Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 38, 2009 - Issue 7
83
Views
13
CrossRef citations to date
0
Altmetric
Original

Macrolide Antibiotics Aggravate Experimental Autoimmune Encephalomyelitis and Inhibit Inducible Nitric Oxide Synthase

, , , &
Pages 602-612 | Published online: 19 Sep 2009

REFERENCES

  • Asano K., Kamakazu K., Hisamitsu T., Suzaki H. Suppressive activity of macrolide antibiotics on nitric oxide production from nasal polyp fibroblasts in vitro. Acta Otolaryngol. 2003; 123: 1064–1069
  • Bouwman J. J., Visseren F. L., Bevers L. M., van der Vlist W. E., Bouter K. P., Diepersloot R. J. Azithromycin reduces Chlamydia pneumoniae-induced attenuation of eNOS and cGMP production by endothelial cells. Eur. J. Clin. Invest. 2005; 35: 573–582
  • Cao X. Y., Dong M., Shen J. Z., Wu B. B., Wu C. M., Du X. D., Wang Z., Qi Y. T., Li B. Y. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. Int. J. Antimicrob. Agents 2006; 27: 431–438
  • Colasanti M, Suzuki H. The dual peronality of NO. Trends Pharmacol. Sci. 2000; 21: 249–252
  • Contini C., Cultrera R., Seraceni S., Castellazzi M., Granieri E., Fainardi E. Cerebrospinal fluid molecular demonstration of Chlamydia pneumoniae DNA is associated to clinical and brain magnetic resonance imaging activity in a subset of patients with relapsing-remitting multiple sclerosis. Mult. Scler. 2004; 10: 360–369
  • Cowden W. B., Cullen F. A., Staykova M. A., Willenborg D. O. Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE. J. Neuroimmunol 1998; 88: 1–8
  • Dalton D. K., Wittmer S. Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice. J. Neuroimmunol. 2005; 160: 110–121
  • Fainardi E., Castellazzi M., Seraceni S., Granieri E., Contini C. Under the microscope: Focus on Chlamydia pneumoniae infection and multiple sclerosis. Curr. Neurovasc. Res. 2008; 5: 60–70
  • Fenyk-Melody J. E., Garrison A. E., Brunnert S. R., Weidner J. R., Shen F., Shelton B. A., Mudgett J. S. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene. J. Immunol. 1998; 160: 2940–2946
  • Gao X., Ray R., Xiao Y., Ray P. Suppression of inducible nitric oxide synthase expression and nitric oxide production by macrolide antibiotics in sulfur mustard-exposed airway epithelial cells. Basic Clin. Pharmacol. Toxicol. 2008; 103: 255–261
  • Ianaro A., Ialenti A., Maffia P., Sautebin L., Rombolà L., Carnuccio R., Iuvone T., D'Acquisto F, Di Rosa M. Anti-inflammatory activity of macrolide antibiotics. J. Pharmacol. Exp. Ther. 2000; 292: 156–163
  • Kahl K. G., Schmidt H. H., Jung S., Sherman P., Toyka K. V., Zielasek J. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci. Lett. 2004; 358: 58–62
  • Kahl K. G., Zielasek J., Uttenthal L. O., Rodrigo J., Toyka K. V., Schmidt H. H. Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. J. Neurosci. Res. 2003; 73: 198–205
  • Khan A. A., Slifer T. R., Araujo F. G., Remington J. S. Effect of clarithromycin and azithromycin on production of cytokines by human monocytes. Int. J. Antimicrob. Agents. 1999; 11: 121–132
  • Lotter K., Höcherl K., Bucher M., Kees F. In vivo efficacy of telithromycin on cytokine and nitric oxide formation in lipopolysaccharide-induced acute systemic inflammation in mice. J. Antimicrob. Chemother. 2006; 58: 615–621
  • Mitsuyama T., Hidaka K., Furuno T., Hara N. Release of nitric oxide and expression of constitutive nitric oxide synthase of human endothelial cells: enhancement by a 14-membered ring macrolide. Mol. Cell Biochem. 1998; 181: 157–161
  • Persichini T, Cantoni O., Suzuki H., Colasanti M. Cross-talk between constitutive and inducible NO synthase: an update. Antioxid. Redox. Signal. 2006; 8: 949–954
  • Sahrbacher U. C., Lechner F., Eugster H. P., Frei K., Lassmann H., Fontana A. Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis. Eur. J. Immunol. 1998; 28: 1332–1338
  • Smith K. J., Lassmann H. The role of nitric oxide in multiple sclerosis. Lancet Neurol. 2002; 1: 232–241
  • Sriram S., Yao S. Y., Stratton C., Moses H., Narayana P. A., Wolinsky J. S. A pilot study to examine the effect of antibiotic therapy on MRI outcomes in relapsing remitting MS. J. Neurol. Sci. 2005; 234: 87–91
  • Staykova M. A., Fordham S. A., Bartell G. J., Cowden W. B., Willenborg D. O. Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis. J. Neuroimmunol 2006; 176: 1–8
  • Staykova M. A., Paridaen J. T., Cowden W. B., Willenborg D. O. Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis. Am. J. Pathol. 2005; 166: 147–157
  • Stratton C. W., Wheldon D. B. Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae. Trends Microbiol 2006; 14: 474–479
  • Tamaoki J., Kondo M., Kohri K., Aoshiba K., Tagaya E., Nagai A. Macrolide antibiotics protect against immune complex-induced lung injury in rats: role of nitric oxide from alveolar macrophages. J. Immunol. 1999; 163: 2909–2915
  • Teixeira S. A., Castro G. M., Papes F., Martins M. L., Rogério F., Langone F., Santos L. M., Arruda P., de Nucci G, Muscará M. N. Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. Brain Res. Mol. Brain. Res. 2002; 99: 17–25
  • Terao H., Asano K., Kanai K., Kyo Y., Watanabe S., Hisamitsu T., Suzaki H. Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice. Mediators Inflamm. 2003; 12: 195–202
  • Woessner R., Grauer M. T., Frese A., Bethke F., Ginger T., Hans A., Treib J. Long-term antibiotic treatment with roxithromycin in patients with multiple sclerosis. Infection 2006; 34: 342–344

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.