Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 26, 2009 - Issue 4
670
Views
82
CrossRef citations to date
0
Altmetric
Original

Clock Genes Display Rhythmic Expression in Human Hearts

, , , , , , & show all
Pages 621-636 | Received 29 Oct 2008, Accepted 05 Feb 2009, Published online: 07 Jul 2009

References

  • Abe M, Herzog E D, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block G D. Circadian rhythms in isolated brain regions. J. Neurosci. 2002; 22: 350–356
  • Ackermann K, Dehghani F, Bux R, Kauert G, Stehle J H. Day-night expression patterns of clock genes in the human pineal gland. J. Pineal Res. 2007; 43: 185–194
  • Albrecht U. Invited review: Regulation of mammalian circadian clock genes. J. Appl. Physiol. 2002; 92: 1348–1355
  • Balsalobre A, Damiola F, Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 1998; 93: 929–937
  • Bjarnason G A, Jordan R C, Sothern R B. Circadian variation in the expression of cell-cycle proteins in human oral epithelium. Am. J. Pathol. 1999; 154: 613–622
  • Bjarnason G A, Jordan R C, Wood P A, Li Q, Lincoln D W, Sothern R B, Hrushesky W J, Ben-David Y. Circadian expression of clock genes in human oral mucosa and skin: Association with specific cell-cycle phases. Am. J. Pathol. 2001; 158: 1793–1801
  • Boivin D B, James F O, Wu A, Cho-Park P F, Xiong H, Sun Z S. Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood 2003; 102: 4143–4145
  • Bray M S, Young M E. Diurnal variations in myocardial metabolism. Cardiovasc Res. 2008; 15: 228–237
  • Bray M S, Shaw C A, Moore M W, Garcia R A, Zanquetta M M, Durgan D J, Jeong W J, Tsai J Y, Bugger H, Zhang D, Rohrwasser A, Rennison J H, Dyck J R, Litwin S E, Hardin P E, Chow C W, Chandler M P, Abel E D, Young M E. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am. J. Physiol. Heart Circ. Physiol. 2008; 294: H1036–H1047
  • Cermakian N, Boivin D B. A molecular perspective of human circadian rhythm disorders. Brain Res. Brain Res. Rev. 2003; 42: 204–220
  • Chen S T, Choo K B, Hou M F, Yeh K T, Kuo S J, Chang J G. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 2005; 26: 1241–1246
  • Chen-Goodspeed M, Lee C C. Tumor suppression and circadian function. J. Biol. Rhythms 2007; 22: 291–298
  • Dardente H, Cermakian N. Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol Int. 2007; 24: 195–213
  • Desan P H, Oren D A, Malison R, Price L H, Rosenbaum J, Smoller J, Charney D S, Gelernter J. Genetic polymorphism at the CLOCK gene locus and major depression. Am. J. Med. Genet. 2000; 96: 418–421
  • Durgan D J, Hotze M A, Tomlin T M, Egbejimi O, Graveleau C, Abel E D, Shaw C A, Bray M S, Hardin P E, Young M E. The intrinsic circadian clock within the cardiomyocyte. Am. J. Physiol. Heart Circ. Physiol. 2005; 289: H1530–H1541
  • Durgan D J, Moore M W, Ha N P, Egbejimi O, Fields A, Mbawuike U, Egbejimi A, Shaw C A, Bray M S, Nannegari V, Hickson-Bick D L, Heird W C, Dyck J R, Chandler M P, Young M E. Circadian rhythms in myocardial metabolism and contractile function: Influence of workload and oleate. Am. J. Physiol. Heart Circ. Physiol. 2007; 293: H2385–H2393
  • Fukuya H, Emoto N, Nonaka H, Yagita K, Okamura H, Yokoyama M. Circadian expression of clock genes in human peripheral leukocytes. Biochem. Biophys. Res. Commun. 2007; 354: 924–928
  • Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler H P. The circadian gene Per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol. Cell 2006; 22: 375–382
  • Gery S, Komatsu N, Kawamata N, Miller C W, Desmond J, Virk R K, Marchevsky A, McKenna R, Taguchi H, Koeffler H P. Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer. Clin. Cancer Res. 2007; 13: 1399–1404
  • Gomez-Abellan P, Hernandez-Morante J J, Lujan J A, Madrid J A, Garaulet M. Clock genes are implicated in the human metabolic syndrome. Int. J. Obes. (Lond.) 2008; 32: 121–128
  • Herichova I, Mravec B, Stebelova K, Krizanova O, Jurkovicova D, Kvetnansky R, Zeman M. Rhythmic clock gene expression in heart, kidney and some brain nuclei involved in blood pressure control in hypertensive TGR(mREN-2)27 rats. Mol. Cell. Biochem. 2007; 296: 25–34
  • James F O, Boivin D B, Charbonneau S, Belanger V, Cermakian N. Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles. Chronobiol. Int. 2007; 24: 1009–1034
  • Kawakami C, Ohshige K, Tochikubo O. Circadian variation in cardiovascular emergencies among the elderly. Clin. Exp. Hypertens 2008; 30: 23–31
  • Konopka R J, Benzer S. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 1971; 68: 2112–2116
  • Krugluger W, Brandstaetter A, Kallay E, Schueller J, Krexner E, Kriwanek S, Bonner E, Cross H S. Regulation of genes of the circadian clock in human colon cancer: Reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 2007; 67: 7917–7922
  • Lee C C. Tumor suppression by the mammalian Period genes. Cancer Causes Control. 2006; 17: 525–530
  • Liu S, Cai Y, Sothern R B, Guan Y, Chan P. Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice. Chronobiol. Int. 2007; 24: 793–820
  • Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402–408
  • Okamura H. Clock genes in cell clocks: Roles, actions, and mysteries. J. Biol. Rhythms 2004; 19: 388–399
  • Paul T, Lemmer B. Disturbance of circadian rhythms in analgosedated intensive care patients with and without craniocerebral injury. Chronobiol. Int. 2007; 24: 45–61
  • Portaluppi F, Touitou Y, Smolensky M H. Ethical and methodological standards for laboratory and medical biological rhythm research. Chronobiol. Int. 2008; 25: 999–1016
  • Sahar S, Sassone-Corsi P. Circadian clock and breast cancer: A molecular link. Cell Cycle 2007; 6: 1329–1331
  • Storch K F, Lipan O, Leykin I, Viswanathan N, Davis F C, Wong W H, Weitz C J. Extensive and divergent circadian gene expression in liver and heart. Nature 2002; 417: 78–83
  • Takata M, Burioka N, Ohdo S, Takane H, Terazono H, Miyata M, Sako T, Suyama H, Fukuoka Y, Tomita K, Shimizu E. Daily expression of mRNAs for the mammalian Clock genes Per2 and clock in mouse suprachiasmatic nuclei and liver and human peripheral blood mononuclear cells. Jpn. J. Pharmacol. 2002; 90: 263–269
  • Takeda N, Maemura K, Horie S, Oishi K, Imai Y, Harada T, Saito T, Shiga T, Amiya E, Manabe I, Ishida N, Nagai R. Thrombomodulin is a clock-controlled gene in vascular endothelial cells. J. Biol. Chem. 2007; 282: 32561–32567
  • Takimoto M, Hamada A, Tomoda A, Ohdo S, Ohmura T, Sakato H, Kawatani J, Jodoi T, Nakagawa H, Terazono H, Koyanagi S, Higuchi S, Kimura M, Tukikawa H, Irie S, Saito H, Miike T. Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005; 289: R1273–R1279
  • Tsinkalovsky O, Smaaland R, Rosenlund B, Sothern R B, Hirt A, Steine S, Badiee A, Abrahamsen J F, Eiken H G, Laerum O D. Circadian variations in clock gene expression of human bone marrow CD34+ cells. J. Biol. Rhythms 2007; 22: 140–150
  • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002; 3, RESEARCH0034
  • Willich S N, Lowel H, Lewis M, Arntz R, Baur R, Winther K, Keil U, Schroder R. Association of wake time and the onset of myocardial infarction. Triggers and mechanisms of myocardial infarction (TRIMM) pilot study. TRIMM Study Group. Circulation 1991; 84: VI62–VI67
  • Winter S L, Bosnoyan-Collins L, Pinnaduwage D, Andrulis I L. Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors. Neoplasia 2007; 9: 797–800
  • Wu Y H, Fischer D F, Kalsbeek A, Garidou-Boof M L, van der Vliet J, van Heijningen C, Liu R Y, Zhou J N, Swaab D F. Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the “master clock.”. FASEB J 2006; 20: 1874–1876
  • Young M E, Razeghi P, Taegtmeyer H. Clock genes in the heart: Characterization and attenuation with hypertrophy. Circ. Res. 2001; 88: 1142–1150
  • Zambon A C, McDearmon E L, Salomonis N, Vranizan K M, Johansen K L, Adey D, Takahashi J S, Schambelan M, Conklin B R. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 2003; 4: R61

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.