Blood pressure medication should be routinely dosed at bedtime. An internist’s critical appraisal of the editorial by Rainhold Kreutz et al. (2020). Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure. 29 (3):135–136

References

• Allen FM, Sherrill JW. 1922. The treatment of arterial hypertension. J Metabol Res. 2:429–545. (doi not available).
   Google Scholar
• Bowles NP, Thosar SS, Herzig MX, Shea SA. 2018. Chronotherapy for hypertension. Curr Hypertens Rep. 20(11):97. doi:10.1007/s11906-018-0897-4.
   PubMed Web of Science ®Google Scholar
• De Giorgi A, Menegatti AM, Fabbian F, Portaluppi F, Manfredini R. 2013. Circadian rhythms and medical diseases: does it matter when drugs are taken?. European Journal of Internal Medicine. 24(8):698–706. doi:10.1016/j.ejim.2013.03.019.
   PubMed Web of Science ®Google Scholar
• Hay JA. 1931. British Medical Association lecture on the significance of raised blood pressure. BMJ. 2(3679):43–47. (doi not available). doi:10.1136/bmj.2.3679.43.
   PubMedGoogle Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2010. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 27(8):1629–1651. doi:10.3109/07420528.2010.510230.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Smolensky MH, Fernández JR, Mojón A, Portaluppi F. 2016. Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks. Hypertens Res. 39(5):277–292. doi:10.1007/s00125-015-3748-8.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, et al. 2019. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. In press. doi:10.1093/eurheartj/ehz475.
   Google Scholar
• Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, et al. 2018. Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention. Eur Heart J. 39(47):4159–4171. doi:10.1093/eurheartj/ehy754.
   PubMed Web of Science ®Google Scholar
• Hoshide Y, Kario K, Schwartz JE, Hoshide S, Pickering TG, Shimada K. 2002. Incomplete benefit of antihypertensive therapy on stroke reduction in older hypertensives with abnormal nocturnal blood pressure dipping (extreme-dippers and reverse-dippers). Am J Hypertens. 15:844–850. doi:10.1016/s0895-7061(02)03020-0.
   PubMed Web of Science ®Google Scholar
• Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K. 2001. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension. 38(4):852–857. doi:10.1161/hy1001.092640.
   PubMed Web of Science ®Google Scholar
• Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G. 2020. Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the Hygia project. Blood Pressure. 29(3):135–136. doi:10.1080/08037051.2020.1747696.
   PubMed Web of Science ®Google Scholar
• Myers MG, Godwin M, Dawes M, Kiss A, Tobe SW, Kaczorowski J. 2010. Measurement of blood pressure in the office: recognizing the problem and proposing the solution. Hypertension. 55(2):195–200. doi:10.1161/HYPERTENSIONAHA.109.141879.
   PubMed Web of Science ®Google Scholar
• Pierdomenico SD, Bucci A, Costantini F, Lapenna D, Cuccurullo F, Mezzetti A. 1998. Circadian blood pressure changes and myocardial ischemia in hypertensive patients with coronary artery disease. J Am Coll Cardiol. 31(7):1627–1634. doi:10-1016/s0735-1097(98)00163-6.
   PubMed Web of Science ®Google Scholar
• Pierdomenico SD, Pierdomenico AM, Coccina F, Lapenna D, Porreca E. 2016. Circadian blood pressure changes and cardiovascular risk in elderly-treated hypertensive patients. Hypertens Res. 39(11):805–811. doi:10.1038/hr.2016.74.
   PubMed Web of Science ®Google Scholar
• Salles GF, Reboldi G, Fagard RH, Cardoso C, Pierdomenico SD, Verdecchia P, Eguchi K, Kario K, Hoshide S, Polonia J, et al. 2016. Prognostic impact of the nocturnal blood pressure fall in hypertensive patients: the ambulatory blood pressure collaboration in patients with hypertension (ABC-H) meta-analysis. Hypertension. 67(4):693–700. doi:10.1161/HYPERTENSIONAHA.115.06981
   PubMed Web of Science ®Google Scholar
• Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, et al. 1997. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 350(9080):757–764. doi:10.1016/s0140-6736(97)05381-6.
   PubMed Web of Science ®Google Scholar
• Staessen JA, O’Brien ET, Amery AK, Atkins N, Baumgart P, De Cort P, Degaute JP, Dolenc P, De Gaudemaris R, Enström I, et al. 1994. Ambulatory blood pressure in normotensive and hypertensive subjects: results from an international database. J Hypertens. 12(Suppl7):S1–12. doi:10.1097/00004872-199400127-00001. (doi not available).
   PubMedGoogle Scholar
• Stranges PM, Drew AM, Rafferty P, Shuster JE, Brooks AD. 2015. Treatment of hypertension with chronotherapy. Annals of Pharmacotherapy. 49(3):323–334. doi:10.1177/1060028014563535.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Kuwajima I, Aono T, Kanemaru A, Nishinaga M, Shibata H, Ozawa T. 2000. Prognostic Value of Nighttime Blood Pressure in the Elderly: A Prospective Study of 24-Hour Blood Pressure.. Hypertens Res. 23(4):323–330. doi:10.1291/hypres.23.323.
   PubMed Web of Science ®Google Scholar
• Uen S, Asghari S, Nickenig G, Mengden T. 2009. Early morning surge and dipping status of blood pressure: are these of predictive value for silent myocardial ischemia? The Journal of Clinical Hypertension. 11(7):351–357. doi:10.1111/j.1751-7176.2009.00139.x.
   Web of Science ®Google Scholar
• White PD. 1937. Heart Disease. 2nd. New York (NY): MacMillan Co:326. (doi not available).
   Google Scholar
• Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, et al. 2018. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 39:3021–3104. doi:10.1093/eaurheartj/ehy339.
   PubMed Web of Science ®Google Scholar
• Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. 2000. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients: the Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 342(3):145–153. doi:10.1056/NEJM200001203420301.
   PubMed Web of Science ®Google Scholar