507
Views
48
CrossRef citations to date
0
Altmetric
REVIEW ARTICLE

Endothelial progenitor cells in health and atherosclerotic disease

&
Pages 82-90 | Published online: 08 Jul 2009

References

  • Lusis A. J. Atherosclerosis. Nature 2000; 407: 233–41
  • Jimenez J. J., Jy W., Mauro L. M., Horstman L. L., Ahn Y. S. Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease. Br J Haematol 2001; 112: 81–90
  • Sabatier F., Darmon P., Hugel B., Combes V., Sanmarco M., Velut J. G., et al. Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes 2002; 51: 2840–5
  • Preston R. A., Jy W., Jimenez J. J., Mauro L. M., Horstman L. L., Valle M., et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension 2003; 41: 211–17
  • Mallat Z., Benamer H., Hugel B., Benessiano J., Steg P. G., Freyssinet J. M., et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000; 101: 841–3
  • Libby P., Schwartz D., Brogi E., Tanaka H., Clinton S. K. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992; 86(Suppl)III47–52
  • Schwartz S. M., Benditt E. P. Clustering of replicating cells in aortic endothelium. Proc Natl Acad Sci U S A 1976; 73: 651–3
  • Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221–8
  • Crosby J. R., Kaminski W. E., Schatteman G., Martin P. J., Raines E. W., Seifert R. A., et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res 2000; 87: 728–30
  • Asahara T., Murohara T., Sullivan A., Silver M., van der Z. R., Li T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964–7
  • Gill M., Dias S., Hattori K., Rivera M. L., Hicklin D., Witte L., et al. Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells. Circ Res 2001; 88: 167–74
  • Handgretinger R., Gordon P. R., Leimig T., Chen X., Buhring H. J., Niethammer D., et al. Biology and plasticity of CD133+ hematopoietic stem cells. Ann N Y Acad Sci 2003; 996: 141–51
  • Rafii S., Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003; 9: 702–12
  • Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89: E1–7
  • Shepherd R. M., Capoccia B. J., Devine S. M., Dipersio J., Trinkaus K. M., Ingram D., et al. Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood 2006 Aug 15, [Epub ahead of print]
  • Rehman J., Li J., Orschell C. M., March K. L. Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107: 1164–9
  • Ingram D. A., Caplice N. M., Yoder M. C. Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood 2005; 106: 1525–31
  • Friedrich E. B., Walenta K., Scharlau J., Nickenig G., Werner N. CD34‐/CD133+/VEGFR‐2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities. Circ Res 2006; 98: e20–5
  • Simper D., Stalboerger P. G., Panetta C. J., Wang S., Caplice N. M. Smooth muscle progenitor cells in human blood. Circulation 2002; 106: 1199–204
  • Hill J. M., Zalos G., Halcox J. P., Schenke W. H., Waclawiw M. A., Quyyumi A. A., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348: 593–600
  • Tepper O. M., Galiano R. D., Capla J. M., Kalka C., Gagne P. J., Jacobowitz G. R., et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002; 106: 2781–6
  • Walter D. H., Rittig K., Bahlmann F. H., Kirchmair R., Silver M., Murayama T., et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow‐derived endothelial progenitor cells. Circulation 2002; 105: 3017–24
  • Werner N., Priller J., Laufs U., Endres M., Böhm M., Dirnagl U., et al. Bone marrow‐derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol 2002; 22: 1567–72
  • Rauscher F. M., Goldschmidt‐Clermont P. J., Davis B. H., Wang T., Gregg D., Ramaswami P., et al. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 2003; 108: 457–63
  • George J., Afek A., Abashidze A., Shmilovich H., Deutsch V., Kopolovich J., et al. Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2005; 25: 2636–41
  • Werner N., Junk S., Laufs U., Link A., Walenta K., Böhm M., et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003; 93: e17–24
  • Sata M., Saiura A., Kunisato A., Tojo A., Okada S., Tokuhisa T., et al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002; 8: 403–09
  • Campbell J. H., Han C. L., Campbell G. R. Neointimal formation by circulating bone marrow cells. Ann N Y Acad Sci 2001; 947: 18–24
  • Badorff C., Brandes R. P., Popp R., Rupp S., Urbich C., Aicher A., et al. Transdifferentiation of blood‐derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation 2003; 107: 1024–32
  • Koyanagi M., Urbich C., Chavakis E., Hoffmann J., Rupp S., Badorff C., et al. Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E‐cadherin. FEBS Lett 2005; 579: 6060–6
  • Strehlow K., Werner N., Berweiler J., Link A., Dirnagl U., Priller J., et al. Estrogen Increases Bone Marrow‐Derived Endothelial Progenitor Cell Production and Diminishes Neointima Formation. Circulation 2003; 107: 3059–65
  • Hattori K., Dias S., Heissig B., Hackett N. R., Lyden D., Tateno M., et al. Vascular endothelial growth factor and angiopoietin‐1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J Exp Med 2001; 193: 1005–14
  • Hattori K., Heissig B., Wu Y., Dias S., Tejada R., Ferris B., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone‐marrow microenvironment. Nat Med 2002; 8: 841–9
  • Heeschen C., Aicher A., Lehmann R., Fichtlscherer S., Vasa M., Urbich C., et al. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood 2003; 102: 1340–6
  • Yamaguchi J., Kusano K. F., Masuo O., Kawamoto A., Silver M., Murasawa S., et al. Stromal cell‐derived factor‐1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 2003; 107: 1322–8
  • Laufs U., Werner N., Link A., Endres M., Wassmann S., Jurgens K., et al. Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis. Circulation 2004; 109: 220–6
  • Aicher A., Heeschen C., Mildner‐Rihm C., Urbich C., Ihling C., Technau‐Ihling K., et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370–6
  • Heissig B., Hattori K., Dias S., Friedrich M., Ferris B., Hackett N. R., et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP‐9 mediated release of kit‐ligand. Cell 2002; 109: 625–37
  • Ripa R. S., Jorgensen E., Wang Y., Thune J. J., Nilsson J. C., Sondergaard L., et al. Stem cell mobilization induced by subcutaneous granulocyte‐colony stimulating factor to improve cardiac regeneration after acute ST‐elevation myocardial infarction: result of the double‐blind, randomized, placebo‐controlled stem cells in myocardial infarction (STEMMI) trial. Circulation 2006; 113: 1983–92
  • Zohlnhofer D., Ott I., Mehilli J., Schomig K., Michalk F., Ibrahim T., et al. Stem cell mobilization by granulocyte colony‐stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA 2006; 295: 1003–10
  • Nienaber C. A., Petzsch M., Kleine H. D., Eckard H., Freund M., Ince H. Effects of granulocyte‐colony‐stimulating factor on mobilization of bone‐marrow‐derived stem cells after myocardial infarction in humans. Nat Clin Pract Cardiovasc Med 2006; 3(Suppl 1)S73–7
  • Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999–1007
  • Jimenez J. J., Jy W., Mauro L. M., Soderland C., Horstman L. L., Ahn Y. S. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 2003; 109: 175–80
  • Bernal‐Mizrachi L., Jy W., Jimenez J. J., Pastor J., Mauro L. M., Horstman L. L., et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Am Heart J 2003; 145: 962–70
  • Boulanger C. M., Scoazec A., Ebrahimian T., Henry P., Mathieu E., Tedgui A., et al. Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation 2001; 104: 2649–52
  • Myers J. E., Baker P. N. Isolated microparticles, but not whole plasma, from women with preeclampsia impair endothelium‐dependent relaxation in isolated myometrial arteries from healthy pregnant women. Am J Obstet Gynecol 2003; 189: 1209–10
  • Werner N., Wassmann S., Ahlers P., Kosiol S., Nickenig G. Circulating CD31+/Annexin V+ Apoptotic Microparticles Correlate with Coronary Endothelial Function in Patients With Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2006; 26: 112–6
  • Op D. B., Musters M., Verrips T., Post J. A., Braam B., Van Riel N. Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening. Am J Physiol Heart Circ Physiol 2004; 287: H2651–8
  • Stoll B. R., Migliorini C., Kadambi A., Munn L. L., Jain R. K. A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood 2003; 102: 2555–61

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.