3,870
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Effect of age, period and birth–cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults

ORCID Icon, , & ORCID Icon
Pages 68-73 | Received 22 Jun 2017, Accepted 04 Oct 2017, Published online: 16 Oct 2017

References

  • Luzzatto L, Mehta AB, Vulliamy T. Glucose-6-phosphate dehydrogenase. In: Scriver CR, Beaudet AL, Sly WS, et al., editors. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill; 2001. p. 4517–4553.
  • Beutler E. G6PD: population genetics and clinical manifestations. Blood Rev. 1996;10:45–52.
  • Szabo P, Purrello M, Rocchi M, et al. Cytological mapping of the human glucose-6-phosphate dehydrogenase gene distal to the fragile-X site suggests a high rate of meiotic recombination across this site. Proc Natl Acad Sci U S A. 1984;81:7855–7859.
  • Rinaldi A, Filippi G, Siniscalco M. Variability of red cell phenotypes between and within individuals in an unbiased sample of 77 heterozygotes for G6PD deficiency in Sardinia. Am J Hum Genet. 1976;28:496–505.
  • Luzzatto L, Notaro R. Malaria. Protecting against bad air. Science. 2001;293:442–443.
  • Luzzatto L. G6PD deficiency: a polymorphism balanced by heterozygote advantage against malaria. Lancet Haematol. 2015;2:e400–e401.
  • Siniscalco M, Bernini L, Latte B, et al. Favism and thalassemia in Sardinia and their relationship to malaria. Nature. 1961;190:1179–1180.
  • Fiorelli G, Meloni T, Palomba V, et al. Gene frequency of glucose-6-phosphate dehydrogenase (G6PD) polymorphic variants in Sardinia. Gene Geogr. 1990;4:139–142.
  • Cocco P, Todde P, Fornera S, et al. Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency. Blood. 1998;91:706–709.
  • Hecker PA, Leopold JA, Gupte SA, et al. Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease. Am J Physiol Heart Circ Physiol. 2013;304:H491–H500.
  • Yang HC, Wu YH, Liu HY, et al. What has passed is prolog: new cellular and physiological roles of G6PD. Free Radic Res. 2016;50:1047–1064.
  • Manganelli G, Masullo U, Passarelli S, et al. Glucose-6-phosphate dehydrogenase deficiency: disadvantages and possible benefits. Cardiovasc Hematol Disord Drug Targets. 2013;13:73–82.
  • Schwartz AG, Pashko LL. Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004;3:171–187.
  • Meloni L, Manca MR, Loddo I, et al. Glucose-6-phosphate dehydrogenase deficiency protects against coronary heart disease. J Inherit Metab Dis. 2008;31:412–417.
  • Muntoni S, Batetta B, Dessi S, et al. Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency. Eur J Epidemiol. 1992;8 Suppl 1:48–53.
  • Sanna F, Bonatesta RR, Frongia B, et al. Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-phosphate dehydrogenase-deficient subjects. J Vasc Res. 2007;44:253–263.
  • Muntoni S, Muntoni S. Gene-nutrient interactions in G6PD-deficient subjects – implications for cardiovascular disease susceptibility. J Nutrigenet Nutrigenomics. 2008;1:49–54.
  • Pascale R, Garcea R, Ruggiu ME, et al. Decreased stimulation by 12-O-tetradecanoylphorbol-13-acetate of superoxide radical production by polymorphonuclear leukocytes carrying the Mediterranean variant of glucose-6-phosphate dehydrogenase. Carcinogenesis. 1987;8:1567–1570.
  • Feo F, Pirisi L, Pascale R, et al. Modulatory mechanisms of chemical carcinogenesis: the role of the NADPH pool in the benzo(a)pyrene activation. Toxicol Pathol. 1984;12:261–268.
  • Dore MP, Davoli A, Longo N, et al. Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: a retrospective observational study. Medicine (Baltimore). 2016;95:e5254.
  • Kowalik MA, Columbano A, Perra A. Emerging role of the pentose phosphate pathway in hepatocellular carcinoma. Front Oncol. 2017;7:87.
  • Mosca A, Paleari R, Rosti E, et al. Simultaneous automated determination of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in whole blood. Eur J Clin Chem Clin Biochem. 1996;34:431–438.
  • Holford TR. Understanding the effects of age, period, and cohort on incidence and mortality rates. Annu Rev Public Health. 1991;12:425–457.
  • Pes GM, Cocco F, Bibbò S, et al. Cancer time trend in a population following a socio-economic transition: results of age-period-cohort analysis. Int J Public Health. 2017;62:407–414.
  • Meloni T, Forteleoni G, Dore A, et al. Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. Acta Haematol. 1983;70:83–90.
  • Yang HC, Chen TL, Wu YH, et al. Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death Dis. 2013;4:e616.
  • Legan SK, Rebrin I, Mockett RJ, et al. Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster. J Biol Chem. 2008;283:32492–32499.
  • Nóbrega-Pereira S, Fernandez-Marcos PJ, Thomas B, et al. G6PD protects from oxidative damage and improves healthspan in mice. Nat Commun. 2016;7:10894.
  • Jeng W, Loniewska MM, Wells PG. Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice. ACS Chem Neurosci. 2013;4:1123–1132.
  • Felix K, Rockwood LD, Pretsch W, et al. Moderate G6PD deficiency increases mutation rates in the brain of mice. Free Radic Biol Med. 2002;32:663–673.
  • Ulusu NN. Glucose-6-phosphate dehydrogenase deficiency and Alzheimer's disease: Partners in crime? The hypothesis. Med Hypotheses. 2015;85:219–223.
  • Ho HY, Cheng ML, Lu FJ, et al. Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)–deficient human fibroblasts. Free Radic Biol Med. 2000;29:156–169.
  • Tognotti E. The spread of malaria in Sardinia: an historical perspective. In: Greene LS, Danubio ME, editors. Adaptation to malaria: the interaction of biology and culture. New York (NY): Gordon & Breach; 1997. p. 237–247.
  • Sanna E, Cosseddu GG, Floris G, et al. Micromapping the distribution of G6PD deficiency in Sardinia with data collected from the 1950s to the 1980s. In: Greene LS, Danubio ME, editors. Adaptation to malaria. The interaction of biology and culture. New York (NY): Gordon & Breach; 1997. p. 293–322.
  • Pes GM, Bassotti G, Dore MP. Colorectal cancer mortality in relation to glucose-6-phosphate dehydrogenase deficiency and consanguinity in Sardinia: a spatial correlation analysis. Asian Pac J Cancer Prev. 2017;18:2403–2407.
  • Santos-Lozano A, Santamarina A, Pareja-Galeano H, et al. The genetics of exceptional longevity: Insights from centenarians. Maturitas. 2016;90:49–57.
  • Pandolfi PP, Sonati F, Rivi R, et al. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995;14:5209–5215.
  • Christensen K, Kristiansen M, Hagen-Larsen H, et al. X-linked genetic factors regulate hematopoietic stem-cell kinetics in females. Blood. 2000;95:2449–2451.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.