21 protein. Nature 1984; 310: 644–649
  • Murray M. J., Cunningham J. M., Parada L. F., et al. The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell 1983; 33: 749–757
  • Souyri I. M., Fleissner E. Identification by transfection of transforming sequences in DNA of human T-cell leukemias. Proc Natl Acad Sci (USA) 1983; 80: 6676–6679
  • Eva A., Tronick S. R., Gol R. A., et al. Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci (USA) 1983; 80: 4926–4930
  • Collard J. G., van Beek W. P., Janssen J. W. G., et al. Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer 1985; 35: 207–214
  • Gambke C., Signer E., Moroni C. Activation of N-ras gene in bone marrow cells from a patient with acute myeloblastic leukaemia. Nature 1984; 307: 476–478
  • Gambke C., Hall A., Moroni C. Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon. Proc Natl Acad Sci (USA) 1985; 82: 879–882
  • Bos J. L., Toksoz D., Marshall C. J., et al. Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Nature 1985; 315: 726–730
  • Guerrero I., Calzada P., Mayer A., et al. A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci (USA) 1984; 81: 202–205
  • Guerrero I., Villasante A., Corces V., et al. Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation. Science 1984; 225: 1159–1162
  • Vousden K. H., Marshall C. J. Three different activated ras genes in mouse tumours: evidence for oncogene activation during progression of a mouse lymphoma. EMBO J 1984; 3: 913–917
  • Yoakum G. H., Lechner J. F., Gabrielson E. W., et al. Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science 1985; 227: 1174–1179
  • Blick M., Westin E., Gutterman J., et al. Oncogene expression in human leukemia. Blood 1984; 64: 1234–1239
  • Spandidos D. A., Wilkie N. M. Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature 1984; 310: 469–475
  • Pulciani S., Santos E., Long L. K., et al. ras gene amplification and malignant transformation. Mol Cell Biol 1985; 5: 2836–2841
  • Holmes K. L., Pierce J. H., Davidson W. S., Morse H. C., III. Murine hematopoietic cells with pre-B/myeloid characteristics are generated by in vitro transformation with retrovirus containing fes, abl, and src oncogenes. J Exp Med 1986; 164: 443–457
  • Diamond A., Devine J. M., Cooper G. M. Nucleotide sequence of a human Blym transforming gene activated in a Burkitt's lymphoma. Science 1984; 225: 516–519
  • Eva A., Aaronson S. A. Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 1985; 316: 273–275
  • Takahashi M., Ritz J., Cooper G. M. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 1985; 42: 581–588
  • Canaani E., Dreazen O., Klar A., et al. Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome. Proc Natl Acad Sci (USA) 1983; 80: 7118–7122
  • Gattoni-Celli S., Hsiao W-L. W., Weinstein I. B. Rearranged c-mos locus in a MOPC21 murine myeloma cell line and its persistence in hybridomas. Nature 1983; 306: 795–796
  • Propst F., van de Woude G. F. Expression of c-mos proto-oncogene transcripts in mouse tissues. Nature 1985; 315: 516–518
  • Diaz M. O., LeBeau M. M., Rowley J. D., et al. The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia. Science 1985; 229: 767–769
  • Revoltella R. P., Park M., Fruscalzo A. Identification in several human myeloid leukemias or cell lines of a DNA rearrangement next to the c-mos 3′-end. FEBS Lett 1985; 189: 97–101
  • Yunis J. J. The chromosomal basis of human neoplasia. Science 1983; 221: 227–236
  • Rowley J. D. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res 1984; 44: 3159–3168
  • Pearson M., Rowley J. D. The relation of oncogenesis and cytogenetics in leukemia and lymphoma. Ann Rev Med 1985; 36: 471–483
  • Yunis J. J. Fragile sites and predisposition to leukemia and lymphoma. Cancer Genet Cytogenet 1984; 12: 85–88
  • Tsujimoto Y., Cossman J., Jaffe E., et al. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440–1443
  • Bakhshi A., Jensen J. P., Goldman P., et al. Cloning the chromosomal breakpoint of t(14; 18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41: 899–906
  • Garfinkel N., Unger T., Girol D., Mushinski J. F. Expression of the bcl-2 gene in mouse B lymphocytic lines is differentiation stage specific. Eur J Immunol 1987; 17: 567–570
  • van Beveren C., van Straaten F., Curran T., et al. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell 1983; 32: 1241–1255
  • Mueller R., Mueller D., Guilbert L. Differential expression of c-fos in hematopoietic cells: correlation with differentiation of monomyelocytic cells in vitro. EMBO I 1984; 3: 1887–1890
  • Mitchell R. L., Zokas L., Schreiber R. D., et al. Rapid induction of the expression of proto-oncogene fos during human monocyte differentiation. Cell 1985; 40: 209–217
  • Ferrari S., Torelli U., Selleri L., et al. Expression of human c-fesone-gene occurs at detectable levels in myeloid but not in lymphoid cell population. Br J Haematol 1985; 59: 21–25
  • Sariban E., Mitchell T., Kufe D. Expression of the c-fins proto-oncogene during human monocytic differentiation. Nature 1985; 316: 64–66
  • Shen-Ong G. L. C., Holmes K. L., Morse H. C., III. Phorbol ester-induced growth arrest of murine myelomonocytic leukemia cells with virus-disrupted myb locus is not accompanied by decreased myc and myb expression. Proc Natl Acad Sci (USA) 1987; 84: 199–203
  • Eliyahu D., Raz A., Gruss P., et al. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 1984; 312: 646–649
  • Rogel A., Popliker M., Webb C. G., et al. P53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos and tumors. Mol Cell Biol 1985; 5: 1851–1855
  • Leprince D., Gegonne A., Coll J., et al. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature 1983; 306: 395–397
  • Rovigatti U., Watson D., Yunis J. J. Amplification and rearrangement of Hu-ets-1 in leukemia and lymphoma with involvement of llq23. Science 1986; 232: 398–400
  • Chen J. H. The proto-oncogene c-ets is preferentially expressed in lymphoid cells. Mol Cell Biol 1983; 5: 2993–3000
  • Rosenberg Y. J., Malek T. R., Schaeffer D. E., et al. Unusual expression of IL 2 receptors and both the c-myb and c-raf oncogenes in T cell lines and clones derived from autoimmune MRL-Ipr/Ipr mice. J Immunol 1985; 134: 3120–3123
  • Mountz J. D., Mushinski J. F., Mark G. E., et al. Oncogene expression and auto-immunity. J Mol Cell Immunol 1985; 2: 121–131
  • Erikson J., Miller D. A., Miller O. J., et al. The c-myc oncogene is translocated to the involved chromosome 12 in mouse plasmacytoma. Proc Natl Acad Sci (USA) 1985; 82: 4212–4216
  • Groffen J., Heisterkamp N., Stephenson J. R., et al. C-sis is translocated from chromosome 22 to chromosome 9 in chronic myelogenous leukemia. J Exp Med 1983; 158: 9–15
  • Clarke M. F., Westin E., Schmidt D., et al. Transformation of NIH 3T3 cells by a human c-sis cDNA clone. Nature 1984; 308: 464–467
  • Kincade P. W. Formation of B lymphocytes in fetal and adult life. Adv Immunol 1981; 31: 177–245
  • Coffman R. L. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol Rev 1982; 69: 5–23
  • Davidson W. F., Frederickson T. N., Rudikoff E. K., et al. A unique series of lymphomas related to the Ly-1+ lineage of B lymphocyte differentiation. J Immunol 1984; 133: 744–753
  • Holmes K. L., Palfree R. G. E., Hammerling U., et al. Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG Fc receptor. Proc Natl Acad Sci (USA) 1985; 82: 7706–7710
  • Coffman R. L., Weissman I. L. B220: a B cell-specific member of the T200 glycoprotein family. Nature 1981; 289: 681–683
  • Symington F. W., Subbarao B., Mosier D. E., et al. Lyb-8.2: a new B cell antigen defined and characterized with a monoclonal an tibody. Immunogenetics 1982; 16: 381–391
  • Osmond D. G., Nossal G. J. V. Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labelling. Cell Immunol 1974; 13: 132–141
  • Osmond D. G. Generation of B lymphocytes in bone marrow. B Lymphocytes in the Immune Response, M. Cooper, D. E. Mosier, I. Scher, E. Vitetta. Elsevier-North Holland, New York 1979; 65–66
  • Pattengale P. K., Taylor C. R. Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias. Am J Pathol 1983; 113: 237–265
  • Fredrickson T. N., Morse H. C., III, Yetter R. A., et al. Multiparameter analysis of spontaneous non-thymic lymphomas occurring in NFS/N mice congenic for ecotropic murine leukemia viruses. Am J Pathol 1985; 121: 349–360
  • Paige C. J., Kincade P. W., Ralph P. Murine B cell leukemia line with inducible surface immunoglobulin expression. J Immunol 1978; 121: 641–647
  • Hardy R. R., Herzenberg L. A., Morse H. C., III, et al. Ly-1 as a differentiation antigen on normal and neoplastic B cells. Curr Top Micro Immunol 1984; 113: 231–236
  • Pierce J. H., Aaronson S. A. BALB- and Harvey-murine sarcoma virus transformation of a novel lymphoid progenitor cell. J Exp Med 1982; 156: 873–887
  • Piechaczyk M., Blanchard J-M., Marty L., et al. Post-transcriptional regulation of glyceraldehyde dehydrogenase gene expression in rat tissues. Nucleic Acids Res 1984; 12: 6951–6963
  • Rapp U., Cleveland J. L., Fredrickson T. N., et al. Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol 1985; 55: 23–33
  • Risser R., Potter M., Rowe W. P. Abelson virus-induced lymphomagenesis in mice. J Exp Med 1978; 148: 714–726
  • Alt F., Rosenberg N., Lewis S., et al. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 1981; 27: 381–390
  • Raschke W. C., Baird S., Ralph P., et al. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 1978; 15: 261–267
  • Risser R. The pathogenesis of Abelson virus lymphomas of the mouse. Biochim Biophys Acta 1982; 651: 213–244
  • Langdon W. Y., Hartley J. W., Holmes K. L., et al. Identification of a transforming virus from a lymphoma of a mouse infected with a wild mouse retrovirus. Curr Top Micro Immunol 1984; 113: 421–429
  • Holmes K. L., Landgon W. Y., Frederickson T. N., et al. Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. J Immunol 1986; 137: 679–688
  • Teich N., Wyke J., Mak T., . Pathogenesis of retrovirus-induced disease. RNA Tumor Viruses. Molecular Biology of Tumor Viruses second edition, R. Weiss, N. Teich, H. Varmus, J. Coffin, et al. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1982; 785–998
  • Morse H. C., III, Hartley J. W., Fredrickson T. N., et al. Recombinant murine retrovirus containing avian V-myc induce a wide spectrum of neoplasms in newborn mice. Proc Natl Acad Sci (USA) 1986; 83: 6868–6872
  • Potter M., Mushinski J. F., Mushinski E. B., et al. Avian V-myc replaces chromosomal translocation in murine plasmacytoma genesis. Science 1987; 235: 787–789
  • Anderson S. M., Scolnick E. M. Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus. J Virol, 46: 594–605
  • Rosenberg N., Baltimore D. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med 1976; 143: 1453–1463
  • Rosenberg N. E. Abelson leukemia virus. Curr Top Micro Immunol 1982; 101: 95–126
  • Pierce J. H., Aaronson S. A. In vitro transformation of murine pre-B lymphoid cells by Snyder-Theilen feline sarcoma virus. J Virol 1983; 46: 993–1002
  • Pierce J. H., Aaronson S. A., Anderson S. M. Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus. Proc Natl Acad Sci (USA) 1984; 81: 2374–2378
  • Pierce J. H., Aaronson S. A. Myeloid cell transformation by ras-containing murine sarcoma viruses. Mol Cell Biol 1985; 5: 667–674
  • Stewart T. A., Pattengale P. K., Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 1984; 38: 627–637
  • Adams J. M., Harris A. W., Pinkert C. A., et al. C-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985; 318: 533–538
  • Pattengale P., Leder A., Kuo A., et al. Lymphohematopoietic and other malignant neoplasms occurring spontaneously in transgenic mice carrying and expresing MTV/myc fusion genes. Curr Top Micro Immunol 1986; 132: 9–16
  • Schwartz R. C., Stanton L. W., Marcu K. B., et al. An in vitro model for tumor progression in murine lymphoid cells. Curr Top Micro Immunol 1986; 132: 75–80
  • Schrier P. I., Bernards R., Vaessen R. TMJ., et al. Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature 1983; 305: 771–775
  • Sullivan N., Green C., Pasdar M., Watt R. Characterization and nuclear localization of the v- and c-myc proteins. Curr Top Micro Immunol 1986; 132: 355–361

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