Phytoestrogens: End of a tale?

References

• Adlercreutz H., Mazur H. Phyto‐oestrogens and Western Diseases. Ann Med 1997; 29: 95–120
   PubMed Web of Science ®Google Scholar
• Bennetts H. W., Underwood E. J., Shier F. L. A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust Vet J 1946; 22: 2–12
   PubMedGoogle Scholar
• Cornwell T., Cohick W., Raskin I. Dietary phytoestrogens and health. Phytochemistry 2004; 65: 995–1016
   PubMed Web of Science ®Google Scholar
• Lamikanra O., Grimm C. C., Rodin J. B., Inyang I. D. Hydroxylated stilbenes in selected american wines. J Agric Food Chem 1996; 44: 1111–5
   Web of Science ®Google Scholar
• Fremont L. Biological effects of resveratrol. Life Sci 2000; 66: 663–73
   PubMed Web of Science ®Google Scholar
• Franke A. A., Custer L. J., Cerna C. M., Narala K. K. Quantitation of phytoestrogens in legumes by HPLC. J Agric Food Chem 1994; 42: 1905–13
   Web of Science ®Google Scholar
• Setchell K. D., Lawson A. M., Borriello S. P., Harkness R., Gordon H., Morgan D. M. Lignan formation in man – microbial involvement and possible roles in relation to cancer. Lancet 1981; 2: 4–7
   PubMed Web of Science ®Google Scholar
• Duncan A. M., Phipps W. R., Kurzer M. S. Phyto‐oestrogens. Best Practice Res Clin Endocrinol Metab 2003; 17: 253–71
   PubMed Web of Science ®Google Scholar
• Munro I. C., Harwood M., Hlywka J. J., Stephen A. M., Doull J., Flamm W. G. Soy isoflavones: A safety review. Nutr Rev 2003; 61: 1–33
   PubMed Web of Science ®Google Scholar
• Meyer B. J., Larkin T. A., Owen A. J., Astheimer L. B., Tapsell L. C., Howe P. R. C. Limited lipid‐lowering effects of regular consumption of whole soybean foods. Ann Nutr Metab 2004; 48: 67–78
   PubMed Web of Science ®Google Scholar
• Rowland I. R., Wiseman H., Sanders T. A. B., Adlercreutz H., Bowey E. A. Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000; 36: 27–32
   PubMed Web of Science ®Google Scholar
• Duncan A. M., Merz‐Demlow B. E., Xu X., Phipps W. R., Kurzer M. S. Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2000; 9: 581–6
   PubMed Web of Science ®Google Scholar
• Setchell K. D. R., Brown N. M., Lydeking‐Olsen E. The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J Nutr 2002; 132: 3577–84
   PubMed Web of Science ®Google Scholar
• Nagata C., Kabuto M., Kurisu Y., Shimizu H. Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women. Nutr Cancer 1997; 29: 228–33
   PubMed Web of Science ®Google Scholar
• Chen Z., Zheng W., Custer L. J., Dai Q., Shu X. O., Jin F. Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutr Cancer 1999; 33: 82–7
   PubMed Web of Science ®Google Scholar
• Horn‐Ross P. L., John E. M., Lee M., Stewart S. L., Koo J., Sakoda L. C. Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol 2001; 154: 434–41
   PubMed Web of Science ®Google Scholar
• Kiely M., Faughnan M., Wähälä K., Brandts H., Mulligan A. Phyto‐oestrogen levels in foods: the design and construction of the VENUS database. Br J Nutr 2003; 89: 808–13
   Web of Science ®Google Scholar
• Van Erp‐Baart M. A. J., Brants H. A. M., Kiely M. Isoflavone intake in four different European countries: the VENUS approach. Br J Nutr 2003; 89: 25–30
   PubMed Web of Science ®Google Scholar
• FDA Food labeling health claims. soybean protein and coronary heart disease. Food and Drug Administration. Final rule. Federal Register 1999; 64: 57699–733
   Google Scholar
• Sirtori C. R., Lovati M. R. Soy proteins and cardiovascular disease. Curr Atheroscl Rep 2001; 3: 47–53
   PubMedGoogle Scholar
• Sirtori C. R., Pazzucconi F., Colombo L., Battistin P., Bondioli A., Descheemaeker K. Double‐blind study of the addition of high‐protein soya milk v. cow's milk to the diet of patients with severe hypercholesterolaemia and resistance to or intolerance of statins. Br J Nutr 1999; 82: 91–6
   PubMed Web of Science ®Google Scholar
• de Kleijn M. J., van der Schouw Y. T., Wilson P. W., Grobbee D. E., Jacques P. F. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in post‐menopausal U.S. women: the Framingham study. J Nutr 2002; 132: 276–82
   PubMed Web of Science ®Google Scholar
• Anderson J. W., Johnstone B. M., Cook‐Newell M. E. Meta‐analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995; 333: 276–82
   PubMed Web of Science ®Google Scholar
• Sirtori C. R., Agradi E., Conti F., Mantero O., Gatti E. Soybean‐protein diet in the treatment of type II hyperlipoproteinaemia. Lancet 1977; i: 275–7
   Google Scholar
• Descovich G. C., Ceredi C., Gaddi A., Benassi M. S., Mannino G., Colombo L. Multicentre study of soybean protein diet for outpatient hyper‐cholesterolaemic patients. Lancet 1980; ii: 709–12
   Google Scholar
• Crouse 3rd J. R., Morgan T., Terry J. G., Ellis J., Vitolins M., Burke G. L. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 1999; 159: 2070–6
   PubMedGoogle Scholar
• Anthony S., Clarkson T. B., Bullock B. C., Wagner J. D. Soy protein versus soy phytoestrogens in the prevention of diet‐induced coronary artery atherosclerosis of male cynomolgus monkeys. Arterioscler Thromb Vasc Biol 1997; 17: 2524–31
   PubMed Web of Science ®Google Scholar
• Greaves K. A., Parks J. S., Williams J. K., Wagner J. D. Intact dietary soy protein, but not adding an isoflavone‐rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. J Nutr 1999; 129: 1585–92
   PubMed Web of Science ®Google Scholar
• Nestel P. J., Yamashita T., Sasahara T., Pomeroy S., Dart A., Komesaroff P. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 1997; 17: 3392–8
   PubMed Web of Science ®Google Scholar
• Hodgson J. M., Puddey I. B., Beilin L. J., Mori T. A., Croft K. D. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 1998; 128: 728–32
   PubMed Web of Science ®Google Scholar
• Dewell A., Hollenbeck C. B., Bruce B. The effects of soy‐derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 2002; 87: 118–21
   PubMed Web of Science ®Google Scholar
• Gianazza E., Eberini I., Arnoldi A., Wait R., Sirtori C. R. A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies. J Nutr 2003; 133: 9–14
   PubMed Web of Science ®Google Scholar
• Fukui K., Tachibana N., Wanezaki S., Tsuzaki S., Takamatsu K., Yamamoto T. Isoflavone‐free soy protein prepared by column chromatography reduces plasma cholesterol in rats. J Agr Food Chem 2002; 50: 5717–21
   PubMed Web of Science ®Google Scholar
• Anderson J. W. Diet first, then medication for hypercholesterolemia. JAMA 2003; 290: 531–3
   PubMed Web of Science ®Google Scholar
• Lovati M. R., Manzoni C., Corsini A., Granata A., Frattini R., Fumagalli R. Low density lipoprotein receptor activity is modulated by soybean globulins in cell culture. J Nutr 1992; 122: 1971–8
   PubMed Web of Science ®Google Scholar
• Lovati M. R., Manzoni C., Gianazza E., Sirtori C. R. Soybean protein products as regulators of liver low‐density lipoprotein receptors. I. Identification of active β‐conglycinin subunits. J Agric Food Chem 1998; 46: 2474–80
   Web of Science ®Google Scholar
• Manzoni C., Lovati M. R., Gianazza E., Sirtori C. R. Soybean protein products as regulators of liver low‐density lipoprotein receptors. II. α‐α' rich commercial soy concentrate and α' deficient mutant differently affect low‐density lipoprotein receptor activation. J Agric Food Chem 1998; 46: 2481–4
   Web of Science ®Google Scholar
• Lovati M. R., Manzoni C., Gianazza E., Arnoldi A., Kurowska E., Carroll K. K. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J Nutr 2000; 130: 2543–9
   PubMed Web of Science ®Google Scholar
• Lovati M. R., Manzoni C., Canavesi A., Sirtori M., Vaccarino V., Marchi M. Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 1987; 80: 1498–502
   PubMed Web of Science ®Google Scholar
• Baum J. A., Teng H., Erdman J. W. J., Weigel R. M., Klein B. P., Persky V. W. Long‐term intake of soy protein improves blood lipid profiles and increases mononuclear cell low‐density‐lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr 1998; 68: 545–51
   PubMed Web of Science ®Google Scholar
• Duranti M., Lovati M. R., Dani V., Barbiroli A., Scarafoni A., Castiglioni S. The alpha' subunit from soybean 7S globulin lowers plasma lipids and upregulates liver beta‐VLDL receptors in rats fed a hypercholesterolemic diet. J Nutr 2004; 134: 1334–9
   PubMed Web of Science ®Google Scholar
• Erdman J. W. Soy protein and cardiovascular disease ‐ A statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation 2000; 102: 2555–9
   PubMed Web of Science ®Google Scholar
• Borradaile N. M., de Dreu L. E., Wilcox L. J., Edwards J. Y., Huff M. W. Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochem J 2002; 366: 531–9
   PubMed Web of Science ®Google Scholar
• Walker H. A., Dean T. S., Sanders T. A. B., Jackson G., Ritter J. M., Chowienczyk P. J. The phytoestrogen genistein produces acute nitric oxide‐dependent dilation of human forearm vasculature with similar potency to 17β‐estradiol. Circulation 2001; 103: 258–62
   PubMed Web of Science ®Google Scholar
• Squadrito F., Altavilla D., Morabito N., Crisafulli A., D'Anna R., Corrado F. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin‐1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002; 163: 339–47
   PubMed Web of Science ®Google Scholar
• Squadrito F., Altavilla D., Crisafulli A., Saitta A., Cucinotta D., Morabito N. Effect of genistein on endothelial function in postmenopausal women: a randomized, double‐blind, controlled study. Am J Med 2003; 114: 470–6
   PubMed Web of Science ®Google Scholar
• Simons L. A., van Konigsmark M., Simons J., Celermajer D. S. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 2000; 85: 1297–301
   PubMed Web of Science ®Google Scholar
• Kreijkamp‐Kaspers S., Kok L., Bots M. L., Grobbee D. E., Lampe J. W., van der Schouw Y. T. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 2005; 81: 189–95
   PubMed Web of Science ®Google Scholar
• Wagner J. D., Zhang L., Greaves K. A., Shadoan M. K., Schwenke D. C. Soy protein reduces the arterial low‐density lipoprotein (LDL) concentration and delivery of LDL cholesterol to the arteries of diabetic and nondiabetic male cynomolgus monkeys. Metabolism 2000; 49: 1188–96
   PubMed Web of Science ®Google Scholar
• Kurzer M. S., Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997; 17: 353–81
   PubMed Web of Science ®Google Scholar
• Wagner J. D., Cefalu W. T., Anthony M. S., Litwak K. N., Zhang L., Clarkson T. B. Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynomolgus monkeys. Metabolism 1997; 46: 698–705
   PubMed Web of Science ®Google Scholar
• Tikkanen M. J., Wahala K., Ojala S., Vihma V., Adlercreutz H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci U S A 1998; 95: 3106–10
   PubMed Web of Science ®Google Scholar
• Wiseman H., O'Reilly J. D., Adlercreutz H., Mallet A. I., Bowey E. A., Rowland I. R. Isoflavone phytoestrogens consumed in soy decrease F2‐isoprostane concentrations and increase resistance of low‐density lipoprotein to oxidation in humans. Am J Clin Nutr 2000; 72: 395–400
   PubMed Web of Science ®Google Scholar
• Samman S., Lyons Wall P. M., Chan G. S., Smith S. J., Petocz P. The effect of supplementation with isoflavones on plasma lipids and oxidizability of low density lipoprotein in premenopausal women. Atherosclerosis 1999; 147: 277–83
   PubMed Web of Science ®Google Scholar
• Castiglioni S., Manzoni C., D'Uva A., Spiezie R., Monteggia E., Chiesa G. Soy proteins reduce progression of a focal lesion and lipoprotein oxidability in rabbits fed a cholesterol‐rich diet. Atherosclerosis 2003; 171: 163–70
   PubMed Web of Science ®Google Scholar
• Vega‐Lopez S., Yeum K‐J., Lecker J. L., Ausman L. M., Johnson E. J., Devaray S. Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones. Am J Clin Nutr 2005; 81: 43–9
   PubMed Web of Science ®Google Scholar
• van der Schouw Y. T., Kreikamp‐Kaspers S., Peeters P. H. M., Keinan‐Boker L., Rimm E. B., Grobbee D. E. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation 2005; 111: 465–71
   PubMed Web of Science ®Google Scholar
• Arora A., Nair M. G., Strasburg G. M. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system. Arch Biochem Biophys 1998; 356: 133–41
   PubMed Web of Science ®Google Scholar
• Chin‐Dusting J. P. F., Boak L., Husband A., Nestel P. J. The isoflavone metabolite dehydroequol produced vasodilation in human resistance arteries via a nitric‐oxide dependent mechanism. Atherosclerosis 2004; 176: 45–8
   PubMed Web of Science ®Google Scholar
• Matoba N., Doyama N., Yamada Y., Maruyama N., Utsumi S., Yoshikawa M. Design and production of genetically modified soybean protein with anti‐hypertensive activity by incorporating potent analogue of ovokinin(2–7). FEBS Lett 2001; 497: 50–4
   PubMed Web of Science ®Google Scholar
• Sirtori C. R., Lovati M. R., Manzoni C., Castiglioni S., Duranti M., Magni C. Proteins of white lupin seed, a naturally isoflavone‐poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells. J Nutr 2004; 134: 18–23
   PubMed Web of Science ®Google Scholar
• Kuiper G. G., Lemmen J. G., Carlsson B., Corton J. C., Safe S. H., van der Saag P. T. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor ß. Endocrinology 1998; 139: 4252–63
   PubMed Web of Science ®Google Scholar
• Mäkelä S., Savolainen H., Aavik E., Myllarniemi M., Strauss L., Taskinen E. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta. Proc Natl Acad Sci U S A 1999; 96: 7077–82
   PubMed Web of Science ®Google Scholar
• Shimokado K., Yokota T., Umezawa K., Sasaguri T., Ogata J. Protein tyrosine kinase inhibitors inhibit chemotaxis of vascular smooth muscle cells. Arterioscler Thromb 1994; 14: 973–81
   PubMed Web of Science ®Google Scholar
• Shimokado K., Umezawa K., Ogata J. Tyrosine kinase inhibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells. Exp Cell Res 1995; 220: 266–73
   PubMed Web of Science ®Google Scholar
• Parkin D. M. Cancers of the breast, endometrium and ovary: geographic correlations. Eur J Cancer Clin Oncol 1989; 25: 1917–25
   PubMedGoogle Scholar
• Ziegler R. G., Hoover R. N., Pike M. C., Hildesheim A., Nomura A. M., West DW. Migration patterns and breast cancer risk in Asian‐American women. J Nat Cancer Inst 1993; 85: 1819–27
   PubMed Web of Science ®Google Scholar
• Adlercreutz H., Fotsis T., Heikkinen R., Dwyer J. T., Woods M., Goldin B. R. Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian post‐menopausal women and in women with breast cancer. Lancet 1982; ii: 1295–9
   Google Scholar
• Yuan J. M., Wang Q. S., Ross R. K., Henderson B. E. Yu MC. Diet and breast cancer in Shanghai and Tianjin, China. Br J Cancer 1995; 71: 1353–8
   PubMed Web of Science ®Google Scholar
• Key T. J., Sharp G. B., Appleby P. N., Beral V., Goodman M. T., Soda M. Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. Br J Cancer 1999; 81: 1248–56
   PubMed Web of Science ®Google Scholar
• Horn‐Ross P. L., John E. M., Lee M., Stewart S. L., Koo J., Sakoda L. C. Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol 2001; 154: 434–41
   PubMed Web of Science ®Google Scholar
• den Tonkelaar I., Keinan‐Boker L., Veer P. V., Arts C. J., Adlercreutz H., Thijssen J. H. Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention 2001; 10: 223–8
   PubMed Web of Science ®Google Scholar
• Ingram D., Sanders K., Kolybaba M., Lopez D. Case‐control study of phyto‐estrogens and breast cancer. Lancet 1997; 350: 990–4
   PubMed Web of Science ®Google Scholar
• Markiewicz L., Garey J., Adlercreutz H., Gurpide E. In vitro bioassays of non‐steroidal phytoestrogens. J Steroid Biochem 1993; 45: 399–405
   Google Scholar
• Sathyamoorthy N., Wang T. T. Y. Differential effects of dietary phyto‐oestrogens daidzein and equol on human breast cancer MCF‐7 cells. Eur J Cancer 1997; 33: 2384–9
   PubMed Web of Science ®Google Scholar
• Krazeisen A., Breitling R., Moller G., Adamski J. Phytoestrogens inhibit human 17beta‐hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol 2001; 171: 151–62
   PubMed Web of Science ®Google Scholar
• Adlercreutz H. Phyto‐oestrogens and cancer. Lancet Oncology 2002; 3: 364–73
   PubMed Web of Science ®Google Scholar
• Lamartiniere C. A., Cotroneo M. S., Fritz W. A. Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate. J Nutr 2002; 132: 552S–8
   PubMed Web of Science ®Google Scholar
• Liu B., Edgerton S., Yang X., Kim A., Ordonez‐Ercan D., Mason T., Alvarez K. Low‐dose dietary phytoestrogen abrogates tamoxifen‐associated mammary tumor prevention. Cancer Res 2005; 65: 879–86
   PubMed Web of Science ®Google Scholar
• Pienta K. J., Goodson J. A., Esper P. S. Epidemiology of prostate cancer: molecular and environmental clues. Urology 1996; 48: 676–83
   PubMed Web of Science ®Google Scholar
• Shimizu H., Ross R. K., Bernstein L., Yatani R., Henderson B. E., Mack T. M. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer 1991; 63: 963–6
   PubMed Web of Science ®Google Scholar
• Jacobsen B. K., Knutsen S. F., Fraser G. E. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes Control 1998; 9: 553–7
   PubMed Web of Science ®Google Scholar
• Kolonel L. N., Hankin J. H., Whittemore A. S., Wu A. H., Gallagher R. P., Wilkens L. R. Vegetables, fruits, legumes and prostate cancer: a multiethnic case‐control study. Cancer Epidemiol Biomarkers Prev 2000; 9: 795–804
   PubMed Web of Science ®Google Scholar
• Lee M. M., Wang R. T., Hsing A. W., Wang T. Spitz M. Case‐control study of diet and prostate cancer in China. Cancer Causes Control 1998; 9: 545–52
   PubMed Web of Science ®Google Scholar
• Oishi K., Okada K., Yoshida O., Yamabe H., Ohno Y., Hayes R. B., Schroeder F. H. A case‐control study of prostatic cancer with reference to dietary habits. Prostate 1988; 12: 179–90
   PubMed Web of Science ®Google Scholar
• Hirayama T. Epidemiology of prostate cancer with special reference to the role of diet. National Cancer Institute Monograph 1979; 53: 149–55
   PubMedGoogle Scholar
• Urban D., Irwin W., Kirk M., Markiewicz M. A., Myers R., Smith M. The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol 2001; 165: 294–300
   PubMed Web of Science ®Google Scholar
• Adams K. F., Chen C., Newton K. M., Potter J. D., Lampe J. W. Soy isoflavones do not modulate prostate‐specific antigen concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2004; 13: 644–8
   PubMed Web of Science ®Google Scholar
• Demark‐Wahnefried W., Price D. T., Polascik T. J., Robertson C. N., Anderson E. E., Paulson D. F. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate‐specific antigen, and histopathologic features. Urology 2001; 58: 47–52
   PubMed Web of Science ®Google Scholar
• Wu A. H., Yang D., Pike M. C. A meta‐analysis of soyfoods and risk of stomach cancer: the problem of potential confounders. Cancer Epidemiol Biomarkers Prev 2000; 9: 1051–8
   PubMed Web of Science ®Google Scholar
• McKeown‐Eyssen G. E., Bright‐See E. Dietary factors in colon cancer: international relationships. Nutr Cancer 1984; 6: 160–70
   PubMedGoogle Scholar
• Tajima K., Tominaga S. Dietary habits and gastro‐intestinal cancers: a comparative case‐control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 1985; 76: 705–16
   PubMedGoogle Scholar
• Goodman M. T., Wilkens L. R., Hankin J. H., Lyu L. C., Wu A. H., Kolonel L. N. Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiology 1997; 146: 294–306
   PubMed Web of Science ®Google Scholar
• Nelson H. D., Humphrey L. L., Nygren P., Fanelli M., Venturelli E., Cantatore F. Postmenopausal hormone replacement therapy: scientific review. JAMA 2002; 288: 872–1
   PubMed Web of Science ®Google Scholar
• Gennari C., Agnusdei D., Crepaldi G., Isaia G., Mazzuoli G., Ortolani S. Effect of ipriflavone – a synthetic derivative of natural isoflavones – on bone mass loss in the early years after menopause. Menopause 1998; 5: 9–15
   PubMed Web of Science ®Google Scholar
• Lauderdale D. S., Jacobsen S. J., Furner S. E., Levy P. S., Brody J. A., Goldberg J. Hip fracture incidence among elderly Asian‐American populations. Am J Epidemiol 1997; 146: 502–9
   PubMed Web of Science ®Google Scholar
• Tsuchida K., Mizushima S., Toba M., Soda K. Dietary soybeans intake and bone mineral density among 995 middle‐aged women in Yokohama. J Epidemiol 1999; 9: 14–9
   PubMedGoogle Scholar
• Kritz‐Silverstein D., Goodman‐Gruen D. L. Usual dietary isoflavone intake, bone mineral density, and bone metabolism in post‐menopausal women. J Womens Health Gend Based Med 2002; 11: 69–78
   PubMedGoogle Scholar
• Somekawa Y., Chiguchi M., Ishibashi T., Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001; 97: 109–15
   PubMed Web of Science ®Google Scholar
• Kardinaal A. F., Morton M. S., Bruggemann Rotgans I. E., van Beresteijn E. C. Phyto‐oestrogen excretion and rate of bone loss in postmenopausal women. Eur J Clin Nutr 1998; 52: 850–5
   PubMed Web of Science ®Google Scholar
• Potter S. M., Baum J. A., Teng H. Soy protein and isoflavones: their effects on blood lipids and bone density in post‐menopausal women. Am J Clin Nutr 1998; 68: 1375S–9
   PubMed Web of Science ®Google Scholar
• Wangen K. E., Duncan A. M., Merz‐Demlow B. E., Xu X., Marcus R., Phipps W. R. Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J Clin Endocrinol Metab 2000; 85: 3043–8
   PubMed Web of Science ®Google Scholar
• Burke G. L., Vitolins M. Z., Bland D. Soybean isoflavones as an alternative to traditional hormone replacement therapy: are we there yet?. J Nutr 2000; 130: 664S–5
   Web of Science ®Google Scholar
• Alekel D. L., Germain A. S., Peterson C. T., Hanson K. B., Stewart J. W., Toda T. Isoflavone‐rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000; 72: 844–52
   PubMed Web of Science ®Google Scholar
• Lydeking‐Olsen E., Beck‐Jensen J‐E., Setchell K. D. R., Holm‐Jensen T. Soymilk or progesterone for prevention of bone loss. A 2 year randomized, placebo‐controlled trial. Eur J Nutr 2004; 43: 246–57
   PubMed Web of Science ®Google Scholar
• Chen Y. M., Ho S. C., Lam S. S., Ho S. S., Woo J. L. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double‐blind, randomized, controlled trial. Menopause 2004; 11: 246–54
   PubMed Web of Science ®Google Scholar
• Vitolins M., Anthony M., Lenschik L., Bland D. r., Burke G. L. Does soy protein and its isoflavones prevent bone loss in peri‐ and post‐menopausal women? Results of a Two‐Year Randomized Clinical Trial. J Nutr 2002; 582S, (Abstr)
   Google Scholar
• Kreikamp‐Kaspers S., Kok L., Grobbee D. E., de Haan E. H. F., Aleman A., Lampe J. W., van der Schouw Y. T. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women. JAMA 2004; 292: 65–74
   PubMed Web of Science ®Google Scholar
• Arjmandi B. H., Lucas E. A., Khalil D. A., Devareddy L., Smith B. J., McDonald J. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr J 2005; 4: 8
   PubMed Web of Science ®Google Scholar
• Spence L. A., Lipscomb E. R., Cadogan J., Martin B., Wastney M. E., Peacocock M. The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study. Am J Clin Nutr 2005; 81: 916–22
   PubMed Web of Science ®Google Scholar
• Chiechi L., Secreto G., D'Amore M., Fanelli M., Venturelli E., Cantatore F. Efficacy of a soy rich diet in preventing post‐menopausal osteoporosis: the Menfis randomized trial. Maturitas 2002; 42: 295–300
   PubMed Web of Science ®Google Scholar
• Glazier M. G., Bowman M. A. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 2001; 161: 1161–72
   PubMed Web of Science ®Google Scholar
• Sirtori C. R. Risks of benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Safety 2001; 24: 665–82
   PubMed Web of Science ®Google Scholar
• Adlercreutz H., Hamalainen E., Gorbach S., Goldin B. Dietary phyto‐oestrogens and the menopause in Japan. Lancet 1992; 339: 1233
   PubMed Web of Science ®Google Scholar
• Nagata C., Takatsuka N., Kawakami N., Shimizu H. Soy product intake and hot flushes in Japanese women: results from a community‐based prospective study. Am J Epidemiol 2001; 153: 790–3
   PubMed Web of Science ®Google Scholar
• Yaffe K., Grady D., Pressman A., Cummings S. Serum estrogen levels, cognitive performance, and risk of cognitive decline in older community women. J Am Geriatr Soc 1998; 46: 816–21
   PubMed Web of Science ®Google Scholar
• Espeland M. A., Rapp S. R., Shumaker S. A., Brunner R., Manson J. E., Sherwin B. B. Women's Health Initiative Memory Study. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004; 291: 2959–68
   PubMed Web of Science ®Google Scholar
• Hersh A. L., Stefanick M. L., Stafford R. S. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA 2004; 291: 47–53
   PubMed Web of Science ®Google Scholar
• Murkies A. L., Lombard C., Strauss B. J. G., Wilcox G., Burger H. G., Morton M. S. Dietary flour supplementation decreases post‐menopausal hot flushes: effect of soy and wheat. Maturitas 1995; 21: 189–95
   PubMed Web of Science ®Google Scholar
• Washburn S., Burke G. L., Morgan T., Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999; 6: 7–13
   PubMed Web of Science ®Google Scholar
• Duncan A. M., Underhill K. E., Xu X., Lavalleur J., Phipps W. R., Kurzer M. S. Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999; 84: 3479–84
   PubMed Web of Science ®Google Scholar
• Albertazzi P., Pansini F., Bonaccorsi G., Zanotti L., Forini E., De Aloysio D. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998; 91: 6–11
   PubMed Web of Science ®Google Scholar
• Quella S. K., Loprinzi C. L., Barton D. L., Knost J. A., Sloan J. A., LaVasseur B. I. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol 2000; 18: 1068–74
   PubMed Web of Science ®Google Scholar
• Van Patten C. L., Olivotto I. A., Chambers G. K., Gelmon K. A., Hislop T. G., Templeton E. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol 2002; 20: 1449–55
   PubMed Web of Science ®Google Scholar
• MacGregor C. A., Canney P. A., Patterson G., McDonald R., Paul J. A randomised double‐blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer. Eur J Cancer 2005; 41: 708–14
   PubMed Web of Science ®Google Scholar
• Washburn S., Burke G. L., Morgan T., Anthony M. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 1999; 6: 7–13
   PubMed Web of Science ®Google Scholar
• Faure E. D., Chantre P., Mares P. Effects of a standardized soy extract on hot flushes: a multicenter, double‐blind, randomized, placebo‐controlled study. Menopause 2002; 9: 329–34
   PubMed Web of Science ®Google Scholar
• Han K. K., Soares J. M, Jr., Haidar M. A., de Lima G. R., Baracat E. C. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002; 99: 389–94
   PubMed Web of Science ®Google Scholar
• Colacurci N., Zarcone R., Borrelli A., De Franciscis P., Fortunato N., Cirillo M. Effects of soy isoflavones on menopausal neurovegetative symptoms. Minerva Ginecologica 2004; 56: 407–12
   PubMedGoogle Scholar
• Petri Nahas E., Nahas Neto J., De Luca L., Traiman P., Pontes A., Dalben I. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas 2004; 48: 372–80
   PubMed Web of Science ®Google Scholar
• Baber R. J., Templeman C., Morton T., Kelly G. E. West L. Randomized placebo‐controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 1999; 2: 85–92
   PubMedGoogle Scholar
• Knight D. C., Howes J. B., Eden J. A. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric 1999; 2: 79–84
   PubMedGoogle Scholar
• Kronenberg F., Fugh‐Berman A. Complimentary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805–13
   PubMed Web of Science ®Google Scholar
• Anonymous. The role of isoflavones in menopausal health‐consensus opinion of The North American Menopause Society. Menopause 2000; 7: 215–29
   PubMed Web of Science ®Google Scholar
• Setchell K. D., Zimmer‐Nechemias L., Cai J., Heubi J. E. Exposure of infants to phyto‐oestrogens from soy‐based infant formula. Lancet 1997; 350: 23–7
   PubMed Web of Science ®Google Scholar
• Kulling S. E., Rosenberg B., Jacobs E., Metzler M. The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lynphocytes. Arch Toxicol 1999; 73: 50–4
   PubMed Web of Science ®Google Scholar
• Yellayi S., Naaz A., Szewcczykowski M., Sato T., Woods J. A., Chang J. The phytoestrogen genistein induces thymic and immmune changes: a human health concern?. Proc Natl Acad Sci U S A 2002; 99: 7616–21
   PubMed Web of Science ®Google Scholar
• Sakabe K., Okuma M., Karaki S., Matsuura S., Yoshida T., Aikawa H. Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture. Int J Immunopharmacol 1999; 21: 861–8
   PubMed Web of Science ®Google Scholar
• Strom B. L., Schinnar R., Ziegler E. E., Barnhart K. T., Sammel M. D., Macones G. A. Exposure to soy‐based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA 2001; 286: 807–14
   PubMed Web of Science ®Google Scholar
• Doerge D. R., Sheehan D. M. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect 2002; 110: 349–53
   PubMed Web of Science ®Google Scholar
• Chen A. C., Berhow M. A., Tappenden K. A., Donovan S. M. Genistein inhibits intestinal cell proliferation in piglets. Pediatr Res 2005; 57: 192–200
   PubMed Web of Science ®Google Scholar
• Chen A., Rogan W. J. Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annu Rev Nutr 2004; 24: 33–54
   PubMed Web of Science ®Google Scholar
• Committee on Toxicity of Chemicals in Food Consumer Products the Environment. (1996) Annual report of the Committees on Toxicity, Mutagenicity and Carcinogenicity. HMSO, London 1996; 20–2
   Google Scholar
• Agence Française de sécurité sanitaire des aliments. Présentation du rapport sur "Sécurité et bénéfices des phyto‐estrogènes apportés par l'alimentation Recommandations
   Google Scholar
• Arici A., Bukulmez O. Phyto‐oestrogens and the endometrium. Lancet 2004; 364: 2081–2
   PubMed Web of Science ®Google Scholar
• Gazzetta Ufficiale Italiana 18/7/2002, number 188, annex 2
   Google Scholar
• Morandi S., D'Agostina A., Ferrario F., Arnoldi A. Isoflavone content of Italian soy food products and daily intakes of some specific classes of consumers. Eur Food Res Technol 2005; 221: 84–91
   Web of Science ®Google Scholar
• Kreikamp‐Kaspers, Kok L., Bots M. L., Grobbee D. E., van der Schouw Y. T. Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross‐sectional study. Atherosclerosis 2005; 178: 95–100
   PubMed Web of Science ®Google Scholar
• Arnoldi A. Grain legumes as a source of food ingredients for the prevention of cardiovascular disease. Functional Foods, Diet, Cardiovascular Disease and Diabetes, A Arnoldi. Woodhead Publications Ltd, CambridgeUK 2004; 422–47
   Google Scholar
• Hall R. S., Johnson S. K., Baxter A. L., Ball M. J. Lupin kernel fibre‐enriched foods beneficially modify serum lipids in men. Eur J Clin Nutr 2005; 59: 325–33
   PubMed Web of Science ®Google Scholar
• Martins J. M., Riottot M., Abreu M. C., Viegas‐Crespo A. M., Lanca M. J., Almeida J. A. Cholesterol‐lowering effects of dietary blue lupin seeds (Lupinus angustifolius L.) in intact and ileo‐rectal anastomosed growing pigs fed cholesterol‐rich diets. J Lipid Res 2005; 46: 1539–47
   PubMed Web of Science ®Google Scholar