M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling

References

• Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):1–14. doi: 10.1016/j.immuni.2016.02.015.
   PubMed Web of Science ®Google Scholar
• Willenborg S, Eming SA. Cellular networks in wound healing. Science. 2018;362(6417):891–892. doi: 10.1126/science.aav5542.
   PubMed Web of Science ®Google Scholar
• Smigiel KS, Parks WC. Macrophages, wound healing, and fibrosis: recent insights. Curr Rheumatol Rep. 2018;20(4):17. doi: 10.1126/science.aav5542.
   PubMed Web of Science ®Google Scholar
• Murray PJ. Macrophage polarization. Annu Rev Physiol. 2017;79(1):541–566. doi: 10.1146/annurev-physiol-022516-034339.
   PubMed Web of Science ®Google Scholar
• Gieseck RL3rd, Wilson MS, Wynn TA. Type 2 immunity in tissue repair and fibrosis. Nat Rev Immunol. 2018;18(1):62–76. doi: 10.1038/nri.2017.90.
   PubMed Web of Science ®Google Scholar
• Murray PJ, Allen JE, Biswas SK, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20. doi: 10.1016/j.immuni.2014.06.008.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang L, Wu GR, et al. MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program. Sci Adv. 2021;7(1):eabb6075. doi: 10.1126/sciadv.abb6075.
   PubMed Web of Science ®Google Scholar
• Wang J, Xu L, Xiang Z, et al. Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206(+) M2-like macrophage polarization. Cell Death Dis. 2020;11(2):136. doi: 10.1038/s41419-020-2329-z.
   PubMed Web of Science ®Google Scholar
• Chen B, Yang Y, Yang C, et al. M2 macrophage accumulation contributes to pulmonary fibrosis, vascular dilatation, and hypoxemia in rat hepatopulmonary syndrome. J Cell Physiol. 2021;236(11):7682–7697. doi: 10.1002/jcp.30420.
   PubMed Web of Science ®Google Scholar
• Yang G, Yang Y, Liu Y, et al. Regulation of alveolar macrophage death in pulmonary fibrosis: a review. Apoptosis. 2023;28(11–12):1505–1519. doi: 10.1007/s10495-023-01888-4.
   PubMed Web of Science ®Google Scholar
• Kim MG, Kim SC, Ko YS, et al. The role of M2 macrophages in the progression of chronic kidney disease following acute kidney injury. PLoS One. 2015;10(12):e0143961. doi: 10.1371/journal.pone.0143961.
   PubMed Web of Science ®Google Scholar
• Tang PM, Nikolic-Paterson DJ, Lan HY. Macrophages: versatile players in renal inflammation and fibrosis. Nat Rev Nephrol. 2019;15(3):144–158. doi: 10.1038/s41581-019-0110-2.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Ding J, Ma Z, et al. Alternatively activated macrophages derived from THP-1 cells promote the fibrogenic activities of human dermal fibroblasts. Wound Repair Regen. 2017;25(3):377–388. doi: 10.1111/wrr.12532.
   PubMed Web of Science ®Google Scholar
• Gu S, Dai H, Zhao X, et al. AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling. Aging. 2020;12(8):6928–6946. doi: 10.18632/aging.103051.
   PubMedGoogle Scholar
• Peet C, Ivetic A, Bromage DI, et al. Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc Res. 2020;116(6):1101–1112. doi: 10.1093/cvr/cvz336.
   PubMed Web of Science ®Google Scholar
• Kim Y, Nurakhayev S, Nurkesh A, et al. Macrophage polarization in cardiac tissue repair following myocardial infarction. Int J Mol Sci. 2021;22(5):2715. doi: 10.3390/ijms22052715.
   PubMed Web of Science ®Google Scholar
• Cao X, Shen D, Patel MM, et al. Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol Int. 2011;61(9):528–535. doi: 10.1111/j.1440-1827.2011.02695.x.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Yoshida S, Nakao S, et al. M2 macrophages enhance pathological neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2015;56(8):4767–4777. doi: 10.1167/iovs.14-16012.
   PubMed Web of Science ®Google Scholar
• Xu N, Bo Q, Shao R, et al. Chitinase-3-like-1 promotes M2 macrophage differentiation and induces choroidal neovascularization in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2019;60(14):4596–4605. doi: 10.1167/iovs.19-27493.
   PubMed Web of Science ®Google Scholar
• Vannella KM, Wynn TA. Mechanisms of organ injury and repair by macrophages. Annu Rev Physiol. 2017;79(1):593–617. doi: 10.1146/annurev-physiol-022516-034356.
   PubMedGoogle Scholar
• Mia MM, Singh MK. New insights into Hippo/YAP signaling in fibrotic diseases. Cells. 2022;11(13):2065. doi: 10.3390/cells11132065.
   PubMed Web of Science ®Google Scholar
• Meng Z, Moroishi T, Guan KL. Mechanisms of hippo pathway regulation. Genes Dev. 2016;30(1):1–17. doi: 10.1101/gad.274027.115.
   PubMed Web of Science ®Google Scholar
• Futakuchi A, Inoue T, Wei FY, et al. YAP/TAZ are essential for TGF-β2-mediated conjunctival fibrosis. Invest Ophthalmol Vis Sci. 2018;59(7):3069–3078. doi: 10.1167/iovs.18-24258.
   PubMed Web of Science ®Google Scholar
• Nakamura R, Hiwatashi N, Bing R, et al. Concurrent YAP/TAZ and SMAD signaling mediate vocal fold fibrosis. Sci Rep. 2021;11(1):13484. doi: 10.1038/s41598-021-92871-z.
   PubMed Web of Science ®Google Scholar
• He X, Tolosa MF, Zhang T, et al. Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis. JCI Insight. 2022;7(4):e146243. doi: 10.1172/jci.insight.146243.
   PubMedGoogle Scholar
• Grannas K, Arngården L, Lönn P, et al. Crosstalk between hippo and TGFβ: subcellular localization of YAP/TAZ/smad complexes. J Mol Biol. 2015;427(21):3407–3415. doi: 10.1016/j.jmb.2015.04.015.
   PubMed Web of Science ®Google Scholar
• Li Z, Liu R, Guo Z, et al. Celastrol-based nanomedicine promotes corneal allograft survival. J Nanobiotechnol. 2021;19(1):341. doi: 10.1186/s12951-021-01079-w.
   PubMed Web of Science ®Google Scholar
• Tong J, Fu Y, Xu X, et al. TGF-β1 stimulates human Tenon’s capsule fibroblast proliferation by miR-200b and its targeting of p27/kip1 and RND3. Invest Ophthalmol Vis Sci. 2014;55(4):2747–2756. doi: 10.1167/iovs.13-13422.
   PubMed Web of Science ®Google Scholar
• Cai X, Yang Y, Chen P, et al. Tetramethylpyrazine attenuates transdifferentiation of TGF-β2-treated human Tenon’s fibroblasts. Invest Ophthalmol Vis Sci. 2016;57(11):4740–4748. doi: 10.1167/iovs.16-19529.
   PubMed Web of Science ®Google Scholar
• Schlunck G, Meyer-ter-Vehn T, Klink T, et al. Conjunctival fibrosis following filtering glaucoma surgery. Exp Eye Res. 2016;142:76–82. doi: 10.1016/j.exer.2015.03.021.
   PubMed Web of Science ®Google Scholar
• Shu DY, Lovicu FJ. Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. Prog Retin Eye Res. 2017;60:44–65. doi: 10.1016/j.preteyeres.2017.08.001.
   PubMed Web of Science ®Google Scholar
• Das A, Sinha M, Datta S, et al. Monocyte and macrophage plasticity in tissue repair and regeneration. Am J Pathol. 2015;185(10):2596–2606. doi: 10.1016/j.ajpath.2015.06.001.
   PubMed Web of Science ®Google Scholar
• Sheridan CM, Unger WG, Ayliffe W, et al. Macrophages during fibrosis following scleral fistulising surgery in a rat model. Curr Eye Res. 1996;15(5):559–568. doi: 10.3109/02713689609000767.
   PubMed Web of Science ®Google Scholar
• Shima I, Katsuda S, Ueda Y, et al. Expression of matrix metalloproteinases in wound healing after glaucoma filtration surgery in rabbits. Ophthalmic Res. 2007;39(6):315–324. doi: 10.1159/000109987.
   PubMed Web of Science ®Google Scholar
• Thieme H, Choritz L, Hofmann-Rummelt C, et al. Histopathologic findings in early encapsulated blebs of young patients treated with the Ahmed glaucoma valve. J Glaucoma. 2011;20(4):246–251. doi: 10.1097/IJG.0b013e3181e080ef.
   PubMed Web of Science ®Google Scholar
• Martin KE, García AJ. Macrophage phenotypes in tissue repair and the foreign body response: implications for biomaterial-based regenerative medicine strategies. Acta Biomater. 2021;133:4–16. doi: 10.1016/j.actbio.2021.03.038.
   PubMed Web of Science ®Google Scholar
• Hesketh M, Sahin KB, West ZE, et al. Macrophage phenotypes regulate scar formation and chronic wound healing. Int J Mol Sci. 2017;18(7):1545. doi: 10.3390/ijms18071545.
   PubMed Web of Science ®Google Scholar
• Fatehi N, Morales E, Parivisutt N, et al. Long-term outcome of second Ahmed valves in adult glaucoma. Am J Ophthalmol. 2018;186:96–103. doi: 10.1016/j.ajo.2017.11.018.
   PubMed Web of Science ®Google Scholar
• Genin M, Clement F, Fattaccioli A, et al. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer. 2015;15(1):577. doi: 10.1186/s12885-015-1546-9.
   PubMedGoogle Scholar
• Li X, Leng Y, Jiang Q, et al. Eye drops of metformin prevents fibrosis after glaucoma filtration surgery in rats via activating AMPK/Nrf2 signaling pathway. Front Pharmacol. 2020;11:1038. doi: 10.3389/fphar.2020.01038.
   PubMed Web of Science ®Google Scholar
• Zhu L, Fu X, Chen X, et al. M2 macrophages induce EMT through the TGF-β/Smad2 signaling pathway. Cell Biol Int. 2017;41(9):960–968. doi: 10.1002/cbin.10788.
   PubMed Web of Science ®Google Scholar
• Corpuz AB. Role of macrophages in ocular surface fibrosis [master’s thesis]. Irvine (CA): Chapman University; 2022. doi: 10.36837/chapman.000407.
   Google Scholar
• Tripathi RC, Li J, Chan WF, et al. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp Eye Res. 1994;59(6):723–727. doi: 10.1006/exer.1994.1158.
   PubMed Web of Science ®Google Scholar
• Inatani M, Tanihara H, Katsuta H, et al. Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol. 2001;239(2):109–113. doi: 10.1007/s004170000241.
   PubMed Web of Science ®Google Scholar
• Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-β: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12(6):325–338. doi: 10.1038/nrneph.2016.48.
   PubMed Web of Science ®Google Scholar
• Frangogiannis N. Transforming growth factor-β in tissue fibrosis. J Exp Med. 2020;217(3):e20190103. doi: 10.1084/jem.20190103.
   PubMed Web of Science ®Google Scholar
• Zada M, Pattamatta U, White A. Modulation of fibroblasts in conjunctival wound healing. Ophthalmology. 2018;125(2):179–192. doi: 10.1016/j.ophtha.2017.08.028.
   PubMed Web of Science ®Google Scholar
• Nukuda A, Sasaki C, Ishihara S, et al. Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. Oncogenesis. 2015;4(9):e165–e165. doi: 10.1038/oncsis.2015.24.
   PubMedGoogle Scholar
• Szeto SG, Narimatsu M, Lu M, et al. YAP/TAZ are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis. J Am Soc Nephrol. 2016;27(10):3117–3128. doi: 10.1681/ASN.2015050499.
   PubMed Web of Science ®Google Scholar
• Brown SB, Mellish KJ. Verteporfin: a milestone in opthalmology and photodynamic therapy. Expert Opin Pharmacother. 2001;2(2):351–361. doi: 10.1517/14656566.2.2.351.
   PubMedGoogle Scholar