Triggers of IgE class switching and allergy development

References

• Holt P. G., Sly P. D., Martinez F. D., Weiss S. T., Bjorksten B., von Mutius E., et al. Drug development strategies for asthma: in search of a new paradigm. Nat Immunol 2004; 5: 695–8
   Google Scholar
• Krause T., Koch A., Friborg J., Poulsen L. K., Kristensen B., Melbye M. Frequency of atopy in the Arctic in 1987 and 1998. Lancet 2002; 360: 691–2
   Web of Science ®Google Scholar
• Yazdanbakhsh M., van den Biggelaar A., Maizels R. M. Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 2001; 22: 372–7
   PubMed Web of Science ®Google Scholar
• Bhalla R. B., Rappaport I., DeFilippi I., Schwartz M. K. Serum IgE levels in a Northeast United States caucasian population. Advanced interpretation of clinical laboratory data, C Heusghem, A Albert, E. S Benson. Marcel Dekker, Inc., New York 1982; 295–305
   Google Scholar
• Hansen D., Hornnes P., Poulsen L. K. IgE levels in cord blood in capillary blood at 4–6 days of age. Pediatr Allergy Immunol 1993; 4: 30–3
   Google Scholar
• Waldman T. A., Strober W., Blaese R. M. Variations in the metabolism of immunoglobulins measured by turnover rates. Immunoglobulins, E Merler. National Academy of Science, Washington 1970; 33–51
   Google Scholar
• Dreskin S. C., Goldsmith P. K., Strober W., Zech L. A., Gallin J. I. Metabolism of immunoglobulin E in patients with markedly elevated serum immunoglobulin E levels. J Clin Invest 1987; 79: 1764–72
   Google Scholar
• Johansson S. G., Nopp A., van Hage M., Olofsson N., Lundahl J., Wehlin L., et al. Passive IgE‐sensitization by blood transfusion. Allergy 2005; 60: 1192–9
   PubMed Web of Science ®Google Scholar
• Ramirez M. A. Horse asthma following blood tranfusion. JAMA 1919; 73: 984
   Google Scholar
• Savliwala M. N., Reisman R. E. Studies of the natural history of stinging‐insect allergy: Long‐term follow‐up of patients without immunotherapy. J Allergy Clin Immunol 1987; 80: 741–5
   Google Scholar
• Hansen T. K., Bindslev‐Jensen C., Poulsen L. K. Long‐term changes in specific IgE to codfish. 2004, Proceedings from 9th International Symposium on Immunological, Chemical and Clinical Problems of Food Allergy. Budapest, Hungary. April 18–21, 2004
   Google Scholar
• Ober C., Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006; 7: 95–100
   PubMed Web of Science ®Google Scholar
• Bodtger U., Poulsen L. K., Malling H. J. Asymptomatic skin sensitization to birch predicts later development of birch pollen allergy in adults: A 3‐year follow‐up study. J Allergy Clin Immunol 2003; 111: 149–54
   Google Scholar
• Bodtger U. Prognostic value of asymptomatic skin sensitization to aeroallergens. Curr Opin Allergy Clin Immunol 2004; 4: 5–10
   Google Scholar
• Lynch N. R., Hagel I., Vargas M., Perez M., Lopez R. I., Garcia N. M., et al. Effect of age and helminthic infection on IgE levels in slum children. J Investig Allergol Clin Immunol 1993; 3: 96–9
   Google Scholar
• Kartasamita C. B., Rosmayudi O., Demedts M. Total serum IgE and eosinophil count in children with and without a history of asthma, wheezing, or atopy in an urban community in Indonesia. The Respiratory Disease Working Group. J Allergy Clin Immunol 1994; 94: 981–8
   PubMed Web of Science ®Google Scholar
• Hagel I., Lynch N. R., Di P. M., Rojas E., Perez M., Alvarez N. Ascaris reinfection of slum children: relation with the IgE response. Clin Exp Immunol 1993; 94: 80–3
   Google Scholar
• Pedersen M. Type 1 allergiske in vitro reaktioner overfor mikororganismer hos patienter med AIDS [Thesis]. Københavns Universitet, Copenhagen 1990
   Google Scholar
• Szczeklik A., Jawien J. Immunoglobulin E in acute phase response to surgical stress. Clin Exp Allergy 1996; 26: 303–7
   Google Scholar
• Kampen G. T., Poulsen L. K., Nielsen H. J., Schulze F., Petersen L. J. IgE levels in surgery. Effect of ranitidine and prednisolone. Allergy 1999; 544: 171–6
   Google Scholar
• Hällgren R., Lundin L. Increased total serum IgE in alcoholics. Acta Med Scand 1983; 213: 99–103
   Google Scholar
• Strachan D. P. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259–60
   PubMed Web of Science ®Google Scholar
• Matricardi P. M., Rosmini F., Ferrigno L., Nisini R., Rapicetta M., Chionne P., et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 1997; 314: 999–1003
   PubMed Web of Science ®Google Scholar
• Matricardi P. M., Rosmini F., Riondino S., Fortini M., Ferrigno L., Rapicetta M., et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000; 320: 412–7
   PubMed Web of Science ®Google Scholar
• Riedler J., Braun‐Fahrlander C., Eder W., Schreuer M., Waser M., Maisch S., et al. Exposure to farming in early life and development of asthma and allergy: a cross‐sectional survey. Lancet 2001; 358: 1129–33
   PubMed Web of Science ®Google Scholar
• Alm J. S., Swartz J., Lilja G., Scheynius A., Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet 1999; 353: 1485–8
   PubMed Web of Science ®Google Scholar
• Yazdanbakhsh M., Matricardi P. M. Parasites and the hygiene hypothesis: regulating the immune system?. Clin Rev Allergy Immunol 2004; 26: 15–24
   Google Scholar
• Olesen A. B., Juul S., Birkebaek N., Thestrup‐Pedersen K. Association between atopic dermatitis and insulin‐dependent diabetes mellitus: a case‐control study. Lancet 2001; 357: 1749–52
   PubMed Web of Science ®Google Scholar
• Sheikh A., Smeeth L., Hubbard R. There is no evidence of an inverse relationship between TH2‐mediated atopy and TH1‐mediated autoimmune disorders: Lack of support for the hygiene hypothesis. J Allergy Clin Immunol 2003; 111: 131–5
   PubMed Web of Science ®Google Scholar
• Tirosh A., Mandel D., Mimouni F. B., Zimlichman E., Shochat T., Kochba I. Autoimmune diseases in asthma. Ann Intern Med 2006; 144: 877–83
   PubMed Web of Science ®Google Scholar
• Yazdanbakhsh M., Kremsner P. G., Van Ree R. Allergy, parasites, and the hygiene hypothesis. Science 2002; 296: 490–4
   PubMed Web of Science ®Google Scholar
• Macpherson A. J., Harris N. L. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004; 4: 478–85
   PubMed Web of Science ®Google Scholar
• Poulsen L. K., Pedersen M. F., Malling H‐J., Søndergaard I., Weeke B. Maxisorp RAST. A sensitive method for detection of absolute quantities of antigen‐specific IgE. Allergy 1989; 44: 178–89
   Google Scholar
• Paull B. R., Jacob G. L., Yunginger J. W., Gleich G. J. Comparison between binding of IgE and IgG antibodies to honey bee venom phospholipase‐A. J Immunol 1978; 120: 1917–23
   Google Scholar
• Zeiss C. R., Pruzansky J. J., Patterson R., Roberts M. A solid phase radioimmunoassay for the quantitation of human reaginic antibody against ragweed antigen E. J Immunol 1973; 110: 414–21
   PubMedGoogle Scholar
• Schellenberg R. R., Adkinson N. F. Measurement of absolute amounts of antigen‐specific human IgE by a radioallergosorbent test (RAST) elution technique. J Immunol 1975; 115: 1577–83
   PubMed Web of Science ®Google Scholar
• Eder W., Ege M. J., von Mutius E. The asthma epidemic. N Engl J Med 2006; 355: 2226–35
   PubMed Web of Science ®Google Scholar
• Skov P. S., Pelck I., Ebbesen F., Poulsen L. K. Case report: Hypersensitivity to the diphteria component in the Di‐Te‐Pol vaccine. A type I allergic reaction demonstrated by basophil histamine release. Pediatr Allergy Immunol 1997; 8: 156–8
   Google Scholar
• Wahn U., Lau S., Bergmann R., Kulig M., Forster J., Bergmann K., et al. Indoor allergen exposure is a risk factor for sensitization during the first three years of life. J Allergy Clin Immunol 1997; 99: 763–9
   PubMed Web of Science ®Google Scholar
• Johnsen C. R., Sorensen T. B., Ingemann L. A., Bertelsen S. A., Andreasen E., Kofoed G. S., et al. Allergy risk in an enzyme producing plant: a retrospective follow up study. Occup Environ Med 1997; 54: 671–5
   PubMed Web of Science ®Google Scholar
• Paulsen E., Skov P. S., Bindslev‐Jensen C., Voitenko V., Poulsen L. K. Occupational type I allergy to Christmas cactus (Schlumbergera). Allergy 1997; 52: 656–60
   Google Scholar
• Diaz‐Sanchez D., Garcia M. P., Wang M., Jyrala M., Saxon A. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol 1999; 104: 1183–8
   PubMed Web of Science ®Google Scholar
• Riedl M. A., Landaw E. M., Saxon A., Diaz‐Sanchez D. Initial high‐dose nasal allergen exposure prevents allergic sensitization to a neoantigen. J Immunol 2005; 174: 7440–5
   PubMed Web of Science ®Google Scholar
• Traidl‐Hoffmann C., Mariani V., Hochrein H., Karg K., Wagner H., Ring J., et al. Pollen‐associated phytoprostanes inhibit dendritic cell interleukin‐12 production and augment T helper type 2 cell polarization. J Exp Med 2005; 201: 627–36
   PubMed Web of Science ®Google Scholar
• Van Der Kleij D., Latz E., Brouwers J. F., Kruize Y. C., Schmitz M., Kurt‐Jones E. A., et al. A novel host‐parasite lipid cross talk: schistosomal lyso‐phosphatidylserine activates Toll‐like receptor‐2 and affects immune polarization. J Biol Chem 2002; 277: 48122–9
   PubMed Web of Science ®Google Scholar
• Seong S. Y., Matzinger P. Hydrophobicity: an ancient damage‐associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 2004; 4: 469–78
   PubMed Web of Science ®Google Scholar
• Mosmann T. R., Cherwinski H., Bond M. W., Giedlin M. A., Coffman R. L. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348–57
   PubMed Web of Science ®Google Scholar
• Asseman C., Mauze S., Leach M. W., Coffman R. L., Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995–1004
   PubMed Web of Science ®Google Scholar
• Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell‐mediated tissue damage. Nat Med 2007; 13: 139–45
   PubMed Web of Science ®Google Scholar
• Cosman D. A family of ligands for the TNF receptor superfamily. Stem Cells 1994; 12: 440–55
   PubMed Web of Science ®Google Scholar
• Bossen C., Ingold K., Tardivel A., Bodmer J. L., Gaide O., Hertig S., et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem 2006; 281: 13964–71
   PubMed Web of Science ®Google Scholar
• Ito T., Wang Y. H., Duramad O., Hori T., Delespesse G. J., Watanabe N., et al. TSLP‐activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 2005; 202: 1213–23
   PubMed Web of Science ®Google Scholar
• Ito T., Wang Y. H., Duramad O., Hanabuchi S., Perng O. A., Gilliet M., et al. OX40 ligand shuts down IL‐10‐producing regulatory T cells. Proc Natl Acad Sci U S A 2006; 103: 13138–43
   PubMedGoogle Scholar
• Liu Y. J., Soumelis V., Watanabe N., Ito T., Wang Y. H., Malefyt R. D., et al. TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation. Annu Rev Immunol 2007; 25: 193–219
   PubMed Web of Science ®Google Scholar
• Takei M., Umeyama A., Arihara S. Diterpenes inhibit IL‐12 production by DC and enhance Th2 cells polarization. Biochem Biophys Res Commun 2007; 355: 603–10
   Google Scholar
• Shapiro‐Shelef M., Calame K. Regulation of plasma‐cell development. Nat Rev Immunol 2005; 5: 230–42
   PubMed Web of Science ®Google Scholar
• Rolink A., Streb M., Nishikawa S., Melchers F. The c‐kit‐encoded tyrosine kinase regulates the proliferation of early pre‐B cells. Eur J Immunol 1991; 21: 2609–12
   Google Scholar
• Duchosal M. A. B‐cell development and differentiation. Semin Hematol 1997; 34: 2–12
   PubMed Web of Science ®Google Scholar
• Janeway J., Travers P. The humoral immune response. Publishing Inc., New York 1997; 8:2–8:51
   Google Scholar
• Kelsoe G., Zheng B. Sites of B‐cell activation in vivo. Curr Opin Immunol 1993; 5: 418–22
   PubMed Web of Science ®Google Scholar
• Henderson A., Calame K. Transcriptional regulation during B cell development. Annu Rev Immunol 1998; 16: 163–200
   PubMed Web of Science ®Google Scholar
• Karasuyama H., Rolink A., Shinkai Y., Young F., Alt F. W., Melchers F. The expression of Vpre‐B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell‐deficient mutant mice. Cell 1994; 77: 133–43
   PubMedGoogle Scholar
• Melchers F., Haasner D., Grawunder U., Kalberer C., Karasuyama H., Winkler T., et al. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol 1994; 12: 209–25
   PubMed Web of Science ®Google Scholar
• Thomas M. D., Srivastava B., Allman D. Regulation of peripheral B cell maturation. Cell Immunol 2006; 239: 92–102
   PubMedGoogle Scholar
• Garraud O., Nutman T. B. The role of cytokines in human B‐cell differentiation into immunoglobulin‐secreting cells. Bull Inst Pasteur 1996; 94: 285–309
   Google Scholar
• Wabl M., Jack H. M., Meyer J., Beck‐Engeser G., von Borstel R. C., Steinberg C. M. Measurements of mutation rates in B lymphocytes. Immunol Rev 1987; 96: 91–107
   PubMed Web of Science ®Google Scholar
• Wu J., Qin D., Burton G. F., Szakal A. K., Tew J. G. Follicular dendritic cell‐derived antigen and accessory activity in initiation of memory IgG responses in vitro. J Immunol 1996; 157: 3404–11
   Google Scholar
• Warren W. D., Berton M. T. Induction of germ‐line gamma 1 and epsilon Ig gene expression in murine B cells. IL‐4 and the CD40 ligand‐CD40 interaction provide distinct but synergistic signals. J Immunol 1995; 155: 5637–46
   PubMedGoogle Scholar
• Iciek L. A., Delphin S. A., Stavnezer J. CD40 cross‐linking induces Ig epsilon germline transcripts in B cells via activation of NF‐kappaB: synergy with IL‐4 induction. J Immunol 1997; 158: 4769–79
   PubMed Web of Science ®Google Scholar
• Armitage R. J., Macduff B. M., Spriggs M. K., Fanslow W. C. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J Immunol 1993; 150: 3671–80
   PubMed Web of Science ®Google Scholar
• Ivashkiv L. B. Cytokines and STATs: how can signals achieve specificity?. Immunity 1995; 3: 1–4
   PubMedGoogle Scholar
• Schindler C., Kashleva H., Pernis A., Pine R., Rothman P. STF‐IL‐4: a novel IL‐4‐induced signal transducing factor. EMBO J 1994; 13: 1350–6
   PubMedGoogle Scholar
• Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL‐4 and IL‐3 but are not required for mitogenesis. Mol Cell Biol 1995; 15: 3336–43
   PubMed Web of Science ®Google Scholar
• Wick K. R., Berton M. T. IL‐4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes. Mol Immunol 2000; 37: 641–52
   PubMed Web of Science ®Google Scholar
• Oettgen H. C. Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts. Curr Opin Immunol 2000; 12: 618–23
   PubMed Web of Science ®Google Scholar
• Bacharier L. B., Jabara H., Geha R. S. Molecular mechanisms of immunoglobulin E regulation. Int Arch Allergy Immunol 1998; 115: 257–69
   Google Scholar
• Gauchat J. F., Lebman D. A., Coffman R. L., Gascan H., de Vries J. E. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 1990; 172: 463–73
   PubMed Web of Science ®Google Scholar
• Lutzker S., Alt F. W. Structure and expression of germ line immunoglobulin gamma 2b transcripts. Mol Cell Biol 1988; 8: 1849–52
   PubMed Web of Science ®Google Scholar
• Stavnezer‐Nordgren J., Sirlin S. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J 1986; 5: 95–102
   PubMed Web of Science ®Google Scholar
• Fear D. J., McCloskey N., O'Connor B., Felsenfeld G., Gould H. J. Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination. J Immunol 2004; 173: 4529–38
   PubMed Web of Science ®Google Scholar
• Stavnezer J. Immunoglobulin class switching. Curr Opin Immunol 1996; 8: 199–205
   PubMed Web of Science ®Google Scholar
• Stavnezer J., Radcliffe G., Lin Y. C., Nietupski J., Berggren L., Sitia R., et al. Immunoglobulin heavy‐chain switching may be directed by prior induction of transcripts from constant‐region genes. Proc Natl Acad Sci U S A 1988; 85: 7704–8
   PubMed Web of Science ®Google Scholar
• Jung S., Rajewsky K., Radbruch A. Shutdown of class switch recombination by deletion of a switch region control element. Science 1993; 259: 984–7
   PubMed Web of Science ®Google Scholar
• Yu K., Chedin F., Hsieh C. L., Wilson T. E., Lieber M. R. R‐loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol 2003; 4: 442–51
   PubMed Web of Science ®Google Scholar
• Daniels G. A., Lieber M. R. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res 1995; 23: 5006–11
   PubMed Web of Science ®Google Scholar
• Dickerson S. K., Market E., Besmer E., Papavasiliou F. N. AID mediates hypermutation by deaminating single stranded DNA. J Exp Med 2003; 197: 1291–6
   PubMed Web of Science ®Google Scholar
• Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., Alt F. W. Transcription‐targeted DNA deamination by the AID antibody diversification enzyme. Nature 2003; 422: 726–30
   PubMed Web of Science ®Google Scholar
• Pham P., Bransteitter R., Petruska J., Goodman M. F. Processive AID‐catalysed cytosine deamination on single‐stranded DNA simulates somatic hypermutation. Nature 2003; 424: 103–7
   PubMed Web of Science ®Google Scholar
• Ramiro A. R., Stavropoulos P., Jankovic M., Nussenzweig M. C. Transcription enhances AID‐mediated cytidine deamination by exposing single‐stranded DNA on the nontemplate strand. Nat Immunol 2003; 4: 452–6
   PubMed Web of Science ®Google Scholar
• Bransteitter R., Pham P., Scharff M. D., Goodman M. F. Activation‐induced cytidine deaminase deaminates deoxycytidine on single‐stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A 2003; 100: 4102–7
   PubMed Web of Science ®Google Scholar
• Petersen‐Mahrt S. K., Harris R. S., Neuberger M. S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002; 418: 99–103
   PubMed Web of Science ®Google Scholar
• Rada C., Williams G. T., Nilsen H., Barnes D. E., Lindahl T., Neuberger M. S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG‐deficient mice. Curr Biol 2002; 12: 1748–55
   PubMed Web of Science ®Google Scholar
• Di Noia J., Neuberger M. S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil‐DNA glycosylase. Nature 2002; 419: 43–8
   PubMed Web of Science ®Google Scholar
• Kenter A. L. Class‐switch recombination: after the dawn of AID. Curr Opin Immunol 2003; 15: 190–8
   PubMed Web of Science ®Google Scholar
• Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation‐induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102: 553–63
   PubMed Web of Science ®Google Scholar
• Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., et al. Activation‐induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper‐IgM syndrome (HIGM2). Cell 2000; 102: 565–75
   PubMed Web of Science ®Google Scholar
• McHeyzer‐Williams M. G., Ahmed R. B cell memory and the long‐lived plasma cell. Curr Opin Immunol 1999; 11: 172–9
   PubMed Web of Science ®Google Scholar
• Heyzer‐Williams L. J., Heyzer‐Williams M. G. Antigen‐specific memory B cell development. Annu Rev Immunol 2005; 23: 487–513
   Google Scholar
• Reimold A. M., Iwakoshi N. N., Manis J., Vallabhajosyula P., Szomolanyi‐Tsuda E., Gravallese E. M., et al. Plasma cell differentiation requires the transcription factor XBP‐1. Nature 2001; 412: 300–7
   PubMed Web of Science ®Google Scholar
• Iwakoshi N. N., Lee A. H., Vallabhajosyula P., Otipoby K. L., Rajewsky K., Glimcher L. H. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP‐1. Nat Immunol 2003; 4: 321–9
   PubMed Web of Science ®Google Scholar
• Calame K. L., Lin K. I., Tunyaplin C. Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 2003; 21: 205–30
   PubMed Web of Science ®Google Scholar
• Nutt S. L., Heavey B., Rolink A. G., Busslinger M. Commitment to the B‐lymphoid lineage depends on the transcription factor Pax5. Nature 1999; 401: 556–62
   PubMed Web of Science ®Google Scholar
• Morrison A. M., Nutt S. L., Thevenin C., Rolink A., Busslinger M. Loss‐ and gain‐of‐function mutations reveal an important role of BSAP (Pax‐5) at the start and end of B cell differentiation. Semin Immunol 1998; 10: 133–42
   PubMedGoogle Scholar
• Nutt S. L., Eberhard D., Horcher M., Rolink A. G., Busslinger M. Pax5 determines the identity of B cells from the beginning to the end of B‐lymphopoiesis. Int Rev Immunol 2001; 20: 65–82
   PubMedGoogle Scholar
• Barberis A., Widenhorn K., Vitelli L., Busslinger M. A novel B‐cell lineage‐specific transcription factor present at early but not late stages of differentiation. Genes Dev 1990; 4: 849–59
   PubMedGoogle Scholar
• Turner C. A Jr., Mack D. H., Davis M. M. Blimp‐1, a novel zinc finger‐containing protein that can drive the maturation of B lymphocytes into immunoglobulin‐secreting cells. Cell 1994; 77: 297–306
   PubMed Web of Science ®Google Scholar
• Angelin‐Duclos C., Cattoretti G., Lin K. I., Calame K. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp‐1 expression in vivo. J Immunol 2000; 165: 5462–71
   PubMedGoogle Scholar
• Eisenbeis C. F., Singh H., Storb U. Pip, a novel IRF family member, is a lymphoid‐specific, PU.1‐dependent transcriptional activator. Genes Dev 1995; 9: 1377–87
   PubMed Web of Science ®Google Scholar
• Calame K. L. Plasma cells: finding new light at the end of B cell development. Nat Immunol 2001; 2: 1103–8
   Google Scholar
• Bernfield M., Sanderson R. D. Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors. Philos Trans R Soc Lond B Biol Sci 1990; 327: 171–86
   PubMed Web of Science ®Google Scholar
• Ridley R. C., Xiao H., Hata H., Woodliff J., Epstein J., Sanderson R. D. Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen. Blood 1993; 81: 767–74
   PubMed Web of Science ®Google Scholar
• Finkelman F. D., Katona I. M., Urban J. F Jr., Holmes J., Ohara J., Tung A. S., et al. IL‐4 is r113. equired to generate and sustain in vivo IgE responses. J Immunol 1988; 141: 2335–41
   PubMed Web of Science ®Google Scholar
• Jabara H. H., Fu S. M., Geha R. S., Vercelli D. CD40 and IgE: synergism between anti‐CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 1990; 172: 1861–4
   PubMed Web of Science ®Google Scholar
• Punnonen J., de Vries J. E. IL‐13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells. J Immunol 1994; 152: 1094–102
   PubMedGoogle Scholar
• Pene J., Rousset F., Briere F., Chretien I., Bonnefoy J. Y., Spits H., et al. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A 1988; 85: 6880–4
   PubMed Web of Science ®Google Scholar
• Gascan H., Gauchat J. F., Aversa G., Van Vlasselaer P., de Vries J. E. Anti‐CD40 monoclonal antibodies or CD4+ T cell clones and IL‐4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol 1991; 147: 8–13
   PubMed Web of Science ®Google Scholar
• Lebman D. A., Coffman R. L. Interleukin 4 causes isotype switching to IgE in T cell‐stimulated clonal B cell cultures. J Exp Med 1988; 168: 853–62
   PubMed Web of Science ®Google Scholar
• Gauchat J. F., Aversa G., Gascan H., de Vries J. E. Modulation of IL‐4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor‐alpha, anti‐CD40 monoclonal antibodies or transforming growth factor‐beta correlates with levels of IgE production. Int Immunol 1992; 4: 397–406
   PubMed Web of Science ®Google Scholar
• Punnonen J., Punnonen K., Jansen C. T., Kalimo K. Interferon (IFN)‐alpha, IFN‐gamma, interleukin (IL)‐2, and arachidonic acid metabolites modulate IL‐4‐induced IgE synthesis similarly in healthy persons and in atopic dermatitis patients. Allergy 1993; 48: 189–95
   PubMed Web of Science ®Google Scholar
• Xu L., Rothman P. IFN‐gamma represses epsilon germline transcription and subsequently down‐regulates switch recombination to epsilon. Int Immunol 1994; 6: 515–21
   PubMed Web of Science ®Google Scholar
• de Boer B. A., Kruize Y. C., Rotmans P. J., Yazdanbakhsh M. Interleukin‐12 suppresses immunoglobulin E production but enhances immunoglobulin G4 production by human peripheral blood mononuclear cells. Infect Immun 1997; 65: 1122–5
   Google Scholar
• Kiniwa M., Gately M., Gubler U., Chizzonite R., Fargeas C., Delespesse G. Recombinant interleukin‐12 suppresses the synthesis of immunoglobulin E by interleukin‐4 stimulated human lymphocytes. J Clin Invest 1992; 90: 262–6
   PubMed Web of Science ®Google Scholar
• Finkelman F. D., Katona I. M., Mosmann T. R., Coffman R. L. IFN‐gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol 1988; 140: 1022–7
   PubMed Web of Science ®Google Scholar
• Bossie A., Vitetta E. S. IFN‐gamma enhances secretion of IgG2a from IgG2a‐committed LPS‐stimulated murine B cells: implications for the role of IFN‐gamma in class switching. Cell Immunol 1991; 135: 95–104
   PubMed Web of Science ®Google Scholar
• Briere F., Servet‐Delprat C., Bridon J. M., Saint‐Remy J. M., Banchereau J. Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3. J Exp Med 1994; 179: 757–62
   PubMed Web of Science ®Google Scholar
• Malisan F., Briere F., Bridon J. M., Harindranath N., Mills F. C., Max E. E., et al. Interleukin‐10 induces immunoglobulin G isotype switch recombination in human CD40‐activated naive B lymphocytes. J Exp Med 1996; 183: 937–47
   PubMed Web of Science ®Google Scholar
• Fujieda S., Saxon A., Zhang K. Direct evidence that gamma 1 and gamma 3 switching in human B cells is interleukin‐10 dependent. Mol Immunol 1996; 33: 1335–43
   Google Scholar
• Banchereau J. Converging and diverging properties of human interleukin‐4 and interleukin‐10. Behring Inst Mitt 1995; 58–77
   Google Scholar
• Defrance T., Vanbervliet B., Briere F., Durand I., Rousset F., Banchereau J. Interleukin 10 and transforming growth factor beta cooperate to induce anti‐CD40‐activated naive human B cells to secrete immunoglobulin A. J Exp Med 1992; 175: 671–82
   PubMed Web of Science ®Google Scholar
• Kitani A., Strober W. Differential regulation of C alpha 1 and C alpha 2 germ‐line and mature mRNA transcripts in human peripheral blood B cells. J Immunol 1994; 153: 1466–77
   Google Scholar
• McIntyre T. M., Kehry M. R., Snapper C. M. Novel in vitro model for high‐rate IgA class switching. J Immunol 1995; 154: 3156–61
   PubMedGoogle Scholar
• Stavnezer J. Regulation of antibody production and class switching by TGF‐beta. J Immunol 1995; 155: 1647–51
   PubMed Web of Science ®Google Scholar
• Van Vlasselaer P., Punnonen J., de Vries J. E. Transforming growth factor‐beta directs IgA switching in human B cells. J Immunol 1992; 148: 2062–7
   PubMed Web of Science ®Google Scholar
• Conti P., Kempuraj D., Kandere K., Di Gioacchino M., Barbacane R. C., Castellani M. L., et al. IL‐10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett 2003; 86: 123–9
   PubMed Web of Science ®Google Scholar
• Moore K. W., de Waal M. R., Coffman R. L., O'Garra A. Interleukin‐10 and the interleukin‐10 receptor. Annu Rev Immunol 2001; 19: 683–765
   PubMed Web of Science ®Google Scholar
• Dumoutier L., Louahed J., Renauld J. C. Cloning and characterization of IL‐10‐related T cell‐derived inducible factor (IL‐TIF), a novel cytokine structurally related to IL‐10 and inducible by IL‐9. J Immunol 2000; 164: 1814–9
   PubMed Web of Science ®Google Scholar
• Dumoutier L., Van Roost E., Colau D., Renauld J. C. Human interleukin‐10‐related T cell‐derived inducible factor: molecular cloning and functional characterization as an hepatocyte‐stimulating factor. Proc Natl Acad Sci U S A 2000; 97: 10144–9
   PubMed Web of Science ®Google Scholar
• Fickenscher H., Hor S., Kupers H., Knappe A., Wittmann S., Sticht H. The interleukin‐10 family of cytokines. Trends Immunol 2002; 23: 89–96
   PubMed Web of Science ®Google Scholar
• Kotenko S. V. The family of IL‐10‐related cytokines and their receptors: related, but to what extent?. Cytokine Growth Factor Rev 2002; 13: 223–40
   PubMed Web of Science ®Google Scholar
• Wang M., Tan Z., Zhang R., Kotenko S. V., Liang P. Interleukin 24 (MDA‐7/MOB‐5) signals through two heterodimeric receptors, IL‐22R1/IL‐20R2 and IL‐20R1/IL‐20R2. J Biol Chem 2002; 277: 7341–7
   PubMed Web of Science ®Google Scholar
• Hummelshoj L., Ryder L. P., Poulsen L. K. The role of the interleukin‐10 subfamily members in immunoglobulin production by human B cells. Scand J Immunol 2006; 64: 40–7
   PubMed Web of Science ®Google Scholar
• Parrish‐Novak J., Dillon S. R., Nelson A., Hammond A., Sprecher C., Gross J. A., et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000; 408: 57–63
   PubMed Web of Science ®Google Scholar
• Asao H., Okuyama C., Kumaki S., Ishii N., Tsuchiya S., Foster D., et al. Cutting edge: the common gamma‐chain is an indispensable subunit of the IL‐21 receptor complex. J Immunol 2001; 167: 1–5
   PubMed Web of Science ®Google Scholar
• Kasaian M. T., Whitters M. J., Carter L. L., Lowe L. D., Jussif J. M., Deng B., et al. IL‐21 limits NK cell responses and promotes antigen‐specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002; 16: 559–69
   PubMed Web of Science ®Google Scholar
• Brandt K., Bulfone‐Paus S., Jenckel A., Foster D. C., Paus R., Ruckert R. Interleukin‐21 inhibits dendritic cell‐mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol 2003; 121: 1379–82
   PubMed Web of Science ®Google Scholar
• Brandt K., Bulfone‐Paus S., Foster D. C., Ruckert R. Interleukin‐21 inhibits dendritic cell activation and maturation. Blood 2003; 102: 4090–8
   PubMed Web of Science ®Google Scholar
• Ozaki K., Spolski R., Feng C. G., Qi C. F., Cheng J., Sher A., et al. A critical role for IL‐21 in regulating immunoglobulin production. Science 2002; 298: 1630–4
   PubMed Web of Science ®Google Scholar
• Kovanen P. E., Leonard W. J. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev 2004; 202: 67–83
   PubMed Web of Science ®Google Scholar
• Suto A., Nakajima H., Hirose K., Suzuki K., Kagami S., Seto Y., et al. Interleukin 21 prevents antigen‐induced IgE production by inhibiting germ line C (epsilon) transcription of IL‐4‐stimulated B cells. Blood 2002; 100: 4565–73
   PubMed Web of Science ®Google Scholar
• Pene J., Gauchat J. F., Lecart S., Drouet E., Guglielmi P., Boulay V., et al. Cutting edge: IL‐21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol 2004; 172: 5154–7
   PubMed Web of Science ®Google Scholar
• Wood N., Bourque K., Donaldson D. D., Collins M., Vercelli D., Goldman S. J., et al. IL‐21 effects on human IgE production in response to IL‐4 or IL‐13. Cell Immunol 2004; 231: 133–45
   PubMed Web of Science ®Google Scholar
• Romagnani S. Atopic allergy and other hypersensitivities interactions between genetic susceptibility, innocuous and/or microbial antigens and the immune system. Curr Opin Immunol 1997; 9: 773–5
   Google Scholar
• Behringwerke A. G. Enzygnost‐IgE. Enzymimmunoassay zur Bestimmung von Human‐IgE [manual for Behringwerke IgE assay]. Behringwerke AG, Marburg 1985, June 1985 ed
   Google Scholar
• Kjellman N‐I., Johansson S. G. O., Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy 1976; 6: 51–9
   PubMedGoogle Scholar
• Kjellman N‐I. Atopic allergy and serum IgE concentrations in randomly selected children followed from 8 to 12 years of age. Allergy 1984; 39: 443–50
   Google Scholar
• Berciano F. A., Crespo M., Bao C. G., Alvarez F. V. Serum levels of total IgE in non‐allergic children. Influence of genetic and environmental factors. Allergy 1987; 42: 276–83
   Google Scholar
• Holford‐Strevens V., Warren P., Wong C., Manfreda J. Serum total immunoglobulin E levels in Canadian adults. J Allergy Clin Immunol 1984; 73: 516–22
   PubMedGoogle Scholar
• Lindberg R. E., Arroyave C. Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay. J Allergy Clin Immunol 1986; 78: 614–8
   Google Scholar
• Klink M., Cline M. G., Halonen M., Burrows B. Problems in defining normal limits for serum IgE. J Allergy Clin Immunol 1990; 85: 440–4
   PubMed Web of Science ®Google Scholar