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Review Article

Present and future of stem cells for cardiovascular therapy

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Pages 412-427 | Published online: 08 Jul 2009

References

  • Rogers W. J., Canto J. G., Lambrew C. T., Tiefenbrunn A. J., Kinkaid B., Shoultz D. A., et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J Am Coll Cardiol 2000; 36: 2056–63
  • Beltrami A. P., Urbanek K., Kajstura J., Yan S. M., Finato N., Bussani R., et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344: 1750–7
  • Anversa P., Nadal‐Ginard B. Myocyte renewal and ventricular remodelling. Nature 2002; 415: 240–3
  • Kocher A. A., Schuster M. D., Szabolcs M. J., Takuma S., Burkhoff D., Wang J., et al. Neovascularization of ischemic myocardium by human bone‐marrow‐derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430–6
  • Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S. M., Li B., et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701–5
  • Orlic D., Kajstura J., Chimenti S., Limana F., Jakoniuk I., Quaini F., et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001; 98: 10344–9
  • Sanchez P. L., San Roman J. A., Villa A., Fernandez M. E., Fernandez‐Aviles F. Contemplating the bright future of stem cell therapy for cardiovascular disease. Nat Clin Pract Cardiovasc Med 2006; 3 Suppl 1: S138–51
  • Menasche P., Hagege A. A., Vilquin J. T., Desnos M., Abergel E., Pouzet B., et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol 2003; 41: 1078–83
  • Fernandes S., Amirault J. C., Lande G., Nguyen J. M., Forest V., Bignolais O., et al. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias. Cardiovasc Res 2006; 69: 348–58
  • Fouts K., Fernandes B., Mal N., Liu J., Laurita K. R. Electrophysiological consequence of skeletal myoblast transplantation in normal and infarcted canine myocardium. Heart Rhythm 2006; 3: 452–61
  • de la Fuente R., Abad J. L., Garcia‐Castro J., Fernandez‐Miguel G., Petriz J., Rubio D., et al. Dedifferentiated adult articular chondrocytes: a population of human multipotent primitive cells. Exp Cell Res 2004; 297: 313–28
  • Villaron E. M., Almeida J., Lopez‐Holgado N., Alcoceba M., Sanchez‐Abarca L. I., Sanchez‐Guijo F. M., et al. Mesenchymal stem cells are present in peripheral blood and can engraft after allogeneic hematopoietic stem cell transplantation. Haematologica 2004; 89: 1421–7
  • Schatteman G. C., Awad O. Hemangioblasts, angioblasts, and adult endothelial cell progenitors. Anat Rec A Discov Mol Cell Evol Biol 2004; 276: 13–21
  • Sanchez P. L., Sanchez‐Guijo F. M., Villa A., Del Canizo C., Arnold R., San Roman J. A., et al. Launching a clinical program of stem cell therapy for cardiovascular repair. Nat Clin Pract Cardiovasc Med 2007; 4 Suppl 1: S123–9
  • Fernandez‐Aviles F., San Roman J. A., Garcia‐Frade J., Fernandez M. E., Penarrubia M. J., de la Fuente L., et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 2004; 95: 742–8
  • Torella D., Ellison G. M., Mendez‐Ferrer S., Ibanez B., Nadal‐Ginard B. Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat Clin Pract Cardiovasc Med 2006; 3 Suppl 1: S8–13
  • Fuchs E., Tumbar T., Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004; 116: 769–78
  • Beltrami A. P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763–76
  • Chien K. R. Lost and found: cardiac stem cell therapy revisited. J Clin Invest 2006; 116: 1838–40
  • Pittenger M. F., Martin B. J. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004; 95: 9–20
  • Hofmann M., Wollert K. C., Meyer G. P., Menke A., Arseniev L., Hertenstein B., et al. Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 2005; 111: 2198–202
  • Flomenberg N., DiPersio J., Calandra G. Role of CXCR4 chemokine receptor blockade using AMD3100 for mobilization of autologous hematopoietic progenitor cells. Acta Haematol 2005; 114: 198–205
  • Bel A., Messas E., Agbulut O., Richard P., Samuel J. L., Bruneval P., et al. Transplantation of autologous fresh bone marrow into infarcted myocardium: a word of caution. Circulation 2003; 108 Suppl 1: II247–52
  • Vulliet P. R., Greeley M., Halloran S. M., MacDonald K. A., Kittleson M. D. Intra‐coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 2004; 363: 783–4
  • Zhou R., Acton P. D., Ferrari V. A. Imaging stem cells implanted in infarcted myocardium. J Am Coll Cardiol 2006; 48: 2094–106
  • Schachinger V., Erbs S., Elsasser A., Haberbosch W., Hambrecht R., Holschermann H., et al. Intracoronary bone marrow‐derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355: 1210–21
  • Lunde K., Solheim S., Aakhus S., Arnesen H., Abdelnoor M., Egeland T., et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006; 355: 1199–209
  • Seeger F. H., Tonn T., Krzossok N., Zeiher A. M., Dimmeler S. Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J 2007; 28: 766–72
  • Ripa R. S., Jorgensen E., Wang Y., Thune J. J., Nilsson J. C., Sondergaard L., et al. Stem cell mobilization induced by subcutaneous granulocyte‐colony stimulating factor to improve cardiac regeneration after acute ST‐elevation myocardial infarction: result of the double‐blind, randomized, placebo‐controlled stem cells in myocardial infarction (STEMMI) trial. Circulation 2006; 113: 1983–92
  • Zohlnhofer D., Ott I., Mehilli J., Schomig K., Michalk F., Ibrahim T., et al. Stem cell mobilization by granulocyte colony‐stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA 2006; 295: 1003–10
  • Ellis S. G., Penn M. S., Bolwell B., Garcia M., Chacko M., Wang T., et al. Granulocyte colony stimulating factor in patients with large acute myocardial infarction: results of a pilot dose‐escalation randomized trial. Am Heart J 2006; 152: 1051 e9–14
  • Engelmann M. G., Theiss H. D., Hennig‐Theiss C., Huber A., Wintersperger B. J., Werle‐Ruedinger A. E., et al. Autologous bone marrow stem cell mobilization induced by granulocyte colony‐stimulating factor after subacute ST‐segment elevation myocardial infarction undergoing late revascularization: final results from the G‐CSF‐STEMI (Granulocyte Colony‐Stimulating Factor ST‐Segment Elevation Myocardial Infarction) trial. J Am Coll Cardiol 2006; 48: 1712–21
  • Assmus B., Honold J., Schachinger V., Britten M. B., Fischer‐Rasokat U., Lehmann R., et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 355: 1222–32
  • Herreros J., Prosper F., Perez A., Gavira J. J., Garcia‐Velloso M. J., Barba J., et al. Autologous intramyocardial injection of cultured skeletal muscle‐derived stem cells in patients with non‐acute myocardial infarction. Eur Heart J 2003; 24: 2012–20
  • Bartunek J., Vanderheyden M., Wijns W., Timmermans F., Vandekerkhove B., Villa A., et al. Bone‐marrow‐derived cells for cardiac stem cell therapy: safe or still under scrutiny?. Nat Clin Pract Cardiovasc Med 2007; 4 Suppl 1: S100–5
  • Bartunek J., Vanderheyden M., Vandekerckhove B., Mansour S., De Bruyne B., De Bondt P., et al. Intracoronary injection of CD133‐positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation 2005; 112 Suppl: I178–83
  • Kang H. J., Kim H. S., Zhang S. Y., Park K. W., Cho H. J., Koo B. K., et al. Effects of intracoronary infusion of peripheral blood stem‐cells mobilised with granulocyte‐colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 2004; 363: 751–6
  • Ince H., Petzsch M., Kleine H. D., Eckard H., Rehders T., Burska D., et al. Prevention of left ventricular remodeling with granulocyte colony‐stimulating factor after acute myocardial infarction: final 1‐year results of the Front‐Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony‐Stimulating Factor (FIRSTLINE‐AMI) Trial. Circulation 2005; 112 Suppl: I73–80
  • Kang H. J., Kim H. S., Koo B. K., Kim Y. J., Lee D., Sohn D. W., et al. Intracoronary infusion of the mobilized peripheral blood stem cell by G‐CSF is better than mobilization alone by G‐CSF for improvement of cardiac function and remodeling: 2‐year follow‐up results of the Myocardial Regeneration and Angiogenesis in Myocardial Infarction with G‐CSF and Intra‐Coronary Stem Cell Infusion (MAGIC Cell) 1 trial. Am Heart J 2007; 153: 237.e1–8
  • Bartunek J., Dimmeler S., Drexler H., Fernandez‐Aviles F., Galinanes M., Janssens S., et al. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J 2006; 27: 1338–40
  • Rosenzweig A. Cardiac cell therapy—mixed results from mixed cells. N Engl J Med 2006; 355: 1274–7
  • Strauer B. E., Brehm M., Zeus T., Gattermann N., Hernandez A., Sorg R. V., et al. [Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction]. Dtsch Med Wochenschr 2001; 126: 932–8
  • Strauer B. E., Brehm M., Zeus T., Kostering M., Hernandez A., Sorg R. V., et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106: 1913–8
  • Assmus B., Schachinger V., Teupe C., Britten M., Lehmann R., Dobert N., et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE‐AMI). Circulation 2002; 106: 3009–17
  • Schachinger V., Assmus B., Britten M. B., Honold J., Lehmann R., Teupe C., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one‐year results of the TOPCARE‐AMI Trial. J Am Coll Cardiol 2004; 44: 1690–9
  • Chen S. L., Fang W. W., Ye F., Liu Y. H., Qian J., Shan S. J., et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004; 94: 92–5
  • Kuethe F., Richartz B. M., Sayer H. G., Kasper C., Werner G. S., Hoffken K., et al. Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int J Cardiol 2004; 97: 123–7
  • Aviles F. F., San Roman J. A., Garcia Frade J., Valdes M., Sanchez A., de la Fuente L., et al. [Intracoronary stem cell transplantation in acute myocardial infarction]. Rev Esp Cardiol 2004; 57: 201–8
  • Wollert K. C., Meyer G. P., Lotz J., Ringes‐Lichtenberg S., Lippolt P., Breidenbach C., et al. Intracoronary autologous bone‐marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004; 364: 141–8
  • Meyer G. P., Wollert K. C., Lotz J., Steffens J., Lippolt P., Fichtner S., et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow‐up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST‐elevation infarct regeneration) trial. Circulation 2006; 113: 1287–94
  • Katritsis D. G., Sotiropoulou P. A., Karvouni E., Karabinos I., Korovesis S., Perez S. A., et al. Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheter Cardiovasc Interv 2005; 65: 321–9
  • Ge J., Li Y., Qian J., Shi J., Wang Q., Niu Y., et al. Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT‐STAMI). Heart 2006; 92: 1764–7
  • Janssens S., Dubois C., Bogaert J., Theunissen K., Deroose C., Desmet W., et al. Autologous bone marrow‐derived stem‐cell transfer in patients with ST‐segment elevation myocardial infarction: double‐blind, randomised controlled trial. Lancet 2006; 367: 113–21
  • Schachinger V., Erbs S., Elsasser A., Haberbosch W., Hambrecht R., Holschermann H., et al. Improved clinical outcome after intracoronary administration of bone‐marrow‐derived progenitor cells in acute myocardial infarction: final 1‐year results of the REPAIR‐AMI trial. Eur Heart J 2006; 27: 2775–83
  • Kuethe F., Figulla H. R., Voth M., Richartz B. M., Opfermann T., Sayer H. G., et al. [Mobilization of stem cells by granulocyte colony‐stimulating factor for the regeneration of myocardial tissue after myocardial infarction]. Dtsch Med Wochenschr 2004; 129: 424–8
  • Kuethe F., Figulla H. R., Herzau M., Voth M., Fritzenwanger M., Opfermann T., et al. Treatment with granulocyte colony‐stimulating factor for mobilization of bone marrow cells in patients with acute myocardial infarction. Am Heart J 2005; 150: 115
  • Valgimigli M., Rigolin G. M., Cittanti C., Malagutti P., Curello S., Percoco G., et al. Use of granulocyte‐colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile. Eur Heart J 2005; 26: 1838–45
  • Suarez de Lezo J., Torres A., Herrera I., Pan M., Romero M., Pavlovic D., et al. [Effects of stem‐cell mobilization with recombinant human granulocyte colony stimulating factor in patients with percutaneously revascularized acute anterior myocardial infarction]. Rev Esp Cardiol 2005; 58: 253–61
  • Ince H., Petzsch M., Kleine H. D., Schmidt H., Rehders T., Korber T., et al. Preservation from left ventricular remodeling by front‐integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte‐colony‐stimulating factor (FIRSTLINE‐AMI). Circulation 2005; 112: 3097–106
  • Jorgensen E., Ripa R. S., Helqvist S., Wang Y., Johnsen H. E., Grande P., et al. In‐stent neo‐intimal hyperplasia after stem cell mobilization by granulocyte‐colony stimulating factor Preliminary intracoronary ultrasound results from a double‐blind randomized placebo‐controlled study of patients treated with percutaneous coronary intervention for ST‐elevation myocardial infarction (STEMMI Trial). Int J Cardiol 2006; 111: 174–7
  • Kang H. J., Lee H. Y., Na S. H., Chang S. A., Park K. W., Kim H. K., et al. Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony‐stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell‐3‐DES randomized, controlled trial. Circulation 2006; 114 Suppl: I145–51
  • Steinwender C., Hofmann R., Kammler J., Kypta A., Pichler R., Maschek W., et al. Effects of peripheral blood stem cell mobilization with granulocyte‐colony stimulating factor and their transcoronary transplantation after primary stent implantation for acute myocardial infarction. Am Heart J 2006; 151: 1296.e7–13
  • Hagege A. A., Marolleau J. P., Vilquin J. T., Alheritiere A., Peyrard S., Duboc D., et al. Skeletal myoblast transplantation in ischemic heart failure: long‐term follow‐up of the first phase I cohort of patients. Circulation 2006; 114 Suppl: I108–13
  • Gavira J. J., Herreros J., Perez A., Garcia‐Velloso M. J., Barba J., Martin‐Herrero F., et al. Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1‐year follow‐up. J Thorac Cardiovasc Surg 2006; 131: 799–804
  • Siminiak T., Kalawski R., Fiszer D., Jerzykowska O., Rzezniczak J., Rozwadowska N., et al. Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow‐up. Am Heart J 2004; 148: 531–7
  • Chachques J. C., Herreros J., Trainini J., Juffe A., Rendal E., Prosper F., et al. Autologous human serum for cell culture avoids the implantation of cardioverter‐defibrillators in cellular cardiomyoplasty. Int J Cardiol 2004; 95 Suppl 1: S29–33
  • Dib N., Michler R. E., Pagani F. D., Wright S., Kereiakes D. J., Lengerich R., et al. Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four‐year follow‐up. Circulation 2005; 112: 1748–55
  • Stamm C., Westphal B., Kleine H. D., Petzsch M., Kittner C., Klinge H., et al. Autologous bone‐marrow stem‐cell transplantation for myocardial regeneration. Lancet 2003; 361: 45–6
  • Stamm C., Kleine H. D., Westphal B., Petzsch M., Kittner C., Nienaber C. A., et al. CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiovasc Surg 2004; 52: 152–8
  • Mocini D., Staibano M., Mele L., Giannantoni P., Menichella G., Colivicchi F., et al. Autologous bone marrow mononuclear cell transplantation in patients undergoing coronary artery bypass grafting. Am Heart J 2006; 151: 192–7
  • Patel A. N., Geffner L., Vina R. F., Saslavsky J., Urschel H. C Jr., Kormos R., et al. Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study. J Thorac Cardiovasc Surg 2005; 130: 1631–8
  • Archundia A., Aceves J. L., Lopez‐Hernandez M., Alvarado M., Rodriguez E., Diaz Quiroz G., et al. Direct cardiac injection of G‐CSF mobilized bone‐marrow stem‐cells improves ventricular function in old myocardial infarction. Life Sci 2005; 78: 279–83
  • Galinanes M., Loubani M., Davies J., Chin D., Pasi J., Bell P. R. Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans. Cell Transplant 2004; 13: 7–13
  • Hamano K., Nishida M., Hirata K., Mikamo A., Li T. S., Harada M., et al. Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn Circ J 2001; 65: 845–7
  • Li T. S., Hamano K., Hirata K., Kobayashi T., Nishida M. The safety and feasibility of the local implantation of autologous bone marrow cells for ischemic heart disease. J Card Surg 2003; 18 Suppl 2: S69–75
  • Ozbaran M., Omay S. B., Nalbantgil S., Kultursay H., Kumanlioglu K., Nart D., et al. Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease. Eur J Cardiothorac Surg 2004; 25: 342–50; discussion 350–1
  • Pompilio G., Cannata A., Peccatori F., Bertolini F., Nascimbene A., Capogrossi M. C., et al. Autologous peripheral blood stem cell transplantation for myocardial regeneration: a novel strategy for cell collection and surgical injection. Ann Thorac Surg 2004; 78: 1808–12
  • Siminiak T., Fiszer D., Jerzykowska O., Grygielska B., Rozwadowska N., Kalmucki P., et al. Percutaneous trans‐coronary‐venous transplantation of autologous skeletal myoblasts in the treatment of post‐infarction myocardial contractility impairment: the POZNAN trial. Eur Heart J 2005; 26: 1188–95
  • Smits P. C., van Geuns R. J., Poldermans D., Bountioukos M., Onderwater E. E., Lee C. H., et al. Catheter‐based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six‐month follow‐up. J Am Coll Cardiol 2003; 42: 2063–9
  • Ince H., Petzsch M., Rehders T. C., Chatterjee T., Nienaber C. A. Transcatheter transplantation of autologous skeletal myoblasts in postinfarction patients with severe left ventricular dysfunction. J Endovasc Ther 2004; 11: 695–704
  • Perin E. C., Dohmann H. F., Borojevic R., Silva S. A., Sousa A. L., Mesquita C. T., et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107: 2294–302
  • Perin E. C., Dohmann H. F., Borojevic R., Silva S. A., Sousa A. L., Silva G. V., et al. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 2004; 110 Suppl 1: II213–8
  • Silva G. V., Perin E. C., Dohmann H. F., Borojevic R., Silva S. A., Sousa A. L., et al. Catheter‐based transendocardial delivery of autologous bone‐marrow‐derived mononuclear cells in patients listed for heart transplantation. Tex Heart Inst J 2004; 31: 214–9
  • Tse H. F., Kwong Y. L., Chan J. K., Lo G., Ho C. L., Lau C. P. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003; 361: 47–9
  • Tse H. F., Thambar S., Kwong Y. L., Rowlings P., Bellamy G., McCrohon J., et al. Safety of catheter‐based intramyocardial autologous bone marrow cells implantation for therapeutic angiogenesis. Am J Cardiol 2006; 98: 60–2
  • Fuchs S., Satler L. F., Kornowski R., Okubagzi P., Weisz G., Baffour R., et al. Catheter‐based autologous bone marrow myocardial injection in no‐option patients with advanced coronary artery disease: a feasibility study. J Am Coll Cardiol 2003; 41: 1721–4
  • Fuchs S., Kornowski R., Weisz G., Satler L. F., Smits P. C., Okubagzi P., et al. Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease. Am J Cardiol 2006; 97: 823–9
  • Briguori C., Reimers B., Sarais C., Napodano M., Pascotto P., Azzarello G., et al. Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina. Am Heart J 2006; 151: 674–80
  • Kuethe F., Richartz B. M., Kasper C., Sayer H. G., Hoeffken K., Werner G. S., et al. Autologous intracoronary mononuclear bone marrow cell transplantation in chronic ischemic cardiomyopathy in humans. Int J Cardiol 2005; 100: 485–91
  • Strauer B. E., Brehm M., Zeus T., Bartsch T., Schannwell C., Antke C., et al. Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study. J Am Coll Cardiol 2005; 46: 1651–8
  • Blatt A., Cotter G., Leitman M., Krakover R., Kaluski E., Milo‐Cotter O., et al. Intracoronary administration of autologous bone marrow mononuclear cells after induction of short ischemia is safe and may improve hibernation and ischemia in patients with ischemic cardiomyopathy. Am Heart J 2005; 150: 986
  • Erbs S., Linke A., Adams V., Lenk K., Thiele H., Diederich K. W., et al. Transplantation of blood‐derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo‐controlled study. Circ Res 2005; 97: 756–62
  • Seiler C., Pohl T., Wustmann K., Hutter D., Nicolet P. A., Windecker S., et al. Promotion of collateral growth by granulocyte‐macrophage colony‐stimulating factor in patients with coronary artery disease: a randomized, double‐blind, placebo‐controlled study. Circulation 2001; 104: 2012–7
  • Wang Y., Tagil K., Ripa R. S., Nilsson J. C., Carstensen S., Jorgensen E., et al. Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease. Int J Cardiol 2005; 100: 477–83
  • Hill J. M., Syed M. A., Arai A. E., Powell T. M., Paul J. D., Zalos G., et al. Outcomes and risks of granulocyte colony‐stimulating factor in patients with coronary artery disease. J Am Coll Cardiol 2005; 46: 1643–8
  • Joseph J., Rimawi A., Mehta P., Cottler‐Fox M., Sinha A., Singh B. K., et al. Safety and effectiveness of granulocyte‐colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure. Am J Cardiol 2006; 97: 681–4

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