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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 33, 2016 - Issue 7
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Original Articles

Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep

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References

  • Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE. (2003). Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci. 23:2008–13.
  • Alsaadi SM, McAuley JH, Hush JM, Bartlett DJ, McKeough ZM, Grunstein RR, et al. (2014). Assessing sleep disturbance in low back pain: The validity of portable instruments. PLoS One. 9:e95824.
  • Annerbrink K, Westberg L, Nilsson S, Rosmond R, Holm G, Eriksson E. (2008). Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. Metab Clin Exp. 57:708–11.
  • Arns M, Swanson JM, Arnold LE. (2015). ADHD prevalence: Altitude or sunlight? Better understanding the interrelations of dopamine and the circadian system. J Atten Disord. doi:10.1177/1087054715599574
  • Baron KG, Reid KJ, Kern AS, Zee PC. (2011). Role of sleep timing in caloric intake and BMI. Obesity. 19:1374–81.
  • Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten, Amy FT, Kelley AE, Schmeichel B, et al. (2006). Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biol Psychiatry. 60:1111–20.
  • Bloch KE, Schoch OD, Zhang JN, Russi EW. (1999). German version of the Epworth sleepiness scale. Respiration. 66:440–7.
  • Bodenmann S, Landolt H. (2010). Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 33:1027–35.
  • Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 28:193–213.
  • Castañeda TR, de Prado, Blanca Marquez, Prieto D, Mora F. (2004). Circadian rhythms of dopamine, glutamate and GABA in the striatum and nucleus accumbens of the awake rat: Modulation by light. J Pineal Res. 36:177–85.
  • Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, et al. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet. 75:807–21.
  • Cohen J. (1988). Statistical power analysis for the behavioral sciences. 2nd edition. Hillsdale, N.J.: L. Erlbaum Associates.
  • Cohen J. (1965). Some statistical issues in psychological research. In Wolman BB, ed. Handbook of clinical psychology. New York, NY: McGraw-Hill. pp. 95–121.
  • Dauvilliers Y, Neidhart E, Billiard M, Tafti M. (2002). Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. Pharmacogenomics J. 2:65–8.
  • Dauvilliers Y, Neidhart E, Lecendreux M, Billiard M, Tafti M. (2001). MAO-A and COMT polymorphisms and gene effects in narcolepsy. Mol Psychiatry. 6:367–72.
  • Degen C, Zschocke J, Toro P, Sattler C, Wahl H, Schönknecht P, et al. (2015). The COMTp.Val158Met polymorphism and cognitive performance in adult development, healthy aging and mild cognitive impairment. Dementia Geriatric Cognit. Disorders. 41:27–34.
  • Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, et al. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet. 12:78–80.
  • Engels WR. (2009). Exact tests for Hardy-Weinberg proportions. Genetics. 183:1431–41.
  • Faul F, Erdfelder E, Lang A, Buchner A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 39:175–91.
  • Frauscher B, Högl B, Maret S, Wolf E, Brandauer E, Wenning GK, et al. (2004). Association of daytime sleepiness with COMT polymorphism in patients with Parkinson disease: A pilot study. Sleep. 27:733–6.
  • Gatt JM, Burton, Karen LO, Williams LM, Schofield PR. (2015). Specific and common genes implicated across major mental disorders: A review of meta-analysis studies. J Psychiatr Res. 60:1–13.
  • Geissler J, Romanos M, Hegerl U, Hensch T. (2014). Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? Attention Deficit Hyperactivity Disorders. 6:159–73.
  • Gizer IR, Ficks C, Waldman ID. (2009). Candidate gene studies of ADHD: A meta-analytic review. Hum Genet. 126:51–90.
  • Glass D, Viñuela A, Davies MN, Ramasamy A, Parts L, Knowles D, et al. (2013). Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol. 14:R75.
  • Gottlieb DJ, Hek K, Chen T, Watson NF, Eiriksdottir G, Byrne EM, et al. (2015). Novel loci associated with usual sleep duration: The CHARGE consortium genome-wide association study. Mol. Psychiatry. 20:1232–9.
  • Griefahn B, Kunemund C, Brode P, Mehnert P. (2001). Zur Validitat der deutschen Ubersetzung des morningness-eveningness-questionnaires von Horne und Östberg. The validity of a German version of the morningness-eveningness-questionnaire developed by Horne and Östberg. Somnologie. 5:71–80.
  • Gruber R, Grizenko N, Schwartz G, Ben Amor L, Gauthier J, De Guzman R, et al. (2006). Sleep and COMT polymorphism in ADHD children: Preliminary actigraphic data. J Am Acad Child Adolesc Psychiatry. 45:982–9.
  • Gruner JA, Marcy VR, Lin Y, Bozyczko-Coyne D, Marino MJ, Gasior M. (2009). The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 32:1425–38.
  • Hegerl U, Hensch T. (2014). The vigilance regulation model of affective disorders and ADHD. Neurosci Biobehav Rev. 44:45–57.
  • Hegerl U, Himmerich H, Engmann B, Hensch T. (2010). Mania and attention-deficit/hyperactivity disorder: Common symptomatology, common pathophysiology and common treatment? Curr Opin Psychiatry. 23:1–7.
  • Horne JA, Östberg O. (1976). A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 4:97–110.
  • Huang J, Sander C, Jawinski P, Ulke C, Spada J, Hegerl U, et al. (2015). Test-retest reliability of brain arousal regulation as assessed with VIGALL 2.0. Neuropsychiatr Electrophysiol. 1:263.
  • Jawinski P, Sander C, Mauche N, Spada J, Huang J, Schmidt A, et al. (2015). Brain arousal regulation in carriers of bipolar disorder risk alleles. Neuropsychobiology. 72:65–73.
  • Johns MW. (1991). A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep. 14:540–5.
  • Kereszturi E, Tarnok Z, Bognar E, Lakatos K, Farkas L, Gadoros J, et al. (2008). Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children. Am J Med Genet B Neuropsychiatr Genet. 147B:1431–5.
  • Kim J, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, et al. (2010). Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4). Mol Cell Endocrinol. 314:128–35.
  • Landgraf D, McCarthy MJ, Welsh DK. (2014). Circadian clock and stress interactions in the molecular biology of psychiatric disorders. Curr Psychiatry Rep. 16:483.
  • Laucht M, Becker K, Blomeyer D, Schmidt MH. (2007). Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: Results from a high-risk community sample. Biol Psychiatry. 61:87–92.
  • Léna I, Parrot S, Deschaux O, Muffat-Joly S, Sauvinet V, Renaud B, et al. (2005). Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep—wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. J Neurosci Res. 81:891–9.
  • Li J, Ji L. (2005). Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb). 95:221–7.
  • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature. 518:197–206.
  • Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, Baber R, et al. (2015). The LIFE-adult-study: Objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 15:691.
  • Lu T, Pan Y, Kao S, Li C, Kohane I, Chan J, et al. (2004). Gene regulation and DNA damage in the ageing human brain. Nature. 429:883–91.
  • Mezick EJ, Wing RR, McCaffery JM. (2014). Associations of self-reported and actigraphy-assessed sleep characteristics with body mass index and waist circumference in adults: Moderation by gender. Sleep Med. 15:64–70.
  • Mier D, Kirsch P, Meyer-Lindenberg A. (2010). Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis. Mol Psychiatry. 15:918–27.
  • Monti JM, Monti D. (2007). The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev. 11:113–33.
  • Murphy KR, Myors B, Wolach AH. (2014). Statistical power analysis. A simple and general model for traditional and modern hypothesis tests. 4th edition. London, UK: Routledge.
  • Nakazawa S, Nakamichi K, Imai H, Ichihara J. (2015). Effect of dopamine D4 receptor agonists on sleep architecture in rats. Prog Neuropsychopharmacol Biol Psychiatry. 63:6–13.
  • Oak JN, Oldenhof J, Van Tol HH. (2000). The dopamine D(4) receptor: One decade of research. Eur J Pharmacol. 405:303–27.
  • Ojeda DA, Perea CS, Suárez A, Niño CL, Gutiérrez RM, López-León S, et al. (2014). Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample. Neurol Sci. 35:41–7.
  • Olbrich S, Fischer MM, Sander C, Hegerl U, Wirtz H, Bosse-Henck A. (2015). Objective markers for sleep propensity: Comparison between the multiple sleep latency test and the vigilance algorithm Leipzig. J Sleep Res. 24:450–7.
  • Osaki R, Imaeda H, Ban H, Aomatsu T, Bamba S, Tsujikawa T, et al. (2011). Accuracy of genotyping using the TaqMan PCR assay for single nucleotide polymorphisms responsible for thiopurine sensitivity in Japanese patients with inflammatory bowel disease. Exp Ther Med. 2:783–6.
  • Papenberg G, Lövdén M, Laukka EJ, Kalpouzos G, Keller L, Graff C, et al. (2015). Magnified effects of the COMT gene on white-matter microstructure in very old age. Brain Struct. Funct. 220:2927–38.
  • Proitsi P, Lupton MK, Reeves SJ, Hamilton G, Archer N, Martin BM, et al. (2012). Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiol Aging. 33:791–803.
  • Rissling I, Frauscher B, Kronenberg F, Tafti M, Stiasny-Kolster K, Robyr A, et al. (2006). Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Sleep. 29:108–11.
  • Rosenthal R. (1991). Meta-analytic procedures for social research. 2nd edition. Newbury Park, CA: Sage Publications.
  • Rosenthal R. (1994). Parametric measures of effect size. In Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York, NY: Russell Sage Foundation, pp. 231–244.
  • Rosenthal R, DiMatteo MR. (2001). Meta-analysis: Recent developments in quantitative methods for literature reviews. Annu Rev Psychol. 52:59–82.
  • Salatino-Oliveira A, Genro JP, Zeni C, Polanczyk GV, Chazan R, Guimarães AP, et al. (2011). Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on oppositional symptoms in boys with attention-deficit/hyperactivity disorder. Biol Psychiatry. 70:216–21.
  • Sander C, Hensch T, Wittekind DA, Böttger D, Hegerl U. (2015). Assessment of wakefulness and brain arousal regulation in psychiatric research. Neuropsychobiology. 72:195–205.
  • Sharif MM, Bahammam AS. (2013). Sleep estimation using BodyMedia’s SenseWear™ armband in patients with obstructive sleep apnea. Ann Thorac Med. 8:53–7.
  • Spada J, Sander C, Burkhardt R, Häntzsch M, Mergl R, Scholz M, et al. (2014). Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene. PLoS One. 9:e98789.
  • Spada J, Scholz M, Kirsten H, Hensch T, Horn K, Jawinski P, et al. Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE-Adult-Study. J Sleep Res. in press.
  • Spiegel K, Tasali E, Leproult R, van Cauter E. (2009). Effects of poor and short sleep on glucose metabolism and obesity risk. Nature reviews. Endocrinology. 5:253–61.
  • Strobel A, Lesch KP, Jatzke S, Paetzold F, Brocke B. (2003). Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants. Mol Psychiatry. 8:371–2.
  • Tworoger SS, Chubak J, Aiello EJ, Yasui Y, Ulrich CM, Farin FM, et al. (2004). The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women. Obes Res. 12:972–81.
  • Vallone D, Picetti R, Borrelli E. (2000). Structure and function of dopamine receptors. Neurosci. Biobehav. Rev. 24:125–32.
  • Valomon A, Holst SC, Bachmann V, Viola AU, Schmidt C, Zürcher J, et al. (2014). Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Chronobiol Int. 31:705–14.
  • van den Berg JF, Knvistingh Neven A, Tulen JHM, Hofman A, Witteman JCM, Miedema HME, et al. (2008). Actigraphic sleep duration and fragmentation are related to obesity in the elderly: The Rotterdam Study. Int J Obesity (2005). 32:1083–90.
  • Waples RS. (2015). Testing for Hardy-Weinberg proportions: Have we lost the plot? J Hered. 106:1–19.
  • Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. (2001). Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 21:1787–94.
  • Wulff K, Gatti S, Wettstein JG, Foster RG. (2010). Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci. 11:589–99.
  • Yujnovsky I, Hirayama J, Doi M, Borrelli E, Sassone-Corsi P. (2006). Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci USA. 103:6386–91.

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