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Research Article

The serotonin transporter gene: Function and psychopathology

Pages 171-175 | Published online: 12 Jul 2009

References

  • Cloninger CR. Multilocus genetics of schizophre-nia. Curr Opin Psychiatry 1997;10:5–10.
  • Blackwood DHR, He L, Morris SW, McLean A, Whitton C, Thomson M, et al. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 1996;12:427–30.
  • Craddock N, Owen M, Burge S, Kurian B, Thomas P, McGuffin P. Familial cosegregation of major affective disorder and Darier's disease (Keratosis Follicularis). Br J Psychiatry 1994;164:355–8.
  • Ewald H, Mors 0, Flint T, Koed K, Eiberg H, Kruse TA. A possible locus for manic-depressive illness on chromosome 16p13. Psychiatr Genet 1995;5: 71–81.
  • Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, et al. Chromosome 18 DNA markers and manic-depressive illness: evi-dence for a susceptibility gene. Proc Natl Acad Sci USA 1994;91: 5918–21.
  • Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 1995;57:1384–94.
  • Freimer NB, Reus VI, Escamilla MA, McInnes LA, Spesny M, Leon P, et al. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet 1996;12:436–41.
  • Straub RE, Lehner T, Luo Y, Loth JE, Shao W, Sharpe L, et al. A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nat Genet 1994;8:291–6.
  • Pekkarinen P, Terwilliger J, Bredbacka PE, Lonn-qvist J, Peltonen L. Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Res 1995;5: 105–13.
  • Holmes C, Lovestone S. The molecular genetics of mood disorders. Curr Opin Psychiatry 1997;10:79–83.
  • Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the sero-tonin transporter. Clin Chem 1994;40:288–95.
  • McBride PA, Anderson GM, Shapiro T. Autism research. Bringing together approaches to pull apart the disorder. Arch Gen Psychiatry 1996;53:980–3.
  • Murphy DL. An overview of serotonin neurochem-istry and neuroanatomy. In: Sandler M, Coppen A, Harnett S, editors. 5-Hydroxytryptamine in psychi-atry. Oxford: Oxford University Press; 1991. pp. 23–34.
  • Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, et al. Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993;90: 2542–6.
  • Gelernter J, Pakstis AJ, Kidd KK. Linkage map-ping of serotonin transporter protein gene SLC6A4 on chromosome 17. Hum Genet 1995;95: 677–80.
  • Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, et al. Organization of the human serotonin transporter gene. J Neural Transm 1994;95:157–62.
  • Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 1995;37:215–23.
  • Di Bella D, Catalano M, Balling U, Smeraldi E, Lesch KP. Systematic screening for mutations in the coding region of the human serotonin trans-porter (5-HTT) gene using PCR and DGGE. Am J Med Genet (Neuropsychiatr Genet) 1996;67: 541–5.
  • Kelsoe JR, Remick RA, Sadovnick AD, Krist-bjarnarson H, Flodman P, Spence MA, et al. Ge-netic linkage study of bipolar disorder and the serotonin transporter. Am J Med Genet (Neu-ropsychiatr Genet) 1996;67:215–7.
  • Ewald H, Flint T, Degn B, Mors 0, Kruse TA. A functional variant of the serotonin transporter gene and families with bipolar affective disorder. J Affect Disord 1998;48:135–44.
  • Greenberg DA. Linkage analysis of "necessary" disease loci versus "susceptibility" loci. Am J Hum Genet 1993;52:135–43.
  • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273:1516–7.
  • Ogilvie AD, Battersby S, Bubb VJ, Fink G, Har-mar AJ, Goodwin GM, et al. Polymorphism in serotonin transporter gene associated with suscepti-bility to major depression. Lancet 1996;347:731–3.
  • Kunugi H, Tatsumi M, Sakai T, Hattori M, Nanko S. Serotonin transporter gene polymorphism and affective disorder. Lancet 1996;347:1340.
  • Stöber G, Heils A, Lesch KP. Serotonin trans-porter gene polymorphism and affective disorder. Lancet 1996;347:1340–1.
  • Bellivier F, Laplanche JL, Leboyer M, Feingold J, Bottos C, Allilaire JF, et al. Serotonin transporter gene and manic depressive illness: an association study. Biol Psychiatry 1997;41:750–2.
  • Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P, et al. The serotonin transporter is a potential susceptibility factor for bipolar affec-tive disorder. Neuroreport 1996;7:1675–9.
  • Battersby S, Ogilvie AD, Smith CAD, Blackwood DHR, Muir WJ, Quinn JP, et al. Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective dis-order. Psychiatr Genet 1996;6:177–81.
  • Khoury MJ, Beaty TH, Cohen BH. Fundamentals of genetic epidemiology. New York: Oxford Uni-versity Press; 1993.
  • Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. Allelic variation of human sero-tonin transporter gene expression. J Neurochem 1996;66:2621–4.
  • Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective dis-orders. Mol Psychiatry 1996;1:453–560.
  • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin trans-porter gene regulatory region. Science 1996;274: 1527–31.
  • Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoid-ance. Mol Psychiatry 1997;2:224–6.
  • Li T, Holmes C, Sham PC, Birkett J, Kirov G, Lesch KP, et al. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neurore-port 1997;8:1–5.
  • Cook EH Jr, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, et al. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 1997;2:247–50.

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