Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis

References

• Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Non-alcoholic steatohepatitis, insulin resistance and metabolic syndrome: further evidence for an etiologic association. Hepatology. 2002; 35: 367–72
   PubMed Web of Science ®Google Scholar
• Musso G, Cassader M, Gambino R, Durazzo M, Pagano G. Association between postprandial LDL conjugated dienes and the severity of liver fibrosis in NASH. (Letter). Hepatology. 2006; 43: 1169–70
   PubMed Web of Science ®Google Scholar
• Videla LA, Rodrigo R, Orellana M, Fernandez V, Tapia G, Quinones L, et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Lond) 2004; 106: 261–8
   PubMed Web of Science ®Google Scholar
• Horoz M, Bolukbas C, Bolubkas FF, Sabuncu T, Aslan M, Sarifakiogullari S, et al. Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis. BMC Gastroenterol. 2005; 5: 35
   PubMed Web of Science ®Google Scholar
• Arsov T, Carter CZ, Nolan CJ, Petrovsky N, Goodnow CC, Teoh NC, et al. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Comm. 2006; 342: 1152–9
   Google Scholar
• Westerbacka J, Lammi K, Hakkinen AM, Rissanen A, Salminen I, Aro A, et al. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab. 2005; 90: 2804–9
   PubMed Web of Science ®Google Scholar
• Pedrini MT, Niederwanger A, Kranebitter M, Tautermann C, Ciardi C, Tatarczyk T, et al. Postprandial lipeemia induces an acute decrease of insulin sensitivity in healthy men independently of plasma NEFA levels. Diabetologia. 2006; 49: 1612–8
   Google Scholar
• Owens D. The extended postprandial phase in diabetes. Biochem Soc Transact. 2003; 31: 1085–9
   Google Scholar
• Dersch K, Ichijo H, Bhakdi S, Husman M. Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases. Cell Death Differ. 2005; 12: 1107–14
   Google Scholar
• Targher G. Association between liver histology and early carotid atherosclerosis in patients with nonalcoholic fatty liver disease (Letter). Hepatology. 2005; 42: 974–5
   Google Scholar
• Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005; 115: 1343–51
   PubMed Web of Science ®Google Scholar
• Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K, et al. Non-esterified fatty acid concentration are independently associated with hepatic steatosis in obese subjects. Diabetologia. 2006; 49: 141–8
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Carey PE, Snaar JEM, Deelchand DK, Cook DB, Neely RDG, et al. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. Am J Physiol Endocrinol Metab. 2005; 288: E789–97
   Google Scholar
• Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis. 2001; 21: 3–16
   PubMed Web of Science ®Google Scholar
• Pisani P, Faggiano F, Krogh V, Palli D, Vineis P, Berrino F. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol. 1997; 26 Suppl 1: S152–60
   PubMed Web of Science ®Google Scholar
• Salvini, S, Parpinel, M, Gnagnarella, P, Maisonneuve, P, Turrini, A. Banca Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia. Istituto Europeo di Oncologia. www.nutrizione.com/pubs/tabelle-composizione-alimenti.aspx. Reggio Calabria: Laruffa, 1998.
   Google Scholar
• Nunez C, Gallagher D, Visser M. Bioimpedance analysis: evaluation of leg-to-leg system based on pressure contact footpad electrodes. Med Sci Sports Exerc. 1997; 29: 524–31
   PubMed Web of Science ®Google Scholar
• Matsuda M, DeFronzo R. Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. Diabetes Care. 1999; 22: 1462–70
   PubMed Web of Science ®Google Scholar
• Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, Durazzo M, et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in Nonalcoholic Steatohepatitis. Hepatology. 2003; 37: 909–16
   PubMed Web of Science ®Google Scholar
• Duez H, Lamarche B, Uffelman KD, Valero R, Cohn JS, Lewis GF. Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans. Arterioscler Thromb Vasc Biol. 2006; 26: 1357–63
   PubMed Web of Science ®Google Scholar
• Cassader M, Gambino R, Musso G, Depetris N, Mecca F, Cavallo-Perin P, et al. Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients. Lipids. 2002; 36: 1117–24
   Google Scholar
• Stocks SG, Miller NE. Capillary electrophoresis to monitor the oxidative modification of LDL. J Lipid Res. 1998; 39: 1305–9
   Google Scholar
• On YK, Park R, Hyon MS, Kim SK, Kwon YJ. Are low total serum antioxidant status and elevated levels of C-reactive protein and monocyte chemotactic protein-1 associated with cardiac syndrome X?. Circ J. 2005; 69: 1212–7
   PubMed Web of Science ®Google Scholar
• Belo L, Caslake M, Santos-Silva A, Castro EM, Pereira-Leite L, Quintanilha A, et al. LDL size, total antioxidant status and oxidised LDL in normal human pregnancy: a longitudinal study. Atherosclerosis. 2004; 177: 391–9
   PubMed Web of Science ®Google Scholar
• Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990; 31: 545–8
   PubMed Web of Science ®Google Scholar
• Grundy SM, Brewer B, Cleeman JI, Smith SC, Lenfant C. NHLBI/AHA Conference Proceedings. Definition of the metabolic syndrome. Circulation. 2004; 109: 433–8
   PubMed Web of Science ®Google Scholar
• LARN—Livelli di assunzione giornalieri raccomandati di nutrienti per la popolazione italiana. available at, , www.sinu.it ( Società di Nutrizione Umana, revisione. 1996).
   Google Scholar
• Lu L, Zeng M, Li J, Hua J, Fan J, Fan Z, et al. Effects of Kupffer cells stimulated by triglyceride and very low-density lipoprotein on proliferation of rat hepatic stellate cells. Chin Med. 1999; 112: 325–9
   Google Scholar
• Ustundag Y, Ozer IO, Yenidunia S. Oxidized low density lipoprotein in liver tissue samples of our NASH patients, alcoholic and chronic viral hepatitis cases. Gastroenterology. 2002; 57: 203
   Google Scholar
• Ikura Y, Ohsaka M, Fukushima M, Ryo Y, Muraguchi T. Increased expression of the scavenger receptor CD36 in activated stellate cells in steatotic livers; its relation to fibrotic process in non-alcoholic fatty liver disease. Hepatology. 2005; 42 S1: 620A
   Google Scholar
• Malhi H, Bronk SF, Werneburg NW, Gores G. Free fatty acids induce JNK dependent hepatocyte lipoapoptosis. J Biol Chem. 2006; 281: 12093–101
   PubMed Web of Science ®Google Scholar
• Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology. 2006; 43: 163–72
   PubMed Web of Science ®Google Scholar
• Turgut O, Yilmaz A, Yalta K, Karadas F, Yilmaz MB. Glutamyltransferase is a promising biomarker for cardiovascular risk. Med Hypoth. 2006; 67: 1060–4
   PubMed Web of Science ®Google Scholar
• Andrè, P, Balkau, B, Born, C, Charles, MA, Eschwege, E, DESIR study group. Three-year increase of gamma-glutamyltransferase level and development of type 2 diabetes in middle-aged men and women: the DESIR cohort. Diabetologia. 2006;49:2599–603.
   PubMed Web of Science ®Google Scholar
• Paolicchi A, Emdin M, Passino C, Lorenzini E, Titta F, Marchi S, et al. Lipoprotein- and LDL-associated serum γ-glutamyltransferase in patients with coronary atherosclerosis. Atherosclerosis. 2006; 186: 80–5
   Web of Science ®Google Scholar
• Papadakis JA, Ganotakis ES, Jagroop IA, Winder AF, Mikhailidis DP. Statin + fibrate combination therapy: fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease. Int J Cardiol. 1999; 69: 237–44
   PubMed Web of Science ®Google Scholar
• Lee DH, Jacob DR, Gross M, Kiefe I, Roseman J, Lewis CE, et al. γ-Glutamyltransferase is a predictor of incident diabetes and hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2003; 49: 1358–66
   PubMed Web of Science ®Google Scholar
• Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM, et al. Liver enzymes, the metabolic syndrome, and incident diabetes. The Mexico City Diabetes Study. Diabetes Care. 2005; 28: 1757–62
   PubMed Web of Science ®Google Scholar
• Lee DH, Silventoinen K, Hu G, Jacobs DR, Jr, Jousilahti P, Sundvall J, et al. Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28838 middle-aged men and women. Eur Heart J. 2006; 27: 2170–6
   PubMed Web of Science ®Google Scholar
• Will Y, Fischer KA, Horton RA, Kaetzel RS, Brown MK, Hedstrom O, et al. Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function and cellular function. Hepatology. 2000; 32: 740–9
   PubMed Web of Science ®Google Scholar
• Paolicchi A, Tongiani R, Tonarelli P, Comporti M, Pompella A. Gamma-glutamyl transpeptidase-dependent lipid peroxidation in isolated and HepG2 hepatoma cells. Free Radic Biol Med. 1997; 22: 853–60
   PubMed Web of Science ®Google Scholar
• Paolicchi A, Mintoti G, Tonarelli P, Tongiani R, De Cesare D, Mezzetti A, et al. Gamma-glutamyltranspeptidase-dependent iron reduction and LDL oxidation—a potential mechanism in atherosclerosis. J Investig Med. 1999; 47: 151–60
   PubMed Web of Science ®Google Scholar
• Accaoui MJ, Enoiu M, Mergny M, Masson C, Dominaci S, Wellman M, et al. Gamma-glutamyltranspeptidase-dependent glutathione catabolism results in activation of NF-kB. Biochem Biophys Res Commun. 2000; 276: 1062–7
   Google Scholar
• Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen PT, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001; 98: 2005–10
   PubMed Web of Science ®Google Scholar
• Von Eynatten M, Schneider JG, Humpert PM, Rudofsky G, Schmidt N, Barosch P, et al. Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance. Diabetes Care. 2004; 27: 2925–9
   PubMed Web of Science ®Google Scholar