667
Views
44
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Complement C3 contributes to ethanol‐induced liver steatosis in mice

, , , &
Pages 280-286 | Received 16 Jan 2006, Accepted 28 Feb 2006, Published online: 08 Jul 2009

References

  • Stewart S., Jones D., Day C. P. Alcoholic liver disease: new insights into mechanisms and preventative strategies. Trends Mol Med 2001; 7: 408–13
  • Schenker S., Bay M. K. Alcohol and endotoxin: another path to alcoholic liver injury?. Alcohol Clin Exp Res 1995; 19: 1364–6
  • Campbell W., Okada N., Okada H. Carboxypeptidase R is an inactivator of complement‐derived inflammatory peptides and an inhibitor of fibrinolysis. Immunol Rev 2001; 180: 162–7
  • Baldo A., Sniderman A. D., St‐Luce S., Avramoglu R. K., Maslowska M., Hoang B., et al. The adipsin‐acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J Clin Invest 1993; 92: 1543–7
  • Cianflone K., Xia Z., Chen L. Y. Critical review of acylation‐stimulating protein physiology in humans and rodents. Biochim Biophys Acta 2003; 1609: 127
  • Persson L., Boren J., Robertson A. K., Wallenius V., Hansson G. K., Pekna M. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E−/− low‐density lipoprotein receptor−/− mice. Arterioscler Thromb Vasc Biol 2004; 24: 1062–7
  • Murray I., Sniderman A. D., Cianflone K. Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice. Am J Physiol 1999; 277: E474–E480
  • Strey C. W., Markiewski M., Mastellos D., Tudoran R., Spruce L. A., Greenbaum L. E., et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003; 198: 913–23
  • Puschel G. P., Hespeling U., Oppermann M., Dieter P. Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. Hepatology 1993; 18: 1516–21
  • Schieferdecker H. L., Rothermel E., Timmermann A., Gotze O., Jungermann K. Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver. FEBS Lett 1997; 406: 305–9
  • Ramaiah S., Rivera C., Arteel G. Early‐phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int J Toxicol 2004; 23: 217–31
  • Jarvelainen H. A., Fang C., Ingelman‐Sundberg M., Lukkari T. A., Sippel H., Lindros K. O. Kupffer cell inactivation alleviates ethanol‐induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver. J Hepatol 2000; 32: 900–10
  • Jarvelainen H. A., Vakeva A., Lindros K. O., Meri S. Activation of complement components and reduced regulator expression in alcohol‐induced liver injury in the rat. Clin Immunol 2002; 105: 57–63
  • Bykov I. L., Vakeva A., Jarvelainen H. A., Meri S., Lindros K. O. Protective function of complement against alcohol‐induced rat liver damage. Int Immunopharmaco 2004; 12: 1445–54
  • Pekna M., Hietala M. A., Rosklint T., Betsholtz C., Pekny M. Targeted disruption of the murine gene coding for the third complement component (C3). Scand J Immunol 1998; 47: 25–9
  • Bykov I., Palmen M., Piirainen L., Lindros K. O. Oral chronic ethanol administration to rodents by agar gel diet. Alcohol Alcohol 2004; 39: 499–502
  • Lindros K. O., Jarvelainen H. A. A new oral low‐carbohydrate alcohol liquid diet producing liver lesions: a preliminary account. Alcohol Alcohol 1998; 3: 347–53
  • Hu Y., Ingelman‐Sundberg M., Lindros K. O. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochem Pharmacol 1995; 50: 155–61
  • Ohkawa H., Ohishi N., Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351–58
  • Sissons J. G., West R. J., Fallows J., Williams D. G., Boucher B. J., Amos N., et al. The complement abnormalities of lipodystrophy. N Engl J Med 1976; 294: 461–5
  • Misra A., Peethambaram A., Garg A. Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature. Medicine 2004; 83: 18–34
  • Homann C., Varming K., Hogasen K., Mollnes T. E., Graudal N., Thomsen A. C., et al. Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality. Gut 1997; 40: 544–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.