Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects

References

• Celinska E, Grajek W. Biotechnological production of 2,3-butanediol-current state and prospects. Biotechnol Adv. 2009;27:715–725.
   PubMed Web of Science ®Google Scholar
• Hattikaul R, Tornvall U, Gustafsson L, et al. Industrial biotechnology for the production of bio-based chemicals - a cradle-to-grave perspective. Trends Biotechnol. 2007;25:119–124.
   PubMed Web of Science ®Google Scholar
• Ji XJ, Huang H, Ouyang PK. Microbial 2,3-butanediol production: a state-of-the-art review. Biotechnol Adv. 2011;29:351–364.
   PubMed Web of Science ®Google Scholar
• Lee JW, Na D, Park JM, et al. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat Chem Biol. 2012;8:536–546.
   PubMed Web of Science ®Google Scholar
• Woolston BM, Edgar S, Stephanopoulos G. Metabolic engineering: past and future. Annu Rev Chem Biomol Eng. 2013;4:259–288.
   PubMed Web of Science ®Google Scholar
• Yin X, Li J, Shin HD, et al. Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects. Biotechnol Adv. 2015;33:830–841.
   PubMed Web of Science ®Google Scholar
• Xie NZ, Li JX, Song LF, et al. Genome sequence of type strain Paenibacillus polymyxa DSM 365, a highly efficient producer of optically active (R,R)-2,3-butanediol. J Biotechnol. 2015;195:72–73.
   PubMed Web of Science ®Google Scholar
• Tong YJ, Ji XJ, Liu LG, et al. Sequence of Klebsiella pneumoniae CICC10011, a promising strain for high 2,3-butanediol production. Genome Announc. 2015;3:e00802–e00815.
   Google Scholar
• Shin SH, Kim S, Kim JY, et al. Complete genome sequence of Klebsiella oxytoca KCTC 1686, used in production of 2,3-butanediol. J Bacteriol. 2012;194:2371–2372.
   PubMed Web of Science ®Google Scholar
• Li L, Su F, Wang Y, et al. Genome sequences of two thermophilic Bacillus licheniformis strains, efficient producers of platform chemical 2,3-butanediol. J Bacteriol. 2012;194:4133–4134.
   PubMed Web of Science ®Google Scholar
• Li L, Wang Y, Li K, et al. Genome sequence of meso-2,3-butanediol-producing strain Serratia marcescens ATCC 14041. Genome Announc. 2014d;2:e00590–e00514.
   PubMedGoogle Scholar
• Shin SH, Um Y, Beak JH, et al. Complete genome sequence of Raoultella ornithinolytica strain B6, a 2,3-butanediol-producing bacterium isolated from oil-contaminated soil. Genome Announc. 2013;1:e00395–13.
   PubMedGoogle Scholar
• Xu Y, Wang A, Tao F, et al. Genome sequence of Enterobacter cloacae subsp. dissolvens SDM, an efficient biomass-utilizing producer of platform chemical 2,3-butanediol. J Bacteriol. 2012;194:897–898.
   PubMed Web of Science ®Google Scholar
• Vivijs B, Moons P, Aertsen A, et al. Acetoin synthesis acquisition favors Escherichia coli growth at low pH. Appl Environ Microbiol. 2014;80:6054–6061.
   PubMed Web of Science ®Google Scholar
• Vivijs B, Moons P, Geeraerd AH, et al. 2,3-Butanediol fermentation promotes growth of Serratia plymuthica at low pH but not survival of extreme acid challenge. Int J Food Microbiol. 2014;175:36–44.
   PubMed Web of Science ®Google Scholar
• Nakashimada Y, Marwoto B, Kashiwamura T, et al. Enhanced 2,3-butanediol production by addition of acetic acid in Paenibacillus polymyxa. J Biosci Bioeng. 2000;90:661–664.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Xu P. Acetoin metabolism in bacteria. Crit Rev Microbiol. 2007;33:127–140.
   PubMed Web of Science ®Google Scholar
• Syu MJ. Biological production of 2,3-butanediol. Appl Microbiol Biotechnol. 2001;55:10–18.
   PubMed Web of Science ®Google Scholar
• Rao B, Zhang LY, Sun J, et al. Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens. Appl Microbiol Biotechnol. 2012;93:2147–2159.
   PubMed Web of Science ®Google Scholar
• Jeong D, Yang J, Lee S, et al. Deletion of the budBAC operon in Klebsiella pneumoniae to understand the physiological role of 2,3-butanediol biosynthesis. Prep Biochem Biotechnol. 2016;46:410–419.
   PubMed Web of Science ®Google Scholar
• Blomqvist K, Nikkola M, Lehtovaara P, et al. Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes. J Bacteriol. 1993;175:1392–1404.
   PubMed Web of Science ®Google Scholar
• Renna MC, Najimudin N, Winik LR, et al. Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin. J Bacteriol. 1993;175:3863–3875.
   PubMed Web of Science ®Google Scholar
• Kovacikova G, Lin W, Skorupski K. Dual regulation of genes involved in acetoin biosynthesis and motility/biofilm formation by the virulence activator AphA and the acetate-responsive LysR-type regulator AlsR in Vibrio cholerae. Mol Microbiol. 2005;57:420–433.
   PubMed Web of Science ®Google Scholar
• Mayer D, Schlensog V, Böck A, et al. Identification of the transcriptional activator controlling the butanediol fermentation pathway in Klebsiella terrigena. J Bacteriol. 1995;177:5261–5269.
   PubMed Web of Science ®Google Scholar
• Lee S, Kim B, Jeong D, et al. Observation of 2,3-butanediol biosynthesis in Lys regulator mutated Klebsiella pneumoniae at gene transcription level. J Biotechnol. 2013;168:520–526.
   PubMed Web of Science ®Google Scholar
• Moons P, Van Houdt R, Vivijs B, et al. Integrated regulation of acetoin fermentation by quorum sensing and pH in Serratia plymuthica RVH1. Appl Environ Microbiol. 2011;77:3422–3427.
   PubMed Web of Science ®Google Scholar
• Schell MA. Molecular biology of the LysR family of transcriptional regulators. Annu Rev Microbiol. 1993;47:597–626.
   PubMed Web of Science ®Google Scholar
• Van Houdt R, Aertsen A, Michiels CW. Quorum-sensing-dependent switch to butanediol fermentation prevents lethal medium acidification in Aeromonas hydrophila AH-1N. Res Microbiol. 2007;158:379–385.
   PubMed Web of Science ®Google Scholar
• Priefert H, Hein S, Krüger N, et al. Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism. J Bacteriol. 1991;173:4056–4071.
   PubMed Web of Science ®Google Scholar
• Oppermann FB, Steinbüchel A. Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system. J Bacteriol. 1994;176:469–485.
   PubMed Web of Science ®Google Scholar
• Huang M, Oppermann-Sanio FB, Steinbüchel A. Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway. J Bacteriol. 1999;181:3837–3841.
   PubMed Web of Science ®Google Scholar
• Thanh TN, Jurgen B, Bauch M, et al. Regulation of acetoin and 2,3-butanediol utilization in Bacillus licheniformis. Appl Microbiol Biotechnol. 2010;87:2227–2235.
   PubMed Web of Science ®Google Scholar
• Yang T, Rao Z, Hu G, et al. Metabolic engineering of Bacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels. Biotechnol Biofuels. 2015;8:129.
   PubMed Web of Science ®Google Scholar
• Park JM, Rathnasingh C, Song H. Enhanced production of (R,R)-2,3-butanediol by metabolically engineered Klebsiella oxytoca. J Ind Microbiol Biotechnol. 2015;42:1419–1425.
   PubMed Web of Science ®Google Scholar
• Kim S, Hahn JS. Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing. Metab Eng. 2015;31:94–101.
   PubMed Web of Science ®Google Scholar
• Yang T-W, Rao Z-M, Zhang X, et al. Fermentation of biodiesel-derived glycerol by Bacillus amyloliquefaciens: effects of co-substrates on 2,3-butanediol production. Appl Microbiol Biotechnol. 2013;97:7651–7658.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhao X, Rao Z, et al. Improving acetoin productivity by over-expression of 6-phosphoric acid fructose kinase in Bacillus subtilis. Genom Appl Biol. 2015;34:2101–2107.
   Google Scholar
• Yang T-W, Rao Z-M, Zhang X, et al. Improved production of 2,3-butanediol in Bacillus amyloliquefaciens by over-expression of glyceraldehyde-3-phosphate dehydrogenase and 2,3-butanediol dehydrogenase. PLoS One. 2013;8:e76149.
   PubMed Web of Science ®Google Scholar
• Wang D, Zhou J, Chen C, et al. R-acetoin accumulation and dissimilation in Klebsiella pneumoniae. J Ind Microbiol Biotechnol. 2015;42:1105–1115.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang R, Bao T, et al. The rebalanced pathway significantly enhances acetoin production by disruption of acetoin reductase gene and moderate-expression of a new water-forming NADH oxidase in Bacillus subtilis. Metab Eng. 2014;23:34–41.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Lu JR. Strategies for enhancing fermentative production of acetoin: a review. Biotechnol Adv. 2014;32:492–503.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang R, Bao T, et al. Moderate expression of the transcriptional regulator ALsR enhances acetoin production by Bacillus subtilis. J Ind Microbiol Biotechnol. 2013;40:1067–1076.
   PubMed Web of Science ®Google Scholar
• Gao S, Guo W, Shi L, et al. Characterization of acetoin production in a budC gene disrupted mutant of Serratia marcescens G12. J Ind Microbiol Biotechnol. 2014;41:1267–1274.
   PubMed Web of Science ®Google Scholar
• Cho S, Kim T, Woo HM, et al. Enhanced 2,3-butanediol production by optimizing fermentation conditions and engineering Klebsiella oxytoca M1 through overexpression of acetoin reductase. PLoS One. 2015;10:e0138109.
   PubMed Web of Science ®Google Scholar
• Yang T-W, Rao Z-M, Zhang X, et al. Effects of corn steep liquor on production of 2, 3-butanediol and acetoin by Bacillus subtilis. Process Biochem. 2013;48:1610–1617.
   Web of Science ®Google Scholar
• Guo XW, Zhang YH, Cao CH, et al. Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae. Biotechnol Appl Biochem. 2014;61:707–715.
   PubMed Web of Science ®Google Scholar
• Kim B, Lee S, Jeong D, et al. Redistribution of carbon flux toward 2,3-butanediol production in Klebsiella pneumoniae by metabolic engineering. PLoS One. 2014;9:e105322.
   PubMed Web of Science ®Google Scholar
• de Oliveira RR, Nicholson WL. Synthetic operon for (R,R)-2,3-butanediol production in Bacillus subtilis and Escherichia coli. Appl Microbiol Biotechnol. 2016;100:719–728.
   PubMed Web of Science ®Google Scholar
• Yang T, Rao Z, Zhang X, et al. Enhanced 2,3-butanediol production from biodiesel-derived glycerol by engineering of cofactor regeneration and manipulating carbon flux in Bacillus amyloliquefaciens. Microb Cell Fact. 2015;14:122.
   PubMed Web of Science ®Google Scholar
• Qi G, Kang Y, Li L, et al. Deletion of meso-2,3-butanediol dehydrogenase gene budC for enhanced D-2,3-butanediol production in Bacillus licheniformis. Biotechnol Biofuels. 2014;7:16.
   PubMed Web of Science ®Google Scholar
• Bai F, Dai L, Fan J, et al. Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production. J Ind Microbiol Biotechnol. 2015;42:779–786.
   PubMed Web of Science ®Google Scholar
• Lee S, Kim B, Yang J, et al. A non-pathogenic and optically high concentrated (R,R)-2,3-butanediol biosynthesizing Klebsiella strain. J Biotechnol. 2015;209:7–13.
   PubMed Web of Science ®Google Scholar
• Magee RJ, Kosaric N. The microbial production of 2,3-butanediol. Adv Appl Microbiol. 1987;32:89–161.
   Web of Science ®Google Scholar
• Bao T, Zhang X, Zhao X, et al. Regulation of the NADH pool and NADH/NADPH ratio redistributes acetoin and 2,3-butanediol proportion in Bacillus subtilis. Biotechnol J. 2015;10:1298–1306.
   PubMed Web of Science ®Google Scholar
• Li S, Xu N, Liu L, et al. Engineering of carboligase activity reaction in Candida glabrata for acetoin production. Metab Eng. 2014;22:32–39.
   PubMed Web of Science ®Google Scholar
• Ji X, Xia Z, Fu N, et al. Cofactor engineering through heterologous expression of an NADH oxidase and its impact on metabolic flux redistribution in Klebsiella pneumoniae. Biotechnol Biofuels. 2013;6:7.
   PubMed Web of Science ®Google Scholar
• Sun JA, Zhang LY, Rao B, et al. Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase. Bioresour Technol. 2012;119:94–98.
   PubMed Web of Science ®Google Scholar
• Bao T, Zhang X, Rao Z, et al. Efficient whole-cell biocatalyst for acetoin production with NAD + regeneration system through homologous co-expression of 2,3-butanediol dehydrogenase and NADH oxidase in engineered Bacillus subtilis. PLoS One. 2014;9:e102951.
   PubMed Web of Science ®Google Scholar
• Dai JJ, Cheng JS, Liang YQ, et al. Regulation of extracellular oxidoreduction potential enhanced (R,R)-2,3-butanediol production by Paenibacillus polymyxa CJX518. Bioresour Technol. 2014;167:433–440.
   PubMed Web of Science ®Google Scholar
• Fu J, Wang Z, Chen T, et al. NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen conditions. Biotechnol Bioeng. 2014;111:2126–2131.
   PubMed Web of Science ®Google Scholar
• Ji XJ, Huang H, Zhu JG, et al. Engineering Klebsiella oxytoca for efficient 2, 3-butanediol production through insertional inactivation of acetaldehyde dehydrogenase gene. Appl Microbiol Biotechnol. 2010;85:1751–1758.
   PubMed Web of Science ®Google Scholar
• Jung MY, Ng CY, Song H, et al. Deletion of lactate dehydrogenase in Enterobacter aerogenes to enhance 2,3-butanediol production. Appl Microbiol Biotechnol. 2012;95:461–469.
   PubMed Web of Science ®Google Scholar
• Gaspar P, Neves AR, Gasson MJ, et al. High yields of 2,3-butanediol and mannitol in Lactococcus lactis through engineering of NAD+ cofactor recycling. Appl Environ Microbiol. 2011;77:6826–6835.
   PubMed Web of Science ®Google Scholar
• Kim DK, Rathnasingh C, Song H, et al. Metabolic engineering of a novel Klebsiella oxytoca strain for enhanced 2,3-butanediol production. J Biosci Bioeng. 2013;116:186–192.
   PubMed Web of Science ®Google Scholar
• Wang Q, Chen T, Zhao X, et al. Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure D-2,3-butanediol production. Biotechnol Bioeng. 2012;109:1610–1621.
   PubMed Web of Science ®Google Scholar
• Park JM, Song H, Lee HJ, et al. Genome-scale reconstruction and in silico analysis of Klebsiella oxytoca for 2,3-butanediol production. Microb Cell Fact. 2013;12:20.
   PubMed Web of Science ®Google Scholar
• Park JM, Song H, Lee HJ, et al. In silico aided metabolic engineering of Klebsiella oxytoca and fermentation optimization for enhanced 2,3-butanediol production. J Ind Microbiol Biotechnol. 2013;40:1057–1066.
   PubMed Web of Science ®Google Scholar
• Jung MY, Mazumdar S, Shin SH, et al. Improvement of 2,3-butanediol yield in Klebsiella pneumoniae by deletion of the pyruvate formate-lyase gene. Appl Environ Microbiol. 2014;80:6195–6203.
   PubMed Web of Science ®Google Scholar
• Jantama K, Polyiam P, Khunnonkwao P, et al. Efficient reduction of the formation of by-products and improvement of production yield of 2,3-butanediol by a combined deletion of alcohol dehydrogenase, acetate kinase-phosphotransacetylase, and lactate dehydrogenase genes in metabolically engineered Klebsiella oxytoca in mineral salts medium. Metab Eng. 2015;30:16–26.
   PubMed Web of Science ®Google Scholar
• Guo X, Cao C, Wang Y, et al. Effect of the inactivation of lactate dehydrogenase, ethanol dehydrogenase, and phosphotransacetylase on 2,3-butanediol production in Klebsiella pneumoniae strain. Biotechnol Biofuels. 2014;7:44.
   PubMed Web of Science ®Google Scholar
• Xu Y, Chu H, Gao C, et al. Systematic metabolic engineering of Escherichia coli for high-yield production of fuel bio-chemical 2,3-butanediol. Metab Eng. 2014;23:22–33.
   PubMed Web of Science ®Google Scholar
• Park SY, Kim B, Lee S, et al. Increased 2,3-butanediol production by changing codon usages in Escherichia coli. Biotechnol Appl Biochem. 2014;61:535–540.
   PubMed Web of Science ®Google Scholar
• Mazumdar S, Lee J, Oh MK. Microbial production of 2,3 butanediol from seaweed hydrolysate using metabolically engineered Escherichia coli. Bioresour Technol. 2013;136:329–336.
   PubMed Web of Science ®Google Scholar
• Ui S, Okajima Y, Mimura A, et al. Molecular generation of an Escherichia coli strain producing only the meso-isomer of 2,3-butanediol. J Ferment Bioeng. 1997;84:185–189.
   Google Scholar
• Lee S, Kim B, Park K, et al. Synthesis of pure meso-2,3-butanediol from crude glycerol using an engineered metabolic pathway in Escherichia coli. Appl Biochem Biotechnol. 2012;166:1801–1813.
   PubMed Web of Science ®Google Scholar
• Nielsen DR, Yoon SH, Yuan CJ, et al. Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli. Biotechnol J. 2010;5:274–284.
   PubMed Web of Science ®Google Scholar
• Li Z-J, Jian J, Wei X-X, et al. Microbial production of meso-2,3-butanediol by metabolically engineered Escherichia coli under low oxygen condition. Appl Microbiol Biotechnol. 2010;87:2001–2009.
   PubMed Web of Science ®Google Scholar
• Nakashima N, Akita H, Hoshino T. Establishment of a novel gene expression method, BICES (biomass-inducible chromosome-based expression system), and its application to the production of 2,3-butanediol and acetoin. Metab Eng. 2014;25:204–214.
   PubMed Web of Science ®Google Scholar
• Kay JE, Jewett MC. Lysate of engineered Escherichia coli supports high-level conversion of glucose to 2,3-butanediol. Metab Eng. 2015;32:133–142.
   PubMed Web of Science ®Google Scholar
• Xu Q, Xie L, Li Y, et al. Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin. J Chem Technol Biotechnol. 2015;90:93–100.
   Web of Science ®Google Scholar
• Ji XJ, Liu LG, Shen MQ, et al. Constructing a synthetic metabolic pathway in Escherichia coli to produce the enantiomerically pure (R, R)-2,3-butanediol. Biotechnol Bioeng. 2015;112:1056–1059.
   PubMed Web of Science ®Google Scholar
• Tong YJ, Ji XJ, Shen MQ, et al. Constructing a synthetic constitutive metabolic pathway in Escherichia coli for (R,R)-2,3-butanediol production. Appl Microbiol Biotechnol. 2016;100:637–647.
   PubMed Web of Science ®Google Scholar
• Shen X, Lin Y, Jain R, et al. Inhibition of acetate accumulation leads to enhanced production of (R,R)-2,3-butanediol from glycerol in Escherichia coli. J Ind Microbiol Biotechnol. 2012;39:1725–1729.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li L, Ma C, et al. Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl. Sci Rep. 2013;3:2643.
   PubMed Web of Science ®Google Scholar
• Wang Z, Song Q, Yu M, et al. Characterization of a stereospecific acetoin(diacetyl) reductase from Rhodococcus erythropolis WZ010 and its application for the synthesis of (2S,3S)-2,3-butanediol. Appl Microbiol Biotechnol. 2014;98:641–650.
   PubMed Web of Science ®Google Scholar
• Ui S, Takusagawa Y, Sato T, et al. Production of L-2,3-butanediol by a new pathway constructed in Escherichia coli. Lett Appl Microbiol. 2004;39:533–537.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Lv C, Gao C, et al. A novel whole-cell biocatalyst with NAD + regeneration for production of chiral chemicals. PLoS One. 2010;5:e8860.
   PubMed Web of Science ®Google Scholar
• Chu H, Xin B, Liu P, et al. Metabolic engineering of Escherichia coli for production of (2S,3S)-butane-2,3-diol from glucose. Biotechnol Biofuels. 2015;8:143.
   PubMed Web of Science ®Google Scholar
• Yang J, Kim B, Kim H, et al. Industrial production of 2,3-butanediol from the engineered Corynebacterium glutamicum. Appl Biochem Biotechnol. 2015;178:2303–2313.
   Web of Science ®Google Scholar
• Rados D, Carvalho AL, Wieschalka S, et al. Engineering Corynebacterium glutamicum for the production of 2,3-butanediol. Microb Cell Fact. 2015;14:171.
   PubMed Web of Science ®Google Scholar
• Li S, Gao X, Xu N, et al. Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering. Microb Cell Fact. 2014;13:55.
   PubMed Web of Science ®Google Scholar
• Li S, Liu L, Chen J. Compartmentalizing metabolic pathway in Candida glabrata for acetoin production. Metab Eng. 2015;28:1–7.
   PubMed Web of Science ®Google Scholar
• Ehsani M, Fernandez MR, Biosca JA, et al. Engineering of 2,3-butanediol dehydrogenase to reduce acetoin formation by glycerol-overproducing, low-alcohol Saccharomyces cerevisiae. Appl Environ Microbiol. 2009;75:3196–3205.
   PubMed Web of Science ®Google Scholar
• Romano P, Suzzi G. Origin and production of acetoin during wine yeast fermentation. Appl Environ Microbiol. 1996;62:309–315.
   PubMed Web of Science ®Google Scholar
• Ng CY, Jung MY, Lee J, et al. Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering. Microb Cell Fact. 2012;11:68.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Seo SO, Jin YS, et al. Production of 2,3-butanediol by engineered Saccharomyces cerevisiae. Bioresour Technol. 2013;146:274–281.
   PubMed Web of Science ®Google Scholar
• Lian J, Chao R, Zhao H. Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol. Metab Eng. 2014;23:92–99.
   Google Scholar
• Kim S, Hahn JS. Synthetic scaffold based on a cohesin-dockerin interaction for improved production of 2,3-butanediol in Saccharomyces cerevisiae. J Biotechnol. 2014;192:192–196.
   PubMed Web of Science ®Google Scholar
• Kim JW, Seo SO, Zhang GC, et al. Expression of Lactococcus lactis NADH oxidase increases 2,3-butanediol production in Pdc-deficient Saccharomyces cerevisiae. Bioresour Technol. 2015;191:512–519.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Seo SO, Park YC, et al. Production of 2,3-butanediol from xylose by engineered Saccharomyces cerevisiae. J Biotechnol. 2014;192:376–382.
   PubMed Web of Science ®Google Scholar
• Oliver JW, Machado IM, Yoneda H, et al. Cyanobacterial conversion of carbon dioxide to 2,3-butanediol. Proc Natl Acad Sci USA. 2013;110:1249–1254.
   PubMed Web of Science ®Google Scholar
• Savakis PE, Angermayr SA, Hellingwerf KJ. Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid-and enterobacteria. Metab Eng. 2013;20:121–130.
   PubMed Web of Science ®Google Scholar
• Oliver JW, Machado IM, Yoneda H, et al. Combinatorial optimization of cyanobacterial 2,3-butanediol production. Metab Eng. 2014;22:76–82.
   PubMed Web of Science ®Google Scholar
• Nozzi NE, Atsumi S. Genome engineering of the 2,3-butanediol biosynthetic pathway for tight regulation in Cyanobacteria. ACS Synth Biol. 2015;4:1197–1204.
   PubMed Web of Science ®Google Scholar
• Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11:589–603.
   PubMed Web of Science ®Google Scholar
• Shrivastav A, Lee J, Kim HY, et al. Recent insights in the removal of Klebseilla pathogenicity factors for the industrial production of 2,3-butanediol. J Microbiol Biotechnol. 2013;23:885–896.
   PubMed Web of Science ®Google Scholar
• Jung SG, Jang JH, Kim AY, et al. Removal of pathogenic factors from 2,3-butanediol-producing Klebsiella species by inactivating virulence-related wabG gene. Appl Microbiol Biotechnol. 2013;97:1997–2007.
   PubMed Web of Science ®Google Scholar
• Huynh DT, Kim AY, Seol IH, et al. Inactivation of the virulence factors from 2,3-butanediol-producing Klebsiella pneumoniae. Appl Microbiol Biotechnol. 2015;99:9427–9438.
   PubMed Web of Science ®Google Scholar
• Zhang L, Sun J, Hao Y, et al. Microbial production of 2,3-butanediol by a surfactant (serrawettin)-deficient mutant of Serratia marcescens H30. J Ind Microbiol Biotechnol. 2010;37:857–862.
   PubMed Web of Science ®Google Scholar
• Li H, Tanikawa T, Sato Y, et al. Serratia marcescens gene required for surfactant serrawettin W1 production encodes putative aminolipid synthetase belonging to nonribosomal peptide synthetase family. Microbiol Immunol. 2005;49:303–310.
   PubMed Web of Science ®Google Scholar
• Yang T, Rao Z, Zhang X, et al. Economic conversion of spirit-based distillers’ grain to 2,3-butanediol by Bacillus amyloliquefaciens. Process Biochem. 2015;50:20–23.
   Web of Science ®Google Scholar
• Kopke M, Mihalcea C, Liew F, et al. 2,3-Butanediol production by acetogenic bacteria, an alternative route to chemical synthesis using industrial waste gas. Appl Environ Microbiol. 2011;77:5467–5475.
   PubMed Web of Science ®Google Scholar
• Li L, Li K, Wang K, et al. Efficient production of 2,3-butanediol from corn stover hydrolysate by using a thermophilic Bacillus licheniformis strain. Bioresour Technol. 2014;170:256–261.
   PubMed Web of Science ®Google Scholar
• Tsvetanova F, Petrova P, Petrov K. 2,3-Butanediol production from starch by engineered Klebsiella pneumoniae G31-A. Appl Microbiol Biotechnol. 2014;98:2441–2451.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Zhang H, Zhao L, et al. One-step production of 2,3-butanediol from starch by secretory over-expression of amylase in Klebsiella pneumoniae. J Chem Technol Biotechnol. 2008;83:1409–1412.
   Web of Science ®Google Scholar
• Jung MY, Jung HM, Lee J, et al. Alleviation of carbon catabolite repression in Enterobacter aerogenes for efficient utilization of sugarcane molasses for 2,3-butanediol production. Biotechnol Biofuels. 2015;8:106.
   PubMed Web of Science ®Google Scholar
• Da Silva GP, Mack M, Contiero J. Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnol Adv. 2009;27:30–39.
   PubMed Web of Science ®Google Scholar
• Petrov K, Petrova P. Enhanced production of 2,3-butanediol from glycerol by forced pH fluctuations. Appl Microbiol Biotechnol. 2010;87:943–949.
   PubMed Web of Science ®Google Scholar
• Cho S, Kim T, Woo HM, et al. High production of 2,3-butanediol from biodiesel-derived crude glycerol by metabolically engineered Klebsiella oxytoca M1. Biotechnol Biofuels. 2015;8:146.
   PubMed Web of Science ®Google Scholar
• Tyurin M, Kiriukhin M. Synthetic 2,3-butanediol pathway integrated using Tn7-tool and powered Via elimination of sporulation and acetate production in acetogen biocatalyst. Appl Biochem Biotechnol. 2013;170:1503–1524.
   PubMed Web of Science ®Google Scholar
• Gorke B, Stulke J. Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol. 2008;6:613–624.
   PubMed Web of Science ®Google Scholar
• Li L, Li K, Wang Y, et al. Metabolic engineering of Enterobacter cloacae for high-yield production of enantiopure (2R,3R)-2,3-butanediol from lignocellulose-derived sugars. Metab Eng. 2015;28:19–27.
   PubMed Web of Science ®Google Scholar
• Ji XJ, Nie ZK, Huang H, et al. Elimination of carbon catabolite repression in Klebsiella oxytoca for efficient 2,3-butanediol production from glucose-xylose mixtures. Appl Microbiol Biotechnol. 2011;89:1119–1125.
   PubMed Web of Science ®Google Scholar
• Shin HD, Yoon SH, Wu J, et al. High-yield production of meso-2,3-butanediol from cellodextrin by engineered E. coli biocatalysts. Bioresour Technol. 2012;118:367–373.
   PubMed Web of Science ®Google Scholar
• Zhang X, Bao T, Rao Z, et al. Two-stage pH control strategy based on the pH preference of acetoin reductase regulates acetoin and 2,3-butanediol distribution in Bacillus subtilis. PLoS One. 2014;9:e91187.
   PubMed Web of Science ®Google Scholar