Sudden cardiac death: Prevalence, pathogenesis, and prevention

References

• Sen-Chowdhry S, McKenna WJ. Sudden cardiac death in the young: a strategy for prevention by targeted evaluation. Cardiology. 2006; 105: 196–206
   PubMed Web of Science ®Google Scholar
• Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998; 98: 2334–51
   PubMed Web of Science ®Google Scholar
• Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, et al. Task force on sudden cardiac death of the European Society of Cardiology. Eur Heart J. 2001; 22: 1374–450
   PubMed Web of Science ®Google Scholar
• Yannopoulos D, Aufderheide T. Acute management of sudden cardiac death in adults based upon the new CPR guidelines. Europace. 2007; 9: 2–9
   Google Scholar
• Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med. 2001; 345: 1473–82
   PubMed Web of Science ®Google Scholar
• Myerburg RJ, Interian A, Jr, Mitrani RM, Kessler KM, Castellanos A. Frequency of sudden cardiac death and profiles of risk. Am J Cardiol. 1997; 80: 10–19F
   PubMed Web of Science ®Google Scholar
• Tester DJ, Will ML, Ackerman MJ. Mutation detection in congenital long QT syndrome: cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing. Methods Mol Med. 2006; 128: 181–207
   Google Scholar
• Kloner RA. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis. 2006; 48: 285–300
   PubMed Web of Science ®Google Scholar
• Jouven X, Zureik M, Desnos M, Guerot C, Ducimetiere P. Resting heart rate as a predictive risk factor for sudden death in middle-aged men. Cardiovasc Res. 2001; 50: 373–8
   PubMed Web of Science ®Google Scholar
• Denjoy I, Extramiana F, Lupoglazoff JM, Leenhardt A. Brugada syndrome. Press Med. 2007; 36: 1109–16
   Google Scholar
• Pozzati A, Pancaldi LG, Di Pasquale G, Pinelli G, Bugiardini R. Transient sympathovagal imbalance triggers ‘ischemic’ sudden death in patients undergoing electrocardiographic Holter monitoring. J Am Coll Cardiol. 1996; 27: 847–52
   PubMed Web of Science ®Google Scholar
• Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, et al. Cardiac autonomic dysfunction in Brugada syndrome. Circulation. 2002; 105: 702–6
   Google Scholar
• Piippo K, Swan H, Pasternack M, Chapman H, Paavonen K, Viitasalo M, et al. A founder mutation of the potassium channel KCNQ1 in long QT syndrome: implications for estimation of disease prevalence and molecular diagnostics. J Am Coll Cardiol. 2001; 37: 562–8
   PubMed Web of Science ®Google Scholar
• Priori SG, Napolitano C, Schwartz PJ. Electrophysiologic mechanisms involved in the development of torsades de pointes. Cardiovasc Drugs Ther. 1991; 5: 203–12
   Google Scholar
• Schwartz PJ, Priori SG, Napolitano C. The long QT syndrome. Cardiac electrophysiology: From Cell to Bedside3rd ed, DP Zipes, J Jalife. Saunders, Philadelphia 2000; 597–615
   Google Scholar
• Ward OC. A new familial cardiac syndrome in children. J Isr Med Assoc. 1964; 54: 103–6
   Google Scholar
• Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996; 12: 17–23
   PubMed Web of Science ®Google Scholar
• Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell. 2004; 119: 19–31
   PubMed Web of Science ®Google Scholar
• Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, et al. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 2003; 421: 634–9
   PubMed Web of Science ®Google Scholar
• Loussouarn G, Baro I, Escande D. KCNQ1 K+ channel-mediated cardiac channelopathies. Methods Mol Biol. 2006; 337: 167–83
   Google Scholar
• Goldenberg I, Moss AJ, Zareba W, McNitt S, Robinson JL, Qi M, et al. Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome. J Cardiovasc Electrophysiol. 2006; 17: 1161–8
   PubMed Web of Science ®Google Scholar
• Vincent GM, Zhang L, Timothy KW, Fox J. Long QT syndrome patients with normal to borderline prolonged QTc intervals are at risk for syncope, cardiac arrest and sudden death. Circulation. 1999; 100: 1272
   Google Scholar
• Khositseth A, Tester DJ, Will ML, Bell CM, Ackerman MJ. Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome. Heart Rhythm. 2004; 1: 60–4
   PubMed Web of Science ®Google Scholar
• Siebrands CC, Binder S, Eckhoff U, Schmitt N, Friederich P. Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current. Anesthesiology. 2006; 105: 511–20
   PubMed Web of Science ®Google Scholar
• Sicouri S, Timothy KW, Zygmunt AC, Glass A, Goodrow RJ, Belardinelli L, et al. Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: Effects of ranolazine. Heart Rhythm. 2007; 4: 638–47
   PubMed Web of Science ®Google Scholar
• Brugada R, Hong K, Cordeiro JM, Dumaine R. Short QT syndrome. CMAJ. 2005; 173: 1349–54
   PubMed Web of Science ®Google Scholar
• Bellocq C, Van Ginneken AC, Bezzina CR, Alders M, Escande D, Mannens MM, et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation. 2004; 109: 2394–7
   PubMed Web of Science ®Google Scholar
• Gaita F, Giustetto C, Bianchi F, Schimpf R, Haissaguerre M, Calo L, et al. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003; 108: 965–70
   PubMed Web of Science ®Google Scholar
• Wolpert C, Schimpf R, Giustetto C, Antzelevitch C, Cordeiro J, Dumaine R, et al. Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005; 16: 54–8
   PubMed Web of Science ®Google Scholar
• Packer M, Gottlieb SS, Blum MA. Immediate and long-term pathophysiologic mechanisms underlying the genesis of sudden cardiac death in patients with congestive heart failure. Am J Med. 1987; 82: 4–10
   Google Scholar
• Laurita KR, Katra R, Wible B, Wan X, Koo MH. Transmural heterogeneity of calcium handling in canine. Circ Res. 2003; 92: 668–75
   Google Scholar
• Johnson CJ, Peterson DR, Smith EK. Myocardial tissue concentrations of magnesium and potassium in men dying suddenly from ischemic heart disease. Am J Clin Nutr. 1979; 32: 967–70
   PubMed Web of Science ®Google Scholar
• Chipperfield B, Chipperfield JR. Differences in metal content of the heart muscle in death from ischemic heart disease. Am Heart J. 1978; 95: 732–7
   PubMed Web of Science ®Google Scholar
• Vaturi M, Strasberg B. Magnesium in the management of acute myocardial infarction—has it proved beneficial?. Int J Cardiol. 1999; 71: 217–8
   Google Scholar
• Nimmannit S, Malasit P, Chaovakul V, Susaengrat W, Vasuvattakul S, Nilwarangkur S. Pathogenesis of sudden unexplained nocturnal death (lai tai) and endemic distal renal tubular acidosis. Lancet. 1991; 338: 930–2
   Google Scholar
• Pachulski RT, Lopez F, Sharaf R. Gitelman's not-so-benign syndrome. N Engl J Med. 2005; 353: 850–1
   Google Scholar
• Courson R. Preventing sudden death on the athletic field: the emergency action plan. Curr Sports Med Rep. 2007; 6: 93–100
   PubMedGoogle Scholar
• Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, et al. Update of the guidelines on sudden cardiac death of the European Society of Cardiology. Eur Heart J. 2003; 24: 13–15
   PubMedGoogle Scholar
• Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. New Engl J Med. 1984; 310: 1137–40
   PubMed Web of Science ®Google Scholar
• Shin J, Edelberg JE, Hong MK. Vulnerable atherosclerotic plaque: clinical implications. Curr Vasc Pharmacol. 2003; 1: 183–204
   PubMedGoogle Scholar
• Turakhia M, Tseng ZH. Sudden cardiac death: epidemiology, mechanisms, and therapy. Curr Probl Cardiol. 2007; 32: 501–46
   PubMedGoogle Scholar
• Doig JC, Saito J, Harris L, Mickleborough L, Sevaptsidis E, Masse S, et al. Ventricular tachycardia in ischaemic heart disease: insights into the mechanisms from cardiac mapping and implications for patient management. Eur Heart J. 1995; 16: 1027–35
   Google Scholar
• Podrid PJ, Myerburg RJ. Epidemiology and stratification of risk for sudden cardiac death. Clin Cardiol. 2005; 28: I3–11
   PubMedGoogle Scholar
• Myerburg RJ, Spooner PM. Opportunities for sudden death prevention: directions for new clinical and basic research. Cardiovasc Res. 2001; 50: 177–85
   Google Scholar
• Meissner MD, Akhtar M, Lehmann MH. Nonischemic sudden tachyarrhythmic death in atherosclerotic heart disease. Circulation. 1991; 84: 905–12
   Web of Science ®Google Scholar
• Davies MJ. Anatomic features in victims of sudden coronary death: coronary artery pathology. Circulation. 1992; 85 suppl I: I19–24
   Google Scholar
• Farb A, Tang AL, Burke AP, Sessums L, Liang Y, Virmani R. Sudden coronary death: frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction. Circulation. 1995; 92: 1701–9
   PubMed Web of Science ®Google Scholar
• Maron BJ. Hypertrophic cardiomyopathy. A systematic review. JAMA. 2002; 287: 1308–20
   PubMed Web of Science ®Google Scholar
• Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, et al. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. 1990; 62: 999–1006
   PubMed Web of Science ®Google Scholar
• Bos JM, Ommen SR, Ackerman MJ. Genetics of hypertrophic cardiomyopathy: one, two, or more diseases?. Curr Opin Cardiol. 2007; 22: 193–9
   Google Scholar
• Murphy RT, Mogensen J, McGarry K, Bahl A, Evans A, Osman E, et al. Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 2005; 45: 922–30
   PubMed Web of Science ®Google Scholar
• Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation. 1997; 96: 1557–65
   PubMed Web of Science ®Google Scholar
• Rashba EJ, Estes NA, Wang P, Schaechter A, Howard A, Zareba W, et al. Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial. Heart Rhythm. 2006; 3: 281–6
   PubMed Web of Science ®Google Scholar
• Basso C, Frescura C, Corrado D, Muriago M, Angelini A, Daliento L, et al. Congenital heart disease and sudden death in the young. Hum Pathol. 1995; 26: 1065–72
   PubMedGoogle Scholar
• Wolfe RR, Driscoll DJ, Gersony WM, Hayes CJ, Keane JF, Kidd L, et al. Arrhythmias in patients with valvar aortic stenosis, valvar pulmonary stenosis, and ventricular septal defect: results of 24-hour ECG monitoring. Circulation. 1993; 87 suppl I: I89–101
   Google Scholar
• Von Olshausen KV, Schwarz F, Apfelbach J, Röhrig N, Krämer B, Kübler W. Determinants of the incidence and severity of ventricular arrhythmias in aortic valve disease. Am J Cardiol. 1983; 51: 1103–9
   Google Scholar
• Rodriguez-Revenga L, Badenas C, Carrió A, Milà M. Elastin mutation screening in a group of patients affected by vascular abnormalities. Pediatr Cardiol. 2005; 26: 827–31
   PubMed Web of Science ®Google Scholar
• Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO. Sudden death in young competitive athletes. Clinical, demographic, and pathologic profiles. JAMA. 1996; 276: 199–204
   PubMed Web of Science ®Google Scholar
• Peters S, Trummel M, Meyners W. Prevalence of right ventricular dysplasia: cardiomyopathy in a non-referral hospital. Int J Cardiol. 2004; 97: 499–501
   PubMed Web of Science ®Google Scholar
• Moric-Janiszewska E, Markiewicz-Loskot G. Review on the genetics of arrhythmogenic right ventricular dysplasia. Europace. 2007; 9: 259–66
   Google Scholar
• Green KJ, Gaudry CA. Are desmosomes more than tethers for intermediate filaments?. Nat Rev Mol Cell Biol. 2000; 1: 208–16
   PubMedGoogle Scholar
• Gerul B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, et al. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet. 2004; 36: 1162–4
   Google Scholar
• Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA. 2006; 296: 1593–601
   PubMed Web of Science ®Google Scholar
• Furlanello F, Bettini R, Bertoldi A, Vergara G, Visona L, Durante GB, et al. Arrhythmia patterns in athletes with arrhythmogenic right ventricular dysplasia. Eur Heart J. 1989; 10 Suppl D: 16–9
   Google Scholar
• Mazur A, Meisel S, Shotan A, Strasberg B. The mechanism of sudden death in the Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 2005; 16: 1393
   Google Scholar
• Chang ST, Chern MS. Sudden death in Wolff-Parkinson-White syndrome combined with syncope: a case report. Int J Clin Pract Suppl. 2005; 147: 15–18
   Google Scholar
• Shimizu W, Matsuo K, Kokubo Y, Satomi K, Kurita T, Noda T, et al. Sex hormone and gender difference—role of testosterone on male predominance in Brugada syndrome. J Cardiovasc Electrophysiol. 2007; 18: 415–21
   PubMed Web of Science ®Google Scholar
• Koopmann TT, Beekman L, Alders M, Meregalli PG, Mannens MM, Moorman AF, et al. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. Heart Rhythm. 2007; 4: 752–5
   Web of Science ®Google Scholar
• Rossenbacker T, Priori SG. The Brugada syndrome. Curr Opin Cardiol. 2007; 22: 163–70
   Google Scholar
• Jani S, Schweitzer P. The initial (earliest) report of polymorphous ventricular tachycardia. Ann Noninvasive Electrocardiol. 2006; 11: 281–3
   Google Scholar
• Leenhardt A, Lucet V, Denjoy I, Grau F, Ngoc DD, Coumel P. Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients. Circulation. 1995; 91: 1512–9
   PubMed Web of Science ®Google Scholar
• Laitinen PJ, Brown KM, Piippo K, Swan H, Devaney JM, Brahmbhatt B, et al. Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation. 2001; 103: 485–90
   PubMed Web of Science ®Google Scholar
• Lahat H, Pras E, Olender T, Avidan N, Ben-Asher E, Man O, et al. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am J Hum Genet. 2001; 69: 1378–84
   PubMed Web of Science ®Google Scholar
• Postma AV, Bhuiyan ZA, Bikker H. Molecular diagnostics of catecholaminergic polymorphic ventricular tachycardia using denaturing high-performance liquid chromatography and sequencing. Methods Mol Med. 2006; 126: 171–83
   Google Scholar
• Muller JE, Ludmer PL, Willich SN, Tofler GH, Aylmer G, Klangos I, et al. Circadian variation in the frequency of sudden cardiac death. Circulation. 1987; 75: 131–8
   PubMed Web of Science ®Google Scholar
• Kupari M, Koskinen P, Leinonen H. Double-peaking circadian variation in the occurrence of sustained supraventricular tachyarrhythmias. Am Heart J. 1990; 120: 1364–9
   PubMed Web of Science ®Google Scholar
• Willich SN, Levy D, Rocco MB, Tofler GH, Stone PH, Muller JE. Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study Population. Am J Cardiol. 1987; 60: 801–6
   PubMed Web of Science ®Google Scholar
• Arntz H-R, Willich SN, Schreiber C, Bruggemann T, Stern R, Schultheiß HP. Diurnal, weekly and seasonal variation of sudden Death. Eur Heart J. 2000; 21: 315–20
   PubMed Web of Science ®Google Scholar
• Friedmann, E, Thomas, SA, Liu, F, Morton, PG, Chapa, D, Gottlieb, SS; Sudden Cardiac Death in Heart Failure Trial Investigators. Relationship of depression, anxiety, and social isolation to chronic heart failure outpatient mortality. Am Heart J. 2006;152:940.e1–8.
   Google Scholar
• Lampert R, Shusterman V, Burg MM, Lee FA, Earley C, Goldberg A, et al. Effects of psychologic stress on repolarization and relationship to autonomic and hemodynamic factors. J Cardiovasc Electrophysiol. 2005; 16: 372–7
   PubMedGoogle Scholar
• Pignalberi C, Ricci R, Santini M. Psychological stress and sudden death. Ital Heart J Suppl. 2002; 3: 1011–21
   Google Scholar
• Philippsen C, Hahn M, Schwabe L, Richter S, Drewe J, Schachinger H. Cardiovascular reactivity to mental stress is not affected by alpha2-adrenoreceptor activation or inhibition. Psychopharmacology (Berl) 2007; 190: 181–8
   PubMed Web of Science ®Google Scholar
• Muller JE. Sexual activity as a trigger for cardiovascular events: what is the risk?. Am J Cardiol. 1999; 84: 2N–5N
   PubMed Web of Science ®Google Scholar
• Porres JM, Brugada J, Urbistondo V, Garcia F, Reviejo K, Marco P. Fever unmasking the Brugada syndrome. Pacing Clin Electrophysiol. 2002; 25: 1646–8
   PubMed Web of Science ®Google Scholar
• Shehab AM, MacFadyen RJ, McLaren M, Tavendale R, Belch JJ, Struthers AD. Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study. Heart. 2004; 90: 1263–8
   Google Scholar
• Bhagat K, Vallance P. Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation. 1997; 96: 3042–7
   PubMed Web of Science ®Google Scholar
• Uretsky BF, Thygesen K, Armstrong PW, Cleland JG, Horowitz JD, Massie BM, et al. Acute coronary findings at autopsy in heart failure patients with sudden death. Circulation. 2000; 102: 611–6
   PubMed Web of Science ®Google Scholar
• Albert CM, Ma J, Rifai N, Stampfer MJ, Ridker PM. Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation. 2002; 105: 2595–9
   PubMed Web of Science ®Google Scholar
• Bode F, Franz MR, Wilke I, Bonnemeier H, Schunkert H, Wiegand UK. Ventricular fibrillation induced by stretch pulse: implications for sudden death due to commotio cordis. J Cardiovasc Electrophysiol. 2006; 17: 1011–7
   Google Scholar
• Garan AR, Maron BJ, Wang PJ, Estes NA 3rd, Link MS. Role of streptomycin-sensitive stretch-activated channel in chest wall impact induced sudden death (commotio cordis). J Cardiovasc Electrophysiol. 2005; 16: 433–8
   PubMed Web of Science ®Google Scholar
• Li W, Kohl P, Trayanova N. Induction of ventricular arrhythmias following mechanical impact: a simulation study in 3D. J Mol Histol. 2004; 35: 679–86
   Google Scholar
• Link MS, Maron BJ, Wang PJ, VanderBrink BA, Zhu W, Estes NA 3rd. Upper and lower limits of vulnerability to sudden arrhythmic death with chest-wall impact (commotio cordis). J Am Coll Cardiol. 2003; 41: 99–104
   PubMed Web of Science ®Google Scholar
• Perticone F, Ceravolo R, Maio R, Cosco C, Mattioli PL. Heart rate variability and sudden infant death syndrome. Pacing Clin Electrophysiol. 1990; 13: 2096–9
   Google Scholar
• Moise NS, Moon PF, Flahive WJ, Brittain D, Pride HP, Lewis BA, et al. Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death. J Cardiovasc Electrophysiol. 1996; 7: 217–30
   Google Scholar
• Zipes, DP, Camm, AJ, Borggrefe, M, Buxton, AE, Chaitman, B, Fromer, M, , et al; American College of Cardiology/American Heart Association Task Force; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association; Heart Rhythm Society. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e385–484.
   PubMed Web of Science ®Google Scholar
• La Rovere MT, Pinna GD, Hohnloser SH, Marcus FI, Mortara A, Nohara R, et al. Barore?ex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet. 1998; 351: 478–84
   PubMed Web of Science ®Google Scholar
• Bednar MM, Harrigan EP, Ruskin JN. Torsades de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc. Am J Cardiol. 2002; 89: 1316–9
   PubMed Web of Science ®Google Scholar
• Titier K, Canal M, Deridet E, Abouelfath A, Gromb S, Molimard M, et al. Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice. Toxicol Appl Pharmacol. 2004; 199: 52–60
   PubMed Web of Science ®Google Scholar
• Cox RD, Koelliker DE, Bradley KG. Association between droperidol use and sudden death in two patients intoxicated with illicit stimulant drugs. Vet Hum Toxicol. 2004; 46: 21–3
   PubMedGoogle Scholar
• Kim KS, Shin WH, Park SJ, Kim EJ. Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarization. Int J Toxicol. 2007; 26: 25–31
   PubMed Web of Science ®Google Scholar
• Dhar R, Stout CW, Link MS, Homoud MK, Weinstock J, Estes NA 3rd. Cardiovascular toxicities of performance-enhancing substances in sports. Mayo Clin Proc. 2005; 80: 1307–15
   PubMed Web of Science ®Google Scholar
• Aouate P, Clerc J, Viard P, Seoud J. Propranolol intoxication revealing a Brugada syndrome. J Cardiovasc Electrophysiol. 2005; 16: 348–51
   Google Scholar
• Eckhardt LL, Rajamani S, January CT. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol. 2005; 145: 3–4
   PubMed Web of Science ®Google Scholar
• Kahila H, Saisto T, Kivitie-Kallio S, Haukkamaa M, Halmesmaki E. A prospective study on buprenorphine use during pregnancy: effects on maternal and neonatal outcome. Acta Obstet Gynecol Scand. 2007; 86: 185–90
   PubMed Web of Science ®Google Scholar
• Ehret GB, Desmeules JA, Broers B. Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology. Expert Opin Drug Saf. 2007; 6: 289–303
   PubMed Web of Science ®Google Scholar
• Heinemann A, Miyaishi S, Iwersen S, Schmoldt A, Puschel K. Body-packing as cause of unexpected sudden death. Forensic Sci Int. 1998; 92: 1–10
   PubMed Web of Science ®Google Scholar
• Pfeiffer H, Al Khaddam M, Brinkmann B, Kohler H, Beike J. Sudden death after isobutane sniffing: a report of two forensic cases. Int J Legal Med. 2005; 120: 168–73
   Google Scholar
• Scragg RK, Mitchell EA, Ford RP, Thompson JM, Taylor BJ, Stewart AW. Maternal cannabis use in the sudden death syndrome. Acta Paediatr. 2001; 90: 57–60
   Google Scholar
• Patel MM, Belson MG, Wright D, Lu H, Heninger M, Miller MA. Methylenedioxymethamphetamine (ecstasy)-related myocardial hypertrophy: an autopsy study. Resuscitation. 2005; 66: 197–202
   Web of Science ®Google Scholar
• De Letter EA, Piette MH, Lambert WE, Cordonnier JA. Amphetamines as potential inducers of fatalities: a review in the district of Ghent from 1976–2004. Med Sci Law. 2006; 46: 37–65
   PubMed Web of Science ®Google Scholar
• Hool LC. Acute hypoxia differentially regulates K(+) channels. Implications with respect to cardiac arrhythmia. Eur Biophys J. 2005; 34: 369–76
   Google Scholar
• Luqman N, Sung RJ, Wang CL, Kuo CT. Myocardial ischemia and ventricular fibrillation: Pathophysiology and clinical implications. Int J Cardiol. 2007; 119: 283–90
   PubMed Web of Science ®Google Scholar
• Rodriguez B, Trayanova N, Noble D. Modeling cardiac ischemia. Ann N Y Acad Sci. 2006; 1080: 395–414
   PubMed Web of Science ®Google Scholar
• Cascio WE, Yang H, Muller-Borer BJ, Johnson TA. Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation. J Electrocardiol. 2005; 38: 55–9
   PubMedGoogle Scholar
• Heller SR. Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome?. Int J Clin Pract Suppl. 2002; 129: 27–32
   Google Scholar
• El-Atat FA, McFarlane SI, Sowers JR, Bigger JT. Sudden cardiac death in patients with diabetes. Curr Diab Rep. 2004; 4: 187–93
   PubMedGoogle Scholar
• Singh JP, Larson MG, O'Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, et al. Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol. 2000; 86: 309–12
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xiao J, Wang H, Luo X, Wang J, Villeneuve LR, et al. Restoring depressed HERG K+ channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits. Am J Physiol Heart Circ Physiol. 2006; 291: H1446–55
   PubMed Web of Science ®Google Scholar
• Chen-Scarabelli C, Scarabelli TM. Suboptimal glycemic control, independently of QT interval duration, is associated with increased risk of ventricular arrhythmias in a high-risk population. Pacing Clin Electrophysiol. 2006; 29: 9–14
   Google Scholar
• Ahmed W, Flynn MA, Alpert MA. Cardiovascular complications of weight reduction diets. Am J Med Sci. 2001; 321: 280–4
   Google Scholar
• Fisler JS. Cardiac effects of starvation and semistarvation diets: safety and mechanisms of action. Am J Clin Nutr. 1992; 56 Suppl: 230S–4S
   Google Scholar
• Halle M, Wolfarth B. Sudden cardiac death in sports. MMW Fortschr Med. 2006; 148: 38–40
   Google Scholar
• Tanaka Y, Yoshinaga M, Anan R, Tanaka Y, Nomura Y, Oku S, et al. Usefulness and cost effectiveness of cardiovascular screening of young adolescents. Med Sci Sports Exerc. 2006; 38: 2–6
   Google Scholar
• Fuller CM, McNulty CM, Spring DA, Arger KM, Bruce SS, Chryssos BE, et al. Prospective screening of 5,615 high school athletes for risk of sudden cardiac death. Med Sci Sports Exerc. 1997; 29: 1131–8
   PubMed Web of Science ®Google Scholar
• Kusmirek SL, Gold MR. Sudden cardiac death: the role of risk stratification. Am Heart J. 2007; 153 Suppl: 25–33
   Google Scholar
• Zimetbaum PJ, Buxton AE, Batsford W, Fisher JD, Hafley GE, Lee KL, et al. Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial. Circulation. 2004; 110: 766–9
   PubMed Web of Science ®Google Scholar
• Corrado D, Pelliccia A, Bjornstad HH, Thiene G. Cardiovascular preparticipation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol: Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J. 2005; 26: 516–24
   PubMed Web of Science ®Google Scholar
• Leischik R, Dworrak B, Littwitz H, Gülker H. Prognostic significance of exercise stress echocardiography in 3329 outpatients (5-year longitudinal study). Int J Cardiol. 2007; 119: 297–305
   Google Scholar
• Coskun KO, Coskun ST, El Arousy M, Parsa MA, Beinert B, Kortke H, et al. Acute myocardial infarction in a young adult: a case report and literature review. ASAIO J. 2006; 52: 605–7
   Google Scholar
• Tapanainen JM, Lindgren KS, Mäkikallio TH, Vuolteenaho O, Leppäluoto J, Huikuri HV. Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era. J Am Coll Cardiol. 2004; 43: 757–6
   PubMed Web of Science ®Google Scholar
• Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, et al. Expert panel participating in a Duke's Center for the Prevention of Sudden Cardiac Death conference. Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. Am Heart J. 2007; 153: 941–50
   Google Scholar
• Arking DE, Chugh SS, Chakravarti A, Spooner PM. Genomics in sudden cardiac death. Circ Res. 2004; 94: 712–23
   Google Scholar
• Tomaselli GF, Zipes DP. What Causes Sudden Death in Heart Failure?. Circ Res. 2004; 95: 754–63
   PubMed Web of Science ®Google Scholar
• Harvard Medical School-Partners HealthCare Center for Genetics and Genomics. Available at: http://www.ageofpersonalizedmedicine.org/ (accessed 23 May 2007).
   Google Scholar
• Vincent GM. Role of DNA testing for diagnosis, management, and genetic screening in long QT syndrome, hypertrophic cardiomyopathy, and Marfan syndrome. Heart. 2001; 86: 12–14
   Google Scholar
• , Statement Development Group HRGarratt, CJ, Elliott, PM, Behr, E, Blair, E, Connelly, D, Cowan, C, , et al. Heart Rhythm UK Familial Sudden Death Syndromes Statement Development Group. Clinical Indications for Genetic Testing in Familial Sudden Cardiac Death Syndromes: an HRUK Position Statement. Heart. 2008;94:502–7.
   Google Scholar
• Kirchhof P, Breithardt G, Eckardt L. Primary prevention of sudden cardiac death. Heart. 2006; 92: 1873–8
   PubMed Web of Science ®Google Scholar
• Jouven X, Charles MA, Desnos M, Ducimetiere P. Circulating nonesterified fatty acid level as a predictive risk factor for sudden death in the population. Circulation. 2001; 104: 756–61
   PubMed Web of Science ®Google Scholar
• Jabbar R, Saldeen T. A new predictor of risk for sudden cardiac death. Ups J Med Sci. 2006; 111: 169–77
   PubMed Web of Science ®Google Scholar
• Desai AS, Fang JC, Maisel WH, Baughman KL. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials. JAMA. 2004; 292: 2874–9
   PubMed Web of Science ®Google Scholar
• Sukhija R, Mehta V, Leonardi M, Mehta JL. Implantable cardioverter defibrillators for prevention of sudden cardiac death. Clin Cardiol. 2007; 30: 3–8
   Google Scholar
• Bänsch D, Antz M, Boczor S, Volkmer M, Tebbenjohanns J, Seidl K, et al. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation. 2002; 105: 1453–8
   PubMed Web of Science ®Google Scholar