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Original Paper

Why do some individuals develop social phobia? A review with emphasis on the neurobiological influences

Pages 267-276 | Accepted 14 Mar 2003, Published online: 12 Jul 2009

References

  • Jefferys D. Social phobia. The most common anxiety disorder. Aust Fam Physician 1997;26:1064–7.
  • Herbert JD. An overview of the current status of social phobia. Appl Prey Psychol 1995;4:39–51.
  • Stemberger RT, Turner SM, Beidel DC, Calhoun KS. Social phobia: an analysis of possible developmental factors. J Abnorm Psychol 1995;104:525–31.
  • Ohman A. Rddsla, ângest, fobi. Lund, AS: Scandinavian University Press/Universitetsförlaget; 1994.
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV). Washington, DC: APA; 1994.
  • Furmark T, Tillfors M, Everz P-0, Marteinsdottir I, Gefvert 0, Fredrikson M. Social phobia in the general population: Pre-valence and sociodemographic profile. Soc Psychiatry Psychiatr Epidemiol 1999;34: 416–24.
  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Arch Gen Psychiatry 1994;51:8–19.
  • Lang AJ, Stein MB. Social phobia: Prevalence and diagnostic threshold. J Clin Psychiatry 2001;62:5–10.
  • Stein MB, Walker JR, Forde DR. Public-speaking fears in a community sample. Prevalence, impact on functioning and diagnostic classification. Arch Gen Psychiatry 1996;53:169–74.
  • Magee WJ, Eaton WW, Wittchen H-U, McGonagle KA, Kessler RC. Agoraphobia, simple phobia and social phobia in the National Comorbidity Survey. Arch Gen Psychiatry 1996;53:159–68.
  • Merikangas KR, Stevens DE, Fenton B, Stolar M, O'Malley S, Woods SW, et al. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 1998;4:773–88.
  • Moutier CY, Stein MB. The history, epidemiology, and differ-ential diagnosis of social anxiety disorder. J Clin Psychiatry 1999;60:4–8.
  • Stein MB, Torgrud LJ, Walker JR. Social phobia symptoms, subtypes, and severity: Findings from a community survey. Arch Gen Psychiatry 2000;57:1046–52.
  • Kessler RC, Stein MB, Berglund P. Social phobia subtypes in the National Comorbidity Survey. Am J Psychiatry 1998;155:613–9.
  • Bruce TJ, Saeed SA. Social anxiety disorder: A common under-recognized mental disorder. Am Fam Physician 1999;60:2311–20.
  • Liebowitz MR, Gorman JM, Fyer AJ, Klein DE Social phobia: Review of a neglected anxiety disorder. Arch Gen Psychiatry 1985;42:729–35.
  • Hudson JL, Rapee RM. The origins of social phobia. Behav Modif 2000;24:102–29.
  • Fyer AJ, Mannuzza S, Chapman TF, Liebowitz MR, Klein DE A direct interview family study of social phobia. Arch Gen Psychiatry 1993;50:286–93.
  • Kendler KS, Myers J, Prescott CA, Neale MC. The genetic epidemiology of irrational fears and phobias in men. Arch Gen Psychiatry 2001;58:257–65.
  • Fyer AJ, Mannuzza S, Chapman TF, Martin LY, Klein DE Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry 1995;52:564–73.
  • Mannuzza S, Schneier FR, Chapman TF, Liebowitz MR, Klein DF, Fyer AI Generalized social phobia. Reliability and validity. Arch Gen Psychiatry 1995;52:230–7.
  • Reich J, Yates W Family history of psychiatric disorders in social phobia. Compr Psychiat 1988;29:72–5.
  • Stein MB, Chartier MJ, Hazen AL, Kozak MV, Tancer ME, Lander S, et al. A direct-interview family study of generalized social phobia. Am J Psychiatry 1998;155:90–7.
  • Lieb R, Wittchen H-U, Höfler M, Fuetsch M, Stein MB, Merikangas KR. Parental psychopathology, parenting styles, and the risk of social phobia in offspring: A prospective-longitudinal community study. Arch Gen Psychiatry 2000;57:859–66.
  • Tillfors M, Furmark T, Ekselius L, Fredrikson M. Social phobia and avoidant personality disorder as related to parental history of social anxiety: A general population study. Behav Res Ther 2001;39:289–98.
  • Mancini C, Van Ameringen M, Szatmari P, Fugere C, Boyle M. A high-risk pilot study of the children of adults with social phobia. J Am Acad Child Psy 1996;35:1511–7.
  • Merikangas KR, Avenevoli S, Dierker L, Grillon C. Vulnerability factors among children at risk for anxiety disorders. Biol Psychiatry 1999;46:1523–35.
  • Cooper PJ, Eke M. Childhood shyness and maternal social phobia: A community study. Br J Psychiat 1999;174:439–43.
  • Skre I, Onstad S, Edvardsen J, Torgersen S, Kringlen E. A family study of anxiety disorders: Familial transmission and relationship to mood disorder and psychoactive substance use disorder. Acta Psychiatr Scand 1994;90:366–74.
  • Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves U. The genetic epidemiology of phobias in women. Arch Gen Psychiatry 1992;49:273–81.
  • Buss AH, Plomin R, Willerman L. The inheritance of personality traits. J Pers 1973;41:513–24.
  • Skre I, Onstad S, Torgersen S, Lygren S, Kringlen E. The heritability of common phobic fear: A twin study of a clinical sample. J Anxiety Disord 2000;14:549–62.
  • Daniels D, Plomin R. Origins of individual differences in infant shyness. Dev Psychol 1985;21:118–21.
  • Robinson JL, Kagan J, Reznick JS, Corley R. The heritability of inhibited and uninhibited behavior: A twin study. Dev Psychol 1992;28:1030–7.
  • Henderson ND. Human behavior genetics. Annu Rev Psychol 1982;33:403–40.
  • Andrews G, Stewart GW, Allen R, Hendersen AS. The genetics of six neurotic disorders: A twin study. J Affect Disorders 1990;19:23–9.
  • Andrews G, Stewart G, Morris-Yates A, Holt P, Henderson S. Evidence for a general neurotic syndrome. Br J Psychiatry 1990;157:6–12.
  • Torgersen S. Genetic factors in anxiety disorders. Arch Gen Psychiatry 1983;40:1085–9.
  • Stein MB, Chartier MJ, Lizak MV, Jang KJ. Familial aggregation of anxiety-related quantitative traits in generalized social phobia: Clues to understanding "disorder" heritability? Am J Med Genet 2001;105:79–83.
  • Davidson RJ, Ekman P. Afterword: How are emotions distin-guished from moods, temperament, and other related affective constructs? In: Ekman P, Davidson RJ, editors. The nature of emotion: Fundamental questions. Oxford: Oxford University Press; 1994. p. 95.
  • Kagan J, Reznick JS, Snidman N. Biological bases of childhood shyness. Science 1988;240:167–71.
  • Reznick JS, Kagan J, Snidman N, Gersten G, Baak K, Rosenberg A. Inhibited and uninhibited children: A follow-up study. Child Dev 1986;57:660–80.
  • Cloniger CR. Unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 1986;3:167–26.
  • Kagan J, Snidman N, Arcus D. On the temperamental categories of inhibited and unhibited children. In: Rubin KH, Asendorf J, editors. Social withdrawal, inhibition, and shyness in childhood. New Jersey: Lawrence Erlbaum Associates; 1993. p. 19–28.
  • Smoller JW, Tsuang MT. Panic and phobic anxiety: Defining phenotypes for genetic studies. Am J Psychiatry 1998;155:1152–62.
  • Turner SM, Beidel DC, Wolff PL. Is behavioral inhibition related to the anxiety disorders? Clin Psychol Rev 1996;16:157–72.
  • DiLalla LF, Kagan J, Reznick JS. Genetic etiology of behavioral inhibition among two-year-old children. Infant Behav Dev 1994;17:401–8.
  • Matheny AR Children's behavioral inhibition over age and across situations: Genetic similarity for a trait during change. J Pers 1989;57:215–35.
  • Rosenbaum JF, Biederman J, Hirshfeld DR, Bolduc EA, Kagan J, Snidman N, et al. Further evidence of an association between behavioral inhibition and anxiety disorders: Results from a family study of children from a nonclinical sample. J Psychiat Res 1991;25:49–65.
  • Rosenbaum JF, Biederman J, Bolduc EA, Faraone SV, Hirshfeld DR, Kagan J. Comorbidity of parental anxiety disorders as risk for childhood-onset anxiety in inhibited children. Am J Psychia-try 1992;149:475–81.
  • Biederman J, Rosenbaum JF, Bolduc-Murphy EA, Faraone SV, ChaloffJ, Hirshfeld D R, et al. A three year follow-up of children with and without behavioral inhibition. J Am Acad Child Psy 1993;32:814–21.
  • Biederman J, Hirshfeld-Becker DR, Rosenbaum JF, Hérot C, Fredman D, Snidman N, et al. Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry 2001;158:1673–9.
  • Mineka S, Zinbarg R. Conditioning and ethological models of social phobia. In: Heimberg RG, Liebowitz MR, Hope DA, Schneier FR, editors. Social phobia. Diagnosis, assessment and treatment. New York: The Guilford Press; 1995. p. 134–62.
  • Merckelbach H, de Jong PJ, Muris P, van den Hout MA. The etiology of specific phobias: A review. Clin Psychol Rev 1996;16:337–61.
  • Ost LG, Hugdahl K. Acquisition of phobias and anxiety response patterns in clinical patients. Behav Res Ther 1981;19:439–47.
  • Menzies RG, Clarke JC. The etiology of phobias: A nonassocia-tive account. Clin Psychol Rev 1995;15:23–48.
  • Seligman MEP. Phobias and preparedness. Behav Ther 1971;15:185–90.
  • Ohman A. Face the beast and fear the face: Animal and social fears as prototypes of evolutionary analyses of emotion. Psy-chophysiology 1986;23:123–45.
  • Ohman A, Dimberg U. Facial expressions as conditioned stimuli for electrodermal responses: A case of "preparedness"? J Pers Soc Psychol 1978;36:1251–8.
  • Bell CJ, Malizia AL, Nutt DJ. The neurobiology of social phobia. Eur Arch Psychiatry Clin Neurosci 1999;249:S11–8.
  • Potts NS, Book S, Davidson JRT. The neurobiology of social phobia. Int Clin Psychopharmacol 1996;11:43–8.
  • Tancer ME. Neurobiology of social phobia. J Clin Psychiatry 1993;54:26–30.
  • Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527–31.
  • Graeff FG, Guimaraes FS, De Andrade TGCS, Deakin JFW. Role of 5-HT in stress, anxiety and depression. Pharmacol Biochem Behav 1996;54:129–41.
  • Graeff FG, Viana MB, Mora PO. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav R 1997;21: 791–9.
  • Handley S. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol Ther 1995;66:103–48.
  • Stein DJ, Stahl S. Serotonin and anxiety: Current models. Int Clin Psychopharmacol 2000;15:S1–6.
  • Van Ameringen M, Mancini C, Oakman JM, Farvolden P. Selective serotonin reuptake inhibitors in the treatment of social phobia. The emerging gold standard. CNS Drugs 1999;11:307–15.
  • Mathew SJ, Coplan JD, Gorman JM. Neurobiological mechan-isms of social anxiety disorder. Am J Psychiatry 2001;158:1558–67.
  • Nutt DJ, Bell CJ, Malizia AL. Brain mechanisms of social anxiety disorder. J Clin Psychiatry 1998;59:4–9.
  • Stein MB. Neurobiological perspectives on social phobia: From affiliation to zoology. Biol Psychiatry 1998;44:1277–85.
  • Deakin JWF. Graeff FG. 5-HT and mechanisms of defence. J Psychopharmacol 1991;5:305–15.
  • Nickell PV, Uhde TW. Neurobiology of social phobia. In: Heimberg RG, Liebowitz MR, Hope DA, Schneier FR, editors. Social phobia. Diagnosis, assessment and treatment. New York: Guilford Press; 1995. p. 113–33.
  • Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, et al. Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 1998;155:373–9.
  • Raleigh MJ, McGuire MT, Brammer GL, Pollack DB, Yuwiler A. Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 1991;559:181–90.
  • Herbst JH, Zonderman AB, McCrae RR, Costa PT. Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. Am J Psychiatry 2000;157:1285–90.
  • Katsugari S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, et al. Association between serotonin transporter gene poly-morphism and anxiety-related traits. Biol Psychiatry 1999;45:368–70.
  • Ricketts M, Hamer R, Sage J, Manowitz P, Feng F, Menza M. Association of a serotonin transporter gene promoter poly-morphism with harm avoidance behavior in an elderly popula-tion. Psychiatr Genet 1998;8:41–4.
  • Ebstein R, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker R. No association between the serotonin transporter generegulatory region polymorphism and the Tridimensional Person-ality Questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 1997;2:224–6.
  • Gelernter J, Kranzler H, Coccaro E, Siever LJ, New AS. Serotonin transporter protein gene polymorphism and person-ality measures in African American and European American subjects. Am J Psychiatry 1998;155:1332–8.
  • Kumakiri C, Kodama K, Shimizu E, Yamanouchi N, Okada S, Noda S, et al. Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neurosci Lett 1999;263:205–7.
  • Mazzanti C, Lappalainen J, Long J, Bengel D, Naukkarinen H, Eggert M, et al. Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 1998;55:936–40.
  • Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297:400–3.
  • Lauterbach EC, Duvoisin RC. Anxiety disorders in familial Parkinsonism (letter). Am J Psychiatry 1987;148:1274.
  • Stein MB, Heuser IJ, Juncos JL, Uhde TW. Anxiety disorders in patients with Parkinson's disease. Am J Psychiatry 1990;147:217–20.
  • Tancer ME, Mailman RB, Stein MB, Mason GA, Carson SW, Golden RN. Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia. Anxiety 1994/ 1995;1:216–23.
  • Ebstein R, Novick 0, Umansky R, Priel B, Osher Y, Blaine D, et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 1996;12: 78–80.
  • Benjamin J, Li L, Patterson C, Greenberg B, Murphy D, Hamer D. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 1996;12:81–4.
  • Ebstein R, Nemanov L, Klotz I, Gritsenko I, Belmaker R. Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking. Mol Psychiatry 1997;2: 472–7.
  • Noble E, Ozkaragoz T, Ritchie T, Zhang X, Belin T, Sparks R. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 1998;81:257–67.
  • Ono Y, Manki H, Yoshimura K, Muramatsu T, Mizushima H, Higuchi S, et al. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. Am J Med Genet 1997;74:501–3.
  • Strobel A, Wehr A, Michel A, Brocke B. Association between dopamine D4 receptor (D4DR) exon III polymorphism and measures of novelty seeking in a German population. Mol Psychiatry 1999;4:378–84.
  • Ekelund J, Lichtermann D, Järvelin M-R, Peltonen L. Associa-tion between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am J Psychiatry 1999;156: 1453–5.
  • Gelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew C. D4 dopamine receptor (D4DR) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am J Hum Genet 1997;61:1144–52.
  • Kuhn K, Meyer K, Nöthen M, Gänsicke M, Papassotiropoulos A, Maier W. Allelic variants of dopamine receptor D4 (D4DR) and serotonin receptor 5HT2c (HTR2c) and temperament factors: Replication tests. Am J Med Genet 1999;88: 168–72.
  • Malhotra A, Virkkunen M, Rooney W, Eggert M, Linnoila M, Goldman D. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry 1996;1:388–91.
  • Pogue-Geile M, Ferrell R, Deka R, Debski T, Manuck S. Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: A twin and genetic association study. Am J Med Genet 1998;81: 44–8.275
  • Sander T, Harms H, Dufeu P, Kuhn S, Rommelspacher H, Schmidt L. Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics. Am J Med Genet 1997;74:483–7.
  • Sullivan PF, Fifield WI Kennedy MA, Mulder RT, Sellman JD, Joyce PR. No association between novelty seeking and the type 4 dopamine receptor gene (D4DR) in two New Zealand samples. Am J Psychiatry 1998;155:98–101.
  • Rowe DC, Stever C, Gard JMC, Cleveland HH, Sanders ML, Abramowitz A, et al. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behav Genet 1998;28:215–25.
  • Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, et al. Prediction of dopamine transporter binding availability by genotype: A preliminary report. Am J Psychiatry 2000;157: 1700–3.
  • Charney DS, Deutch A. Functional neuroanatomy of anxiety and fear: Implications for the pathophysiology and treatment of anxiety disorders. Crit Rev Neurobiol 1996;10:419–46.
  • Charney DS, Grillon C, Bremner JD. The neurobiological basis of anxiety and fear: Circuits, mechanisms and neurochemical interactions (part I). Neuroscientist 1998;4:35–44.
  • Davidson RI Jackson DC, Kahn NH. Emotion, plasticity, context, and regulation: Perspectives from affective neuroscience. Psychol Bull 2000;126:890–909.
  • Gorman JM, Kent JM, Sullivan GM, Coplan JD. Neuroanato-mical hypothesis of panic disorder, revised. Am J Psychiatry 2000;157:493–505.
  • LeDoux JE. The emotional brain: The mysterious underpinnings of emotional life. New York: Simon & Schuster; 1996.
  • Davidson RI Sutton SK. Affective neuroscience: the emergence of a discipline. Curr Opin Neurobiol 1995;5:217–24.
  • Tillfors M, Furmark T, Marteinsdottir I, Fischer H, Pissiota A, Längstrom B, Fredrikson M. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: A PET-study. Am J Psychiatry 2001;158:1220–6.
  • Davis M, Whalen PJ. The amygdala: Vigilance and emotion. Mol Psychiatry 2001;6:13–34.
  • Davidson RI Irwin W. The functional neuroanatomy of emotion and affective style. Trends Cognit Sci 1999;3:11–21.
  • Sutton SK, Davidson RI Prefrontal brain asymmetry: A biological substrate of the behavioral approach and inhibition systems. Psychol Sci 1997;8:204–9.
  • Van Ameringen M, Mancini C, Oakman JM, Kamath M, Nahmias C, Szechtman H. A pilot study of PET in social phobia. Biol Psychiatry 1998;43:315.
  • Davidson RI Marshall JR, Tomarken AI Henriques JB. While a phobic waits: Regional brain electrical and autonomic activity in social phobics during anticipation of public speaking. Biol Psychiatry 2000;47:85–95.
  • Tillfors M, Furmark T, Marteinsdottir I, Fredrikson M. Cerebral blood flow during anticipation of public speaking in social phobia: A PET study. Biol Psychiatry 2002;52:1113–9.
  • Birbaumer N, Grodd W, Diedrich 0, Klose U, Erb M, Lotze M, et al. fMRI reveals amygdala activation to human faces in social phobics. NeuroReport 1998;9:1223–6.
  • Veit R, Flor H, Erb M, Hermann C, Lotze M, Grodd W, et al. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 2002;328:233–6.
  • Schneider F, Weiss U, Kessler C, Müller-Gartner H-W, Posse S, Salloum JB, et al. Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry 1999;45:863–71.
  • Potts NLS, Davidson JRT, Krishnan KRR, Doraiswamy PM. Magnetic resonance imaging in social phobia. Psychiatry Res 1994;52:35–42.
  • Davidson JRT, Krishnan KRR, Charles HC, Boyko 0, Potts NLS, Ford SM, et al. Magnetic resonance spectroscopy in social phobia: Preliminary findings. J Chin Psychiatry 1993;54: 19–25.
  • Stein MB, Leslie WD. A brain single photon-emission computed tomography (SPECT) study of generalized social phobia. Biol Psychiatry 1996;39:825–8.
  • Tupler LA, Davidson JRT, Smith RD, Lazeyras F, Charles HC, Krishnan KRR. A repeat proton magnetic resonance spectro-scopy study in social phobia. Biol Psychiatry 1997;42:419–24.
  • Furmark T, Tillfors M, Marteinsdottir I, Fischer H, Pissiota A, Lângström, et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry 2002;59:425–33.
  • Reiman EM. The application of positron emission tomography to the study of normal and pathologic emotions. J Chin Psychiatry 1997;58:4–12.
  • Paradiso S, Johnson DL, Andreasen N C, O'Leary DS, Watkins GL, Boles Ponto LL, et al. Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant and neutral visual stimuli in a PET study of normal subjects. Am J Psychiatry 1999;156:1618–29.
  • Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin S-H, Laruelle M. Low dopamine D2 receptor binding potential in social phobia. Am J Psychiatry 2000;157: 457–9.
  • Tiihonen J, Kuikka J, Bergstrom K, Lepola U, Koponen H, Leinonen E. Dopamine reuptake site densities in patients with social phobia. Am J Psychiatry 1997;154:239–42.
  • Caldji C, Tannenbaum B, Sharma S, Francis D, Plotsky PM, Meaney MJ. Maternal care during infancy regulates the devel-opment of neural systems mediating the expression fearfulness in the rat. Proc Natl Acad Sci USA 1998;95:5335–40.
  • Francis DD, Meany MJ. Maternal care and the development of stress responses. Curr Opin Neurobiol 1999;9:128–34.
  • Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999;156:675–82.
  • Morgan MA, Romanski LM, LeDoux JE. Extinction of emo-tional learning: contribution of medial prefrontal cortex. Neu-rosci Lett 1993;163:109–13.
  • Thomas KM, Drevets WC, Whalen PI Eccard CH, Dahl RE, Ryan ND, et al. Amygdala response to facial expressions in children and adults. Biol Psychiatry 2001;49:309–16.

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