Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 37, 2020 - Issue 6
1,487
Views
19
CrossRef citations to date
0
Altmetric
Review

Melatonin and alcohol-related disorders

ORCID Icon &
Pages 781-803 | Received 25 Feb 2020, Accepted 22 Apr 2020, Published online: 18 May 2020

References

  • Adamska I, Marhelava K, Walkiewicz D, Kedzierska U, Markowska M, Majewski PM. 2016. All genes encoding enzymes participating in melatonin biosynthesis in the chicken pineal gland are transcribed rhythmically. J Physiol Pharmacol. 67(4):521–530. PMID: 27779473
  • Aktas C, Kanter M, Erboga M, Mete R, Oran M. 2014. Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats. Toxicol Ind Health. 30(9):835–844. doi:10.1177/0748233712464811
  • Ali SS, Ahsan H, Zia MK, Siddiqui T, Khan FH. 2020. Understanding oxidants and antioxidants: classical team with new players. J Food Biochem. 2020:e13145. doi:10.1111/jfbc.13145
  • André P, Laugerette F, Féart C. 2019. Metabolic endotoxemia: a potential underlying mechanism of the relationship between dietary fat intake and risk for cognitive impairments in humans? Nutrients. 11(8):1887. doi:10.3390/nu11081887
  • Anttila P, Järvi K, Latvala J, Romppanen J, Punnonen K, Niemelä O. 2005. Biomarkers of alcohol consumption in patients classified according to the degree of liver disease severity. Scand J Clin Lab Invest. 65(2):141–151. doi:10.1080/00365510510013532
  • Appelqvist H, Wäster P, Kågedal K, Öllinger K. 2013. The lysosome: from waste bag to potential therapeutic target. J Mol Cell Biol. 5(4):214–226. doi:10.1093/jmcb/mjt022
  • Apte MV, Wilson JS, Korsten MA, McCaughan GW, Haber PS, Pirola RC. 1995. Effects of ethanol and protein deficiency on pancreatic digestive and lysosomal enzymes. Gut. 36(2):287–293. doi:10.1136/gut.36.2.287
  • Armstrong LE, Lee EC, Armstrong EM. 2018. Interactions of gut microbiota, endotoxemia, immune function, and diet in exertional heatstroke. J Sports Med (Hindawi Publ Corp). 2018:5724575. doi:10.1155/2018/5724575
  • Aubin HJ, Monfort JC, Benoît O, Goldenberg F, Roullet-Volmi MC, Barrucand D. 1993. Alcool, sommeil et rythmes biologiques [Alcohol, sleep and biological rhythms]. Neurophysiol Clin. 23(1):61–70. doi:10.1016/s0987-7053(05)80283-7
  • Barcia JM, Flores-Bellver M, Muriach M, Sancho-Pelluz J, Lopez-Malo D, Urdaneta AC, Martinez-Gil N, Atienzar-Aroca S, Romero FJ. 2015. Matching diabetes and alcoholism: oxidative stress, inflammation, and neurogenesis are commonly involved. Mediators Inflamm. 2015:624287. doi:10.1155/2015/624287
  • Bartosz G. 2010. Non-enzymatic antioxidant capacity assays: limitations of use in biomedicine. Free Radic Res. 44(7):711–720. doi:10.3109/10715761003758114
  • Baydas G, Yasar A, Tuzcu M. 2005. Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats. J Pineal Res. 39(4):346–352. doi:10.1111/j.1600-079X.2005.00257.x
  • Bendiske J, Bahr BA. 2003. Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis – an approach for slowing Alzheimer disease? J Neuropathol Exp Neurol. 62(5):451–463. doi:10.1093/jnen/62.5.451
  • Beriwal N, Namgyal T, Sangay P, Al Quraan AM. 2019. Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies. Heliyon. 5(1):e01190. doi:10.1016/j.heliyon.2019.e01190
  • Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S. 2019. Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem. 462(1–2):133–155. doi:10.1007/s11010-019-03617-5
  • Bird MD, Kovacs EJ. 2008. Organ-specific inflammation following acute ethanol and burn injury. J Leukoc Biol. 84(3):607–613. doi:10.1189/jlb.1107766
  • Blomgran R, Zheng L, Stendahl O. 2007. Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol. 81(5):1213–1223. doi:10.1189/jlb.0506359
  • Bonnefont-Rousselot D, Collin F. 2010. Melatonin: action as antioxidant and potential applications in human disease and aging. Toxicology. 278(1):55–67. doi:10.1016/j.tox.2010.04.008
  • Brunk UT, Jones CB, Sohal RS. 1992. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res. 275(3–6):395–403. doi:10.1016/0921-8734(92)90042-n
  • Bykov, Yu. V, Hannanova AN, Bekker RA. 2016. Melatonin vs benzodiazepines in pharmacotherapy of insomnias: positive and negative sides of both (a review of the literature). Rev Lect World Sci Discoveries. 7(79):60–82. doi:10.12731/wsd-2016-7-4
  • Campino C, Valenzuela FJ, Torres-Farfan C, Reynolds HE, Abarzua-Catalan L, Arteaga E, Trucco C, Guzmán S, Valenzuela GJ, Seron-Ferre M. 2011. Melatonin exerts direct inhibitory actions on ACTH responses in the human adrenal gland. Horm Metab Res. 43(5):337–342. doi:10.1055/s-0031-1271693
  • Cardinali DP, Esquifino AI, Srinivasan V, Pandi-Perumal SR. 2008. Melatonin and the immune system in aging. Neuroimmunomodulation. 15(4–6):272–278. doi:10.1159/000156470
  • Carrascal L, Nunez-Abades P, Ayala A, Cano M. 2018. Role of melatonin in the inflammatory process and its therapeutic potential. Curr Pharm Des. 24(14):1563–1588. doi:10.2174/1381612824666180426112832
  • Carrasko C, Rodriguez AB, Pariente JA. 2015. Melatonin as a stabilizer of mitochondrial function: role in diseases and aging. Turk J Biol. 39:822–831. doi:10.3906/biy-1504-26
  • Carrillo-Vico A, Lardone PJ, Alvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM. 2013. Melatonin: buffering the immune system. Int J Mol Sci. 14(4):8638–8683. doi:10.3390/ijms14048638
  • Carrillo-Vico A, Reiter RJ, Lardone PJ, Herrera JL, Fernández-Montesinos R, Guerrero JM, Pozo D. 2006. The modulatory role of melatonin on immune responsiveness. Curr Opin Investig Drugs. 7(5):423–431. PMID: 16729718
  • Catorce MN, Gevorkian G. 2016. LPS-induced murine neuroinflammation model: main features and suitability for pre-clinical assessment of nutraceuticals. Curr Neuropharmacol. 14(2):155–164. doi:10.2174/1570159x14666151204122017
  • Cederbaum AI. 2012. Alcohol metabolism. Clin Liver Dis. 16(4):667–685. doi:10.1016/j.cld.2012.08.002
  • Chan KL, Guan XY, Ng IO. 2004. High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma. Hum Pathol. 35(11):1324–1331. doi:10.1016/j.humpath.2004.06.012
  • Chen CP, Boyadjieva NI, Advis JP, Sarkar DK. 2006. Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cells. Alcohol Clin Exp Res. 30(11):1925–1932. doi:10.1111/j.1530-0277.2006.00237.x
  • Chen L, Zhou T, Wu N, O’Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, et al. 2019. Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. Biochim Biophys Acta Mol Basis Dis. 1865(6):1525–1539. doi:10.1016/j.bbadis.2019.03.002
  • Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. 2016. SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway. Clin Cancer Res. 22(10):2496–2507. doi:10.1158/1078-0432.CCR-15-1760
  • Cho S, Namkoong K, Shin M, Park J, Yang E, Ihm J, Thu VT, Kim HK, Han J. 2017. Cardiovascular protective effects and clinical applications of resveratrol. J Med Food. 20(4):323–334. doi:10.1089/jmf.2016.3856
  • Claustrat B, Leston J. 2015. Melatonin: physiological effects in humans. Neurochirurgie. 61(2–3):77–84. doi:10.1016/j.neuchi.2015.03.002
  • Correa M, Sanchis-Segura C, Pastor R, Aragon CM. 2004. Ethanol intake and motor sensitization: the role of brain catalase activity in mice with different genotypes. Physiol Behav. 82(2–3):231–240. doi:10.1016/j.physbeh.2004.03.033
  • Csaba G. 2013. The pineal regulation of the immune system: 40 years since the discovery. Acta Microbiol Immunol Hung. 60(2):77–91. doi:10.1556/AMicr.60.2013.2.1
  • Czarnecki T, Czarnecka E. 2003. Chronobiologiczne aspekty działania alkoholu etylowego [Aspects of chronobiological effects of ethanol]. Psychiatr Pol. 37(3):503–510. PMID: 13677979
  • Damaggio AS, Gorman MR. 2014. The circadian timing system in ethanol consumption and dependence. Behav Neurosci. 128(3):371–386. doi:10.1037/a0036408
  • Danel T, Cottencin O, Tisserand L, Touitou Y. 2009. Inversion of melatonin circadian rhythm in chronic alcoholic patients during withdrawal: preliminary study on seven patients. Alcohol Alcohol. 44(1):42–45. doi:10.1093/alcalc/agn091
  • Danel T, Touitou Y. 2004. Chronobiology of alcohol: from chronokinetics to alcohol-related alterations of the circadian system. Chronobiol Int. 21(6):923–935. doi:10.1081/cbi-200036886
  • Danel T, Touitou Y. 2006. Alcohol consumption does not affect melatonin circadian synchronization in healthy men. Alcohol Alcohol. 41(4):386–390. doi:10.1093/alcalc/agl036
  • Das SK, Dhanya L, Vasudevan DM. 2008. Biomarkers of alcoholism: an updated review. Scand J Clin Lab Invest. 68(2):81–92. doi:10.1080/00365510701532662
  • Das SK, Varadhan S, Gupta G, Mukherjee S, Dhanya L, Rao DN, Vasudevan DM. 2009. Time-dependent effects of ethanol on blood oxidative stress parameters and cytokines. Indian J Biochem Biophys. 46(1):116–121. PMID: 19374264
  • Davis BT 4th, Voigt RM, Shaikh M, Forsyth CB, Keshavarzian A. 2018. Circadian mechanisms in alcohol use disorder and tissue injury. Alcohol Clin Exp Res. 42(4):668–677. doi:10.1111/acer.13612
  • Del Giudice M, Buck CL, Chaby LE, Gormally BM, Taff CC, Thawley CJ, Vitousek MN, Wada H. 2018. What is stress? A systems perspective. Integr Comp Biol. 58(6):1019–1032. doi:10.1093/icb/icy114
  • Donohue TM Jr, Osna NA. 2003. Intracellular proteolytic systems in alcohol-induced tissue injury. Alcohol Res Health. 27(4):317–324. PMCID: PMC6668871
  • Ekman AC, Leppäluoto J, Huttunen P, Aranko K, Vakkuri O. 1993. Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. J Clin Endocrinol Metab. 77(3):780–783. doi:10.1210/jcem.77.3.8370699
  • El-Mas MM, Abdel-Rahman AA. 2019. Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects. Adv Exp Med Biol. 1193:1–33. doi:10.1007/978-981-13-6260-6_1
  • Esteban-Zubero E, López-Pingarrón L, Alatorre-Jiménez MA, Ochoa-Moneo P, Buisac-Ramón C, Rivas-Jiménez M, Castán-Ruiz S, Antoñanzas-Lombarte Á, Tan DX, García JJ, et al. 2017. Melatonin’s role as a co-adjuvant treatment in colonic diseases: A review. Life Sci. 170:72–81. doi:10.1016/j.lfs.2016.11.031
  • Fan J, Edsen-Moore MR, Turner LE, Cook RT, Legge KL, Waldschmidt TJ, Schlueter AJ. 2011. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res. 35(1):47–59. doi:10.1111/j.1530-0277.2010.01321.x
  • Fernandes PA, Tamura EK, D’Argenio-Garcia L, Muxel SM, da Silveira Cruz-machado S, Marçola M, Carvalho-Sousa CE, Cecon E, Ferreira ZS, Markus RP. 2017. Dual effect of catecholamines and corticosterone crosstalk on pineal gland melatonin synthesis. Neuroendocrinology. 104(2):126–134. doi:10.1159/000445189
  • Fonzi S, Solinas GP, Costelli P, Parodi C, Murialdo G, Bo P, Albergati A, Montalbetti L, Savoldi F, Polleri A. 1994. Melatonin and cortisol circadian secretion during ethanol withdrawal in chronic alcoholics. Chronobiologia. 21(1–2):109–112. PMID: 7924629
  • Forsyth CB, Voigt RM, Shaikh M, Tang Y, Cederbaum AI, Turek FW, Keshavarzian A. 2012. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Am J Physiol Gastrointest Liver Physiol. 305:G185–G195. doi:10.1152/ajpgi.00354.2012
  • Foster JH, Powell JE, Marshall EJ, Peters TJ. 1999. Quality of life in alcohol-dependent subjects – a review. Qual Life Res. 8(3):255–261. doi:10.1023/a:1008802711478
  • Furuhata N, Shiba K, Nara N. 1995. [N-acetyl-beta-D-glucosaminidase]. Nihon Rinsho. 53(5):1267–1276. PMID: 7602790
  • Ganesan M, Poluektova LY, Kharbanda KKOsna NA. 2018. Liver as a target of human immunodeficiency virus infection. World J Gastroenterol. 14;24(42):4728-4737. doi:10.3748/wjg.v24.i42.4728.
  • Ge W, Li D, Gao Y, Cao X. 2015. The roles of lysosomes in inflammation and autoimmune diseases. Int Rev Immunol. 34(5):415–431. doi:10.3109/08830185.2014.936587
  • Gheban BA, Rosca IA, Crisan M. 2019. The morphological and functional characteristics of the pineal gland. Med Pharm Rep. 92(3):226–234. doi:10.15386/mpr-1235
  • Ghiselli A, Serafini M, Natella F, Scaccini C. 2000. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med. 29(11):1106–1114. doi:10.1016/s0891-5849(00)00394-4
  • Gonzalez A. 2020. Antioxidants and neuron-astrocyte interplay in brain physiology: melatonin, a neighbor to rely on. Neurochem Res. 2020. doi:10.1007/s11064-020-02972-w
  • Grant AJ, Jessup W, Dean RT. 1992. Accelerated endocytosis and incomplete catabolism of radical-damaged protein. Biochim Biophys Acta. 1134(3):203–209. doi:10.1016/0167-4889(92)90177-d
  • Gutteridge JMC, Halliwell B. 2018. Mini-Review: Oxidative stress, redox stress or redox success? Biochem Biophys Res Commun. 502(2):183–186. doi:10.1016/j.bbrc.2018.05.045
  • Hallberg P, Lind L, Michaëlsson K, Kurland L, Kahan T, Malmqvist K, Ohman KP, Nyström F, Liljedahl U, Syvänen AC, et al. 2003. Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy. BMC Cardiovasc Disord. 3:11. doi:10.1186/1471-2261-3-11
  • Halliwell B. 2012. Free radicals and antioxidants: updating a personal view. Nutr Rev. 70(5):257–265. doi:10.1111/j.1753-4887.2012.00476.x
  • Handy DE, Loscalzo J. 2012. Redox regulation of mitochondrial function. Antioxid Redox Signal. 16(11):1323–1367. doi:10.1089/ars.2011.4123
  • Hardeland R. 2019. Aging, melatonin, and the pro- and anti-inflammatory networks. Int J Mol Sci. 20(5):1223. doi:10.3390/ijms20051223
  • Hatonen T, Forsblom S, Kieseppä T, Lönnqvist J, Partonen T. 2008. Circadian phenotype in patients with the co-morbid alcohol use and bipolar disorders. Alkohol. 43:564–568. doi:10.1093/alcalc/agn057
  • Haus E, Halberg F. 1959. 24-hour rhythms in susceptibility of C mice to a toxic dose of ethanol. J Appl Physiol. 14:878–880. doi:10.1152/jappl.1959.14.6.878
  • Hayakawa T, Noda A, Kondo T. 1982. Changes in serum pancreatic enzymes during 2 months’ abstinence in asymptomatic chronic alcoholics. Am J Gastroenterol. 77(9):625–629. PMID: 6180632
  • Heresbach D, Boutroux D, Bretagne JF, Raoul JL, Siproudhis L, Lebert P, Nicol M, Gosselin M. 1994. L’identification des pancréatites aiguës biliaires et alcooliques par le dosage précoce des enzymes pancréatiques est-elle possible? [Is the identification of acute biliary and alcoholic pancreatitis by early pancreatic enzyme assay possible?] Gastroenterol. Clin Biol. 18(2):135–140. PMID: 7516903
  • Hitzerd SM, Verbrugge SE, Ossenkoppele G, Jansen G, Peters GJ. 2014. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 46(4):793–808. doi:10.1007/s00726-013-1648-0
  • Hu C, Zhao L, Tao J, Li L. 2019. Protective role of melatonin in early-stage and end-stage liver cirrhosis. J Cell Mol Med. 23(11):7151–7162. doi:10.1111/jcmm.14634
  • Hu S, Yin S, Jiang X, Huang D, Shen G. 2009. Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. Eur J Pharmacol. 616(1–3):287–292. doi:10.1016/j.ejphar.2009.06.044
  • Hu W, Ma Z, Jiang S, Fan C, Deng C, Yan X, Di S, Lv J, Reiter RJ, Yang Y. 2016. Melatonin: the dawning of a treatment for fibrosis? J Pineal Res. 60(2):121–131. doi:10.1111/jpi.12302
  • Huang WY, Jou MJ, Peng TI. 2014. mtDNA T8993G mutation-induced F1F0-ATP synthase defect augments mitochondrial dysfunction associated with hypoxia/reoxygenation: the protective role of melatonin. PLoS One. 9(1). doi:10.1016/j.freeradbiomed.2013.11.019
  • Isoda H, Takahashi H, Eguchi Y, Kojima M, Inoue K, Murayama K, Matsuda Y, Anzai K. 2017. Re-evaluation of glycated hemoglobin and glycated albumin with continuous glucose monitoring system as markers of glycemia in patients with liver cirrhosis. Biomed Rep. 7(3):286. doi:10.3892/br.2017.928
  • Jou MJ, Peng TI, Yu PZ, Jou SB, Reiter RJ, Chen JY, Wu HY, Chen CC, Hsu LF. 2007. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J Pineal Res. 43(4):389–403. doi:10.1111/j.1600-079X.2007.00490.x
  • Jung YC, Namkoong K. 2014. Alcohol: intoxication and poisoning - diagnosis and treatment. Handb Clin Neurol. 125:115–121. doi:10.1016/B978-0-444-62619-6.00007-0
  • Kato S, Kawase T, Alderman J, Inatomi N, Lieber CS. 1990. Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats. Gastroenterology. 98(1):203–210. doi:10.1016/0016-5085(90)91311-s
  • Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H. 2013. The effect of inflammatory cytokines in alcoholic liver disease. Mediators Inflamm. 2013:495156. doi:10.1155/2013/495156
  • Kim C, Kim N, Joo H, Youm JB, Park WS, Cuong DV, Park YS, Kim E, Min CK, Han J. 2005. Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin. J Cardiovasc Pharmacol. 46(2):200–210. doi:10.1097/01.fjc.0000171750.97822.a2
  • Kim YD, Hwang SL, Lee EJ, Kim HM, Chung MJ, Elfadl AK, Lee SE, Nedumaran B, Harris RA, Jeong KS 2017. Melatonin ameliorates alcohol-induced bile acid synthesis by enhancing miR-497 expression. J Pineal Res. 62(2). doi:10.1111/jpi.12386
  • Kirkegaard T, Jäättelä M. 2009. Lysosomal involvement in cell death and cancer. Biochim Biophys Acta. 1793(4):746–754. doi:10.1016/j.bbamcr.2008.09.008
  • Koll M, Ahmed S, Mantle D, Donohue TM, Palmer TN, Simanowski UA, Seltz HK, Peters TJ, Preedy VR. 2002. Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo. Metabolism. 51(1):97–104. doi:10.1053/meta.2002.28967
  • Kolter T, Sandhoff K. 2010. Lysosomal degradation of membrane lipids. FEBS Lett. 584(9):1700–1712. doi:10.1016/j.febslet.2009.10.021
  • Kuhn C, Swartzwelder S, Wilson W, Wilson LH, Foster J. 2008. Buzzed: the straight facts about the most used and abused drugs from alcohol to ecstasy. third ed. New York, NY: WW Norton & Company Ltd.
  • Kulkarni SS, Cantó C. 2015. The molecular targets of resveratrol. Biochim Biophys Acta. 1852(6):1114–1123. doi:10.1016/j.bbadis.2014.10.005
  • Kurhaluk N, Sliuta A, Kyriienko S, Winklewski PJ. 2017. Melatonin restores white blood cell count, diminishes glycated haemoglobin level and prevents liver, kidney and muscle oxidative stress in mice exposed to acute ethanol intoxication. Alcohol Alcoholism. 52(5):521–528. doi:10.1093/alcalc/agx045
  • Kurhaluk N, Szarmach A, Zaitseva O, Sliuta A, Kyriienko S, Winklewski PJ. 2018a. Effects of melatonin on low-dose lipopolysaccharide-induced oxidative stress in mouse liver, muscle and kidney. Can J Physiol Pharmacol. 96:1153–1160. doi:10.1139/cjpp-2018-0011
  • Kurhaluk N, Zaitseva O, Sliuta A, Kyriienko S, Winklewski PJ. 2018b. Melatonin diminishes oxidative stress in plasma, retains erythrocyte resistance and restores white blood cell count after low-dose lipopolysaccharide exposure in mice. Gen Physiol Biophys. 37(5):571–580. doi:10.4149/gpb_2018010
  • Kuršvietienė L, Stanevičienė I, Mongirdienė A, Bernatonienė J. 2016. Multiplicity of effects and health benefits of resveratrol. Medicina (Kaunas). 52(3):148–155. doi:10.1016/j.medici.2016.03.003
  • Laios K. 2017. The Pineal Gland and its earliest physiological description. Hormones (Athens). 16(3):328–330. doi:10.14310/horm.2002.1751
  • Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell. 149(2):274–293. doi:10.1016/j.cell.2012.03.017
  • Lash LH. 2019. Environmental and genetic factors influencing kidney toxicity. Semin Nephrol. 39(2):132–140. doi:10.1016/j.semnephrol.2018.12.003
  • Lawrence BM, Herbert M, Jeffcoate WJ. 1983. Circadian variation in effects of ethanol in man. Pharmacol Biochem Behav. 18(Suppl. 1):555–558. doi:10.1016/0091-3057(83)90235-6
  • Lee J, Giordano S, Zhang J. 2012. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 441(2):523–540. doi:10.1042/BJ20111451
  • Lemoine P, Garfinkel D, Laudon M, Zisapel N. 2011. Prolonged–release melatonin for insomnia – an open–label long–term study of efficacy, safety, and withdrawal. Ther Clin Risk Manag. 7:301–311. doi:10.2147/TCRM.S23036
  • Lewiński A, Sewerynek E. 1986. Melatonin inhibits the basal and TSH-stimulated mitotic activity of thyroid follicular cells in vivo and in organ culture. J Pineal Res. 3(3):291–299. doi:10.1111/j.1600-079x.1986.tb00752.x
  • Li H, Xia N, Förstermann U. 2012a. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 26(2):102–110. doi:10.1016/j.niox.2011.12.006
  • Li S, Korkmaz S, Loganathan S, Weymann A, Radovits T, Barnucz E, Hirschberg K, Hegedüs P, Zhou Y, Tao L, et al. 2012b. Acute ethanol exposure increases the susceptibility of the donor hearts to ischemia/reperfusion injury after transplantation in rats. PLoS One. 7(11):e49237. doi:10.1371/journal.pone.0049237
  • Li Y, Wang S, Ni HM, Huang H, Ding WX. 2014. Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. Biomed Res Int. 2014:498491. doi:10.1155/2014/498491
  • Liang Y, Harris FL, Brown LA. 2014. Alcohol-induced mitochondrial oxidative stress and alveolar macrophage dysfunction. Biomed Res Int. 2014:371593. doi:10.1155/2014/371593
  • Liu L, Zhang N, Dou Y, Mao G, Bi C, Pang W, Liu X, Song D, Deng H. 2017. Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells. Sci Rep. 7:41862. doi:10.1038/srep41862
  • Lloyd JB. 1996. Metabolite efflux and influx across the lysosome membrane. Subcell Biochem. 27:361–386. doi:10.1007/978-1-4615-5833-0_11
  • Loiseau F, Le Bihan C, Hamon M, Thiébot M-H. 2006. Effects of melatonin and agomelatine in anxiety-related procedures in rats: interaction with diazepam. Eur Neuropsychopharmacol. 16(6):417–428. doi:10.1016/j.euroneuro.2005.11.007
  • Ma Q, Reiter RJ, Chen Y. 2019. Role of melatonin in controlling angiogenesis under physiological and pathological conditions. Angiogenesis. 2019. doi:10.1007/s10456-019-09689-7
  • Majumdar SK, Miles A. 1987. Disturbed melatonin secretion in chronic alcoholism and withdrawal. Clin Chem. 33(7):1291. PMID: 3594887
  • Mäkelä P, Raitasalo K, Wahlbeck K. 2015. Mental health and alcohol use: a cross-sectional study of the Finnish general population. Eur J Public Health. 25(2):225–231. doi:10.1093/eurpub/cku133
  • Maldonado MD, Moreno H, Calvo JR. 2009. Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum. Clin Nutr. 28(2):188–191. doi:10.1016/j.clnu.2009.02.001
  • Maldonado RF, Sá-Correia I, Valvano MA. 2016. Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol Rev. 40(4):480–493. doi:10.1093/femsre/fuw007
  • Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. 2001. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther. 298(2):737–743. PMID: 11454938
  • Marchewka Z, Stokłosa A, Długosz A. 2005. Lysosomal enzymes in urine for the assessment of renal function in workers exposed to gasoline. Acta Toxicological. 13(2):77–83.
  • Markus R.P, Fernandes P.A, Kinker G.S, da Silveira Cruz-Machado SMarçola M. 2018. Immune-pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. British Journal Of Pharmacology. 175(16):3239–3250.
  • Markus R.P, Ferreira Z.S, Fernandes Pedro A.C.MCecon E. 2007. The immune-pineal axis: a shuttle between endocrine and paracrine melatonin sources. Neuroimmunomodulation. 14(3–4):126–133.
  • Markus RP, Fernandes PA, Kinker GS, da Silveira Cruz-machado S, Marçola M. 2018. Immune-pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. Br J Pharmacol. 175(16):3239–3250. doi:10.1111/bph.14083
  • Markus RP, Ferreira ZS, Fernandes PA, Cecon E. 2007. The immune-pineal axis: a shuttle between endocrine and paracrine melatonin sources. Neuroimmunomodulation. 14(3–4):126–133. doi:10.1159/000110635
  • Marques SS, Magalhães LM, Tóth IV, Segundo MA. 2014. Insights on antioxidant assays for biological samples based on the reduction of copper complexes-the importance of analytical conditions. Int J Mol Sci. 15(7):11387–11402. doi:10.3390/ijms150711387
  • Matsushima M, Takahashi T, Ichinose M, Miki K, Kurokawa K, Takahashi K. 1991. Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. Biochem Biophys Res Commun. 178(3):1459–1464. doi:10.1016/0006-291x(91)91057-j
  • Mayo JC, Aguado A, Cernuda-Cernuda R, Álvarez-Artime A, Cepas V, Quirós-González I, Hevia D, Sáinz RM. 2018. Melatonin uptake by cells: an answer to its relationship with glucose? Molecules. 23(8):1999. doi:10.1016/0006-291x(91)91057-j
  • Menéndez-Menéndez J, Martínez-Campa C. 2018. Melatonin: an anti-tumor agent in hormone-dependent cancers. Int J Endocrinol. 2018:3271948. doi:10.1155/2018/3271948
  • Meng JF, Shi TC, Song S, Zhang ZW, Fang YL. 2017. Melatonin in grapes and grape-related foodstuffs: A review. Food Chem. 231:185–191. doi:10.1016/j.foodchem.2017.03.137
  • Milnerowicz H, Bukowski R, Jabłonowska M, Ściskalska M, Milnerowicz U. 2014. The antioxidant profiles, lysosomal and membrane enzymes activity in patients with acute pancreatitis. Mediators Inflamm. 2014:376518. doi:10.1155/2014/376518
  • Mindell JA. 2012. Lysosomal acidification mechanisms. Annu Rev Physiol. 74:69–86. doi:10.1146/annurev-physiol-012110-142317
  • Molfino A, Laviano A, Rossi Fanelli F. 2010. Sleep-inducing effect of beer: a melatonin- or alcohol-mediated effect? Clin Nutr. 29(2):272. doi:10.1016/j.clnu.2009.08.018
  • Mukai M, Uchimura N, Hirano T, Ohshima H, Ohshima M, Nakamura J. 1998. Circadian rhythms of hormone concentrations in alcohol withdrawal. Psychiatry Clin Neurosci. 52(2):238–240. doi:10.1111/j.1440-1819.1998.tb01051.x
  • Muriach M, Bosch-Morell F, Alexander G, Blomhoff R, Barcia J, Arnal E, Almansa I, Romero FJ, Miranda M. 2006. Lutein effect on retina and hippocampus of diabetic mice. Free Radic Biol Med. 41(6):979–984. doi:10.1016/j.freeradbiomed.2006.06.023
  • Niemelä O. 2007. Biomarkers in alcoholism. Clin Chim Acta. 377(1–2):39–49. doi:10.1016/j.cca.2006.08.035
  • Nordmann R, Ribière C, Rouach H. 1987. Involvement of iron and iron-catalyzed free radical production in ethanol metabolism and toxicity. Enzyme. 37(1–2):57–69. doi:10.1159/000469241
  • Owino S, Buonfiglio DDC, Tchio C, Tosini G. 2019. Melatonin signaling a key regulator of glucose homeostasis and energy metabolism. Front Endocrinol (Lausanne). 10:488. doi:10.3389/fendo.2019.00488
  • Paradies G, Paradies V, Ruggiero FM, Petrosillo G. 2017. Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin. Cell Mol Life Sci. 74(21):3897–3911. doi:10.1007/s00018-017-2619-5
  • Patere SN, Majumdar AS, Saraf MN. 2011. Exacerbation of alcohol-induced oxidative stress in rats by polyunsaturated Fatty acids and iron load. Indian J Pharm Sci. 73(2):152–158. doi:10.4103/0250-474x.91578
  • Perera RM, Zoncu R. 2016. The lysosome as a regulatory hub. Annu Rev Cell Dev Biol. 32:223–253. doi:10.1146/annurev-cellbio-111315-125125
  • Persson HL, Yu Z, Tirosh O, Eaton JW, Brunk UT. 2003. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med. 34(10):1295–1305. doi:10.1016/s0891-5849(03)00106-0
  • Petrosillo G, Fattoretti P, Matera M, Ruggiero FM, Bertoni-Freddari C, Paradies G. 2008. Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection. Rejuvenation Res. 11(5):935–943. doi:10.1089/rej.2008.0772
  • Piesiewicz A, Kedzierska U, Adamska I, Usarek M, Zeman M, Skwarlo-Sonta K, Majewski PM. 2012. Pineal arylalkylamine N-acetyltransferase (Aanat) gene expression as a target of inflammatory mediators in the chicken. Gen Comp Endocrinol. 179(2):143–151. doi:10.1016/j.ygcen.2012.08.013
  • Pinchuk I, Shoval H, Dotan Y, Lichtenberg D. 2012. Evaluation of antioxidants: scope. Chem Phys Lipids. 165(6):638–647. doi:10.1016/j.chemphyslip.2012.05.003
  • Pisoschi AM, Pop A. 2015. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem. 97:55–74. doi:10.1016/j.ejmech.2015.04.040
  • Pohanka M. 2016. Toxicology and the biological role of methanol and ethanol: current view. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 160(1):54–63. doi:10.5507/bp.2015.023
  • Ponnappa BC, Rubin E. 2000. Modeling alcohol’s effects on organs in animal models. Alcohol Res Health. 24(2):93–104. PMCID: PMC6713009
  • Powers MS, Chester JA. 2014. Effects of stress, acute alcohol treatment, or both on pre-pulse inhibition in high- and low-alcohol preferring mice. Alcohol. 48(2):113–122. doi:10.1016/j.alcohol.2013.12.002
  • Puntarulo S, Cederbaum AI. 1989. Chemiluminescence from acetaldehyde oxidation by xanthine oxidase involves generation of and interactions with hydroxyl radicals. Alcohol Clin Exp Res. 13(1):84–90. doi:10.1111/j.1530-0277.1989.tb00288.x
  • Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L. 2018. S-nitrosoglutathione reductase dysfunction contributes to obesity-associated hepatic insulin resistance via regulating autophagy. Diabetes. 67(2):193–207. doi:10.2337/db17-0223
  • Rajput P, Jangra A, Kwatra M, Mishra A, Lahkar M. 2017. Alcohol aggravates stress-induced cognitive deficits and hippocampal neurotoxicity: protective effect of melatonin. Biomed Pharmacother. 91:457–466. doi:10.1016/j.biopha.2017.04.077
  • Reinberg A, Clench J, Aymard N, Galliot M, Bourdon R, Gervais P, Abulker C, Dupont J. 1975. Circadian variations of the effects of ethanol and blood ethanol values in the healthy adult man. Chronopharmacological Study J Physiol (Paris). 70:435–456. PMID: 1221110
  • Reiter RJ, Tan DX, Manchester LC, Lopez-Burillo S, Sainz RM, Mayo JC. 2003a. Melatonin: detoxification of oxygen and nitrogen-based toxic reactants. Adv Exp Med Biol. 527:539–548. doi:10.1007/978-1-4615-0135-0_62
  • Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. 2003b. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 50(4):1129–1146. PMID: 14740000
  • Reiter RJ, Tan DX, Osuna C, Gitto E. 2000. Actions of melatonin in the reduction of oxidative stress. A Review J Biomed Sci. 7(6):444–458. doi:10.1007/BF02253360
  • Ren W, Liu G, Chen S, Yin J, Wang J, Tan B, Wu G, Bazer F.W, Peng Y, Li T, Reiter R.JYin Y. 2017. Melatonin signaling in T cells: functions and applications. J. Pineal Res. 62(3):3.
  • Ren W, Liu G, Chen S, Yin J, Wang J, Tan B, Wu G, Bazer FW, Peng Y, Li T, et al. 2017. Melatonin signaling in T cells: functions and applications. J Pineal Res. 62:3. doi:10.1111/jpi.12394
  • Roberg K, Ollinger K. 1998. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol. 152(5):1151–1156. PMCID: PMC1858594
  • Rosenwasser AM. 2015. Chronobiology of ethanol: animal models. Alcohol. 49(4):311–319. doi:10.1016/j.alcohol.2015.04.001
  • Rupp TL, Acebo C, Carskadon MA. 2007. Evening alcohol suppresses salivary melatonin in young adults. Chronobiol Int. 24(3):463–470. doi:10.1080/07420520701420675
  • Saar H, Paulus W. 1941. Experimentelle untersuchungen ubdie ausscheidung des alkohols in schlaf. Dst Z Gesamte Gerichtl Med. 35:28–36. doi:10.1007/s00213-003-1532-9
  • Salehi B, Sharopov F, Fokou PVT, Kobylinska A, Jonge L, Tadio K, Sharifi-Rad J, Posmyk MM, Martorell M, Martins N, et al. 2019. Melatonin in medicinal and food plants: occurrence, bioavailability, and health potential for humans. Cells. 8(7):681. doi:10.3390/cells8070681
  • Sánchez AB, Clares B, Rodríguez-Lagunas MJ, Fábrega MJ, Calpena AC. 2020. Study of melatonin as preventive agent of gastrointestinal damage induced by sodium diclofenac. Cells. 9(1):E180. doi:10.3390/cells9010180
  • Santofimia-Castaño P, Ruy DC, Fernandez-Bermejo M, Salido GM, Gonzalez A. 2014. Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells. Mol Cell Biochem. 397(1–2):75–86. doi:10.1007/s11010-014-2174-4
  • Sapède D, Cau E. 2013. The pineal gland from development to function. Curr Top Dev Biol. 106:171–215. doi:10.1016/B978-0-12-416021-7.00005-5
  • Schmitz MM, Sepandj A, Pichler PM, Rudas S. 1996. Disrupted melatonin-secretion during alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 20(6):983–995. doi:10.1016/0278-5846(96)00078-4
  • Schräder M, Danielsson C, Wiesenberg I, Carlberg C. 1996. Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers. J Biol Chem. 271(33):19732–19736. doi:10.1074/jbc.271.33.19732
  • Skwarlo-Sonta K, Majewski P, Markowska M, Oblap R, Olszanska B. 2003. Bidirectional communication between the pineal gland and the immune system. Can J Physiol Pharmacol. 81(4):342–349. doi:10.1139/y03-026
  • Smirnov AN. 2001. Nuclear melatonin receptors. Biochemistry (Mosc). 66(1):19–26. doi:10.1023/a:1002821427018
  • Somani SM, Husain K, Diaz-Phillips L, Lanzotti DJ, Kareti KR, Trammell GL. 1996. Interaction of exercise and ethanol on antioxidant enzymes in brain regions of the rat. Alcohol. 13(6):603–610. doi:10.1016/s0741-8329(96)00075-4
  • Sommavilla M, Sánchez-Villarejo MV, Almansa I, Sánchez-Vallejo V, Barcia JM, Romero FJ, Miranda M. 2012. The effects of acute ethanol exposure and ageing on rat brain glutathione metabolism. Free Radic Res. 46(9):1076–1081. doi:10.3109/10715762.2012.688963
  • Sönmez MF, Narin F, Akkuş D, Türkmen AB. 2012. Melatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidney. Ren Fail. 34(4):480–486. doi:10.3109/0886022X.2011.649678
  • Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, Lleonart ME. 2013. Oxidative stress and cancer: an overview. Ageing Res Rev. 12(1):376–390. doi:10.1016/j.arr.2012.10.004
  • Stauch B, Johansson LC, Cherezov V. 2019. Structural insights into melatonin receptors. Febs J. 2019. doi:10.1111/febs.15128
  • Sugden D. 1983. Psychopharmacological effects of melatonin in mouse and rat. J Pharmacol Exp Ther. 227:587–591. doi:10.1016/j.arr.2012.10.004
  • Szajda S, Waszkiewicz N, Stypułkowska A, Dadan J, Zwierz K. 2010. Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma. Folia Histochem Cytobiol. 48(3):351–357. doi:10.2478/v10042-010-0060-9
  • Szymanska B, Marchewka Z, Długosz A. 2012. [Ocena wybranych markerów nefrotoksyczności u pracowników laboratorium narażonych zawodowo na czynniki chemiczne] Evaluation of nephrotoxicity markers in researcher laboratory worker occupationally exposed to chemicals. Bromat Chem Toksykol. XLV(2):235–240. www.bwmeta1.element.agro-04e719ec-52ad-4715-a856-02377f3a1b17
  • Tan DX, Manchester LC, Reiter RJ, Qi WB, Karbownik M, Calvo JR. 2000. Significance of melatonin in antioxidative defense system: reactions and products. Biol Signals Recept. 9(3–4):137–159. doi:10.1159/000014635
  • Tan DX, Xu B, Zhou X, Reiter RJ. 2018. Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland. Molecules. 23(2):301. doi:10.3390/molecules23020301
  • Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C. 2017. Melatonin: pharmacology, functions and therapeutic benefits. Curr Neuropharmacol. 15(3):434–443. doi:10.2174/1570159X14666161228122115
  • Tosini G, Owino S, Guillaume JL, Jockers R. 2014. Understanding melatonin receptor pharmacology: latest insights from mouse models and their relevance to human disease. Bioessays. 36(8):778–787. doi:10.1002/bies.201400017
  • Trifonov S, Yamashita Y, Kase M, Maruyama M, Sugimoto T. 2016. Overview and assessment of the histochemical methods and reagents for the detection of β-galactosidase activity in transgenic animals. Anat Sci Int. 91(1):56–67. doi:10.1007/s12565-015-0300-3
  • Tsai JP, Lee CJ, Subeq YM, Lee RP, Hsu BG. 2017. Acute alcohol intoxication exacerbates rhabdomyolysis-induced acute renal failure in rats. Int J Med Sci. 14(7):680–689. doi:10.7150/ijms.19479
  • Turk B, Turk V. 2009. Lysosomes as “suicide bags” in cell death: myth or reality? J Biol Chem. 284(33):21783–21787. doi:10.1074/jbc.R109.023820
  • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. doi:10.1016/j.biocel.2006.07.001
  • Varga ZV, Matyas C, Paloczi J, Pacher P. 2017. Alcohol misuse and kidney injury: epidemiological evidence and potential mechanisms. Alcohol Res. 38(2):283–288. PMCID: PMC5513691
  • Vengeliene V, Noori HR, Spanagel R. 2015. Activation of melatonin receptors reduces relapse-like alcohol consumption. Neuropsychopharmacology. 40(13):2897–2906. doi:10.1038/npp.2015.143
  • Vishnoi S, Raisuddin S, Parvez S. 2016. Glutamate excitotoxicity and oxidative stress in epilepsy: modulatory role of melatonin. J Environ Pathol Toxicol Oncol. 35(4):365–374. doi:10.1615/JEnvironPatholToxicolOncol.2016016399
  • Voican CS, Njiké-Nakseu M, Boujedidi H, Barri-Ova N, Bouchet-Delbos L, Agostini H, Maitre S, Prévot S, Cassard-Doulcier AM, Naveau S, et al. 2015. Alcohol withdrawal alleviates adipose tissue inflammation in patients with alcoholic liver disease. Liver Int. 35(3):967–978. doi:10.1111/liv.12575
  • Voss JU, Roller M, Brinkmann E, Mangelsdorf I. 2005. Nephrotoxicity of organic solvents: biomarkers for early detection. Int Arch Occup Environ Health. 78(6):475–485. doi:10.1007/s00420-005-0611-0
  • Wade AG, Crawford G, Ford I, McConnachie A, Nir T, Laudon M, Zisapel N. 2011. Prolonged-release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr Med Res Opin. 27:87–98. doi:10.1185/03007995.2010.537317
  • Waszkiewicz N, Szajda SD, Kępka A, Zalewska A, Konarzewska B, Szulc A, Chojnowska S, Zwierz-Gugała DZ, Zwierz K. 2009. [Hepatotoksyczność „binge drinking”] Hepatotoxicity of “binge drinking”. Med Sci Rev Hepatol. 9:106–112. https://www.umb.edu.pl/photo/pliki/progress-file/phs/phs_2012_2/52-56_waszkiewicz.pdf
  • Waszkiewicz N, Szajda SD, Zalewska A, Szulc A, Kępka A, Minarowska A, Wojewódzka-Żelezniakowicz M, Konarzewska B, Chojnowska S, Ladny JR, et al. 2012. Alcohol abuse and glycoconjugate metabolism. Folia Histochem Cytobiol. 50(1):1–11. doi:10.5603/FHC.2012.0001
  • Watts C. 2012. The endosome-lysosome pathway and information generation in the immune system. Biochim Biophys Acta. 1824(1):14–21. doi:10.1016/j.bbapap.2011.07.006
  • Wetterberg L, Aperia B, Gorelick DA, Gwirtzman HE, McGuire MT, Serafetinides EA, Yuwiler A. 1992. Age, alcoholism and depression are associated with low levels of urinary melatonin. J Psychiatry Neurosci. 17(5):215–224. PMID: 1489763
  • Wilson J.S, Korsten M.A, Apte M.V, Thomas M.C, Haber P.SPirola R.C. 1990. Both ethanol consumption and protein deficiency increase the fragility of pancreatic lysosomes. J. Lab. Clin. Med. 115(6):749–755.
  • Wilson JS, Korsten MA, Apte MV, Thomas MC, Haber PS, Pirola RC. 1990. Both ethanol consumption and protein deficiency increase the fragility of pancreatic lysosomes. J Lab Clin Med. 115(6):749–755. PMID: 2366035
  • Winston GW, Harvey W, Berl L, Cederbaum AI. 1983. The generation of hydroxyl and alkoxyl radicals from the interaction of ferrous bipyridyl with peroxides. Biochem J. 216(2):415–421. doi:10.1042/bj2160415
  • Witek B, Fronczyk W, Jóźwik A, Walczak M, Kamińska A, Kołątaj A. 2014. The effect of dietary protein level on selected degradative enzymes activity of hepatocyte cellular subfractions in experimental mice. Animal Sci Papers Reports. 32(3):269–277. www.bwmeta1.element.agro-93f690be-5729-45fa-b502-1786be6b7a8a
  • Witek B, Ochwanowska E, Kolataj A, Slewa A, Stanislawska I. 2001. Effect of melatonin administration on activities of some lysosomal enzymes in the mouse. Neuro Endocrinol Lett. 22(3):181–185. pii: NEL220301A02
  • Wright ML, Pikula A, Babski AM, Labieniec KE, Wolan RB. 1997. Effect of melatonin on the response of the thyroid to thyrotropin stimulation in vitro. Gen Comp Endocrinol. 108(2):298–305. doi:10.1006/gcen.1997.6979
  • Xia N, Daiber A, Förstermann U, Li H. 2017. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 174(12):1633–1646. doi:10.1111/bph.13492
  • Xia Y, Chen S, Zeng S, Zhao Y, Zhu C, Deng B, Zhu G, Yin Y, Wang W, Hardeland R, et al. 2019. Melatonin in macrophage biology: current understanding and future perspectives. J Pineal Res. 66(2):e12547. doi:10.1111/jpi.12547
  • Yang M, Tao J, Chai M, Wu H, Wang J, Li G, He C, Xie L, Ji P, Dai Y, et al. 2017. Melatonin improves the quality of inferior bovine oocytes and promoted their subsequent IVF embryo development: mechanisms and results. Molecules. 22(12):2059.
  • Yang M., Tao J., Chai M., Wu H., Wang J., Li G., He C., Xie L., Ji P., Dai Y., Yang L.Liu G. 2017. Melatonin improves the quality of inferior bovine oocytes and promoted their subsequent ivf embryo development: mechanisms and results. melatonin improves the quality of inferior bovine oocytes and promoted their subsequent ivf embryo development: mechanisms and results 22(12) 2059. 12 711 doi:10.3390/molecules22122059
  • Yao D, Dong Q, Tian Y, Dai C, Wu S. 2018. Lipopolysaccharide stimulates endogenous β-glucuronidase via PKC/NF-κB/c-myc signaling cascade: a possible factor in hepatolithiasis formation. Mol Cell Biochem. 444(1–2):93–102. doi:10.1007/s11010-017-3234-3
  • Yeh MY, Burnham EL, Moss M, Brown LA. 2007. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med. 176(3):270–276. doi:10.1164/rccm.200611-1722OC
  • Yeligar SM, Harris FL, Hart CM, Brown LA. 2012. Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases. J Immunol. 188(8):3648–3657. doi:10.4049/jimmunol.1101278
  • Yi WJ, Kim TS. 2017. Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization. Int Immunopharmacol. 48:146–158. doi:10.1016/j.intimp.2017.05.006
  • Zakhari S. 2006. Overview: how is alcohol metabolized by the body? Alcohol Res Health. 29(4):245–254. PMCID: PMC6527027
  • Zeng T, Zhang CL, Xiao M, Yang R, Xie KQ. 2016. Critical roles of kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials. Front Immunol. 7:538. doi:10.3389/fimmu.2016.00538
  • Zhang JJ, Meng X, Li Y, Zhou Y, Xu DP, Li S, Li HB. 2017. Effects of melatonin on liver injuries and diseases. Int J Mol Sci. 18(4):673. doi:10.3390/ijms18040673
  • Zhong W, Li Q, Zhang W, Sun Q, Sun X, Zhou Z. 2015. Modulation of intestinal barrier and bacterial endotoxin production contributes to the beneficial effect of nicotinic acid on alcohol-induced endotoxemia and hepatic inflammation in rats. Biomolecules. 5(4):2643–2658. doi:10.3390/biom5042643

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.