Sleep behavior is associated with over two-fold decrease of sperm count in a chronotype-specific pattern: path analysis of 667 young men in the MARHCS study

References

• Allebrandt KV, Teder-Laving M, Cusumano P, Frishman G, Levandovski R, Ruepp A, Hidalgo MPL, Costa R, Metspalu A, Roenneberg T, et al. 2017. Identifying pathways modulating sleep duration: from genomics to transcriptomics. Sci Rep. 7:4555. doi:https://doi.org/10.1038/s41598-017-04027-7
   PubMed Web of Science ®Google Scholar
• Alvarenga TA, Hirotsu C, Mazaro-Costa R, Tufik S, Andersen ML. 2015. Impairment of male reproductive function after sleep deprivation. Fertil Steril. 103:1355–1362 e1351. doi:https://doi.org/10.1016/j.fertnstert.2015.02.002
   PubMed Web of Science ®Google Scholar
• Barratt CLR, De Jonge CJ, Sharpe RM. 2018. 'Man Up': the importance and strategy for placing male reproductive health centre stage in the political and research agenda. Hum Reprod. 33:541–545. doi:https://doi.org/10.1093/humrep/dey020
   Google Scholar
• Basner M, Dinges DF. 2018. Sleep duration in the United States 2003–2016: first signs of success in the fight against sleep deficiency? Sleep. 41. doi:https://doi.org/10.1093/sleep/zsy012
   Google Scholar
• Blum ID, Bell B, Wu MN. 2018. Time for bed: genetic mechanisms mediating the circadian regulation of sleep. Trends Genet. 34:379–388. doi:https://doi.org/10.1016/j.tig.2018.01.001
   PubMed Web of Science ®Google Scholar
• Chen HG, Sun B, Chen YJ, Chavarro JE, Hu SH, Xiong CL, Pan A, Meng TQ, Wang YX, Messerlian C. 2020a. Sleep duration and quality in relation to semen quality in healthy men screened as potential sperm donors. Environ Int. 135. doi:https://doi.org/10.1016/j.envint.2019.105368
   Google Scholar
• Chen Q, Yang H, Zhou NY, Su L, Bao HQ, Tan L, Chen HQ, Ling X, Zhang GW, Huang LP, et al. 2016. Inverse U-shaped association between sleep duration and semen quality: longitudinal observational study (MARHCS) in Chongqing, China. Sleep. 39:79–86. doi:https://doi.org/10.5665/sleep.5322
   PubMed Web of Science ®Google Scholar
• Chen WY, Guo XD, Jin ZP, Li RN, Shen LX, Li W, Cai WT, Zhang GR. 2020b. Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction. Syst Biol Reprod Med. 66:99–111. doi:https://doi.org/10.1080/19396368.2019.1678694
   PubMed Web of Science ®Google Scholar
• Cheng ST, Liang X, Wang YH, Jiang Z, Liu YY, Hou W, Li SP, Zhang J, Wang ZR. 2016. The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K. Exp Biol Med. 241:205–215. doi:https://doi.org/10.1177/1535370215597199
   PubMed Web of Science ®Google Scholar
• Cho JW, Duffy JF. 2019. Sleep, sleep disorders, and sexual dysfunction. World J Mens Health. 37:261–275. doi:https://doi.org/10.5534/wjmh.180045
   PubMedGoogle Scholar
• Funato H, Miyoshi C, Fujiyama T, Kanda T, Kanda T, Sato M, Wang ZQ, Ma J, Nakane S, Tomita J, et al. 2016. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 539:378–383. doi:https://doi.org/10.1038/nature20142
   PubMed Web of Science ®Google Scholar
• Gamble KL, Motsinger-Reif AA, Hida A, Borsetti HM, Servick SV, Ciarleglio CM, Robbins S, Hicks J, Carver K, Hamilton N, et al. 2011. Shift work in nurses: contribution of phenotypes and genotypes to adaptation. Plos One. 6(4):e18395. doi:https://doi.org/10.1371/journal.pone.0018395
   PubMed Web of Science ®Google Scholar
• Ghotbi N, Pilz LK, Winnebeck EC, Vetter C, Zerbini G, Lenssen D, Frighetto G, Salamanca M, Costa R, Montagnese S, et al. 2020. The microMCTQ: an ultra-short version of the munich chronotype questionnaire. J Biol Rhythms. 35:98–110. doi:https://doi.org/10.1177/0748730419886986
   PubMed Web of Science ®Google Scholar
• Green A, Barak S, Shine L, Kahane A, Dagan Y. 2020. Exposure by males to light emitted from media devices at night is linked with decline of sperm quality and correlated with sleep quality measures. Chronobiol Int. 37:414–424. doi:https://doi.org/10.1080/07420528.2020.1727918
   PubMed Web of Science ®Google Scholar
• Hodzic A, Ristanovic M, Zorn B, Tulic C, Maver A, Novakovic I, Peterlin B. 2013. Genetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertility. Plos One. 8(3):e59220. doi:https://doi.org/10.1371/journal.pone.0059220
   PubMed Web of Science ®Google Scholar
• Hvidt JEM, Knudsen UB, Zachariae R, Ingerslev HJ, Philipsen MT, Frederiksen Y. 2020. Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study. Basic Clin Androl. 30:5. doi:https://doi.org/10.1186/s12610-020-00103-7
   PubMed Web of Science ®Google Scholar
• Islam Z, Hu HH, Akter S, Kuwahara K, Kochi T, Eguchi M, Kurotani K, Nanri A, Kabe I, Mizoue T. 2020. Social jetlag is associated with an increased likelihood of having depressive symptoms among the Japanese working population: the Furukawa Nutrition and Health Study. Sleep. 43. doi:https://doi.org/10.1186/ARTN zsz204
   Google Scholar
• Jones SE, Lane JM, Wood AR, Van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al. 2019. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nat Commun. 10:343. doi:https://doi.org/10.1038/s41467-018-08259-7
   PubMed Web of Science ®Google Scholar
• Juda M, Vetter C, Roenneberg T. 2013. Chronotype modulates sleep duration, sleep quality, and social jet lag in shift-workers. J Biol Rhythm. 28:141–151. doi:https://doi.org/10.1177/0748730412475042
   PubMed Web of Science ®Google Scholar
• Kantermann T, Sung H, Burgess HJ. 2015. Comparing the morningness-eveningness questionnaire and munich chronotype questionnaire to the dim light melatonin onset. J Biol Rhythm. 30:449–453. doi:https://doi.org/10.1177/0748730415597520
   PubMed Web of Science ®Google Scholar
• Kotwica J, Bebas P, Gvakharia BO, Giebultowicz JM. 2009. RNA interference of the period gene affects the rhythm of sperm release in moths. J Biol Rhythm. 24:25–34. doi:https://doi.org/10.1177/0748730408329109
   PubMed Web of Science ®Google Scholar
• Lang CJ, Reynolds AC, Appleton SL, Taylor AW, Gill TK, McEvoy RD, Ferguson SA, Adams RA. 2018. Sociodemographic and behavioural correlates of social jetlag in Australian adults: results from the 2016 National Sleep Health Foundation Study. Sleep Med. 51:133–139. doi:https://doi.org/10.1016/j.sleep.2018.06.014
   Google Scholar
• Leung L, Grundy A, Siemiatycki J, Arseneau J, Gilbert L, Gotlieb WH, Provencher DM, Aronson KJ, Koushik A. 2019. Shift work patterns, chronotype, and epithelial ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 28:987–995. doi:https://doi.org/10.1158/1055-9965.EPI-18-1112
   Google Scholar
• Leypunskiy E, Kiciman E, Shah M, Walch OJ, Rzhetsky A, Dinner AR, Rust MJ. 2018. Geographically resolved rhythms in Twitter use reveal social pressures on daily activity patterns. Curr Biol. 28:3763-+. doi:https://doi.org/10.1016/j.cub.2018.10.016
   Google Scholar
• Liu K, Hou GZ, Wang XG, Chen H, Shi FQ, Liu C, Zhang X, Han F, Yang H, Zhou NY, et al. 2020. Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study. Hum Reprod. 35:1515–1528. doi:https://doi.org/10.1093/humrep/deaa101
   PubMed Web of Science ®Google Scholar
• Liu MM, Liu L, Chen L, Yin XJ, Liu H, Zhang YH, Li PL, Wang S, Li XX, Yu CH. 2017. Sleep deprivation and late bedtime impair sperm health through increasing antisperm antibody production: a prospective study of 981 healthy men. Med Sci Monitor. 23:1842–1848. doi:https://doi.org/10.12659/Msm.900101
   PubMed Web of Science ®Google Scholar
• Lotti F, Maggi M. 2018. Sexual dysfunction and male infertility. Nat Rev Urol. 15:287–307. doi:https://doi.org/10.1038/nrurol.2018.20
   Google Scholar
• Mao H, Feng L, Yang WX. 2017. Environmental factors contributed to circannual rhythm of semen quality. Chronobiol Int. 34:411–425. doi:https://doi.org/10.1080/07420528.2017.1280046
   PubMed Web of Science ®Google Scholar
• McGowan NM, Voinescu BI, Coogan AN. 2016. Sleep quality, chronotype and social jetlag differentially associate with symptoms of attention deficit hyperactivity disorder in adults. Chronobiol Int. 33:1433–1443. doi:https://doi.org/10.1080/07420528.2016.1208214
   Google Scholar
• Patke A, Murphy PJ, Onat OE, Krieger AC, Ozcelik T, Campbell SS, Young MW. 2017. Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder. Cell. 169:203–215. doi:https://doi.org/10.1016/j.cell.2017.03.027
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Smolensky MH, Touitou Y. 2010. Ethics and methods for biological rhythm research on animals and human beings. Chronobiol Int. 27:1911–1929. doi:https://doi.org/10.3109/07420528.2010.516381
   PubMed Web of Science ®Google Scholar
• Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE, Willett WC, Schernhammer ES. 2019. Shift work, chronotype, and melatonin rhythm in nurses. Cancer Epidem Biomar. 28:1177–1186. doi:https://doi.org/10.1158/1055-9965.Epi-18-1018
   Google Scholar
• Ritonja J, Tranmer J, Aronson KJ. 2019. The relationship between night work, chronotype, and cardiometabolic risk factors in female hospital employees. Chronobiol Int. 36:616–628. doi:https://doi.org/10.1080/07420528.2019.1570247
   PubMed Web of Science ®Google Scholar
• Rizk NI, Rizk MS, Mohamed AS, Naguib YM. 2020. Attenuation of sleep deprivation dependent deterioration in male fertility parameters by vitamin C. Reprod Biol Endocrin. 18(1):2. doi:https://doi.org/10.1186/s12958-020-0563-y
   PubMed Web of Science ®Google Scholar
• Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, Merrow M. 2007. Epidemiology of the human circadian clock. Sleep Med Rev. 11:429–438. doi:https://doi.org/10.1016/j.smrv.2007.07.005
   PubMed Web of Science ®Google Scholar
• Roenneberg T, Pilz LK, Zerbini G, Winnebeck EC. 2019. Chronotype and social jetlag: a (Self-) critical review. Biology-Basel. 8(3):54. doi:https://doi.org/10.3390/biology8030054
   Web of Science ®Google Scholar
• Roenneberg T, Wirz-Justice A, Merrow M. 2003. Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythm. 18:80–90. doi:https://doi.org/10.1177/0748730402239679
   PubMed Web of Science ®Google Scholar
• Shen OX, Ding XL, Nie JH, Xia YK, Wang XR, Tong J, Zhang J. 2015. Variants of the CLOCK gene affect the risk of idiopathic male infertility in the Han-Chinese population. Chronobiol Int. 32:959–965. doi:https://doi.org/10.3109/07420528.2015.1056305
   PubMed Web of Science ®Google Scholar
• Shi G, Wu D, Ptacek LJ, Fu YH. 2017. Human genetics and sleep behavior. Curr Opin Neurobiol. 44:43–49. doi:https://doi.org/10.1016/j.conb.2017.02.015
   PubMed Web of Science ®Google Scholar
• St-Onge MP, Grandner MA, Brown D, Conroy MB, Jean-Louis G, Coons M, Bhatt DL. 2016. Sleep duration and quality: impact on lifestyle behaviors and cardiometabolic health: a scientific statement from the American Heart Association. Circulation. 134:e367–e386. doi:https://doi.org/10.1161/CIR.0000000000000444
   Google Scholar
• Tonetti L, Fabbri M, Filardi M, Martoni M, Natale V. 2015. Effects of sleep timing, sleep quality and sleep duration on school achievement in adolescents. Sleep Med. 16:936–940. doi:https://doi.org/10.1016/j.sleep.2015.03.026
   PubMed Web of Science ®Google Scholar
• Vitale JA, Weydahl A. 2017. Chronotype, physical activity, and sport performance: a systematic review. Sports Med. 47:1859–1868. doi:https://doi.org/10.1007/s40279-017-0741-z
   PubMed Web of Science ®Google Scholar
• Wittmann M, Dinich J, Merrow M, Roenneberg T. 2006. Social jetlag: Misalignment of biological and social time. Chronobiol Int. 23:497–509. doi:https://doi.org/10.1080/07420520500545979
   PubMed Web of Science ®Google Scholar
• Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB. 2015. Social jetlag, chronotype, and cardiometabolic risk. J Clin Endocrinol Metab. 100:4612–4620. doi:https://doi.org/10.1210/jc.2015-2923
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2010. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva World Health Organization.
   Google Scholar
• Xie M, Utzinger KS, Blickenstorfer K, Leeners B. 2018. Diurnal and seasonal changes in semen quality of men in subfertile partnerships. Chronobiol Int. 35:1375–1384. doi:https://doi.org/10.1080/07420528.2018.1483942
   PubMed Web of Science ®Google Scholar
• Yang H, Chen Q, Zhou NY, Sun L, Bao HQ, Tan L, Chen HQ, Zhang GW, Ling X, Huang LP, et al. 2015. Lifestyles associated with human semen quality: results from MARHCS cohort study in Chongqing, China. Medicine. 94(28):e1166. doi:https://doi.org/10.1097/MD.0000000000001166
   PubMed Web of Science ®Google Scholar
• Zhan YQ, Chen RQ, Yu JM. 2014. Sleep duration and abnormal serum lipids: the China health and nutrition survey. Sleep Med. 15:833–839. doi:https://doi.org/10.1016/j.sleep.2014.02.006
   Google Scholar
• Zhang J, Ding XL, Li YC, Xia YK, Nie JH, Yi C, Wang XR, Tong J. 2012. Association of CLOCK gene variants with semen quality in idiopathic infertile Han-Chinese males. Reprod Biomed Online. 25:536–542. doi:https://doi.org/10.1016/j.rbmo.2012.07.018
   PubMed Web of Science ®Google Scholar
• Zhang ZX, Cajochen C, Khatami R. 2019. Social jetlag and chronotypes in the Chinese population: analysis of data recorded by wearable devices. J Med Internet Res. 21(6):e13482. doi:https://doi.org/10.2196/13482
   PubMed Web of Science ®Google Scholar