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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 37, 2020 - Issue 3
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Original Articles

Melatonin does not produce sedation in rats: A chronobiological study

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Pages 353-374 | Received 14 Oct 2019, Accepted 05 Dec 2019, Published online: 18 Dec 2019

References

  • Acil M, Basgul E, Celiker V, Karagöz AH, Demir B, Aypar U. 2004. Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Eur J Anaesthesiol. 21(7):553–557. doi: 10.1017/S0265021504007094.
  • Andersen LP. 2016. The analgesic effects of exogenous melatonin in humans. Dan Med J. 63(10):B5289.
  • Ansari G, Fathi M, Ghajari MF, Bargrizan M, Eghbali A. 2018. Oral melatonin versus midazolam as premedication for intravenous sedation in pediatric dental patients. J Dent (Tehran). 15(5):317–324.
  • Antón-Tay F, Díaz JL, Fernández-Guardiola A. 1971. On the effect of melatonin upon human brain. Its possible therapeutic implications. Life Sci. 10(15):841–850. doi: 10.1016/0024-3205(71)90155-X.
  • Bahna SG, Niles LP. 2018. Epigenetic regulation of melatonin receptors in neuropsychiatric disorders. Br J Pharmacol. 175(16):3209–3219. doi: 10.1111/bph.v175.16.
  • Bilu C, Kronfeld-Schor N. 2013. Effects of circadian phase and melatonin injection on anxiety-like behavior in nocturnal and diurnal rodents. Chronobiol Int. 30(6):828–836. doi: 10.3109/07420528.2013.773439.
  • Borazan H, Tuncer S, Yalcin N, Erol A, Otelcioglu S. 2010. Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a randomized clinical trial. J Anesth. 24(2):155–160. doi: 10.1007/s00540-010-0891-8.
  • Brotto LA, Barr AM, Gorzalka BB. 2000. Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin. Eur J Pharmacol. 402(1–2):87–93. doi: 10.1016/S0014-2999(00)00491-X.
  • Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Baker G, Klassen TP, Vohra S. 2005. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 20(12):1151–1158. doi: 10.1111/j.1525-1497.2005.0243.x.
  • Capuzzo M, Zanardi B, Schiffino E, Buccoliero C, Gragnaniello D, Bianchi S, Alvisi R. 2006. Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesth Analg. 103(1):121–123. doi: 10.1213/01.ane.0000222476.62547.ed.
  • Chamblin MH 1973. Melatonin: an assessment of a possible role in the induction and maintenance of sleep in the normal and parachlorophenylalanine treated cat. Diss Abstr Int. B33: 4535.
  • Corrales A, Martínez P, García S, Vidal V, García E, Flórez J, Sanchez-Barceló EJ, Martínez-Cué C, Rueda N. 2013. Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome. J Pineal Res. 54(3):346–358. doi: 10.1111/jpi.2013.54.issue-3.
  • Corthell JT, Stathopoulos AM, Watson CC, Bertram R, Trombley PQ. 2013. Olfactory bulb monoamine concentrations vary with time of day. Neuroscience. 247:234–241. doi: 10.1016/j.neuroscience.2013.05.040.
  • Deacon RM. 2013. Measuring motor coordination in mice. J Vis Exp. 29:e2609. doi: 10.3791/2609.
  • Dinh QT, Cryer A, Dinh S, Peiser C, Wu S, Springer J, Hamelmann E, Klapp BF, Heppt W, Fischer A. 2005. Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis. Clin Exp Allergy. 35(11):1443–1448. doi: 10.1111/cea.2005.35.issue-11.
  • Dubocovich ML, Markowska M. 2005. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 27(2):101–110. doi: 10.1385/ENDO:27:2.
  • Eison AS, Freeman RP, Guss VB, Mullins UL, Wright RN. 1995. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. J Pharmacol Exp Ther. 273(1):304–308.
  • Esteban S, Garau C, Aparicio S, Moranta D, Barceló P, Fiol MA, Rial R. 2010. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. J Pineal Res. 48(2):170–177. doi: 10.1111/jpi.2010.48.issue-2.
  • Faghihian R, Eshghi A, Faghihian H, Kaviani N. 2018. Comparison of oral melatonin and midazolam as premedication in children undergoing general anesthesia for dental treatment. Anesth Pain Med. 8(2):e64236. doi: 10.5812/aapm.
  • Fagiolini A, Comandini A, Dell’Osso MC, Kasper S. 2012. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 26:1033–1049. doi: 10.1007/s40263-012-0010-5.
  • Fallah R, Yadegari Y, Behdad S, Akhavan Karbasi S. 2014. Melatonin and intravenous midazolam administered orally in drug induced sleep electroencephalography of children: randomized clinical trial of efficacy. Arch Iran Med. 17(11):741–745.
  • Gitto E, Marseglia L, D’Angelo G, Manti S, Crisafi C, Montalto AS, Impellizzeri P, Reiter RJ, Romeo C. 2016. Melatonin versus midazolam premedication in children undergoing surgery: A pilot study. J Pediatric Child Health. 52(3):291–295. doi: 10.1111/jpc.13007.
  • Gomaa AM, Galal HM, Abou-Elgait AT. 2017. Neuroprotective effects of melatonin administration against chronic immobilization stress in rats. Int J Physiol Pathophysiol Pharmacol. 9(2):16–27.
  • Gorzalka BB, Brotto LA, Hong JJ. 1999. Corticosterone regulation of 5-HT2A receptor-mediated behaviors: attenuation by melatonin. Physiol Behav. 67(3):439–442. doi: 10.1016/S0031-9384(99)00096-7.
  • Graw P, Werth E, Kräuchi K, Gutzwiller F, Cajochen C, Wirz-Justice A. 2001. Early morning melatonin administration impairs psychomotor vigilance. Behav Brain Res. 121(1–2):167–172. doi: 10.1016/S0166-4328(01)00158-9.
  • Hansen MV, Halladin NL, Rosenberg J, Gögenur I, Møller AM. 2015. Melatonin for pre- and postoperative anxiety in adults. Cochrane Database Syst Rev. 2015 (4):CD009861. doi: 10.1002/14651858.CD009861.pub2.
  • Hardeland R, Poeggeler B, Srinivasan V, Trakht I, Pandi-Perumal SR, Cardinali DP. 2008. Melatonergic drugs in clinical practice. Arzneimittelforschung. 58(1):1–10. doi: 10.1055/s-0031-1296459.
  • Hattori M, Mizuguchi H, Baba Y, Ono S, Nakano T, Zhang Q, Sasaki Y, Kobayashi M, Kitamura Y, Takeda N, et al. 2013. Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells. Int Immunopharmacol. 15(2):232–239. doi: 10.1016/j.intimp.2012.12.030.
  • Holmes SW, Sugden D. 1982. Effects of melatonin on sleep and neurochemistry in the rat. Br J Pharmacol. 76(1):95–101. doi: 10.1111/bph.1982.76.issue-1.
  • Huang F, Yang Z, Li CQ. 2017. The melatonergic system in anxiety disorders and the role of melatonin in conditional fear. Vitam Horm. 103(2):281–294.
  • Hulihan-Giblin BA, Pivorun EB, Goldman D. 1993. Diurnal rhythms of 5-HT1A and 5-HT2 receptor binding in euthermic and torpor prone deer mice, Peromyscus maniculatus. Pharmacol Biochem Behav. 45(4):785–789. doi: 10.1016/0091-3057(93)90121-9.
  • Impellizzeri P, Vinci E, Gugliandolo MC, Cuzzocrea F, Larcan R, Russo T, Gravina MR, Arena S, D’Angelo G, Gitto E, et al. 2017. Premedication with melatonin vs midazolam: efficacy on anxiety and compliance in paediatric surgical patients. Eur J Pediatr. 176(7):947–953. doi: 10.1007/s00431-017-2933-9.
  • Islam R, Mizuguchi H, Shaha A, Nishida K, Yabumoto M, Ikeda H, Fujino H, Kitamura Y, Fukui H, Takeda N. 2018. Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis. J Med Invest. 65(3.4):242–250. doi: 10.2152/jmi.65.242.
  • Iwase M, Ohshima Y, Izumizaki M, Homma I. 2010. Circadian changes in respiratory responses to acute hypoxia and histamine H1 receptors in mice. Adv Exp Med Biol. 669:235–238.
  • Jawed S, Kim B, Ottenhof T, Brown GM, Werstiuk ES, Niles LP. 2007. Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation. Eur J Pharmacol. 560(1):17–22. doi: 10.1016/j.ejphar.2007.01.022.
  • Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. 2016. Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol. 173(18):2702–2725. doi: 10.1111/bph.13536.
  • Kamal M, Gbahou F, Guillaume J-L, Daulat AM, Benleulmi-Chaachoua A, Luka M, Chen P, Kalbasi Anaraki D, Baroncini M, Mannoury la Cour C, et al. 2015. Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers. J Biol Chem. 290(18):11537–11546. doi: 10.1074/jbc.M114.559542.
  • Kurdi MS, Muthukalai SP. 2016. A comparison of the effect of two doses of oral melatonin with oral midazolam and placebo on pre-operative anxiety, cognition and psychomotor function in children: A randomised double-blind study. Indian J Anaesth. 60(10):744–750. doi: 10.4103/0019-5049.191688.
  • Kurdi MS, Patel T. 2013. The role of melatonin in anaesthesia and critical care. Indian J Anaesth. 57(2):137–144. doi: 10.4103/0019-5049.111837.
  • Lemmer B. 1994. Chronopharmacology: time, a key in drug treatment. Ann Biol Clin (Paris). 52(1):1–7.
  • Lemmer B. 2000. Relevance for chronopharmacology in practical medicine. Semin Perinatol. 24(4):280–290. doi: 10.1053/sper.2000.8595.
  • Lewis SR, Pritchard MW, Schofield-Robinson OJ, Alderson P, Smith AF. 2018. Melatonin for the promotion of sleep in adults in the intensive care unit. Cochrane Database Syst Rev. 5:CD012455. doi: 10.1002/14651858.CD012454.pub2.
  • Liet C, Amenouche F, Freret T, Boulouard M, Mauvieux B, Lelong-Boulouard V, Bocca M-L. 2015. Effects of acute administration of melatonin on attentional, executive, and working memory processes in rats. Fundam Clin Pharmacol. 29(5):472–477. doi: 10.1111/fcp.12134.
  • Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. 2016. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol. 56:361–383. doi: 10.1146/annurev-pharmtox-010814-124742.
  • Marks V, English J, Aherne W, Arendt J. 1985. Chronopharmacology. Clin Biochem. 18(3):154–157. doi: 10.1016/S0009-9120(85)80100-4.
  • Marseglia L, D’Angelo G, Manti S, Aversa S, Arrigo T, Reiter RJ, Gitto E. 2015. Analgesic, anxiolytic and anaesthetic effects of melatonin: new potential uses in pediatrics. Int J Mol Sci. 16(1):1209–1220. doi: 10.3390/ijms16011209.
  • Mendelson WB. 1997. A critical evaluation of the hypnotic efficacy of melatonin. Sleep. 20(10):916–919. doi: 10.1093/sleep/20.10.916.
  • Mendelson WB, Gillin JC, Dawson SD, Lewy AJ, Wyatt RJ. 1980. Effects of melatonin and propranolol on sleep of the rat. Brain Res. 201(1):240–244. doi: 10.1016/0006-8993(80)90793-3.
  • Miyoshi K, Kawakami N, Das AK, Fujimoto K, Horio S, Fukui H. 2007. Heterologous up-regulation of the histamine H1 receptor by M3 muscarinic receptor-mediated activation of H1-receptor gene transcription. J Pharm Pharmacol. 59(6):843–848. doi: 10.1211/jpp.59.6.0010.
  • Mizuguchi H, Miyagi K, Terao T, Sakamoto N, Yamawaki Y, Adachi T, Ono S, Sasaki Y, Yoshimura Y, Kitamura Y, et al. 2012. PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor. Sci Rep. 2:916. doi: 10.1038/srep00916.
  • Mizuguchi H, Terao T, Kitai M, Ikeda M, Yoshimura Y, Das AK, Kitamura Y, Takeda N, Fukui H. 2011. Involvement of protein kinase Cδ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells. J Biol Chem. 286(35):30542–30551. doi: 10.1074/jbc.M111.253104.
  • Mochizuki T, Yamatodani A, Okakura K, Horii A, Inagaki N, Wada H. 1992. Circadian rhythm of histamine release from the hypothalamus of freely moving rats. Physiol Behav. 51(2):391–394. doi: 10.1016/0031-9384(92)90157-W.
  • Naguib M, Hammond DL, Schmid PG 3rd, Baker MT, Cutkomp J, Queral L, Smith T. 2003a. Pharmacological effects of intravenous melatonin: comparative studies with thiopental and propofol. Br J Anaesth. 90(4):504–507. doi: 10.1093/bja/aeg092.
  • Naguib M, Samarkandi AH. 1999. Premedication with melatonin: a double-blind, placebo-controlled comparison with midazolam. Br J Anaesth. 82(6):875–880. doi: 10.1093/bja/82.6.875.
  • Naguib M, Samarkandi AH. 2000. The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesth Analg. 91(2):473–479. doi: 10.1097/00000539-200008000-00046.
  • Naguib M, Samarkandi AH, Moniem MA, Eel-D M, Alshaer AA, Al-Ayyaf HA, Fadin A, Alharby SW. 2006. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesth Analg. 103(6):1448–1452. doi: 10.1213/01.ane.0000244534.24216.3a.
  • Naguib M, Schmid PG 3rd, Baker MT. 2003b. The electroencephalographic effects of IV anesthetic doses of melatonin: comparative studies with thiopental and propofol. Anesth Analg. 97(1):238–243. doi: 10.1213/01.ANE.0000065545.58026.23.
  • Niles LP, Sathiyapalan A, Bahna S, Kang NH, Pan Y. 2012. Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain. Int J Neuropsychopharmacol. 15(9):1343–1350. doi: 10.1017/S1461145711001969.
  • Norouzi A, Fateh S, Modir H, Kamali A, Akrami L. 2019. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial. Med Gas Res. 9(2):62–67. doi: 10.4103/2045-9912.260646.
  • Ohshima Y, Iwase M, Izumizaki M, Kanamaru M, Homma I. 2008. Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice. J Physiol Sci. 58(2):147–150. doi: 10.2170/physiolsci.SC002408.
  • Oishi A, Cecon E, Jockers R. 2018. Melatonin receptor signaling: impact of receptor oligomerization on receptor function. Int Rev Cell Mol Biol. 338:59–77.
  • Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R. 2017. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci Rep. 7(1):8990. doi: 10.1038/s41598-017-08996-7.
  • Onaolapo OJ, Onaolapo AY. 2018. Melatonin in drug addiction and addiction management: exploring an evolving multidimensional relationship. World J Psychiatry. 8(2):64–74. doi: 10.5498/wjp.v8.i2.64.
  • Pandi-Perumal SR, Trakht I, Spence DW, Srinivasan V, Dagan Y, Cardinali DP. 2008. The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Nat Clin Pract Neurol. 4(8):436–447. doi: 10.1038/ncpneuro0847.
  • Pasini AM, Marjanović J, Roić G, Dukarić N, Tripalo Batoš A, Bahtijarević Z, Gagro A. 2018. Melatonin as an alternative sedation method during magnetic resonance imaging in preschool children with musculoskeletal problems. Eur J Pediatr. 177(9):1359–1362. doi: 10.1007/s00431-017-3069-7.
  • Patel T, Kurdi MS. 2015. A comparative study between oral melatonin and oral midazolam on preoperative anxiety, cognitive, and psychomotor functions. J Anaesthesiol Clin Pharmacol. 31(1):37–43. doi: 10.4103/0970-9185.150534.
  • Peña IJ, Hong E, Kim HJ, de la Peña JB, Woo TS, Lee YS, Cheong JH. 2015. Artemisia capillaris Thunberg produces sedative-hypnotic effects in mice, which are probably mediated through potentiation of the GABA(A) receptor. Am J Chin Med. 28:1–13.
  • Phillips JE. 2017. Inhaled efficacious dose translation from rodent to human: A retrospective analysis of clinical standards for respiratory diseases. Pharmacol Ther. 178:141–147. doi: 10.1016/j.pharmthera.2017.04.003.
  • Pinato L, Ramos D, Hataka A, Rossignoli PS, Granado MD Jr., Mazzetto MC, Campos LMG. 2017. Day/night expression of MT(1) and MT(2) receptors in hypothalamic nuclei of the primate Sapajus apella. J Chem Neuroanat. 81:10–17. doi: 10.1016/j.jchemneu.2017.01.005.
  • Prast H, Saxer A, Philippu A. 1988. Pattern of in vivo release of endogenous histamine in the mamillary body and the amygdala. Naunyn Schmiedebergs Arch Pharmacol. 337(1):53–57. doi: 10.1007/BF00169476.
  • Reagan-Shaw S, Nihal M, Ahmad N. 2008. Dose translation from animal to human studies revisited. Faseb J. 22(3):659–661. doi: 10.1096/fj.07-9574LSF.
  • Rebai R, Jasmin L, Boudah A. 2017. The antidepressant effect of melatonin and fluoxetine in diabetic rats is associated with a reduction of the oxidative stress in the prefrontal and hippocampal cortices. Brain Res Bull. 134(1):142–150. doi: 10.1016/j.brainresbull.2017.07.013.
  • Rinaldi-Carmona M, Bouaboula M, Congy C, Oury-Donat F, Simiand J, Shire D, Casellas P, Soubrié P, Brelière J-C, Le Fur G. 1993. Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist. Eur J Pharmacol. 246(1):73–80. doi: 10.1016/0922-4106(93)90012-X.
  • Rozov SV, Zant JC, Karlstedt K, Porkka-Heiskanen T, Panula P. 2014. Periodic properties of the histaminergic system of the mouse brain. Eur J Neurosci. 39(2):218–228. doi: 10.1111/ejn.2014.39.issue-2.
  • Sack RL, Hughes RJ, Edgar DM, Lewy AJ. 1997. Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms? Sleep. 20(10):908–915. doi: 10.1093/sleep/20.10.908.
  • Salazar-Juárez A, Barbosa-Méndez S, Jurado N, Hernández-Miramontes R, Leff P, Antón B. 2016. Mirtazapine prevents induction and expression of cocaine-induced behavioral sensitization in rats. Prog Neuropsychopharmacol Biol Psychiatry. 68(1):15–24. doi: 10.1016/j.pnpbp.2016.02.010.
  • Salazar-Juárez A, Barbosa-Méndez S, Merino-Reyes P, Matus-Ortega M, Hernández-Calderón JA, Antón B. 2017. Chronic dosing with mirtazapine does not produce sedation in rats. Braz J Psychiatry. 39(3):228–236. doi: 10.1590/1516-4446-2016-2058.
  • Samarkandi A, Naguib M, Riad W, Thalaj A, Alotibi W, Aldammas F, Albassam A. 2005. Melatonin vs. midazolam premedication in children: a double-blind. Eur J Anaesthesiol. 22(3):189–196. doi: 10.1017/S0265021505000335.
  • Shavali S, Ho B, Govitrapong P, Sawlom S, Ajjimaporn A, Klongpanichapak S, Ebadi M. 2005. Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of β-endorphin an endogenous opioid. Brain Res Bull. 64(6):471–479. doi: 10.1016/j.brainresbull.2004.09.008.
  • Sircar R. 2000 Feb 28. Effect of melatonin on cocaine-induced behavioral sensitization. Brain Res. 857(1–2):295–299. doi:10.1016/S0006-8993(99)02460-9.
  • Spasojevic N, Stefanovic B, Jovanovic P, Dronjak S. 2016. Anxiety and hyperlocomotion induced by chronic unpredictable mild stress can be moderated with melatonin treatment. Folia Biol (Praha). 62(6):250–257.
  • Srikiatkhachorn A, Govitrapong P, Limthavon C. 1994. Up-regulation of 5-HT2 serotonin receptor: a possible mechanism of transformed migraine. Headache. 34(1):8–11. doi: 10.1111/hed.1994.34.issue-1.
  • Stahl SM. 2009. Mechanism of action of trazodone: a multifunctional drug. CNS Spectr. 14:536–546. doi: 10.1017/S1092852900024020.
  • Stone BM, Turner C, Mills SL, Nicholson AN. 2000. Hypnotic activity of melatonin. Sleep. 23(5):1–7. doi: 10.1093/sleep/23.5.1i.
  • Suhner A, Schlagenhauf P, Tschopp A, Hauri-Bionda R, Friedrich-Koch A, Steffen R. 1998. Impact of melatonin on driving performance. J Travel Med. 5(1):7–13. doi: 10.1111/jtm.1998.5.issue-1.
  • Takahashi TT, Vengeliene V, Spanagel R. 2017. Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. Psychopharmacology (Berl). 234(11):1741–1748. doi: 10.1007/s00213-017-4576-y.
  • Toma CD, Svoboda M, Arrich F, Ekmekcioglu C, Assadian O, Thalhammer T. 2007. Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. J Pineal Res. 43(2):206–213. doi: 10.1111/jpi.2007.43.issue-2.
  • Turkistani A, Abdullah KM, Al-Shaer AA, Mazen KF, Alkatheri K. 2007. Melatonin premedication and the induction dose of propofol. Eur J Anaesthesiol. 24(5):399–402. doi: 10.1017/S0265021506001505.
  • Wang F, Li J, Wu C, Yang J, Xu F, Zhao Q. 2003a. The GABAA receptor mediates the hypnotic activity of melatonin in rats. Pharmacol Biochem Behav. 74(3):573–578. doi: 10.1016/S0091-3057(02)01045-6.
  • Wang F, Li J-C, Wu C-F, Yang J-Y, Xu F, Peng F. 2002. Hypnotic activity of melatonin: involvement of semicarbazide hydrochloride, blocker of synthetic enzyme for GABA. Acta Pharmacol Sin. 23(9):860–864.
  • Wang F, Li JC, Wu CF, Yang JY, Zhang RM, Chai HF. 2003b. Influences of a light-dark profile and the pineal gland on the hypnotic activity of melatonin in mice and rats. J Pharm Pharmacol. 55(9):1307–1312. doi: 10.1211/0022357021729.
  • Wu Y-H, Ursinus J, Zhou J-N, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DF. 2013. Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 148(2–3):357–367. doi: 10.1016/j.jad.2012.12.025.
  • Yi X-Y, Ni S-F, Ghadami MR, Meng H-Q, Chen M-Y, Kuang L, Zhang Y-Q, Zhang L, Zhou X-Y. 2018. Trazodone for the treatment of insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 45:25–32. doi: 10.1016/j.sleep.2018.01.010.
  • Zlotos DP, Jockers R, Cecon E, Rivara S, Witt-Enderby PA. 2014. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J Med Chem. 57(8):3161–3185. doi: 10.1021/jm401343c.

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